GO:0004477
JSON
methenyltetrahydrofolate cyclohydrolase activity
Molecular Function
Definition (GO:0004477 GONUTS page)
Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
formyl-methenyl-methylenetetrahydrofolate synthetase (combined) | related |
5,10-methenyl-THF cyclohydrolase activity | exact |
citrovorum factor cyclodehydrase activity | related |
5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing) | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q62226 | 10090 | SHH_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113 | |
NOT-qualified manual | protein | Q63673 | 10116 | SHH_RAT | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q91YD4 | 10090 | TRPM2_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q9NHA8 | 7227 | BGBP3_DROME | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.5.4.9 | |
MetaCyc | METHENYLTHFCYCLOHYDRO-RXN | |
RHEA | 23700 | |
Reactome | R-HSA-200661 | |
Reactome | R-HSA-200740 | |
Reactome | R-HSA-6801328 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:195366 | (6R)-10-formyltetrahydrofolate(2-) |
has_participant | CHEBI | CHEBI:57455 | (6R)-5,10-methenyltetrahydrofolate |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004477 based on ALL annotations
The top 100 of 299 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
methenyltetrahydrofolate cyclohydrolase activity
|
3,284.67 | 100.00 | 59,348 | 59,348 |
methylenetetrahydrofolate dehydrogenase (NADP+) activity
|
3,106.94 | 93.91 | 58,895 | 62,264 |
tetrahydrofolate interconversion
|
831.35 | 25.24 | 58,695 | 231,906 |
one-carbon metabolic process
|
479.82 | 14.46 | 55,467 | 379,709 |
L-histidine biosynthetic process
|
333.83 | 9.83 | 44,668 | 439,506 |
methionine biosynthetic process
|
331.84 | 9.83 | 46,478 | 460,052 |
purine nucleotide biosynthetic process
|
204.26 | 6.11 | 46,477 | 747,372 |
formate-tetrahydrofolate ligase activity
|
438.96 | 4.91 | 4,276 | 31,997 |
methylenetetrahydrofolate dehydrogenase (NAD+) activity
|
2,060.84 | 4.69 | 2,861 | 4,560 |
hydrolase activity
|
15.14 | 0.46 | 52,819 | 11,461,355 |
Totals | 553671 | 78785782 |
No co-occurrence statistics for GO:0004477 based on MANUAL annotations
The top 52 of 52 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
methenyltetrahydrofolate cyclohydrolase activity
|
3,999.38 | 100.00 | 323 | 323 |
methylenetetrahydrofolate dehydrogenase (NADP+) activity
|
3,999.38 | 100.00 | 323 | 323 |
tetrahydrofolate interconversion
|
1,972.13 | 49.24 | 322 | 653 |
methylenetetrahydrofolate dehydrogenase (NAD+) activity
|
2,666.25 | 11.66 | 40 | 60 |
formate-tetrahydrofolate ligase activity
|
1,384.40 | 2.65 | 9 | 26 |
phosphate ion binding
|
336.79 | 1.95 | 8 | 95 |
10-formyltetrahydrofolate biosynthetic process
|
740.63 | 1.45 | 5 | 27 |
folic acid biosynthetic process
|
639.90 | 1.16 | 4 | 25 |
serine family amino acid metabolic process
|
922.93 | 0.90 | 3 | 13 |
tetrahydrofolate metabolic process
|
53.12 | 0.83 | 7 | 527 |
Totals | 1446 | 948381 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | citrovorum factor cyclodehydrase activity |
2020-10-08 | Added | SYNONYM | 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing) |
2020-10-08 | Added | SYNONYM | formyl-methenyl-methylenetetrahydrofolate synthetase (combined) |
2020-10-08 | Deleted | SYNONYM | 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing) |
2020-10-08 | Deleted | SYNONYM | citrovorum factor cyclodehydrase activity |
2020-10-08 | Deleted | SYNONYM | formyl-methenyl-methylenetetrahydrofolate synthetase (combined) |
2019-04-01 | Deleted | XREF | reactome:R-HSA-200661 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6801328 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-200740 |
2019-04-01 | Added | XREF | Reactome:R-HSA-6801328 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | methenyltetrahydrofolate cyclohydrolase activity |
2002-02-06 | Updated | TERM | methenyltetrahydrofolate cyclohydrolase |
2001-04-03 | Updated | TERM | methenyltetrahydrofolate cyclohydrolase |
2001-03-30 | Added | TERM | methenyltetrahydrofolate cyclohydrolase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | citrovorum factor cyclodehydrase activity |
2020-10-08 | Added | SYNONYM | 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing) |
2020-10-08 | Added | SYNONYM | formyl-methenyl-methylenetetrahydrofolate synthetase (combined) |
2020-10-08 | Deleted | SYNONYM | 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing) |
2020-10-08 | Deleted | SYNONYM | citrovorum factor cyclodehydrase activity |
2020-10-08 | Deleted | SYNONYM | formyl-methenyl-methylenetetrahydrofolate synthetase (combined) |
2009-01-12 | Added | SYNONYM | 5,10-methenyl-THF cyclohydrolase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. |
2007-11-08 | Added | SYNONYM | formyl-methenyl-methylenetetrahydrofolate synthetase (combined) |
2007-11-08 | Added | SYNONYM | citrovorum factor cyclodehydrase activity |
2007-11-08 | Added | SYNONYM | 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing) |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0019238 (cyclohydrolase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Deleted | XREF | reactome:R-HSA-200661 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6801328 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-200740 |
2019-04-01 | Added | XREF | Reactome:R-HSA-6801328 |
2019-04-01 | Added | XREF | Reactome:R-HSA-200740 |
2019-04-01 | Added | XREF | Reactome:R-HSA-200661 |
2018-12-11 | Added | XREF | reactome:R-HSA-6801328 |
2018-12-11 | Added | XREF | reactome:R-HSA-200661 |
2018-12-11 | Added | XREF | reactome:R-HSA-200740 |
2018-07-13 | Deleted | XREF | RHEA:23703 |
2018-07-13 | Added | XREF | RHEA:23700 |
2011-09-16 | Added | XREF | RHEA:23703 |
2003-10-27 | Added | XREF | MetaCyc:METHENYLTHFCYCLOHYDRO-RXN |
2001-03-30 | Added | XREF | EC:3.5.4.9 |
Timestamp | Action | Category | Detail |
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