This term is obsolete.

GO:0004477 JSON

methenyltetrahydrofolate cyclohydrolase activity

Molecular Function

Definition (GO:0004477 GONUTS page)

Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.

59,644 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
formyl-methenyl-methylenetetrahydrofolate synthetase (combined) related
5,10-methenyl-THF cyclohydrolase activity exact
citrovorum factor cyclodehydrase activity related
5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing) related

Ancestor Chart

Ancestor chart for GO:0004477
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q91YD4 10090 TRPM2_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q9NHA8 7227 BGBP3_DROME GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089

Cross-references

Database ID Description
EC 3.5.4.9
MetaCyc METHENYLTHFCYCLOHYDRO-RXN
RHEA 23700
Reactome R-HSA-200661
Reactome R-HSA-200740
Reactome R-HSA-6801328

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:195366 (6R)-10-formyltetrahydrofolate(2-)
has_participant CHEBI CHEBI:57455 (6R)-5,10-methenyltetrahydrofolate

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004477 based on ALL annotations
The top 100 of 299 co-occurring terms
Co-occurring Term PR S% #Together #Compared
methenyltetrahydrofolate cyclohydrolase activity
3,284.67 100.00 59,348 59,348
methylenetetrahydrofolate dehydrogenase (NADP+) activity
3,106.94 93.91 58,895 62,264
tetrahydrofolate interconversion
831.35 25.24 58,695 231,906
one-carbon metabolic process
479.82 14.46 55,467 379,709
L-histidine biosynthetic process
333.83 9.83 44,668 439,506
methionine biosynthetic process
331.84 9.83 46,478 460,052
purine nucleotide biosynthetic process
204.26 6.11 46,477 747,372
formate-tetrahydrofolate ligase activity
438.96 4.91 4,276 31,997
methylenetetrahydrofolate dehydrogenase (NAD+) activity
2,060.84 4.69 2,861 4,560
hydrolase activity
15.14 0.46 52,819 11,461,355
Totals 553671 78785782
No co-occurrence statistics for GO:0004477 based on MANUAL annotations
The top 52 of 52 co-occurring terms
Co-occurring Term PR S% #Together #Compared
methenyltetrahydrofolate cyclohydrolase activity
3,999.38 100.00 323 323
methylenetetrahydrofolate dehydrogenase (NADP+) activity
3,999.38 100.00 323 323
tetrahydrofolate interconversion
1,972.13 49.24 322 653
methylenetetrahydrofolate dehydrogenase (NAD+) activity
2,666.25 11.66 40 60
formate-tetrahydrofolate ligase activity
1,384.40 2.65 9 26
phosphate ion binding
336.79 1.95 8 95
10-formyltetrahydrofolate biosynthetic process
740.63 1.45 5 27
folic acid biosynthetic process
639.90 1.16 4 25
serine family amino acid metabolic process
922.93 0.90 3 13
tetrahydrofolate metabolic process
53.12 0.83 7 527
Totals 1446 948381

Change Log

Timestamp Action Category Detail
2020-10-08 Added SYNONYM citrovorum factor cyclodehydrase activity
2020-10-08 Added SYNONYM 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)
2020-10-08 Added SYNONYM formyl-methenyl-methylenetetrahydrofolate synthetase (combined)
2020-10-08 Deleted SYNONYM 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)
2020-10-08 Deleted SYNONYM citrovorum factor cyclodehydrase activity
2020-10-08 Deleted SYNONYM formyl-methenyl-methylenetetrahydrofolate synthetase (combined)
2019-04-01 Deleted XREF reactome:R-HSA-200661
2019-04-01 Deleted XREF reactome:R-HSA-6801328
2019-04-01 Deleted XREF reactome:R-HSA-200740
2019-04-01 Added XREF Reactome:R-HSA-6801328
Timestamp Action Category Detail
2003-03-19 Updated TERM methenyltetrahydrofolate cyclohydrolase activity
2002-02-06 Updated TERM methenyltetrahydrofolate cyclohydrolase
2001-04-03 Updated TERM methenyltetrahydrofolate cyclohydrolase
2001-03-30 Added TERM methenyltetrahydrofolate cyclohydrolase
Timestamp Action Category Detail
2020-10-08 Added SYNONYM citrovorum factor cyclodehydrase activity
2020-10-08 Added SYNONYM 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)
2020-10-08 Added SYNONYM formyl-methenyl-methylenetetrahydrofolate synthetase (combined)
2020-10-08 Deleted SYNONYM 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)
2020-10-08 Deleted SYNONYM citrovorum factor cyclodehydrase activity
2020-10-08 Deleted SYNONYM formyl-methenyl-methylenetetrahydrofolate synthetase (combined)
2009-01-12 Added SYNONYM 5,10-methenyl-THF cyclohydrolase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.
2007-11-08 Added SYNONYM formyl-methenyl-methylenetetrahydrofolate synthetase (combined)
2007-11-08 Added SYNONYM citrovorum factor cyclodehydrase activity
2007-11-08 Added SYNONYM 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)
2002-11-27 Added DEFINITION Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0019238 (cyclohydrolase activity)
Timestamp Action Category Detail
2019-04-01 Deleted XREF reactome:R-HSA-200661
2019-04-01 Deleted XREF reactome:R-HSA-6801328
2019-04-01 Deleted XREF reactome:R-HSA-200740
2019-04-01 Added XREF Reactome:R-HSA-6801328
2019-04-01 Added XREF Reactome:R-HSA-200740
2019-04-01 Added XREF Reactome:R-HSA-200661
2018-12-11 Added XREF reactome:R-HSA-6801328
2018-12-11 Added XREF reactome:R-HSA-200661
2018-12-11 Added XREF reactome:R-HSA-200740
2018-07-13 Deleted XREF RHEA:23703
2018-07-13 Added XREF RHEA:23700
2011-09-16 Added XREF RHEA:23703
2003-10-27 Added XREF MetaCyc:METHENYLTHFCYCLOHYDRO-RXN
2001-03-30 Added XREF EC:3.5.4.9
Timestamp Action Category Detail
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