This term is obsolete.

GO:0004482 JSON

mRNA 5'-cap (guanine-N7-)-methyltransferase activity

Molecular Function

Definition (GO:0004482 GONUTS page)

Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.

39,183 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
guanine-7-methyltransferase activity related
S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity related
messenger ribonucleate guanine 7-methyltransferase activity related
S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity related
messenger RNA guanine 7-methyltransferase activity related

Ancestor Chart

Ancestor chart for GO:0004482
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A096MJ18 10116 A0A096MJ18_RAT GO:0008174 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A096MK97 10116 A0A096MK97_RAT GO:0008174 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A1W2Q633 10116 A0A1W2Q633_RAT GO:0008174 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5YBY9 10116 A0A8I5YBY9_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AGH5 10116 A0A8I6AGH5_RAT GO:0008168 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A2VDP2 9913 PCMD1_BOVIN GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A6HM36 10116 A6HM36_RAT GO:0008174 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6HM37 10116 A6HM37_RAT GO:0008174 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6JFH4 10116 A6JFH4_RAT GO:0008757 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
EC 2.1.1.56
InterPro IPR005009 Poxvirus mRNA capping enzyme, small subunit
InterPro IPR010311 Reovirus core-spike lambda-2
InterPro IPR011181 Protein VP3, rotavirus
InterPro IPR014023 Mononegavirales RNA-directed RNA polymerase catalytic domain
InterPro IPR014412 Genome polyprotein, Flavivirus
InterPro IPR016899 mRNA cap guanine-N7 methyltransferase, eukaryotes
InterPro IPR026490 mRNA cap 0/1 methyltransferase
InterPro IPR039753 mRNA cap guanine-N7 methyltransferase
InterPro IPR046435 NSP14, guanine-N7-methyltransferase domain, coronavirus

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004482 based on ALL annotations
The top 100 of 305 co-occurring terms
Co-occurring Term PR S% #Together #Compared
mRNA 5'-cap (guanine-N7-)-methyltransferase activity
5,000.74 100.00 38,982 38,982
RNA 5'-cap (guanine-N7)-methylation
4,861.07 97.21 38,982 40,102
mRNA (nucleoside-2'-O-)-methyltransferase activity
3,721.29 36.01 16,020 21,528
7-methylguanosine mRNA capping
1,585.16 31.70 38,982 122,977
induction by virus of host autophagy
1,837.98 19.08 11,070 30,119
symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
3,406.45 15.92 6,707 9,846
symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity
3,903.93 15.10 6,147 7,874
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
1,149.61 10.31 6,138 26,700
host cell endoplasmic reticulum-Golgi intermediate compartment
2,132.42 10.16 4,590 10,764
host cell perinuclear region of cytoplasm
1,180.40 9.75 5,552 23,521
Totals 865796 127099996
No co-occurrence statistics for GO:0004482 based on MANUAL annotations
The top 41 of 41 co-occurring terms
Co-occurring Term PR S% #Together #Compared
mRNA 5'-cap (guanine-N7-)-methyltransferase activity
7,257.30 100.00 178 178
7-methylguanosine mRNA capping
2,725.38 37.31 175 466
mRNA cap methyltransferase RNMT:RAMAC complex
3,907.78 3.80 7 13
snRNA 2,2,7-trimethylguanosine (TMG) capping
7,257.30 1.12 2 2
7-methylguanosine RNA capping
4,838.20 1.12 2 3
double membrane vesicle viral factory outer membrane
3,628.65 1.11 2 4
sno(s)RNA processing
1,451.46 1.08 2 10
RNA capping
1,451.46 1.08 2 10
5'-3' RNA helicase activity
806.37 1.03 2 18
mRNA capping enzyme complex
337.55 0.91 2 43
Totals 606 462142

Change Log

Timestamp Action Category Detail
2023-12-26 Added XREF Reactome:R-HSA-9830848
2023-08-12 Updated TERM mRNA 5'-cap (guanine-N7-)-methyltransferase activity
2020-12-17 Added XREF Reactome:R-HSA-9694737
2020-12-17 Added XREF Reactome:R-HSA-9694476
2020-12-17 Added XREF Reactome:R-HSA-9694492
2020-10-08 Deleted SYNONYM messenger ribonucleate guanine 7-methyltransferase activity
2020-10-08 Added SYNONYM S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity
2020-10-08 Added SYNONYM messenger ribonucleate guanine 7-methyltransferase activity
2020-10-08 Deleted SYNONYM S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity
2020-10-08 Deleted SYNONYM S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity
Timestamp Action Category Detail
2023-08-12 Updated TERM mRNA 5'-cap (guanine-N7-)-methyltransferase activity
2003-09-16 Updated TERM mRNA (guanine-N7-)-methyltransferase activity
2003-03-19 Updated TERM mRNA (guanine-N7)-methyltransferase activity
2002-02-06 Updated TERM mRNA (guanine-N7)-methyltransferase
2001-04-03 Updated TERM mRNA (guanine-N7)-methyltransferase
2001-03-30 Added TERM mRNA (guanine-N7)-methyltransferase
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM messenger ribonucleate guanine 7-methyltransferase activity
2020-10-08 Added SYNONYM S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity
2020-10-08 Added SYNONYM messenger ribonucleate guanine 7-methyltransferase activity
2020-10-08 Deleted SYNONYM S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity
2020-10-08 Deleted SYNONYM S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity
2020-10-08 Deleted SYNONYM messenger RNA guanine 7-methyltransferase activity
2020-10-08 Deleted SYNONYM guanine-7-methyltransferase activity
2020-10-08 Added SYNONYM S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity
2020-10-08 Added SYNONYM messenger RNA guanine 7-methyltransferase activity
2020-10-08 Added SYNONYM guanine-7-methyltransferase activity
2010-09-03 Deleted DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA; m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.
2010-09-03 Added DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.
2008-05-13 Added DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA; m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA; m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.
2007-11-08 Added SYNONYM S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity
2007-11-08 Added SYNONYM S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity
2007-09-06 Added SYNONYM guanine-7-methyltransferase activity
2007-09-06 Added SYNONYM messenger RNA guanine 7-methyltransferase activity
2007-09-06 Added SYNONYM messenger ribonucleate guanine 7-methyltransferase activity
2006-01-26 Updated DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA; m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.
2005-09-09 Updated DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA (mRNA containing an N7-methylguanine cap). R may be guanosine or adenosine.
2002-11-27 Added DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + G(5')PPPR-RNA = S-adenosyl-L-homocysteine + m7G(5')PPPR-RNA (mRNA containing an N7-methylguanine cap).
Timestamp Action Category Detail
2017-04-09 Added RELATION part of GO:0106005 (RNA 5'-cap (guanine-N7)-methylation)
2017-04-09 Deleted RELATION part of GO:0036265 (RNA (guanine-N7)-methylation)
2012-06-27 Added RELATION part of GO:0006370 (7-methylguanosine mRNA capping)
2012-06-27 Added RELATION part of GO:0036265 (RNA (guanine-N7)-methylation)
2008-04-01 Updated RELATION is a GO:0008170 (N-methyltransferase activity)
2008-04-01 Updated RELATION is a GO:0008174 (mRNA methyltransferase activity)
Timestamp Action Category Detail
2023-12-26 Added XREF Reactome:R-HSA-9830848
2020-12-17 Added XREF Reactome:R-HSA-9694737
2020-12-17 Added XREF Reactome:R-HSA-9694476
2020-12-17 Added XREF Reactome:R-HSA-9694492
2020-07-19 Added XREF Reactome:R-HSA-9684018
2020-07-19 Added XREF Reactome:R-HSA-9684017
2020-07-19 Added XREF Reactome:R-HSA-9684016
2019-04-01 Added XREF Reactome:R-HSA-77090
2019-04-01 Deleted XREF reactome:R-HSA-77090
2018-12-11 Added XREF reactome:R-HSA-77090
2009-05-21 Deleted XREF MetaCyc:MRNA-(GUANINE-N7-)-METHYLTRANSFERASE-RXN
2009-05-21 Added XREF MetaCyc:MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN
2003-10-27 Added XREF MetaCyc:MRNA-(GUANINE-N7-)-METHYLTRANSFERASE-RXN
2001-03-30 Added XREF EC:2.1.1.56
Timestamp Action Category Detail
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