GO:0004482
JSON
mRNA 5'-cap (guanine-N7-)-methyltransferase activity
Molecular Function
Definition (GO:0004482 GONUTS page)
Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
guanine-7-methyltransferase activity | related |
S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity | related |
messenger ribonucleate guanine 7-methyltransferase activity | related |
S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity | related |
messenger RNA guanine 7-methyltransferase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A096MJ18 | 10116 | A0A096MJ18_RAT | GO:0008174 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A096MK97 | 10116 | A0A096MK97_RAT | GO:0008174 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A1W2Q633 | 10116 | A0A1W2Q633_RAT | GO:0008174 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5YBY9 | 10116 | A0A8I5YBY9_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AGH5 | 10116 | A0A8I6AGH5_RAT | GO:0008168 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A2VDP2 | 9913 | PCMD1_BOVIN | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | A6HM36 | 10116 | A6HM36_RAT | GO:0008174 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6HM37 | 10116 | A6HM37_RAT | GO:0008174 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6JFH4 | 10116 | A6JFH4_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.1.1.56 | |
InterPro | IPR005009 | Poxvirus mRNA capping enzyme, small subunit |
InterPro | IPR010311 | Reovirus core-spike lambda-2 |
InterPro | IPR011181 | Protein VP3, rotavirus |
InterPro | IPR014023 | Mononegavirales RNA-directed RNA polymerase catalytic domain |
InterPro | IPR014412 | Genome polyprotein, Flavivirus |
InterPro | IPR016899 | mRNA cap guanine-N7 methyltransferase, eukaryotes |
InterPro | IPR026490 | mRNA cap 0/1 methyltransferase |
InterPro | IPR039753 | mRNA cap guanine-N7 methyltransferase |
InterPro | IPR046435 | NSP14, guanine-N7-methyltransferase domain, coronavirus |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004482 based on ALL annotations
The top 100 of 305 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
mRNA 5'-cap (guanine-N7-)-methyltransferase activity
|
5,000.74 | 100.00 | 38,982 | 38,982 |
RNA 5'-cap (guanine-N7)-methylation
|
4,861.07 | 97.21 | 38,982 | 40,102 |
mRNA (nucleoside-2'-O-)-methyltransferase activity
|
3,721.29 | 36.01 | 16,020 | 21,528 |
7-methylguanosine mRNA capping
|
1,585.16 | 31.70 | 38,982 | 122,977 |
induction by virus of host autophagy
|
1,837.98 | 19.08 | 11,070 | 30,119 |
symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
|
3,406.45 | 15.92 | 6,707 | 9,846 |
symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity
|
3,903.93 | 15.10 | 6,147 | 7,874 |
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
|
1,149.61 | 10.31 | 6,138 | 26,700 |
host cell endoplasmic reticulum-Golgi intermediate compartment
|
2,132.42 | 10.16 | 4,590 | 10,764 |
host cell perinuclear region of cytoplasm
|
1,180.40 | 9.75 | 5,552 | 23,521 |
Totals | 865796 | 127099996 |
No co-occurrence statistics for GO:0004482 based on MANUAL annotations
The top 41 of 41 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
mRNA 5'-cap (guanine-N7-)-methyltransferase activity
|
7,257.30 | 100.00 | 178 | 178 |
7-methylguanosine mRNA capping
|
2,725.38 | 37.31 | 175 | 466 |
mRNA cap methyltransferase RNMT:RAMAC complex
|
3,907.78 | 3.80 | 7 | 13 |
snRNA 2,2,7-trimethylguanosine (TMG) capping
|
7,257.30 | 1.12 | 2 | 2 |
7-methylguanosine RNA capping
|
4,838.20 | 1.12 | 2 | 3 |
double membrane vesicle viral factory outer membrane
|
3,628.65 | 1.11 | 2 | 4 |
sno(s)RNA processing
|
1,451.46 | 1.08 | 2 | 10 |
RNA capping
|
1,451.46 | 1.08 | 2 | 10 |
5'-3' RNA helicase activity
|
806.37 | 1.03 | 2 | 18 |
mRNA capping enzyme complex
|
337.55 | 0.91 | 2 | 43 |
Totals | 606 | 462142 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-26 | Added | XREF | Reactome:R-HSA-9830848 |
2023-08-12 | Updated | TERM | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
2020-12-17 | Added | XREF | Reactome:R-HSA-9694737 |
2020-12-17 | Added | XREF | Reactome:R-HSA-9694476 |
2020-12-17 | Added | XREF | Reactome:R-HSA-9694492 |
2020-10-08 | Deleted | SYNONYM | messenger ribonucleate guanine 7-methyltransferase activity |
2020-10-08 | Added | SYNONYM | S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity |
2020-10-08 | Added | SYNONYM | messenger ribonucleate guanine 7-methyltransferase activity |
2020-10-08 | Deleted | SYNONYM | S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity |
2020-10-08 | Deleted | SYNONYM | S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-08-12 | Updated | TERM | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
2003-09-16 | Updated | TERM | mRNA (guanine-N7-)-methyltransferase activity |
2003-03-19 | Updated | TERM | mRNA (guanine-N7)-methyltransferase activity |
2002-02-06 | Updated | TERM | mRNA (guanine-N7)-methyltransferase |
2001-04-03 | Updated | TERM | mRNA (guanine-N7)-methyltransferase |
2001-03-30 | Added | TERM | mRNA (guanine-N7)-methyltransferase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | messenger ribonucleate guanine 7-methyltransferase activity |
2020-10-08 | Added | SYNONYM | S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity |
2020-10-08 | Added | SYNONYM | messenger ribonucleate guanine 7-methyltransferase activity |
2020-10-08 | Deleted | SYNONYM | S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity |
2020-10-08 | Deleted | SYNONYM | S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity |
2020-10-08 | Deleted | SYNONYM | messenger RNA guanine 7-methyltransferase activity |
2020-10-08 | Deleted | SYNONYM | guanine-7-methyltransferase activity |
2020-10-08 | Added | SYNONYM | S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity |
2020-10-08 | Added | SYNONYM | messenger RNA guanine 7-methyltransferase activity |
2020-10-08 | Added | SYNONYM | guanine-7-methyltransferase activity |
2010-09-03 | Deleted | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA; m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine. |
2010-09-03 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA; m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA; m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine. |
2007-11-08 | Added | SYNONYM | S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity |
2007-11-08 | Added | SYNONYM | S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity |
2007-09-06 | Added | SYNONYM | guanine-7-methyltransferase activity |
2007-09-06 | Added | SYNONYM | messenger RNA guanine 7-methyltransferase activity |
2007-09-06 | Added | SYNONYM | messenger ribonucleate guanine 7-methyltransferase activity |
2006-01-26 | Updated | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA; m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine. |
2005-09-09 | Updated | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA (mRNA containing an N7-methylguanine cap). R may be guanosine or adenosine. |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + G(5')PPPR-RNA = S-adenosyl-L-homocysteine + m7G(5')PPPR-RNA (mRNA containing an N7-methylguanine cap). |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-04-09 | Added | RELATION | part of GO:0106005 (RNA 5'-cap (guanine-N7)-methylation) |
2017-04-09 | Deleted | RELATION | part of GO:0036265 (RNA (guanine-N7)-methylation) |
2012-06-27 | Added | RELATION | part of GO:0006370 (7-methylguanosine mRNA capping) |
2012-06-27 | Added | RELATION | part of GO:0036265 (RNA (guanine-N7)-methylation) |
2008-04-01 | Updated | RELATION | is a GO:0008170 (N-methyltransferase activity) |
2008-04-01 | Updated | RELATION | is a GO:0008174 (mRNA methyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-26 | Added | XREF | Reactome:R-HSA-9830848 |
2020-12-17 | Added | XREF | Reactome:R-HSA-9694737 |
2020-12-17 | Added | XREF | Reactome:R-HSA-9694476 |
2020-12-17 | Added | XREF | Reactome:R-HSA-9694492 |
2020-07-19 | Added | XREF | Reactome:R-HSA-9684018 |
2020-07-19 | Added | XREF | Reactome:R-HSA-9684017 |
2020-07-19 | Added | XREF | Reactome:R-HSA-9684016 |
2019-04-01 | Added | XREF | Reactome:R-HSA-77090 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-77090 |
2018-12-11 | Added | XREF | reactome:R-HSA-77090 |
2009-05-21 | Deleted | XREF | MetaCyc:MRNA-(GUANINE-N7-)-METHYLTRANSFERASE-RXN |
2009-05-21 | Added | XREF | MetaCyc:MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN |
2003-10-27 | Added | XREF | MetaCyc:MRNA-(GUANINE-N7-)-METHYLTRANSFERASE-RXN |
2001-03-30 | Added | XREF | EC:2.1.1.56 |
Timestamp | Action | Category | Detail |
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