This term is obsolete.

GO:0004521 JSON

RNA endonuclease activity

Molecular Function

Definition (GO:0004521 GONUTS page)

Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.

1,045,476 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
endonuclease G activity related
endoribonuclease activity exact

Ancestor Chart

Ancestor chart for GO:0004521
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004521

Child Term Relationship to
GO:0004521
GO:0033897
ribonuclease T2 activity
is_a
GO:1902380
positive regulation of endoribonuclease activity
positively_regulates
GO:1902555
endoribonuclease complex
capable_of
GO:0060698
endoribonuclease inhibitor activity
negatively_regulates
GO:0070578
RISC-loading complex
capable_of
GO:0016892
RNA endonuclease activity, producing 3'-phosphomonoesters
is_a
GO:0060699
regulation of endoribonuclease activity
regulates
GO:0000171
ribonuclease MRP activity
is_a
GO:0016891
RNA endonuclease activity, producing 5'-phosphomonoesters
is_a
GO:0060702
negative regulation of endoribonuclease activity
negatively_regulates

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0B4KFF6 7227 A0A0B4KFF6_DROME GO:0004518 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983
NOT-qualified manual protein A0A0G2K5G5 10116 A0A0G2K5G5_RAT GO:0004519 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5Y871 10116 A0A8I5Y871_RAT GO:0004521 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZP12 10116 A0A8I5ZP12_RAT GO:0004521 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A3V5 10116 A0A8I6A3V5_RAT GO:0004540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A4X4 10116 A0A8I6A4X4_RAT GO:0004521 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6ACW3 10116 A0A8I6ACW3_RAT GO:0004540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6G551 10116 A0A8I6G551_RAT GO:0004521 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6ISA8 10116 A6ISA8_RAT GO:0004521 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J211 10116 A6J211_RAT GO:0004519 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR000026 Guanine-specific ribonuclease N1-like
InterPro IPR001887 Barnase
InterPro IPR003212 DNA-binding protein 7a-e
InterPro IPR005229 Endoribonuclease YicC/YloC-like
InterPro IPR017117 Ribonuclease Nob1, eukaryote
InterPro IPR018998 EndoU ribonuclease, C-terminal
InterPro IPR020883 Type I toxin-antitoxin system, SymE toxin
InterPro IPR021127 CRISPR-associated endonuclease Cas2
InterPro IPR022597 Endoribonuclease antitoxin GhoS
InterPro IPR025911 ToxN/AbiQ toxin

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0006988 obsolete unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor consider GO:0004521
GO:0019000 obsolete endonuclease G activity consider GO:0004521
GO:0033168 obsolete conversion of ds siRNA to ss siRNA involved in RNA interference consider GO:0004521
GO:0036404 obsolete conversion of ds siRNA to ss siRNA consider GO:0004521
GO:1902360 obsolete conversion of ds siRNA to ss siRNA involved in gene silencing by small RNA consider GO:0004521

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004521 based on ALL annotations
The top 100 of 1,512 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0004521
RNA endonuclease activity
673.05 100.00 294,413 294,413
GO:0006402
mRNA catabolic process
205.93 15.00 66,917 218,708
GO:0016075
rRNA catabolic process
228.80 9.60 34,757 102,241
GO:0004519
endonuclease activity
54.21 7.67 181,576 2,254,459
GO:0004534
5'-3' RNA exonuclease activity
202.67 7.47 26,589 88,300
GO:0006364
rRNA processing
44.99 5.59 75,121 1,123,906
GO:0043571
maintenance of CRISPR repeat elements
194.45 4.92 16,480 57,041
GO:0042254
ribosome biogenesis
42.09 4.60 43,715 699,013
GO:0008995
ribonuclease E activity
638.05 4.00 11,813 12,461
GO:0033897
ribonuclease T2 activity
340.24 3.44 10,484 20,739
Totals 1723162 144276960
No co-occurrence statistics for GO:0004521 based on MANUAL annotations
The top 100 of 790 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0004521
RNA endonuclease activity
476.55 100.00 2,962 2,962
GO:0031047
regulatory ncRNA-mediated gene silencing
423.60 25.11 768 864
GO:0006401
RNA catabolic process
219.24 12.45 432 939
GO:0036464
cytoplasmic ribonucleoprotein granule
272.56 9.94 318 556
GO:1990604
IRE1-TRAF2-ASK1 complex
427.67 9.35 280 312
GO:0036498
IRE1-mediated unfolded protein response
298.76 9.07 284 453
GO:0035194
regulatory ncRNA-mediated post-transcriptional gene silencing
183.51 5.85 191 496
GO:0035198
miRNA binding
195.24 5.76 186 454
GO:0016442
RISC complex
194.27 5.61 181 444
GO:0070059
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
187.92 4.79 153 388
Totals 13385 583614

Change Log

Timestamp Action Category Detail
2023-05-20 Deleted RELATION part of GO:0090502 (obsolete RNA phosphodiester bond hydrolysis, endonucleolytic)
2023-04-24 Deleted RELATION has part GO:0098789 (obsolete pre-mRNA cleavage required for polyadenylation)
2023-04-02 Added XREF Reactome:R-HSA-9708812
2023-04-02 Added XREF Reactome:R-HSA-9708327
2022-12-18 Updated TERM RNA endonuclease activity
2022-12-18 Added SYNONYM endoribonuclease activity
2019-04-01 Added XREF Reactome:R-HSA-6814555
2019-04-01 Added XREF Reactome:R-HSA-5601887
2019-04-01 Deleted XREF reactome:R-HSA-9009941
2019-04-01 Added XREF Reactome:R-HSA-9023912
Timestamp Action Category Detail
2022-12-18 Updated TERM RNA endonuclease activity
2003-03-19 Updated TERM endoribonuclease activity
2002-02-06 Updated TERM endoribonuclease
2001-04-03 Updated TERM endoribonuclease
2001-03-30 Added TERM endoribonuclease
Timestamp Action Category Detail
2022-12-18 Added SYNONYM endoribonuclease activity
2011-04-10 Deleted SYNONYM endonuclease G activity
2011-04-10 Added SYNONYM endonuclease G activity
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
2007-09-26 Deleted SYNONYM unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor
2007-08-09 Deleted SYNONYM endonuclease G activity
2007-08-09 Added SYNONYM unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor
2007-08-09 Added SYNONYM endonuclease G activity
2007-08-09 Deleted SYNONYM unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor
2005-08-10 Added SYNONYM endonuclease G activity
2005-08-10 Added SYNONYM unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor
2002-11-27 Updated DEFINITION Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
2001-08-06 Added DEFINITION An enzyme that catalyzes the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
Timestamp Action Category Detail
2023-05-20 Deleted RELATION part of GO:0090502 (obsolete RNA phosphodiester bond hydrolysis, endonucleolytic)
2023-04-24 Deleted RELATION has part GO:0098789 (obsolete pre-mRNA cleavage required for polyadenylation)
2015-05-11 Added RELATION has part GO:0098789 (obsolete pre-mRNA cleavage required for polyadenylation)
2013-12-18 Added RELATION part of GO:0090502 (obsolete RNA phosphodiester bond hydrolysis, endonucleolytic)
2008-04-01 Updated RELATION is a GO:0004519 (endonuclease activity)
2008-04-01 Updated RELATION is a GO:0004540 (RNA nuclease activity)
Timestamp Action Category Detail
2023-04-02 Added XREF Reactome:R-HSA-9708812
2023-04-02 Added XREF Reactome:R-HSA-9708327
2019-04-01 Added XREF Reactome:R-HSA-6814555
2019-04-01 Added XREF Reactome:R-HSA-5601887
2019-04-01 Deleted XREF reactome:R-HSA-9009941
2019-04-01 Added XREF Reactome:R-HSA-9023912
2019-04-01 Deleted XREF reactome:R-HSA-9023909
2019-04-01 Deleted XREF reactome:R-HSA-426520
2019-04-01 Added XREF Reactome:R-HSA-426520
2019-04-01 Added XREF Reactome:R-HSA-9023909
2019-04-01 Added XREF Reactome:R-HSA-6791223
2019-04-01 Deleted XREF reactome:R-HSA-5601910
2019-04-01 Deleted XREF reactome:R-HSA-6791223
2019-04-01 Deleted XREF reactome:R-HSA-6814555
2019-04-01 Deleted XREF reactome:R-HSA-9009936
2019-04-01 Added XREF Reactome:R-HSA-9009941
2019-04-01 Deleted XREF reactome:R-HSA-5601887
2019-04-01 Added XREF Reactome:R-HSA-5601910
2019-04-01 Deleted XREF reactome:R-HSA-927836
2019-04-01 Deleted XREF reactome:R-HSA-425923
2019-04-01 Added XREF Reactome:R-HSA-927836
2019-04-01 Deleted XREF reactome:R-HSA-9023912
2019-04-01 Added XREF Reactome:R-HSA-9009936
2019-04-01 Added XREF Reactome:R-HSA-425923
2018-12-11 Added XREF reactome:R-HSA-9009936
2018-12-11 Added XREF reactome:R-HSA-6814555
2018-12-11 Added XREF reactome:R-HSA-6791223
2018-12-11 Added XREF reactome:R-HSA-5601910
2018-12-11 Added XREF reactome:R-HSA-5601887
2018-12-11 Added XREF reactome:R-HSA-9009941
2018-12-11 Added XREF reactome:R-HSA-927836
2018-12-11 Added XREF reactome:R-HSA-9023909
2018-12-11 Added XREF reactome:R-HSA-425923
2018-12-11 Added XREF reactome:R-HSA-9023912
2018-12-11 Added XREF reactome:R-HSA-426520
Timestamp Action Category Detail
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