GO:0004521
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RNA endonuclease activity
Molecular Function
Definition (GO:0004521 GONUTS page)
Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
endoribonuclease activity | exact |
endonuclease G activity | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004521
Child Term | Relationship to GO:0004521 |
---|---|
ribonuclease T2 activity
|
is_a |
RNA endonuclease activity, producing 5'-phosphomonoesters
|
is_a |
RISC-loading complex
|
capable_of |
negative regulation of endoribonuclease activity
|
negatively_regulates |
regulation of endoribonuclease activity
|
regulates |
endoribonuclease inhibitor activity
|
negatively_regulates |
ribonuclease MRP activity
|
is_a |
endoribonuclease complex
|
capable_of |
RNA endonuclease activity, producing 3'-phosphomonoesters
|
is_a |
positive regulation of endoribonuclease activity
|
positively_regulates |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0B4KFF6 | 7227 | A0A0B4KFF6_DROME | GO:0004518 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983 | |
NOT-qualified manual | protein | A0A0G2K5G5 | 10116 | A0A0G2K5G5_RAT | GO:0004519 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5Y871 | 10116 | A0A8I5Y871_RAT | GO:0004521 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZP12 | 10116 | A0A8I5ZP12_RAT | GO:0004521 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A3V5 | 10116 | A0A8I6A3V5_RAT | GO:0004540 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A4X4 | 10116 | A0A8I6A4X4_RAT | GO:0004521 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6ACW3 | 10116 | A0A8I6ACW3_RAT | GO:0004540 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6G551 | 10116 | A0A8I6G551_RAT | GO:0004521 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6ISA8 | 10116 | A6ISA8_RAT | GO:0004521 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J211 | 10116 | A6J211_RAT | GO:0004519 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR000026 | Guanine-specific ribonuclease N1-like |
InterPro | IPR001887 | Barnase |
InterPro | IPR003212 | DNA-binding protein 7a-e |
InterPro | IPR005229 | Endoribonuclease YicC/YloC-like |
InterPro | IPR017117 | Ribonuclease Nob1, eukaryote |
InterPro | IPR018998 | EndoU ribonuclease, C-terminal |
InterPro | IPR020883 | Type I toxin-antitoxin system, SymE toxin |
InterPro | IPR021127 | CRISPR-associated endonuclease Cas2 |
InterPro | IPR022597 | Endoribonuclease antitoxin GhoS |
InterPro | IPR025911 | ToxN/AbiQ toxin |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0006988 | obsolete unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor | consider GO:0004521 |
GO:0019000 | obsolete endonuclease G activity | consider GO:0004521 |
GO:0033168 | obsolete conversion of ds siRNA to ss siRNA involved in RNA interference | consider GO:0004521 |
GO:0036404 | obsolete conversion of ds siRNA to ss siRNA | consider GO:0004521 |
GO:1902360 | obsolete conversion of ds siRNA to ss siRNA involved in gene silencing by small RNA | consider GO:0004521 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004521 based on ALL annotations
The top 100 of 1,519 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
RNA endonuclease activity
|
625.92 | 100.00 | 311,444 | 311,444 |
mRNA catabolic process
|
188.98 | 14.28 | 66,396 | 219,909 |
rRNA catabolic process
|
214.74 | 9.11 | 34,377 | 100,199 |
endonuclease activity
|
56.34 | 8.56 | 198,402 | 2,204,272 |
rRNA processing
|
55.17 | 7.39 | 97,554 | 1,106,747 |
ribonuclease III activity
|
210.05 | 7.19 | 26,128 | 77,858 |
5'-3' RNA exonuclease activity
|
188.16 | 6.99 | 26,009 | 86,518 |
RNA processing
|
38.63 | 5.00 | 64,925 | 1,052,040 |
double-stranded RNA binding
|
75.22 | 4.88 | 23,665 | 196,918 |
maintenance of CRISPR repeat elements
|
181.38 | 4.64 | 16,316 | 56,304 |
Totals | 1982232 | 142594364 |
No co-occurrence statistics for GO:0004521 based on MANUAL annotations
The top 100 of 800 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
RNA endonuclease activity
|
484.00 | 100.00 | 2,669 | 2,669 |
RNA catabolic process
|
223.60 | 12.62 | 395 | 855 |
IRE1-TRAF2-ASK1 complex
|
465.60 | 9.44 | 253 | 263 |
IRE1-mediated unfolded protein response
|
407.58 | 9.42 | 256 | 304 |
cytoplasmic ribonucleoprotein granule
|
262.29 | 9.16 | 265 | 489 |
regulatory ncRNA-mediated post-transcriptional gene silencing
|
168.21 | 5.24 | 155 | 446 |
RISC complex
|
174.58 | 4.96 | 145 | 402 |
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
|
186.67 | 4.84 | 140 | 363 |
piRNA binding
|
422.60 | 4.36 | 117 | 134 |
single-stranded RNA binding
|
41.69 | 4.25 | 207 | 2,403 |
Totals | 10880 | 552313 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-05-20 | Deleted | RELATION | part of GO:0090502 (obsolete RNA phosphodiester bond hydrolysis, endonucleolytic) |
2023-04-24 | Deleted | RELATION | has part GO:0098789 (obsolete pre-mRNA cleavage required for polyadenylation) |
2023-04-02 | Added | XREF | Reactome:R-HSA-9708327 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9708812 |
2022-12-18 | Updated | TERM | RNA endonuclease activity |
2022-12-18 | Added | SYNONYM | endoribonuclease activity |
2019-04-01 | Added | XREF | Reactome:R-HSA-9009941 |
2019-04-01 | Added | XREF | Reactome:R-HSA-6814555 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5601910 |
2019-04-01 | Added | XREF | Reactome:R-HSA-9023912 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-12-18 | Updated | TERM | RNA endonuclease activity |
2003-03-19 | Updated | TERM | endoribonuclease activity |
2002-02-06 | Updated | TERM | endoribonuclease |
2001-04-03 | Updated | TERM | endoribonuclease |
2001-03-30 | Added | TERM | endoribonuclease |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-12-18 | Added | SYNONYM | endoribonuclease activity |
2011-04-10 | Added | SYNONYM | endonuclease G activity |
2011-04-10 | Deleted | SYNONYM | endonuclease G activity |
2008-05-13 | Added | DEFINITION | Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. |
2007-09-26 | Deleted | SYNONYM | unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor |
2007-08-09 | Deleted | SYNONYM | unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor |
2007-08-09 | Deleted | SYNONYM | endonuclease G activity |
2007-08-09 | Added | SYNONYM | unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor |
2007-08-09 | Added | SYNONYM | endonuclease G activity |
2005-08-10 | Added | SYNONYM | unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor |
2005-08-10 | Added | SYNONYM | endonuclease G activity |
2002-11-27 | Updated | DEFINITION | Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. |
2001-08-06 | Added | DEFINITION | An enzyme that catalyzes the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-05-20 | Deleted | RELATION | part of GO:0090502 (obsolete RNA phosphodiester bond hydrolysis, endonucleolytic) |
2023-04-24 | Deleted | RELATION | has part GO:0098789 (obsolete pre-mRNA cleavage required for polyadenylation) |
2015-05-11 | Added | RELATION | has part GO:0098789 (obsolete pre-mRNA cleavage required for polyadenylation) |
2013-12-18 | Added | RELATION | part of GO:0090502 (obsolete RNA phosphodiester bond hydrolysis, endonucleolytic) |
2008-04-01 | Updated | RELATION | is a GO:0004540 (RNA nuclease activity) |
2008-04-01 | Updated | RELATION | is a GO:0004519 (endonuclease activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-04-02 | Added | XREF | Reactome:R-HSA-9708327 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9708812 |
2019-04-01 | Added | XREF | Reactome:R-HSA-9009941 |
2019-04-01 | Added | XREF | Reactome:R-HSA-6814555 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5601910 |
2019-04-01 | Added | XREF | Reactome:R-HSA-9023912 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5601887 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-425923 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-9009941 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-426520 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-9023909 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-927836 |
2019-04-01 | Added | XREF | Reactome:R-HSA-426520 |
2019-04-01 | Added | XREF | Reactome:R-HSA-9023909 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5601910 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6791223 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6814555 |
2019-04-01 | Added | XREF | Reactome:R-HSA-6791223 |
2019-04-01 | Added | XREF | Reactome:R-HSA-927836 |
2019-04-01 | Added | XREF | Reactome:R-HSA-9009936 |
2019-04-01 | Added | XREF | Reactome:R-HSA-425923 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5601887 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-9009936 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-9023912 |
2018-12-11 | Added | XREF | reactome:R-HSA-5601887 |
2018-12-11 | Added | XREF | reactome:R-HSA-9009941 |
2018-12-11 | Added | XREF | reactome:R-HSA-927836 |
2018-12-11 | Added | XREF | reactome:R-HSA-426520 |
2018-12-11 | Added | XREF | reactome:R-HSA-9023912 |
2018-12-11 | Added | XREF | reactome:R-HSA-9023909 |
2018-12-11 | Added | XREF | reactome:R-HSA-425923 |
2018-12-11 | Added | XREF | reactome:R-HSA-9009936 |
2018-12-11 | Added | XREF | reactome:R-HSA-6814555 |
2018-12-11 | Added | XREF | reactome:R-HSA-6791223 |
2018-12-11 | Added | XREF | reactome:R-HSA-5601910 |
Timestamp | Action | Category | Detail |
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