This term is obsolete.

GO:0004521 JSON

RNA endonuclease activity

Molecular Function

Definition (GO:0004521 GONUTS page)

Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.

1,041,425 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
endoribonuclease activity exact
endonuclease G activity related

Ancestor Chart

Ancestor chart for GO:0004521
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004521

Child Term Relationship to
GO:0004521
ribonuclease T2 activity
is_a
RNA endonuclease activity, producing 5'-phosphomonoesters
is_a
RISC-loading complex
capable_of
negative regulation of endoribonuclease activity
negatively_regulates
regulation of endoribonuclease activity
regulates
endoribonuclease inhibitor activity
negatively_regulates
ribonuclease MRP activity
is_a
endoribonuclease complex
capable_of
RNA endonuclease activity, producing 3'-phosphomonoesters
is_a
positive regulation of endoribonuclease activity
positively_regulates

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0B4KFF6 7227 A0A0B4KFF6_DROME GO:0004518 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983
NOT-qualified manual protein A0A0G2K5G5 10116 A0A0G2K5G5_RAT GO:0004519 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5Y871 10116 A0A8I5Y871_RAT GO:0004521 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZP12 10116 A0A8I5ZP12_RAT GO:0004521 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A3V5 10116 A0A8I6A3V5_RAT GO:0004540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A4X4 10116 A0A8I6A4X4_RAT GO:0004521 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6ACW3 10116 A0A8I6ACW3_RAT GO:0004540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6G551 10116 A0A8I6G551_RAT GO:0004521 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6ISA8 10116 A6ISA8_RAT GO:0004521 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J211 10116 A6J211_RAT GO:0004519 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR000026 Guanine-specific ribonuclease N1-like
InterPro IPR001887 Barnase
InterPro IPR003212 DNA-binding protein 7a-e
InterPro IPR005229 Endoribonuclease YicC/YloC-like
InterPro IPR017117 Ribonuclease Nob1, eukaryote
InterPro IPR018998 EndoU ribonuclease, C-terminal
InterPro IPR020883 Type I toxin-antitoxin system, SymE toxin
InterPro IPR021127 CRISPR-associated endonuclease Cas2
InterPro IPR022597 Endoribonuclease antitoxin GhoS
InterPro IPR025911 ToxN/AbiQ toxin

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0006988 obsolete unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor consider GO:0004521
GO:0019000 obsolete endonuclease G activity consider GO:0004521
GO:0033168 obsolete conversion of ds siRNA to ss siRNA involved in RNA interference consider GO:0004521
GO:0036404 obsolete conversion of ds siRNA to ss siRNA consider GO:0004521
GO:1902360 obsolete conversion of ds siRNA to ss siRNA involved in gene silencing by small RNA consider GO:0004521

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004521 based on ALL annotations
The top 100 of 1,519 co-occurring terms
Co-occurring Term PR S% #Together #Compared
RNA endonuclease activity
625.92 100.00 311,444 311,444
mRNA catabolic process
188.98 14.28 66,396 219,909
rRNA catabolic process
214.74 9.11 34,377 100,199
endonuclease activity
56.34 8.56 198,402 2,204,272
rRNA processing
55.17 7.39 97,554 1,106,747
ribonuclease III activity
210.05 7.19 26,128 77,858
5'-3' RNA exonuclease activity
188.16 6.99 26,009 86,518
RNA processing
38.63 5.00 64,925 1,052,040
double-stranded RNA binding
75.22 4.88 23,665 196,918
maintenance of CRISPR repeat elements
181.38 4.64 16,316 56,304
Totals 1982232 142594364
No co-occurrence statistics for GO:0004521 based on MANUAL annotations
The top 100 of 800 co-occurring terms
Co-occurring Term PR S% #Together #Compared
RNA endonuclease activity
484.00 100.00 2,669 2,669
RNA catabolic process
223.60 12.62 395 855
IRE1-TRAF2-ASK1 complex
465.60 9.44 253 263
IRE1-mediated unfolded protein response
407.58 9.42 256 304
cytoplasmic ribonucleoprotein granule
262.29 9.16 265 489
regulatory ncRNA-mediated post-transcriptional gene silencing
168.21 5.24 155 446
RISC complex
174.58 4.96 145 402
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
186.67 4.84 140 363
piRNA binding
422.60 4.36 117 134
single-stranded RNA binding
41.69 4.25 207 2,403
Totals 10880 552313

Change Log

Timestamp Action Category Detail
2023-05-20 Deleted RELATION part of GO:0090502 (obsolete RNA phosphodiester bond hydrolysis, endonucleolytic)
2023-04-24 Deleted RELATION has part GO:0098789 (obsolete pre-mRNA cleavage required for polyadenylation)
2023-04-02 Added XREF Reactome:R-HSA-9708327
2023-04-02 Added XREF Reactome:R-HSA-9708812
2022-12-18 Updated TERM RNA endonuclease activity
2022-12-18 Added SYNONYM endoribonuclease activity
2019-04-01 Added XREF Reactome:R-HSA-9009941
2019-04-01 Added XREF Reactome:R-HSA-6814555
2019-04-01 Added XREF Reactome:R-HSA-5601910
2019-04-01 Added XREF Reactome:R-HSA-9023912
Timestamp Action Category Detail
2022-12-18 Updated TERM RNA endonuclease activity
2003-03-19 Updated TERM endoribonuclease activity
2002-02-06 Updated TERM endoribonuclease
2001-04-03 Updated TERM endoribonuclease
2001-03-30 Added TERM endoribonuclease
Timestamp Action Category Detail
2022-12-18 Added SYNONYM endoribonuclease activity
2011-04-10 Added SYNONYM endonuclease G activity
2011-04-10 Deleted SYNONYM endonuclease G activity
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
2007-09-26 Deleted SYNONYM unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor
2007-08-09 Deleted SYNONYM unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor
2007-08-09 Deleted SYNONYM endonuclease G activity
2007-08-09 Added SYNONYM unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor
2007-08-09 Added SYNONYM endonuclease G activity
2005-08-10 Added SYNONYM unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor
2005-08-10 Added SYNONYM endonuclease G activity
2002-11-27 Updated DEFINITION Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
2001-08-06 Added DEFINITION An enzyme that catalyzes the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
Timestamp Action Category Detail
2023-05-20 Deleted RELATION part of GO:0090502 (obsolete RNA phosphodiester bond hydrolysis, endonucleolytic)
2023-04-24 Deleted RELATION has part GO:0098789 (obsolete pre-mRNA cleavage required for polyadenylation)
2015-05-11 Added RELATION has part GO:0098789 (obsolete pre-mRNA cleavage required for polyadenylation)
2013-12-18 Added RELATION part of GO:0090502 (obsolete RNA phosphodiester bond hydrolysis, endonucleolytic)
2008-04-01 Updated RELATION is a GO:0004540 (RNA nuclease activity)
2008-04-01 Updated RELATION is a GO:0004519 (endonuclease activity)
Timestamp Action Category Detail
2023-04-02 Added XREF Reactome:R-HSA-9708327
2023-04-02 Added XREF Reactome:R-HSA-9708812
2019-04-01 Added XREF Reactome:R-HSA-9009941
2019-04-01 Added XREF Reactome:R-HSA-6814555
2019-04-01 Added XREF Reactome:R-HSA-5601910
2019-04-01 Added XREF Reactome:R-HSA-9023912
2019-04-01 Added XREF Reactome:R-HSA-5601887
2019-04-01 Deleted XREF reactome:R-HSA-425923
2019-04-01 Deleted XREF reactome:R-HSA-9009941
2019-04-01 Deleted XREF reactome:R-HSA-426520
2019-04-01 Deleted XREF reactome:R-HSA-9023909
2019-04-01 Deleted XREF reactome:R-HSA-927836
2019-04-01 Added XREF Reactome:R-HSA-426520
2019-04-01 Added XREF Reactome:R-HSA-9023909
2019-04-01 Deleted XREF reactome:R-HSA-5601910
2019-04-01 Deleted XREF reactome:R-HSA-6791223
2019-04-01 Deleted XREF reactome:R-HSA-6814555
2019-04-01 Added XREF Reactome:R-HSA-6791223
2019-04-01 Added XREF Reactome:R-HSA-927836
2019-04-01 Added XREF Reactome:R-HSA-9009936
2019-04-01 Added XREF Reactome:R-HSA-425923
2019-04-01 Deleted XREF reactome:R-HSA-5601887
2019-04-01 Deleted XREF reactome:R-HSA-9009936
2019-04-01 Deleted XREF reactome:R-HSA-9023912
2018-12-11 Added XREF reactome:R-HSA-5601887
2018-12-11 Added XREF reactome:R-HSA-9009941
2018-12-11 Added XREF reactome:R-HSA-927836
2018-12-11 Added XREF reactome:R-HSA-426520
2018-12-11 Added XREF reactome:R-HSA-9023912
2018-12-11 Added XREF reactome:R-HSA-9023909
2018-12-11 Added XREF reactome:R-HSA-425923
2018-12-11 Added XREF reactome:R-HSA-9009936
2018-12-11 Added XREF reactome:R-HSA-6814555
2018-12-11 Added XREF reactome:R-HSA-6791223
2018-12-11 Added XREF reactome:R-HSA-5601910
Timestamp Action Category Detail
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