This term is obsolete.
Note that triphosphate is used as a phosphate donor by at least one kinase.

GO:0004672 JSON

protein kinase activity

Molecular Function

Definition (GO:0004672 GONUTS page)

Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. PMID:25399640

Comments

Note that triphosphate is used as a phosphate donor by at least one kinase.

Secondary IDs

GO:0050222

13,085,199 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
protamine kinase activity narrow

Ancestor Chart

Ancestor chart for GO:0004672
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004672

Child Term Relationship to
GO:0004672
cyclin-dependent protein kinase activity
is_a
protein serine kinase activity (using GTP as donor)
is_a
protein serine/threonine kinase activity
is_a
protein histidine kinase activity
is_a
negative regulation of protein kinase activity
negatively_regulates
regulation of protein kinase activity
regulates
transmembrane receptor protein kinase activity
is_a
histidine phosphotransfer kinase activity
is_a
positive regulation of protein kinase activity
positively_regulates
protein kinase activator activity
positively_regulates

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A0B4K7S5 7227 A0A0B4K7S5_DROME GO:0004672 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514
NOT-qualified manual protein A0A126GUQ5 7227 A0A126GUQ5_DROME GO:0004672 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514
NOT-qualified manual protein A0A1L8END5 8355 A0A1L8END5_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8EV37 8355 A0A1L8EV37_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A4D6K026 7227 A0A4D6K026_DROME GO:0004672 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A0A6M3Q8Y2 7227 A0A6M3Q8Y2_DROME GO:0004672 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A8I3Q0M1 9615 A0A8I3Q0M1_CANLF GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I5ZTU0 10116 A0A8I5ZTU0_RAT GO:0004672 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZV82 10116 A0A8I5ZV82_RAT GO:0004672 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR000719 Protein kinase domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR008790 Poxvirus serine/threonine kinase
InterPro IPR010615 Herpesvirus UL97
InterPro IPR011104 HPr kinase/phosphorylase, C-terminal
InterPro IPR011126 HPr(Ser) kinase/phosphorylase, N-terminal
InterPro IPR014525 Ethylene receptor
InterPro IPR015725 Myosin Light Chain Kinase 1, Kinase domain

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0007182 obsolete common-partner SMAD protein phosphorylation consider GO:0004672
GO:0060389 obsolete pathway-restricted SMAD protein phosphorylation consider GO:0004672

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004672 based on ALL annotations
The top 100 of 9,183 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein kinase activity
103.03 100.00 1,923,254 1,923,254
protein serine/threonine kinase activity
65.36 43.71 1,123,632 1,771,135
histone H3T3 kinase activity
62.12 9.07 185,545 307,751
AMP-activated protein kinase activity
61.93 9.05 185,227 308,174
Rho-dependent protein serine/threonine kinase activity
61.52 9.00 184,297 308,645
histone H3T11 kinase activity
61.99 8.99 183,935 305,715
histone H3S10 kinase activity
61.98 8.99 183,935 305,781
histone H2AXS139 kinase activity
61.99 8.99 183,902 305,670
histone H2BS36 kinase activity
61.98 8.99 183,894 305,696
histone H3T6 kinase activity
61.97 8.99 183,891 305,760
Totals 12320994 188001504
No co-occurrence statistics for GO:0004672 based on MANUAL annotations
The top 100 of 4,324 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein kinase activity
134.59 100.00 10,488 10,488
signal transduction
21.48 12.44 3,779 23,676
regulation of innate immune response
103.09 8.90 959 1,252
protein phosphorylation
42.88 2.90 324 1,017
plasma membrane
3.76 2.67 4,049 144,998
meiotic sister chromatid cohesion, centromeric
83.02 2.14 227 368
mitotic spindle assembly checkpoint signaling
28.87 2.10 239 1,114
protein serine/threonine kinase activity
3.73 2.07 801 28,921
kinetochore
13.13 2.02 261 2,675
ATP binding
5.01 1.49 255 6,849
Totals 31837 952652

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_candida 86

Change Log

Timestamp Action Category Detail
2025-01-26 Deleted XREF Reactome:R-HSA-5693148
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Timestamp Action Category Detail
2003-03-19 Updated TERM protein kinase activity
2002-02-06 Updated TERM protein kinase
2001-04-03 Updated TERM protein kinase
2001-03-30 Added TERM protein kinase
Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
2008-05-12 Deleted DEFINITION Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
2007-10-25 Updated DEFINITION Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
2007-08-09 Added SYNONYM protamine kinase activity
2007-08-09 Deleted SYNONYM protamine kinase activity
2006-01-22 Added SYNONYM protamine kinase activity
2003-03-26 Added DEFINITION Catalysis of the transfer of a phosphate group, usually from ATP, to a protein substrate.
Timestamp Action Category Detail
2022-02-17 Deleted RELATION part of GO:0006468 (protein phosphorylation)
2017-09-19 Added RELATION is a GO:0140096 (catalytic activity, acting on a protein)
2011-06-03 Added RELATION part of GO:0006468 (protein phosphorylation)
2008-04-01 Updated RELATION is a GO:0016301 (kinase activity)
2008-04-01 Updated RELATION is a GO:0016773 (phosphotransferase activity, alcohol group as acceptor)
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2007-09-26 Deleted XREF EC:2.7.1.37
2003-11-05 Added XREF EC:2.7.1.37
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Timestamp Action Category Detail
2022-04-08 Deleted SUBSET goslim_aspergillus
2016-07-23 Deleted SUBSET goslim_metagenomics
2013-04-18 Updated SUBSET goslim_metagenomics
2013-04-18 Updated SUBSET goslim_candida
2013-04-18 Updated SUBSET goslim_aspergillus
2012-02-17 Added SUBSET goslim_metagenomics
2011-11-05 Added SUBSET goslim_aspergillus
2011-08-14 Deleted SUBSET goslim_yeast
2010-12-05 Deleted SUBSET goslim_generic
2008-06-09 Added SUBSET goslim_yeast
2008-06-09 Added SUBSET goslim_generic
2008-06-09 Added SUBSET goslim_candida
2006-01-22 Added SECONDARY GO:0050222 (protamine kinase activity)
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