This reaction requires the presence of a phosphatidylinositol-3-phosphate.
GO:0004676
JSON
3-phosphoinositide-dependent protein kinase activity
Molecular Function
Definition (GO:0004676 GONUTS page)
Phosphatidylinositol-3-phosphate-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
Comments
This reaction requires the presence of a phosphatidylinositol-3-phosphate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
| Synonym | Type |
|---|---|
| phosphatidylinositol-3-phosphate protein kinase activity | exact |
| PDK activity | related |
Ancestor Chart
Ancestor chart for GO:0004676
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
| Annotating to catalytic activities using the IPI evidence code | Link |
| Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
| Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
|---|---|---|---|---|---|---|---|
| IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
| NOT-qualified manual | protein | A0A0B4K7S5 | 7227 | A0A0B4K7S5_DROME | GO:0004672 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514 | |
| NOT-qualified manual | protein | A0A126GUQ5 | 7227 | A0A126GUQ5_DROME | GO:0004672 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514 | |
| NOT-qualified manual | protein | A0A1L8END5 | 8355 | A0A1L8END5_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | A0A1L8EV37 | 8355 | A0A1L8EV37_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | A0A1L8GLD7 | 8355 | A0A1L8GLD7_XENLA | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | A0A287AG10 | 9823 | A0A287AG10_PIG | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | A0A2I2UNM6 | 9685 | A0A2I2UNM6_FELCA | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | A0A2K5VFW3 | 9541 | A0A2K5VFW3_MACFA | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18508765 | |
| NOT-qualified manual | protein | A0A3B3IMS5 | 8090 | A0A3B3IMS5_ORYLA | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
| Database | ID | Description |
|---|---|---|
| EC | 2.7.11.1 | |
| Reactome | R-HSA-437195 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004676 based on ALL annotations
The top 100 of 5,109 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
3-phosphoinositide-dependent protein kinase activity
|
648.38 | 100.00 | 305,614 | 305,614 |
|
histone H3S57 kinase activity
|
648.38 | 99.99 | 305,570 | 305,570 |
|
histone H4S1 kinase activity
|
648.38 | 99.99 | 305,570 | 305,570 |
|
histone H2AS121 kinase activity
|
648.38 | 99.98 | 305,570 | 305,573 |
|
histone H2BS14 kinase activity
|
648.36 | 99.98 | 305,570 | 305,579 |
|
histone H2AS1 kinase activity
|
648.30 | 99.97 | 305,570 | 305,611 |
|
histone H3S28 kinase activity
|
648.18 | 99.95 | 305,570 | 305,668 |
|
histone H2AXS139 kinase activity
|
648.17 | 99.95 | 305,570 | 305,670 |
|
histone H3T45 kinase activity
|
648.17 | 99.95 | 305,570 | 305,672 |
|
histone H2BS36 kinase activity
|
648.12 | 99.94 | 305,570 | 305,696 |
| Totals | 7406149 | 44010498 | ||
No co-occurrence statistics for GO:0004676 based on MANUAL annotations
The top 69 of 69 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
3-phosphoinositide-dependent protein kinase activity
|
235,255.50 | 100.00 | 6 | 6 |
|
positive regulation of phospholipase activity
|
33,607.93 | 8.33 | 1 | 7 |
|
vascular endothelial cell response to laminar fluid shear stress
|
26,139.50 | 7.14 | 1 | 9 |
|
regulation of endothelial cell migration
|
10,942.12 | 4.26 | 2 | 43 |
|
regulation of mast cell degranulation
|
10,693.43 | 4.17 | 2 | 44 |
|
fungal-type cell wall organization or biogenesis
|
9,802.31 | 3.45 | 1 | 24 |
|
phospholipase activator activity
|
8,254.58 | 3.28 | 2 | 57 |
|
type B pancreatic cell development
|
6,032.19 | 2.44 | 2 | 78 |
|
phospholipase binding
|
5,668.81 | 2.30 | 2 | 83 |
|
positive regulation of vascular endothelial cell proliferation
|
5,535.42 | 2.25 | 2 | 85 |
| Totals | 125 | 806268 | ||
Change Log
- All changes
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- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
- Cross-references
- Other
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| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-08-16 | Added | XREF | EC:2.7.11.1 |
| 2020-11-03 | Added | DEFINITION | Phosphatidylinositol-3-phosphate-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. |
| 2020-11-03 | Deleted | DEFINITION | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a phosphatidylinositol-3-phosphate. |
| 2019-11-28 | Deleted | XREF | EC:2.7.11 |
| 2019-04-01 | Added | XREF | Reactome:R-HSA-437195 |
| 2019-04-01 | Deleted | XREF | reactome:R-HSA-437195 |
| 2018-12-11 | Added | XREF | reactome:R-HSA-437195 |
| 2016-10-03 | Added | XREF | EC:2.7.11 |
| 2016-10-03 | Deleted | XREF | EC:2.7.11.- |
| 2011-03-11 | Added | SYNONYM | PDK activity |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2003-03-19 | Updated | TERM | 3-phosphoinositide-dependent protein kinase activity |
| 2002-02-06 | Updated | TERM | 3-phosphoinositide-dependent protein kinase |
| 2001-04-03 | Updated | TERM | 3-phosphoinositide-dependent protein kinase |
| 2001-03-30 | Added | TERM | 3-phosphoinositide-dependent protein kinase |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2020-11-03 | Added | DEFINITION | Phosphatidylinositol-3-phosphate-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. |
| 2020-11-03 | Deleted | DEFINITION | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a phosphatidylinositol-3-phosphate. |
| 2011-03-11 | Added | SYNONYM | PDK activity |
| 2011-01-30 | Added | DEFINITION | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a phosphatidylinositol-3-phosphate. |
| 2011-01-30 | Deleted | DEFINITION | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a 3-phosphoinositide. |
| 2011-01-30 | Added | SYNONYM | phosphatidylinositol-3-phosphate protein kinase activity |
| 2010-09-24 | Added | DEFINITION | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a 3-phosphoinositide. |
| 2010-09-24 | Deleted | DEFINITION | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of a 3-phosphoinositide. |
| 2008-05-13 | Added | DEFINITION | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of a 3-phosphoinositide. |
| 2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of a 3-phosphoinositide. |
| 2006-01-24 | Updated | DEFINITION | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of a 3-phosphoinositide. |
| 2005-09-21 | Added | DEFINITION | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, dependent on the presence of a 3-phosphoinositide. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2008-04-01 | Updated | RELATION | is a GO:0004674 (protein serine/threonine kinase activity) |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-08-16 | Added | XREF | EC:2.7.11.1 |
| 2019-11-28 | Deleted | XREF | EC:2.7.11 |
| 2019-04-01 | Added | XREF | Reactome:R-HSA-437195 |
| 2019-04-01 | Deleted | XREF | reactome:R-HSA-437195 |
| 2018-12-11 | Added | XREF | reactome:R-HSA-437195 |
| 2016-10-03 | Added | XREF | EC:2.7.11 |
| 2016-10-03 | Deleted | XREF | EC:2.7.11.- |
| 2007-09-26 | Deleted | XREF | EC:2.7.1.- |
| 2007-09-26 | Added | XREF | EC:2.7.11.- |
| 2001-03-30 | Added | XREF | EC:2.7.1.- |
| Timestamp | Action | Category | Detail |
|---|
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