This term is obsolete.

GO:0004706 JSON

JUN kinase kinase kinase activity

Molecular Function

Definition (GO:0004706 GONUTS page)

Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs).

12,398 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
JNKKK exact
JNK kinase kinase activity related

Ancestor Chart

Ancestor chart for GO:0004706
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0004706 JUN kinase kinase kinase activity Never in Taxon 4751 Fungi
GO:0004706 JUN kinase kinase kinase activity Only in Taxon 2759 Eukaryota

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A0B4K7S5 7227 A0A0B4K7S5_DROME GO:0004672 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514
NOT-qualified manual protein A0A126GUQ5 7227 A0A126GUQ5_DROME GO:0004672 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514
NOT-qualified manual protein A0A1L8END5 8355 A0A1L8END5_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8EV37 8355 A0A1L8EV37_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8GLD7 8355 A0A1L8GLD7_XENLA GO:0004674 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A287AG10 9823 A0A287AG10_PIG GO:0004674 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2I2UNM6 9685 A0A2I2UNM6_FELCA GO:0004674 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2K5VFW3 9541 A0A2K5VFW3_MACFA GO:0004674 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18508765
NOT-qualified manual protein A0A3B3IMS5 8090 A0A3B3IMS5_ORYLA GO:0004674 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 2.7.11.25

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004706 based on ALL annotations
The top 100 of 778 co-occurring terms
Co-occurring Term PR S% #Together #Compared
JUN kinase kinase kinase activity
16,110.15 100.00 12,300 12,300
MAP kinase kinase kinase activity
3,758.29 19.03 6,250 26,791
positive regulation of signal transduction
6,571.67 10.02 1,442 3,535
positive regulation of defense response
4,938.58 10.01 1,591 5,190
MAPK cascade
1,322.98 8.04 9,792 119,239
JNK cascade
1,406.69 6.84 2,959 33,888
positive regulation of canonical NF-kappaB signal transduction
1,151.37 6.03 3,418 47,825
cellular response to cytokine stimulus
2,688.27 5.04 828 4,962
enzyme binding
546.59 2.73 1,506 44,388
positive regulation of apoptotic process
442.30 2.32 1,590 57,913
Totals 59061 1115312
No co-occurrence statistics for GO:0004706 based on MANUAL annotations
The top 100 of 379 co-occurring terms
Co-occurring Term PR S% #Together #Compared
JUN kinase kinase kinase activity
9,410.22 100.00 150 150
regulation of dopamine receptor signaling pathway
4,856.89 9.70 16 31
JNK cascade
820.46 7.39 49 562
regulation of cell projection organization
1,552.20 6.93 16 97
regulation of synaptic vesicle endocytosis
1,476.11 6.78 16 102
necroptotic signaling pathway
994.04 5.42 15 142
ERK1 and ERK2 cascade
721.09 5.12 20 261
positive regulation of programmed cell death
884.18 4.91 14 149
stress-activated MAPK cascade
941.02 4.87 13 130
ripoptosome assembly
4,391.44 4.43 7 15
Totals 845 12335

Change Log

Timestamp Action Category Detail
2024-12-05 Added CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
2024-08-16 Added XREF EC:2.7.11.25
2021-06-18 Added RELATION is a GO:0004709 (MAP kinase kinase kinase activity)
2021-06-18 Added DEFINITION Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs).
2021-06-18 Deleted DEFINITION OBSOLETE. Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs).
2021-06-18 Deleted OBSOLETION consider GO:0007254 (JNK cascade)
2021-06-18 Updated TERM JUN kinase kinase kinase activity
2021-06-18 Deleted OBSOLETION consider GO:0043539 (protein serine/threonine kinase activator activity)
2021-06-06 Added OBSOLETION consider GO:0007254 (JNK cascade)
Timestamp Action Category Detail
2021-06-18 Updated TERM JUN kinase kinase kinase activity
2021-06-06 Updated TERM obsolete JUN kinase kinase kinase activity
2003-04-15 Updated TERM JUN kinase kinase kinase activity
2003-04-12 Updated TERM JN kinase kinase kinase activity
2003-03-19 Updated TERM JNK kinase kinase activity
2002-02-06 Updated TERM JNK kinase kinase
2001-04-03 Updated TERM JNK kinase kinase
2001-03-30 Added TERM JNK kinase kinase
Timestamp Action Category Detail
2021-06-18 Added DEFINITION Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs).
2021-06-18 Deleted DEFINITION OBSOLETE. Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs).
2021-06-06 Added DEFINITION OBSOLETE. Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs).
2021-06-06 Deleted DEFINITION Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs).
2010-09-15 Deleted DEFINITION Catalysis of the phosphorylation and activation of JUN kinase kinases (JNKKs).
2010-09-15 Added DEFINITION Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs).
2008-05-13 Added DEFINITION Catalysis of the phosphorylation and activation of JUN kinase kinases (JNKKs).
2008-05-12 Deleted DEFINITION Catalysis of the phosphorylation and activation of JUN kinase kinases (JNKKs).
2007-08-09 Deleted SYNONYM JNKKK
2007-08-09 Added SYNONYM JNKKK
2007-08-09 Added SYNONYM JNK kinase kinase activity
2007-08-09 Deleted SYNONYM JNK kinase kinase activity
2004-04-19 Added SYNONYM JNKKK
2004-04-19 Added SYNONYM JNK kinase kinase activity
2004-04-16 Deleted SYNONYM JNKKK
2004-04-05 Deleted SYNONYM JNK kinase kinase activity
2003-04-12 Added DEFINITION Catalysis of the phosphorylation and activation of JUN kinase kinases (JNKKs).
2003-04-12 Added SYNONYM JNK kinase kinase activity
2001-03-30 Added SYNONYM JNKKK
Timestamp Action Category Detail
2021-06-18 Added RELATION is a GO:0004709 (MAP kinase kinase kinase activity)
2021-06-06 Deleted RELATION is a GO:0004709 (MAP kinase kinase kinase activity)
2021-06-06 Deleted RELATION part of GO:0007256 (obsolete activation of JNKK activity)
2012-01-29 Added RELATION part of GO:0007256 (obsolete activation of JNKK activity)
2008-04-01 Updated RELATION is a GO:0004709 (MAP kinase kinase kinase activity)
Timestamp Action Category Detail
2024-08-16 Added XREF EC:2.7.11.25
2019-11-28 Deleted XREF EC:2.7.11
2016-10-03 Added XREF EC:2.7.11
2016-10-03 Deleted XREF EC:2.7.11.-
2007-09-26 Added XREF EC:2.7.11.-
2007-09-26 Deleted XREF EC:2.7.1.-
2001-03-30 Added XREF EC:2.7.1.-
Timestamp Action Category Detail
2024-12-05 Added CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
2021-06-18 Deleted OBSOLETION consider GO:0007254 (JNK cascade)
2021-06-18 Deleted OBSOLETION consider GO:0043539 (protein serine/threonine kinase activator activity)
2021-06-06 Added OBSOLETION consider GO:0007254 (JNK cascade)
2021-06-06 Added OBSOLETION consider GO:0043539 (protein serine/threonine kinase activator activity)
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