GO:0004706
JSON
JUN kinase kinase kinase activity
Molecular Function
Definition (GO:0004706 GONUTS page)
Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs).
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
JNKKK | exact |
JNK kinase kinase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0004706 | JUN kinase kinase kinase activity | Never in Taxon | 4751 | Fungi | |
GO:0004706 | JUN kinase kinase kinase activity | Only in Taxon | 2759 | Eukaryota |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A0B4K7S5 | 7227 | A0A0B4K7S5_DROME | GO:0004672 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514 | |
NOT-qualified manual | protein | A0A126GUQ5 | 7227 | A0A126GUQ5_DROME | GO:0004672 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514 | |
NOT-qualified manual | protein | A0A1L8END5 | 8355 | A0A1L8END5_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1L8EV37 | 8355 | A0A1L8EV37_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1L8GLD7 | 8355 | A0A1L8GLD7_XENLA | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A287AG10 | 9823 | A0A287AG10_PIG | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2I2UNM6 | 9685 | A0A2I2UNM6_FELCA | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2K5VFW3 | 9541 | A0A2K5VFW3_MACFA | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18508765 | |
NOT-qualified manual | protein | A0A3B3IMS5 | 8090 | A0A3B3IMS5_ORYLA | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.7.11.25 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004706 based on ALL annotations
The top 100 of 778 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
JUN kinase kinase kinase activity
|
16,110.15 | 100.00 | 12,300 | 12,300 |
MAP kinase kinase kinase activity
|
3,758.29 | 19.03 | 6,250 | 26,791 |
positive regulation of signal transduction
|
6,571.67 | 10.02 | 1,442 | 3,535 |
positive regulation of defense response
|
4,938.58 | 10.01 | 1,591 | 5,190 |
MAPK cascade
|
1,322.98 | 8.04 | 9,792 | 119,239 |
JNK cascade
|
1,406.69 | 6.84 | 2,959 | 33,888 |
positive regulation of canonical NF-kappaB signal transduction
|
1,151.37 | 6.03 | 3,418 | 47,825 |
cellular response to cytokine stimulus
|
2,688.27 | 5.04 | 828 | 4,962 |
enzyme binding
|
546.59 | 2.73 | 1,506 | 44,388 |
positive regulation of apoptotic process
|
442.30 | 2.32 | 1,590 | 57,913 |
Totals | 59061 | 1115312 |
No co-occurrence statistics for GO:0004706 based on MANUAL annotations
The top 100 of 379 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
JUN kinase kinase kinase activity
|
9,410.22 | 100.00 | 150 | 150 |
regulation of dopamine receptor signaling pathway
|
4,856.89 | 9.70 | 16 | 31 |
JNK cascade
|
820.46 | 7.39 | 49 | 562 |
regulation of cell projection organization
|
1,552.20 | 6.93 | 16 | 97 |
regulation of synaptic vesicle endocytosis
|
1,476.11 | 6.78 | 16 | 102 |
necroptotic signaling pathway
|
994.04 | 5.42 | 15 | 142 |
ERK1 and ERK2 cascade
|
721.09 | 5.12 | 20 | 261 |
positive regulation of programmed cell death
|
884.18 | 4.91 | 14 | 149 |
stress-activated MAPK cascade
|
941.02 | 4.87 | 13 | 130 |
ripoptosome assembly
|
4,391.44 | 4.43 | 7 | 15 |
Totals | 845 | 12335 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-12-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
2024-08-16 | Added | XREF | EC:2.7.11.25 |
2021-06-18 | Added | RELATION | is a GO:0004709 (MAP kinase kinase kinase activity) |
2021-06-18 | Added | DEFINITION | Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs). |
2021-06-18 | Deleted | DEFINITION | OBSOLETE. Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs). |
2021-06-18 | Deleted | OBSOLETION | consider GO:0007254 (JNK cascade) |
2021-06-18 | Updated | TERM | JUN kinase kinase kinase activity |
2021-06-18 | Deleted | OBSOLETION | consider GO:0043539 (protein serine/threonine kinase activator activity) |
2021-06-06 | Added | OBSOLETION | consider GO:0007254 (JNK cascade) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-06-18 | Updated | TERM | JUN kinase kinase kinase activity |
2021-06-06 | Updated | TERM | obsolete JUN kinase kinase kinase activity |
2003-04-15 | Updated | TERM | JUN kinase kinase kinase activity |
2003-04-12 | Updated | TERM | JN kinase kinase kinase activity |
2003-03-19 | Updated | TERM | JNK kinase kinase activity |
2002-02-06 | Updated | TERM | JNK kinase kinase |
2001-04-03 | Updated | TERM | JNK kinase kinase |
2001-03-30 | Added | TERM | JNK kinase kinase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-06-18 | Added | DEFINITION | Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs). |
2021-06-18 | Deleted | DEFINITION | OBSOLETE. Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs). |
2021-06-06 | Added | DEFINITION | OBSOLETE. Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs). |
2021-06-06 | Deleted | DEFINITION | Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs). |
2010-09-15 | Deleted | DEFINITION | Catalysis of the phosphorylation and activation of JUN kinase kinases (JNKKs). |
2010-09-15 | Added | DEFINITION | Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs). |
2008-05-13 | Added | DEFINITION | Catalysis of the phosphorylation and activation of JUN kinase kinases (JNKKs). |
2008-05-12 | Deleted | DEFINITION | Catalysis of the phosphorylation and activation of JUN kinase kinases (JNKKs). |
2007-08-09 | Deleted | SYNONYM | JNKKK |
2007-08-09 | Added | SYNONYM | JNKKK |
2007-08-09 | Added | SYNONYM | JNK kinase kinase activity |
2007-08-09 | Deleted | SYNONYM | JNK kinase kinase activity |
2004-04-19 | Added | SYNONYM | JNKKK |
2004-04-19 | Added | SYNONYM | JNK kinase kinase activity |
2004-04-16 | Deleted | SYNONYM | JNKKK |
2004-04-05 | Deleted | SYNONYM | JNK kinase kinase activity |
2003-04-12 | Added | DEFINITION | Catalysis of the phosphorylation and activation of JUN kinase kinases (JNKKs). |
2003-04-12 | Added | SYNONYM | JNK kinase kinase activity |
2001-03-30 | Added | SYNONYM | JNKKK |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-06-18 | Added | RELATION | is a GO:0004709 (MAP kinase kinase kinase activity) |
2021-06-06 | Deleted | RELATION | is a GO:0004709 (MAP kinase kinase kinase activity) |
2021-06-06 | Deleted | RELATION | part of GO:0007256 (obsolete activation of JNKK activity) |
2012-01-29 | Added | RELATION | part of GO:0007256 (obsolete activation of JNKK activity) |
2008-04-01 | Updated | RELATION | is a GO:0004709 (MAP kinase kinase kinase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-08-16 | Added | XREF | EC:2.7.11.25 |
2019-11-28 | Deleted | XREF | EC:2.7.11 |
2016-10-03 | Added | XREF | EC:2.7.11 |
2016-10-03 | Deleted | XREF | EC:2.7.11.- |
2007-09-26 | Added | XREF | EC:2.7.11.- |
2007-09-26 | Deleted | XREF | EC:2.7.1.- |
2001-03-30 | Added | XREF | EC:2.7.1.- |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-12-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
2021-06-18 | Deleted | OBSOLETION | consider GO:0007254 (JNK cascade) |
2021-06-18 | Deleted | OBSOLETION | consider GO:0043539 (protein serine/threonine kinase activator activity) |
2021-06-06 | Added | OBSOLETION | consider GO:0007254 (JNK cascade) |
2021-06-06 | Added | OBSOLETION | consider GO:0043539 (protein serine/threonine kinase activator activity) |
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