Note that the bond resulting from this reaction is a carboxylic acid ester bond, linking the alpha carboxyl group of the amino acid to either the 2' or 3' hydroxyl of the 3'- terminal adenyl residue of the tRNA.
GO:0004812
JSON
aminoacyl-tRNA ligase activity
Molecular Function
Definition (GO:0004812 GONUTS page)
Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP.
Comments
Note that the bond resulting from this reaction is a carboxylic acid ester bond, linking the alpha carboxyl group of the amino acid to either the 2' or 3' hydroxyl of the 3'- terminal adenyl residue of the tRNA.
Secondary IDs
GO:0016876, GO:0017100
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
ligase activity, forming aminoacyl-tRNA and related compounds | broad |
aminoacyl-tRNA synthetase activity | exact |
aminoacyl-tRNA synthetase auxiliary protein activity | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004812
Child Term | Relationship to GO:0004812 |
---|---|
glutamine-tRNA ligase activity
|
is_a |
glutamate-tRNA ligase activity
|
is_a |
cysteine-tRNA ligase activity
|
is_a |
phosphoserine-tRNA(Cys) ligase activity
|
is_a |
asparagine-tRNA ligase activity
|
is_a |
aminoacyl-tRNA synthetase multienzyme complex
|
capable_of |
valine-tRNA ligase activity
|
is_a |
tyrosine-tRNA ligase activity
|
is_a |
tryptophan-tRNA ligase activity
|
is_a |
aspartate-tRNA ligase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5Y5Z6 | 10116 | A0A8I5Y5Z6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A2T0 | 10116 | A0A8I6A2T0_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6I4N6 | 10116 | A6I4N6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F7EEB9 | 10116 | F7EEB9_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q13426 | 9606 | XRCC4_HUMAN | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 6.1.1.- | |
InterPro | IPR000738 | WHEP-TRS domain |
InterPro | IPR000924 | Glutamyl/glutaminyl-tRNA synthetase |
InterPro | IPR001412 | Aminoacyl-tRNA synthetase, class I, conserved site |
InterPro | IPR002300 | Aminoacyl-tRNA synthetase, class Ia |
InterPro | IPR002305 | Aminoacyl-tRNA synthetase, class Ic |
InterPro | IPR002312 | Aspartyl/Asparaginyl-tRNA synthetase, class IIb |
InterPro | IPR002314 | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) |
InterPro | IPR002319 | Phenylalanyl-tRNA synthetase |
InterPro | IPR004115 | GAD-like domain superfamily |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004812 based on ALL annotations
The top 100 of 2,824 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
aminoacyl-tRNA ligase activity
|
154.33 | 100.00 | 1,263,165 | 1,263,165 |
tRNA aminoacylation for protein translation
|
153.76 | 30.05 | 379,950 | 381,347 |
aminoacyl-tRNA editing activity
|
124.10 | 20.04 | 266,171 | 331,001 |
aminoacyl-tRNA metabolism involved in translational fidelity
|
110.57 | 19.45 | 266,212 | 371,564 |
tRNA binding
|
47.38 | 18.37 | 396,615 | 1,291,960 |
catalytic activity, acting on a tRNA
|
153.52 | 10.25 | 129,502 | 130,182 |
translation
|
15.66 | 10.06 | 1,160,200 | 11,430,029 |
phenylalanine-tRNA ligase activity
|
136.93 | 8.47 | 108,147 | 121,889 |
phenylalanyl-tRNA aminoacylation
|
147.72 | 8.37 | 106,182 | 110,928 |
glutamyl-tRNA aminoacylation
|
154.12 | 7.65 | 96,688 | 96,820 |
Totals | 10811222 | 156542931 |
No co-occurrence statistics for GO:0004812 based on MANUAL annotations
The top 30 of 30 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
aminoacyl-tRNA ligase activity
|
215,299.84 | 100.00 | 6 | 6 |
tRNA aminoacylation for protein translation
|
18,454.27 | 7.89 | 3 | 35 |
ligase activity
|
2,909.46 | 1.27 | 1 | 74 |
mRNA 5'-UTR binding
|
1,668.99 | 0.75 | 1 | 129 |
threonyl-tRNA aminoacylation
|
1,588.93 | 0.73 | 2 | 271 |
threonine-tRNA ligase activity
|
1,560.14 | 0.71 | 2 | 276 |
tRNA aminoacylation
|
1,548.92 | 0.69 | 1 | 139 |
negative regulation of translational initiation
|
1,189.50 | 0.54 | 1 | 181 |
mRNA regulatory element binding translation repressor activity
|
1,076.50 | 0.49 | 1 | 200 |
tryptophanyl-tRNA aminoacylation
|
936.09 | 0.43 | 1 | 230 |
Totals | 50 | 434149 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-01-04 | Added | XREF | EC:6.1.1.- |
2021-01-04 | Deleted | XREF | EC:6.1.1 |
2020-02-28 | Deleted | XREF | MIPS_funcat:12.10 |
2020-02-07 | Added | XREF | EC:6.1.1 |
2019-05-04 | Added | XREF | MIPS_funcat:12.10 |
2019-03-16 | Deleted | XREF | EC:6.1.1 |
2017-11-22 | Added | RELATION | is a GO:0016875 (ligase activity, forming carbon-oxygen bonds) |
2017-10-22 | Added | SYNONYM | ligase activity, forming aminoacyl-tRNA and related compounds |
2017-10-22 | Deleted | RELATION | is a GO:0016876 (ligase activity, forming aminoacyl-tRNA and related compounds) |
2017-10-22 | Added | XREF | EC:6.1.1 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2006-02-19 | Updated | TERM | aminoacyl-tRNA ligase activity |
2003-03-19 | Updated | TERM | tRNA ligase activity |
2002-02-06 | Updated | TERM | tRNA ligase |
2001-04-03 | Updated | TERM | tRNA ligase |
2001-03-30 | Added | TERM | tRNA ligase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-10-22 | Added | SYNONYM | ligase activity, forming aminoacyl-tRNA and related compounds |
2010-10-31 | Added | SYNONYM | aminoacyl-tRNA synthetase auxiliary protein activity |
2010-10-08 | Deleted | DEFINITION | Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. |
2010-10-08 | Added | DEFINITION | Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. |
2008-05-13 | Added | DEFINITION | Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. |
2007-08-09 | Deleted | SYNONYM | aminoacyl-tRNA synthetase activity |
2007-08-09 | Added | SYNONYM | aminoacyl-tRNA synthetase activity |
2006-02-19 | Added | SYNONYM | aminoacyl-tRNA synthetase activity |
2002-11-27 | Updated | DEFINITION | Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. |
2001-08-06 | Added | DEFINITION | any enzyme of the subclasss EC 6.6.1 catalyzing the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-11-22 | Added | RELATION | is a GO:0016875 (ligase activity, forming carbon-oxygen bonds) |
2017-10-22 | Deleted | RELATION | is a GO:0016876 (ligase activity, forming aminoacyl-tRNA and related compounds) |
2017-09-19 | Added | RELATION | is a GO:0140101 (catalytic activity, acting on a tRNA) |
2008-04-01 | Updated | RELATION | is a GO:0016876 (ligase activity, forming aminoacyl-tRNA and related compounds) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-01-04 | Added | XREF | EC:6.1.1.- |
2021-01-04 | Deleted | XREF | EC:6.1.1 |
2020-02-28 | Deleted | XREF | MIPS_funcat:12.10 |
2020-02-07 | Added | XREF | EC:6.1.1 |
2019-05-04 | Added | XREF | MIPS_funcat:12.10 |
2019-03-16 | Deleted | XREF | EC:6.1.1 |
2017-10-22 | Added | XREF | EC:6.1.1 |
2017-10-16 | Deleted | XREF | EC:6.1.1 |
2016-10-03 | Added | XREF | EC:6.1.1 |
2016-10-03 | Deleted | XREF | EC:6.1.1.- |
2001-03-30 | Added | XREF | EC:6.1.1.- |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-10-22 | Added | SECONDARY | GO:0016876 (ligase activity, forming aminoacyl-tRNA and related compounds) |
2016-07-23 | Deleted | SUBSET | goslim_metagenomics |
2013-04-18 | Updated | SUBSET | goslim_metagenomics |
2012-02-17 | Added | SUBSET | goslim_metagenomics |
2010-10-31 | Added | SECONDARY | GO:0017100 (aminoacyl-tRNA synthetase auxiliary protein activity) |
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