This term is obsolete.
Note that the bond resulting from this reaction is a carboxylic acid ester bond, linking the alpha carboxyl group of the amino acid to either the 2' or 3' hydroxyl of the 3'- terminal adenyl residue of the tRNA.

GO:0004812 JSON

aminoacyl-tRNA ligase activity

Molecular Function

Definition (GO:0004812 GONUTS page)

Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP.

Comments

Note that the bond resulting from this reaction is a carboxylic acid ester bond, linking the alpha carboxyl group of the amino acid to either the 2' or 3' hydroxyl of the 3'- terminal adenyl residue of the tRNA.

Secondary IDs

GO:0016876, GO:0017100

2,659,351 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
aminoacyl-tRNA synthetase activity exact
ligase activity, forming aminoacyl-tRNA and related compounds broad
aminoacyl-tRNA synthetase auxiliary protein activity related

Ancestor Chart

Ancestor chart for GO:0004812
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004812

Child Term Relationship to
GO:0004812
tRNA ligase activator activity
positively_regulates
aminoacyl-tRNA synthetase multienzyme complex
capable_of
arginine-tRNA ligase activity
is_a
alanine-tRNA ligase activity
is_a
tryptophan-tRNA ligase activity
is_a
tyrosine-tRNA ligase activity
is_a
valine-tRNA ligase activity
is_a
glutamate-tRNA ligase activity
is_a
cysteine-tRNA ligase activity
is_a
phosphoserine-tRNA(Cys) ligase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5Y5Z6 10116 A0A8I5Y5Z6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A2T0 10116 A0A8I6A2T0_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6I4N6 10116 A6I4N6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F7EEB9 10116 F7EEB9_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q13426 9606 XRCC4_HUMAN GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 6.1.1.-
InterPro IPR000738 WHEP-TRS domain
InterPro IPR000924 Glutamyl/glutaminyl-tRNA synthetase
InterPro IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
InterPro IPR002300 Aminoacyl-tRNA synthetase, class Ia
InterPro IPR002305 Aminoacyl-tRNA synthetase, class Ic
InterPro IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb
InterPro IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
InterPro IPR002319 Phenylalanyl-tRNA synthetase
InterPro IPR004115 GAD-like domain superfamily

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004812 based on ALL annotations
The top 100 of 2,843 co-occurring terms
Co-occurring Term PR S% #Together #Compared
aminoacyl-tRNA ligase activity
155.12 100.00 1,277,409 1,277,409
tRNA aminoacylation for protein translation
154.55 30.13 385,323 386,749
aminoacyl-tRNA editing activity
124.48 20.10 270,129 336,632
aminoacyl-tRNA metabolism involved in translational fidelity
110.88 19.50 270,170 377,961
tRNA binding
47.41 18.36 402,154 1,315,720
catalytic activity, acting on a tRNA
154.32 10.27 131,244 131,926
translation
15.56 9.93 1,156,334 11,526,905
phenylalanine-tRNA ligase activity
137.49 8.49 109,636 123,695
phenylalanyl-tRNA aminoacylation
148.48 8.40 107,682 112,503
glutamyl-tRNA aminoacylation
154.91 7.66 97,902 98,038
Totals 10847909 159605198
No co-occurrence statistics for GO:0004812 based on MANUAL annotations
The top 30 of 30 co-occurring terms
Co-occurring Term PR S% #Together #Compared
aminoacyl-tRNA ligase activity
235,255.50 100.00 6 6
tRNA aminoacylation for protein translation
20,164.76 7.89 3 35
ligase activity
3,222.68 1.28 1 73
mRNA 5'-UTR binding
1,729.82 0.71 1 136
threonyl-tRNA aminoacylation
1,611.34 0.68 2 292
threonine-tRNA ligase activity
1,584.21 0.66 2 297
tRNA aminoacylation
1,589.56 0.65 1 148
negative regulation of translational initiation
1,271.65 0.53 1 185
mRNA regulatory element binding translation repressor activity
1,094.21 0.45 1 215
tryptophanyl-tRNA aminoacylation
960.23 0.40 1 245
Totals 50 466858

Change Log

Timestamp Action Category Detail
2021-01-04 Added XREF EC:6.1.1.-
2021-01-04 Deleted XREF EC:6.1.1
2020-02-28 Deleted XREF MIPS_funcat:12.10
2020-02-07 Added XREF EC:6.1.1
2019-05-04 Added XREF MIPS_funcat:12.10
2019-03-16 Deleted XREF EC:6.1.1
2017-11-22 Added RELATION is a GO:0016875 (ligase activity, forming carbon-oxygen bonds)
2017-10-22 Deleted RELATION is a GO:0016876 (ligase activity, forming aminoacyl-tRNA and related compounds)
2017-10-22 Added XREF EC:6.1.1
2017-10-22 Added SECONDARY GO:0016876 (ligase activity, forming aminoacyl-tRNA and related compounds)
Timestamp Action Category Detail
2006-02-19 Updated TERM aminoacyl-tRNA ligase activity
2003-03-19 Updated TERM tRNA ligase activity
2002-02-06 Updated TERM tRNA ligase
2001-04-03 Updated TERM tRNA ligase
2001-03-30 Added TERM tRNA ligase
Timestamp Action Category Detail
2017-10-22 Added SYNONYM ligase activity, forming aminoacyl-tRNA and related compounds
2010-10-31 Added SYNONYM aminoacyl-tRNA synthetase auxiliary protein activity
2010-10-08 Deleted DEFINITION Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP.
2010-10-08 Added DEFINITION Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP.
2008-05-13 Added DEFINITION Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP.
2008-05-12 Deleted DEFINITION Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP.
2007-08-09 Added SYNONYM aminoacyl-tRNA synthetase activity
2007-08-09 Deleted SYNONYM aminoacyl-tRNA synthetase activity
2006-02-19 Added SYNONYM aminoacyl-tRNA synthetase activity
2002-11-27 Updated DEFINITION Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP.
2001-08-06 Added DEFINITION any enzyme of the subclasss EC 6.6.1 catalyzing the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP.
Timestamp Action Category Detail
2017-11-22 Added RELATION is a GO:0016875 (ligase activity, forming carbon-oxygen bonds)
2017-10-22 Deleted RELATION is a GO:0016876 (ligase activity, forming aminoacyl-tRNA and related compounds)
2017-09-19 Added RELATION is a GO:0140101 (catalytic activity, acting on a tRNA)
2008-04-01 Updated RELATION is a GO:0016876 (ligase activity, forming aminoacyl-tRNA and related compounds)
Timestamp Action Category Detail
2021-01-04 Added XREF EC:6.1.1.-
2021-01-04 Deleted XREF EC:6.1.1
2020-02-28 Deleted XREF MIPS_funcat:12.10
2020-02-07 Added XREF EC:6.1.1
2019-05-04 Added XREF MIPS_funcat:12.10
2019-03-16 Deleted XREF EC:6.1.1
2017-10-22 Added XREF EC:6.1.1
2017-10-16 Deleted XREF EC:6.1.1
2016-10-03 Added XREF EC:6.1.1
2016-10-03 Deleted XREF EC:6.1.1.-
2001-03-30 Added XREF EC:6.1.1.-
Timestamp Action Category Detail
2017-10-22 Added SECONDARY GO:0016876 (ligase activity, forming aminoacyl-tRNA and related compounds)
2016-07-23 Deleted SUBSET goslim_metagenomics
2013-04-18 Updated SUBSET goslim_metagenomics
2012-02-17 Added SUBSET goslim_metagenomics
2010-10-31 Added SECONDARY GO:0017100 (aminoacyl-tRNA synthetase auxiliary protein activity)
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