GO:0004824
JSON
lysine-tRNA ligase activity
Molecular Function
Definition (GO:0004824 GONUTS page)
Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
lysyl-transfer RNA synthetase activity | related |
lysine-tRNA synthetase activity | related |
L-lysine-transfer RNA ligase activity | related |
L-lysine:tRNALys ligase (AMP-forming) | related |
lysine translase activity | related |
lysyl-tRNA synthetase activity | exact |
lysyl-transfer ribonucleate synthetase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5Y5Z6 | 10116 | A0A8I5Y5Z6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A2T0 | 10116 | A0A8I6A2T0_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6I4N6 | 10116 | A6I4N6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F7EEB9 | 10116 | F7EEB9_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q13426 | 9606 | XRCC4_HUMAN | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 6.1.1.6 | |
InterPro | IPR002313 | Lysine-tRNA ligase, class II |
InterPro | IPR002904 | Lysine-tRNA ligase |
InterPro | IPR004525 | Elongation factor P--(R)-beta-lysine ligase |
InterPro | IPR018149 | Lysyl-tRNA synthetase, class II, C-terminal |
InterPro | IPR023386 | Lysine-tRNA ligase, insertion domain superfamily |
InterPro | IPR034762 | Bacterial/eukaryotic lysine-tRNA ligase, class II |
MetaCyc | LYSINE--TRNA-LIGASE-RXN | |
RHEA | 20792 | |
Reactome | R-HSA-380008 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:456215 | adenosine 5'-monophosphate(2-) |
has_participant | CHEBI | CHEBI:33019 | diphosphate(3-) |
has_participant | CHEBI | CHEBI:78529 | 3'-(L-lysyl)adenylyl(1+) group |
has_participant | CHEBI | CHEBI:78442 | AMP 3'-end(1-) residue |
has_participant | CHEBI | CHEBI:32551 | L-lysinium(1+) |
has_participant | CHEBI | CHEBI:30616 | ATP(4-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004824 based on ALL annotations
The top 100 of 338 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
lysine-tRNA ligase activity
|
2,817.22 | 100.00 | 70,337 | 70,337 |
lysyl-tRNA aminoacylation
|
2,817.22 | 99.53 | 70,004 | 70,004 |
tRNA binding
|
147.42 | 5.23 | 68,850 | 1,315,720 |
aminoacyl-tRNA ligase activity
|
132.32 | 4.66 | 59,999 | 1,277,409 |
acid-ammonia (or amide) ligase activity
|
2,739.47 | 2.55 | 1,797 | 1,848 |
diadenosine tetraphosphate biosynthetic process
|
2,627.65 | 1.99 | 1,400 | 1,501 |
aminoacyl-tRNA synthetase multienzyme complex
|
121.61 | 1.98 | 2,487 | 57,614 |
basophil activation involved in immune response
|
2,649.71 | 1.98 | 1,392 | 1,480 |
positive regulation of macrophage activation
|
1,556.71 | 1.96 | 1,398 | 2,530 |
ATP:ADP adenylyltransferase activity
|
677.20 | 1.87 | 1,399 | 5,820 |
Totals | 685363 | 184242470 |
No co-occurrence statistics for GO:0004824 based on MANUAL annotations
The top 60 of 60 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
lysine-tRNA ligase activity
|
5,095.79 | 100.00 | 277 | 277 |
lysyl-tRNA aminoacylation
|
5,095.79 | 96.39 | 267 | 267 |
tRNA binding
|
530.32 | 10.38 | 271 | 2,604 |
ATP:ADP adenylyltransferase activity
|
4,891.96 | 8.63 | 24 | 25 |
diadenosine tetraphosphate biosynthetic process
|
3,266.53 | 8.59 | 25 | 39 |
basophil activation involved in immune response
|
4,152.12 | 7.80 | 22 | 27 |
positive regulation of macrophage activation
|
1,088.42 | 6.15 | 22 | 103 |
aminoacyl-tRNA synthetase multienzyme complex
|
287.49 | 4.23 | 40 | 709 |
mitochondrial lysyl-tRNA aminoacylation
|
4,586.21 | 3.24 | 9 | 10 |
tRNA aminoacylation for protein translation
|
582.38 | 1.30 | 4 | 35 |
Totals | 1440 | 1074021 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | lysine translase activity |
2020-10-08 | Added | SYNONYM | lysine-tRNA synthetase activity |
2020-10-08 | Added | SYNONYM | lysine translase activity |
2020-10-08 | Added | SYNONYM | lysyl-transfer RNA synthetase activity |
2020-10-08 | Added | SYNONYM | L-lysine-transfer RNA ligase activity |
2020-10-08 | Added | SYNONYM | L-lysine:tRNALys ligase (AMP-forming) |
2020-10-08 | Added | SYNONYM | lysyl-transfer ribonucleate synthetase activity |
2020-10-08 | Deleted | SYNONYM | L-lysine-transfer RNA ligase activity |
2020-10-08 | Deleted | SYNONYM | L-lysine:tRNALys ligase (AMP-forming) |
2020-10-08 | Deleted | SYNONYM | lysine-tRNA synthetase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | lysine-tRNA ligase activity |
2002-02-06 | Updated | TERM | lysine-tRNA ligase |
2001-11-07 | Updated | TERM | lysine-tRNA ligase |
2001-04-03 | Updated | TERM | lysine--tRNA ligase |
2001-03-30 | Added | TERM | lysine--tRNA ligase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | lysine translase activity |
2020-10-08 | Added | SYNONYM | lysine-tRNA synthetase activity |
2020-10-08 | Added | SYNONYM | lysine translase activity |
2020-10-08 | Added | SYNONYM | lysyl-transfer RNA synthetase activity |
2020-10-08 | Added | SYNONYM | L-lysine-transfer RNA ligase activity |
2020-10-08 | Added | SYNONYM | L-lysine:tRNALys ligase (AMP-forming) |
2020-10-08 | Added | SYNONYM | lysyl-transfer ribonucleate synthetase activity |
2020-10-08 | Deleted | SYNONYM | L-lysine-transfer RNA ligase activity |
2020-10-08 | Deleted | SYNONYM | L-lysine:tRNALys ligase (AMP-forming) |
2020-10-08 | Deleted | SYNONYM | lysine-tRNA synthetase activity |
2020-10-08 | Deleted | SYNONYM | lysyl-transfer RNA synthetase activity |
2020-10-08 | Deleted | SYNONYM | lysyl-transfer ribonucleate synthetase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). |
2007-11-08 | Added | SYNONYM | lysyl-transfer RNA synthetase activity |
2007-11-08 | Added | SYNONYM | lysine-tRNA synthetase activity |
2007-11-08 | Added | SYNONYM | L-lysine:tRNALys ligase (AMP-forming) |
2007-11-08 | Added | SYNONYM | L-lysine-transfer RNA ligase activity |
2007-11-08 | Added | SYNONYM | lysyl-transfer ribonucleate synthetase activity |
2007-09-06 | Added | SYNONYM | lysine translase activity |
2007-08-09 | Deleted | SYNONYM | lysyl-tRNA synthetase activity |
2007-08-09 | Added | SYNONYM | lysyl-tRNA synthetase activity |
2004-04-19 | Added | SYNONYM | lysyl-tRNA synthetase activity |
2004-04-16 | Deleted | SYNONYM | lysyl-tRNA synthetase activity |
2003-12-16 | Added | SYNONYM | lysyl-tRNA synthetase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0004812 (aminoacyl-tRNA ligase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-06-22 | Added | XREF | RHEA:20792 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-380233 |
2019-04-01 | Added | XREF | Reactome:R-HSA-380008 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-380008 |
2019-04-01 | Added | XREF | Reactome:R-HSA-380233 |
2018-12-11 | Added | XREF | reactome:R-HSA-380008 |
2018-12-11 | Added | XREF | reactome:R-HSA-380233 |
2003-10-27 | Added | XREF | MetaCyc:LYSINE--TRNA-LIGASE-RXN |
2001-03-30 | Added | XREF | EC:6.1.1.6 |
Timestamp | Action | Category | Detail |
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