This term is obsolete.

GO:0004824 JSON

lysine-tRNA ligase activity

Molecular Function

Definition (GO:0004824 GONUTS page)

Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).

70,633 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
lysyl-transfer RNA synthetase activity related
lysine-tRNA synthetase activity related
L-lysine-transfer RNA ligase activity related
L-lysine:tRNALys ligase (AMP-forming) related
lysine translase activity related
lysyl-tRNA synthetase activity exact
lysyl-transfer ribonucleate synthetase activity related

Ancestor Chart

Ancestor chart for GO:0004824
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5Y5Z6 10116 A0A8I5Y5Z6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A2T0 10116 A0A8I6A2T0_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6I4N6 10116 A6I4N6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F7EEB9 10116 F7EEB9_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q13426 9606 XRCC4_HUMAN GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 6.1.1.6
InterPro IPR002313 Lysine-tRNA ligase, class II
InterPro IPR002904 Lysine-tRNA ligase
InterPro IPR004525 Elongation factor P--(R)-beta-lysine ligase
InterPro IPR018149 Lysyl-tRNA synthetase, class II, C-terminal
InterPro IPR023386 Lysine-tRNA ligase, insertion domain superfamily
InterPro IPR034762 Bacterial/eukaryotic lysine-tRNA ligase, class II
MetaCyc LYSINE--TRNA-LIGASE-RXN
RHEA 20792
Reactome R-HSA-380008

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:456215 adenosine 5'-monophosphate(2-)
has_participant CHEBI CHEBI:33019 diphosphate(3-)
has_participant CHEBI CHEBI:78529 3'-(L-lysyl)adenylyl(1+) group
has_participant CHEBI CHEBI:78442 AMP 3'-end(1-) residue
has_participant CHEBI CHEBI:32551 L-lysinium(1+)
has_participant CHEBI CHEBI:30616 ATP(4-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004824 based on ALL annotations
The top 100 of 338 co-occurring terms
Co-occurring Term PR S% #Together #Compared
lysine-tRNA ligase activity
2,817.22 100.00 70,337 70,337
lysyl-tRNA aminoacylation
2,817.22 99.53 70,004 70,004
tRNA binding
147.42 5.23 68,850 1,315,720
aminoacyl-tRNA ligase activity
132.32 4.66 59,999 1,277,409
acid-ammonia (or amide) ligase activity
2,739.47 2.55 1,797 1,848
diadenosine tetraphosphate biosynthetic process
2,627.65 1.99 1,400 1,501
aminoacyl-tRNA synthetase multienzyme complex
121.61 1.98 2,487 57,614
basophil activation involved in immune response
2,649.71 1.98 1,392 1,480
positive regulation of macrophage activation
1,556.71 1.96 1,398 2,530
ATP:ADP adenylyltransferase activity
677.20 1.87 1,399 5,820
Totals 685363 184242470
No co-occurrence statistics for GO:0004824 based on MANUAL annotations
The top 60 of 60 co-occurring terms
Co-occurring Term PR S% #Together #Compared
lysine-tRNA ligase activity
5,095.79 100.00 277 277
lysyl-tRNA aminoacylation
5,095.79 96.39 267 267
tRNA binding
530.32 10.38 271 2,604
ATP:ADP adenylyltransferase activity
4,891.96 8.63 24 25
diadenosine tetraphosphate biosynthetic process
3,266.53 8.59 25 39
basophil activation involved in immune response
4,152.12 7.80 22 27
positive regulation of macrophage activation
1,088.42 6.15 22 103
aminoacyl-tRNA synthetase multienzyme complex
287.49 4.23 40 709
mitochondrial lysyl-tRNA aminoacylation
4,586.21 3.24 9 10
tRNA aminoacylation for protein translation
582.38 1.30 4 35
Totals 1440 1074021

Change Log

Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM lysine translase activity
2020-10-08 Added SYNONYM lysine-tRNA synthetase activity
2020-10-08 Added SYNONYM lysine translase activity
2020-10-08 Added SYNONYM lysyl-transfer RNA synthetase activity
2020-10-08 Added SYNONYM L-lysine-transfer RNA ligase activity
2020-10-08 Added SYNONYM L-lysine:tRNALys ligase (AMP-forming)
2020-10-08 Added SYNONYM lysyl-transfer ribonucleate synthetase activity
2020-10-08 Deleted SYNONYM L-lysine-transfer RNA ligase activity
2020-10-08 Deleted SYNONYM L-lysine:tRNALys ligase (AMP-forming)
2020-10-08 Deleted SYNONYM lysine-tRNA synthetase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM lysine-tRNA ligase activity
2002-02-06 Updated TERM lysine-tRNA ligase
2001-11-07 Updated TERM lysine-tRNA ligase
2001-04-03 Updated TERM lysine--tRNA ligase
2001-03-30 Added TERM lysine--tRNA ligase
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM lysine translase activity
2020-10-08 Added SYNONYM lysine-tRNA synthetase activity
2020-10-08 Added SYNONYM lysine translase activity
2020-10-08 Added SYNONYM lysyl-transfer RNA synthetase activity
2020-10-08 Added SYNONYM L-lysine-transfer RNA ligase activity
2020-10-08 Added SYNONYM L-lysine:tRNALys ligase (AMP-forming)
2020-10-08 Added SYNONYM lysyl-transfer ribonucleate synthetase activity
2020-10-08 Deleted SYNONYM L-lysine-transfer RNA ligase activity
2020-10-08 Deleted SYNONYM L-lysine:tRNALys ligase (AMP-forming)
2020-10-08 Deleted SYNONYM lysine-tRNA synthetase activity
2020-10-08 Deleted SYNONYM lysyl-transfer RNA synthetase activity
2020-10-08 Deleted SYNONYM lysyl-transfer ribonucleate synthetase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
2007-11-08 Added SYNONYM lysyl-transfer RNA synthetase activity
2007-11-08 Added SYNONYM lysine-tRNA synthetase activity
2007-11-08 Added SYNONYM L-lysine:tRNALys ligase (AMP-forming)
2007-11-08 Added SYNONYM L-lysine-transfer RNA ligase activity
2007-11-08 Added SYNONYM lysyl-transfer ribonucleate synthetase activity
2007-09-06 Added SYNONYM lysine translase activity
2007-08-09 Deleted SYNONYM lysyl-tRNA synthetase activity
2007-08-09 Added SYNONYM lysyl-tRNA synthetase activity
2004-04-19 Added SYNONYM lysyl-tRNA synthetase activity
2004-04-16 Deleted SYNONYM lysyl-tRNA synthetase activity
2003-12-16 Added SYNONYM lysyl-tRNA synthetase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0004812 (aminoacyl-tRNA ligase activity)
Timestamp Action Category Detail
2020-06-22 Added XREF RHEA:20792
2019-04-01 Deleted XREF reactome:R-HSA-380233
2019-04-01 Added XREF Reactome:R-HSA-380008
2019-04-01 Deleted XREF reactome:R-HSA-380008
2019-04-01 Added XREF Reactome:R-HSA-380233
2018-12-11 Added XREF reactome:R-HSA-380008
2018-12-11 Added XREF reactome:R-HSA-380233
2003-10-27 Added XREF MetaCyc:LYSINE--TRNA-LIGASE-RXN
2001-03-30 Added XREF EC:6.1.1.6
Timestamp Action Category Detail
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