This term is obsolete.

GO:0004930 JSON

G protein-coupled receptor activity

Molecular Function

Definition (GO:0004930 GONUTS page)

Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

Secondary IDs

GO:0001622, GO:0001623, GO:0001624, GO:0001625, GO:0016526

1,161,275 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
SREB receptor narrow
EBV-induced receptor narrow
orphan G-protein coupled receptor activity narrow
orphan GPCR activity narrow
RDC1 receptor activity narrow
super conserved receptor expressed in brain receptor activity narrow
receptor activity, G-protein coupled exact
G-protein coupled receptor activity, unknown ligand narrow
Mas proto-oncogene receptor activity narrow
orphan G protein coupled receptor activity narrow

Ancestor Chart

Ancestor chart for GO:0004930
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004930

Child Term Relationship to
GO:0004930
corticotrophin-releasing factor receptor activity
is_a
thyroid-stimulating hormone receptor activity
is_a
ecdysis-triggering hormone receptor activity
is_a
thyrotropin-releasing hormone receptor activity
is_a
G protein-coupled bile acid receptor activity
is_a
platelet activating factor receptor activity
is_a
icosanoid receptor activity
is_a
parathyroid hormone receptor activity
is_a
melanin-concentrating hormone receptor activity
is_a
choriogonadotropin hormone receptor activity
is_a

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A2ARI4 10090 LGR4_MOUSE GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21693646
NOT-qualified manual protein B0BLW3 8364 LGR4_XENTR GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein D4AC13 10116 LGR5_RAT GO:0004930 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein E5DHB5 8355 LGR5A_XENLA GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein E7FE13 7955 LGR4_DANRE GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein F1MLX5 9913 LGR4_BOVIN GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein F1MT22 9913 LGR5_BOVIN GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein F7D3V9 8364 LGR5_XENTR GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein G3QNC0 9595 G3QNC0_GORGO GO:0007186 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:8910290
NOT-qualified manual protein O15529 9606 GPR42_HUMAN GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12496283

Cross-references

Database ID Description
InterPro IPR000068 GPCR, family 3, extracellular calcium-sensing receptor-related
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR000337 GPCR, family 3
InterPro IPR000344 7TM GPCR, serpentine receptor class a (Sra)
InterPro IPR000820 Proto-oncogene Mas
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR000848 GPCR, cAMP-type
InterPro IPR000935 Thrombin receptor
InterPro IPR001414 G-protein coupled receptor 143
InterPro IPR001740 GPCR family 2, EMR1-like receptor

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0016527 obsolete brain-specific angiogenesis inhibitor activity consider GO:0004930

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004930 based on ALL annotations
The top 100 of 5,260 co-occurring terms
Co-occurring Term PR S% #Together #Compared
G protein-coupled receptor activity
255.76 100.00 774,765 774,765
G protein-coupled receptor signaling pathway
219.93 84.88 763,199 887,535
olfactory receptor activity
212.59 20.58 166,370 200,156
detection of chemical stimulus involved in sensory perception of smell
210.45 20.53 166,407 202,234
sensory perception of smell
198.47 17.82 145,590 187,616
adenylate cyclase-activating G protein-coupled receptor signaling pathway
180.12 9.78 79,053 112,250
cell surface receptor signaling pathway
117.21 9.69 84,819 185,076
neuropeptide signaling pathway
164.12 6.90 55,574 86,603
positive regulation of cytosolic calcium ion concentration
234.86 6.18 48,165 52,452
G protein-coupled peptide receptor activity
213.30 5.27 41,293 49,514
Totals 4916368 86034038
No co-occurrence statistics for GO:0004930 based on MANUAL annotations
The top 100 of 1,770 co-occurring terms
Co-occurring Term PR S% #Together #Compared
G protein-coupled receptor activity
248.20 100.00 5,687 5,687
G protein-coupled receptor signaling pathway
67.56 20.74 2,648 9,728
adenylate cyclase-activating G protein-coupled receptor signaling pathway
90.44 14.83 1,138 3,123
cellular response to hormone stimulus
141.37 8.61 524 920
neuropeptide signaling pathway
43.93 4.34 309 1,746
regulation of metabolic process
131.81 4.20 248 467
phospholipase C-activating G protein-coupled receptor signaling pathway
71.76 4.04 255 882
adenylate cyclase-activating adrenergic receptor signaling pathway
130.93 3.90 230 436
neuropeptide binding
102.88 3.72 223 538
plasma membrane
8.89 3.57 5,191 144,998
Totals 21293 359544

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_chembl 296

Change Log

Timestamp Action Category Detail
2024-11-06 Added XREF Reactome:R-HSA-381706
2024-11-05 Deleted XREF Reactome:R-HSA-381706
2024-11-03 Added XREF Reactome:R-HSA-381706
2024-11-02 Deleted XREF Reactome:R-HSA-381706
2024-11-01 Added XREF Reactome:R-HSA-381706
2024-10-26 Deleted XREF Reactome:R-HSA-381706
2024-10-09 Added XREF Reactome:R-HSA-381706
2024-10-08 Deleted XREF Reactome:R-HSA-381706
2024-09-21 Added XREF Reactome:R-HSA-381706
2024-09-20 Deleted XREF Reactome:R-HSA-381706
Timestamp Action Category Detail
2018-09-08 Updated TERM G protein-coupled receptor activity
2010-06-09 Updated TERM G-protein coupled receptor activity
2010-06-08 Updated TERM G-protein coupled receptor activity
2003-03-19 Updated TERM G-protein coupled receptor activity
2002-02-06 Updated TERM G-protein coupled receptor
2001-04-03 Updated TERM G-protein coupled receptor
2001-03-30 Added TERM G-protein coupled receptor
Timestamp Action Category Detail
2018-09-08 Deleted SYNONYM G-protein-coupled receptor activity
2018-09-08 Added SYNONYM G-protein coupled receptor activity
2011-10-24 Deleted DEFINITION A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
2011-10-24 Added SYNONYM receptor activity, G-protein coupled
2011-10-24 Added DEFINITION Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
2010-10-07 Deleted SYNONYM orphan G protein coupled receptor activity
2010-10-07 Added SYNONYM EBV-induced receptor
2010-10-07 Added SYNONYM SREB receptor
2010-10-07 Added SYNONYM orphan G-protein coupled receptor activity
2010-10-07 Added SYNONYM G-protein coupled receptor activity, unknown ligand
2010-10-07 Added SYNONYM Mas proto-oncogene receptor activity
2010-10-07 Added SYNONYM orphan G protein coupled receptor activity
2010-10-07 Deleted SYNONYM G-protein coupled receptor activity, unknown ligand
2010-10-07 Deleted SYNONYM orphan G-protein coupled receptor activity
2010-10-07 Deleted SYNONYM orphan GPCR activity
2010-10-07 Added SYNONYM orphan GPCR activity
2010-10-07 Added SYNONYM RDC1 receptor activity
2010-10-07 Added SYNONYM super conserved receptor expressed in brain receptor activity
2010-10-07 Added SYNONYM Epstein-Barr Virus-induced receptor activity
2008-10-10 Added SYNONYM ligand-dependent GPCR activity
2008-05-13 Added DEFINITION A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
2008-05-12 Deleted DEFINITION A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
2007-08-09 Added SYNONYM orphan GPCR activity
2007-08-09 Deleted SYNONYM G-protein-coupled receptor activity
2007-08-09 Added SYNONYM orphan G-protein coupled receptor activity
2007-08-09 Added SYNONYM orphan G protein coupled receptor activity
2007-08-09 Added SYNONYM GPCR activity
2007-08-09 Added SYNONYM G-protein-coupled receptor activity
2007-08-09 Added SYNONYM G-protein linked receptor activity
2007-08-09 Added SYNONYM G-protein coupled receptor activity, unknown ligand
2007-08-09 Added SYNONYM G protein linked receptor activity
2007-08-09 Added SYNONYM G protein coupled receptor activity
2007-08-09 Deleted SYNONYM orphan GPCR activity
2007-08-09 Deleted SYNONYM orphan G-protein coupled receptor activity
2007-08-09 Deleted SYNONYM orphan G protein coupled receptor activity
2007-08-09 Deleted SYNONYM GPCR activity
2007-08-09 Deleted SYNONYM G-protein linked receptor activity
2007-08-09 Deleted SYNONYM G-protein coupled receptor activity, unknown ligand
2007-08-09 Deleted SYNONYM G protein linked receptor activity
2007-08-09 Deleted SYNONYM G protein coupled receptor activity
2006-11-02 Added SYNONYM G-protein coupled receptor activity, unknown ligand
2006-11-02 Added SYNONYM orphan GPCR activity
2006-11-02 Added SYNONYM orphan G-protein coupled receptor activity
2006-11-02 Added SYNONYM orphan G protein coupled receptor activity
2005-06-27 Added SYNONYM G-protein linked receptor activity
2005-06-27 Added SYNONYM G-protein-coupled receptor activity
2005-06-27 Deleted SYNONYM G-protein linked receptor
2005-06-27 Deleted SYNONYM GPCR
2005-06-27 Added SYNONYM GPCR activity
2005-06-27 Added SYNONYM G protein coupled receptor activity
2005-06-27 Added SYNONYM G protein linked receptor activity
2004-04-19 Added SYNONYM G-protein linked receptor
2004-04-19 Added SYNONYM GPCR
2004-04-16 Deleted SYNONYM GPCR
2004-04-16 Deleted SYNONYM G-protein linked receptor
2002-11-27 Added DEFINITION A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
2001-03-30 Added SYNONYM G-protein linked receptor
2001-03-30 Added SYNONYM GPCR
Timestamp Action Category Detail
2017-05-01 Added RELATION has part GO:0007186 (G protein-coupled receptor signaling pathway)
2010-06-15 Added RELATION part of GO:0007186 (G protein-coupled receptor signaling pathway)
2010-06-14 Deleted RELATION part of GO:0007186 (G protein-coupled receptor signaling pathway)
2010-06-08 Added RELATION part of GO:0007186 (G protein-coupled receptor signaling pathway)
2008-04-01 Updated RELATION is a GO:0004888 (transmembrane signaling receptor activity)
Timestamp Action Category Detail
2024-11-06 Added XREF Reactome:R-HSA-381706
2024-11-05 Deleted XREF Reactome:R-HSA-381706
2024-11-03 Added XREF Reactome:R-HSA-381706
2024-11-02 Deleted XREF Reactome:R-HSA-381706
2024-11-01 Added XREF Reactome:R-HSA-381706
2024-10-26 Deleted XREF Reactome:R-HSA-381706
2024-10-09 Added XREF Reactome:R-HSA-381706
2024-10-08 Deleted XREF Reactome:R-HSA-381706
2024-09-21 Added XREF Reactome:R-HSA-381706
2024-09-20 Deleted XREF Reactome:R-HSA-381706
2024-09-19 Added XREF Reactome:R-HSA-381706
2024-09-13 Deleted XREF Reactome:R-HSA-381706
2024-09-10 Added XREF Reactome:R-HSA-381706
2024-09-08 Deleted XREF Reactome:R-HSA-381706
2024-09-07 Added XREF Reactome:R-HSA-381706
2024-09-06 Deleted XREF Reactome:R-HSA-381706
2024-09-05 Added XREF Reactome:R-HSA-381706
2024-09-02 Deleted XREF Reactome:R-HSA-381706
2024-08-20 Added XREF Reactome:R-HSA-381706
2024-08-16 Deleted XREF Reactome:R-HSA-381706
2024-08-15 Added XREF Reactome:R-HSA-381706
2024-08-08 Added XREF Reactome:R-HSA-381706
2024-08-08 Deleted XREF Reactome:R-HSA-381706
2024-08-06 Deleted XREF Reactome:R-HSA-381706
2024-08-05 Added XREF Reactome:R-HSA-381706
2024-07-28 Deleted XREF Reactome:R-HSA-381706
2024-07-27 Added XREF Reactome:R-HSA-381706
2024-07-26 Deleted XREF Reactome:R-HSA-381706
2024-07-25 Added XREF Reactome:R-HSA-381706
2024-07-20 Deleted XREF Reactome:R-HSA-381706
2024-07-19 Added XREF Reactome:R-HSA-381706
2024-07-18 Deleted XREF Reactome:R-HSA-381706
2024-07-14 Added XREF Reactome:R-HSA-381706
2024-07-11 Deleted XREF Reactome:R-HSA-381706
2024-07-10 Added XREF Reactome:R-HSA-381706
2024-07-09 Deleted XREF Reactome:R-HSA-381706
2024-07-06 Added XREF Reactome:R-HSA-381706
2024-07-04 Deleted XREF Reactome:R-HSA-381706
2024-07-03 Added XREF Reactome:R-HSA-381706
2024-06-30 Deleted XREF Reactome:R-HSA-381706
2024-06-29 Added XREF Reactome:R-HSA-381706
2024-06-28 Deleted XREF Reactome:R-HSA-381706
2024-06-27 Added XREF Reactome:R-HSA-381706
2024-06-26 Deleted XREF Reactome:R-HSA-381706
2024-06-23 Added XREF Reactome:R-HSA-381706
2024-06-20 Deleted XREF Reactome:R-HSA-381706
2024-06-19 Added XREF Reactome:R-HSA-381706
2024-06-14 Deleted XREF Reactome:R-HSA-381706
2024-06-13 Added XREF Reactome:R-HSA-381706
2024-06-12 Deleted XREF Reactome:R-HSA-381706
2024-06-11 Added XREF Reactome:R-HSA-381706
2024-06-07 Deleted XREF Reactome:R-HSA-381706
2024-06-01 Added XREF Reactome:R-HSA-381706
2024-05-31 Deleted XREF Reactome:R-HSA-381706
2024-05-30 Added XREF Reactome:R-HSA-381706
2024-05-29 Deleted XREF Reactome:R-HSA-381706
2024-05-25 Added XREF Reactome:R-HSA-381706
2024-05-24 Deleted XREF Reactome:R-HSA-381706
2024-05-23 Added XREF Reactome:R-HSA-381706
2024-05-22 Deleted XREF Reactome:R-HSA-381706
2024-05-16 Added XREF Reactome:R-HSA-381706
2024-05-15 Deleted XREF Reactome:R-HSA-381706
2024-05-14 Added XREF Reactome:R-HSA-381706
2024-05-11 Deleted XREF Reactome:R-HSA-381706
2024-05-09 Added XREF Reactome:R-HSA-381706
2024-05-09 Deleted XREF Reactome:R-HSA-381706
2024-05-08 Added XREF Reactome:R-HSA-381706
2024-05-05 Deleted XREF Reactome:R-HSA-381706
2024-05-03 Added XREF Reactome:R-HSA-381706
2024-05-02 Deleted XREF Reactome:R-HSA-381706
2024-05-01 Added XREF Reactome:R-HSA-381706
2024-04-25 Deleted XREF Reactome:R-HSA-381706
2024-04-24 Added XREF Reactome:R-HSA-381706
2024-04-21 Deleted XREF Reactome:R-HSA-381706
2024-04-19 Added XREF Reactome:R-HSA-381706
2024-04-18 Deleted XREF Reactome:R-HSA-381706
2024-04-14 Added XREF Reactome:R-HSA-381706
2024-04-13 Deleted XREF Reactome:R-HSA-381706
2024-04-12 Added XREF Reactome:R-HSA-381706
2024-04-11 Deleted XREF Reactome:R-HSA-381706
2024-04-09 Added XREF Reactome:R-HSA-381706
2024-04-07 Deleted XREF Reactome:R-HSA-381706
2024-04-06 Added XREF Reactome:R-HSA-381706
2019-04-01 Added XREF Reactome:R-HSA-114558
2019-04-01 Added XREF Reactome:R-HSA-114552
2019-04-01 Deleted XREF reactome:R-HSA-114552
2019-04-01 Deleted XREF reactome:R-HSA-114558
2019-04-01 Added XREF Reactome:R-HSA-167408
2019-04-01 Deleted XREF reactome:R-HSA-167408
2018-12-11 Added XREF reactome:R-HSA-114552
2018-12-11 Added XREF reactome:R-HSA-114558
2018-12-11 Added XREF reactome:R-HSA-167408
2011-10-24 Added XREF Wikipedia:GPCR
Timestamp Action Category Detail
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-19 Added SUBSET goslim_chembl
2015-05-11 Added SUBSET goslim_ChEMBL
2010-10-07 Added SECONDARY GO:0001625 (Epstein-Barr Virus-induced receptor activity)
2010-10-07 Added SECONDARY GO:0001623 (Mas proto-oncogene receptor activity)
2010-10-07 Added SECONDARY GO:0001624 (RDC1 receptor activity)
2010-10-07 Added SECONDARY GO:0001622 (super conserved receptor expressed in brain receptor activity)
2006-11-02 Added SECONDARY GO:0016526 (G-protein coupled receptor activity, unknown ligand)
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.