GO:0004930
JSON
G protein-coupled receptor activity
Molecular Function
Definition (GO:0004930 GONUTS page)
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Secondary IDs
GO:0001622, GO:0001623, GO:0001624, GO:0001625, GO:0016526
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
SREB receptor | narrow |
EBV-induced receptor | narrow |
orphan G-protein coupled receptor activity | narrow |
orphan GPCR activity | narrow |
RDC1 receptor activity | narrow |
super conserved receptor expressed in brain receptor activity | narrow |
receptor activity, G-protein coupled | exact |
G-protein coupled receptor activity, unknown ligand | narrow |
Mas proto-oncogene receptor activity | narrow |
orphan G protein coupled receptor activity | narrow |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004930
Child Term | Relationship to GO:0004930 |
---|---|
corticotrophin-releasing factor receptor activity
|
is_a |
thyroid-stimulating hormone receptor activity
|
is_a |
ecdysis-triggering hormone receptor activity
|
is_a |
thyrotropin-releasing hormone receptor activity
|
is_a |
G protein-coupled bile acid receptor activity
|
is_a |
platelet activating factor receptor activity
|
is_a |
icosanoid receptor activity
|
is_a |
parathyroid hormone receptor activity
|
is_a |
melanin-concentrating hormone receptor activity
|
is_a |
choriogonadotropin hormone receptor activity
|
is_a |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A2ARI4 | 10090 | LGR4_MOUSE | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21693646 | |
NOT-qualified manual | protein | B0BLW3 | 8364 | LGR4_XENTR | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | D4AC13 | 10116 | LGR5_RAT | GO:0004930 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | E5DHB5 | 8355 | LGR5A_XENLA | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | E7FE13 | 7955 | LGR4_DANRE | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | F1MLX5 | 9913 | LGR4_BOVIN | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | F1MT22 | 9913 | LGR5_BOVIN | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | F7D3V9 | 8364 | LGR5_XENTR | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | G3QNC0 | 9595 | G3QNC0_GORGO | GO:0007186 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:8910290 | |
NOT-qualified manual | protein | O15529 | 9606 | GPR42_HUMAN | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12496283 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR000068 | GPCR, family 3, extracellular calcium-sensing receptor-related |
InterPro | IPR000276 | G protein-coupled receptor, rhodopsin-like |
InterPro | IPR000337 | GPCR, family 3 |
InterPro | IPR000344 | 7TM GPCR, serpentine receptor class a (Sra) |
InterPro | IPR000820 | Proto-oncogene Mas |
InterPro | IPR000832 | GPCR, family 2, secretin-like |
InterPro | IPR000848 | GPCR, cAMP-type |
InterPro | IPR000935 | Thrombin receptor |
InterPro | IPR001414 | G-protein coupled receptor 143 |
InterPro | IPR001740 | GPCR family 2, EMR1-like receptor |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0016527 | obsolete brain-specific angiogenesis inhibitor activity | consider GO:0004930 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004930 based on ALL annotations
The top 100 of 5,260 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
G protein-coupled receptor activity
|
255.76 | 100.00 | 774,765 | 774,765 |
G protein-coupled receptor signaling pathway
|
219.93 | 84.88 | 763,199 | 887,535 |
olfactory receptor activity
|
212.59 | 20.58 | 166,370 | 200,156 |
detection of chemical stimulus involved in sensory perception of smell
|
210.45 | 20.53 | 166,407 | 202,234 |
sensory perception of smell
|
198.47 | 17.82 | 145,590 | 187,616 |
adenylate cyclase-activating G protein-coupled receptor signaling pathway
|
180.12 | 9.78 | 79,053 | 112,250 |
cell surface receptor signaling pathway
|
117.21 | 9.69 | 84,819 | 185,076 |
neuropeptide signaling pathway
|
164.12 | 6.90 | 55,574 | 86,603 |
positive regulation of cytosolic calcium ion concentration
|
234.86 | 6.18 | 48,165 | 52,452 |
G protein-coupled peptide receptor activity
|
213.30 | 5.27 | 41,293 | 49,514 |
Totals | 4916368 | 86034038 |
No co-occurrence statistics for GO:0004930 based on MANUAL annotations
The top 100 of 1,770 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
G protein-coupled receptor activity
|
248.20 | 100.00 | 5,687 | 5,687 |
G protein-coupled receptor signaling pathway
|
67.56 | 20.74 | 2,648 | 9,728 |
adenylate cyclase-activating G protein-coupled receptor signaling pathway
|
90.44 | 14.83 | 1,138 | 3,123 |
cellular response to hormone stimulus
|
141.37 | 8.61 | 524 | 920 |
neuropeptide signaling pathway
|
43.93 | 4.34 | 309 | 1,746 |
regulation of metabolic process
|
131.81 | 4.20 | 248 | 467 |
phospholipase C-activating G protein-coupled receptor signaling pathway
|
71.76 | 4.04 | 255 | 882 |
adenylate cyclase-activating adrenergic receptor signaling pathway
|
130.93 | 3.90 | 230 | 436 |
neuropeptide binding
|
102.88 | 3.72 | 223 | 538 |
plasma membrane
|
8.89 | 3.57 | 5,191 | 144,998 |
Totals | 21293 | 359544 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_chembl | 296 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-06 | Added | XREF | Reactome:R-HSA-381706 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-11-03 | Added | XREF | Reactome:R-HSA-381706 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-11-01 | Added | XREF | Reactome:R-HSA-381706 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-10-09 | Added | XREF | Reactome:R-HSA-381706 |
2024-10-08 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-09-21 | Added | XREF | Reactome:R-HSA-381706 |
2024-09-20 | Deleted | XREF | Reactome:R-HSA-381706 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-09-08 | Updated | TERM | G protein-coupled receptor activity |
2010-06-09 | Updated | TERM | G-protein coupled receptor activity |
2010-06-08 | Updated | TERM | G-protein coupled receptor activity |
2003-03-19 | Updated | TERM | G-protein coupled receptor activity |
2002-02-06 | Updated | TERM | G-protein coupled receptor |
2001-04-03 | Updated | TERM | G-protein coupled receptor |
2001-03-30 | Added | TERM | G-protein coupled receptor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-09-08 | Deleted | SYNONYM | G-protein-coupled receptor activity |
2018-09-08 | Added | SYNONYM | G-protein coupled receptor activity |
2011-10-24 | Deleted | DEFINITION | A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. |
2011-10-24 | Added | SYNONYM | receptor activity, G-protein coupled |
2011-10-24 | Added | DEFINITION | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
2010-10-07 | Deleted | SYNONYM | orphan G protein coupled receptor activity |
2010-10-07 | Added | SYNONYM | EBV-induced receptor |
2010-10-07 | Added | SYNONYM | SREB receptor |
2010-10-07 | Added | SYNONYM | orphan G-protein coupled receptor activity |
2010-10-07 | Added | SYNONYM | G-protein coupled receptor activity, unknown ligand |
2010-10-07 | Added | SYNONYM | Mas proto-oncogene receptor activity |
2010-10-07 | Added | SYNONYM | orphan G protein coupled receptor activity |
2010-10-07 | Deleted | SYNONYM | G-protein coupled receptor activity, unknown ligand |
2010-10-07 | Deleted | SYNONYM | orphan G-protein coupled receptor activity |
2010-10-07 | Deleted | SYNONYM | orphan GPCR activity |
2010-10-07 | Added | SYNONYM | orphan GPCR activity |
2010-10-07 | Added | SYNONYM | RDC1 receptor activity |
2010-10-07 | Added | SYNONYM | super conserved receptor expressed in brain receptor activity |
2010-10-07 | Added | SYNONYM | Epstein-Barr Virus-induced receptor activity |
2008-10-10 | Added | SYNONYM | ligand-dependent GPCR activity |
2008-05-13 | Added | DEFINITION | A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. |
2008-05-12 | Deleted | DEFINITION | A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. |
2007-08-09 | Added | SYNONYM | orphan GPCR activity |
2007-08-09 | Deleted | SYNONYM | G-protein-coupled receptor activity |
2007-08-09 | Added | SYNONYM | orphan G-protein coupled receptor activity |
2007-08-09 | Added | SYNONYM | orphan G protein coupled receptor activity |
2007-08-09 | Added | SYNONYM | GPCR activity |
2007-08-09 | Added | SYNONYM | G-protein-coupled receptor activity |
2007-08-09 | Added | SYNONYM | G-protein linked receptor activity |
2007-08-09 | Added | SYNONYM | G-protein coupled receptor activity, unknown ligand |
2007-08-09 | Added | SYNONYM | G protein linked receptor activity |
2007-08-09 | Added | SYNONYM | G protein coupled receptor activity |
2007-08-09 | Deleted | SYNONYM | orphan GPCR activity |
2007-08-09 | Deleted | SYNONYM | orphan G-protein coupled receptor activity |
2007-08-09 | Deleted | SYNONYM | orphan G protein coupled receptor activity |
2007-08-09 | Deleted | SYNONYM | GPCR activity |
2007-08-09 | Deleted | SYNONYM | G-protein linked receptor activity |
2007-08-09 | Deleted | SYNONYM | G-protein coupled receptor activity, unknown ligand |
2007-08-09 | Deleted | SYNONYM | G protein linked receptor activity |
2007-08-09 | Deleted | SYNONYM | G protein coupled receptor activity |
2006-11-02 | Added | SYNONYM | G-protein coupled receptor activity, unknown ligand |
2006-11-02 | Added | SYNONYM | orphan GPCR activity |
2006-11-02 | Added | SYNONYM | orphan G-protein coupled receptor activity |
2006-11-02 | Added | SYNONYM | orphan G protein coupled receptor activity |
2005-06-27 | Added | SYNONYM | G-protein linked receptor activity |
2005-06-27 | Added | SYNONYM | G-protein-coupled receptor activity |
2005-06-27 | Deleted | SYNONYM | G-protein linked receptor |
2005-06-27 | Deleted | SYNONYM | GPCR |
2005-06-27 | Added | SYNONYM | GPCR activity |
2005-06-27 | Added | SYNONYM | G protein coupled receptor activity |
2005-06-27 | Added | SYNONYM | G protein linked receptor activity |
2004-04-19 | Added | SYNONYM | G-protein linked receptor |
2004-04-19 | Added | SYNONYM | GPCR |
2004-04-16 | Deleted | SYNONYM | GPCR |
2004-04-16 | Deleted | SYNONYM | G-protein linked receptor |
2002-11-27 | Added | DEFINITION | A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. |
2001-03-30 | Added | SYNONYM | G-protein linked receptor |
2001-03-30 | Added | SYNONYM | GPCR |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-05-01 | Added | RELATION | has part GO:0007186 (G protein-coupled receptor signaling pathway) |
2010-06-15 | Added | RELATION | part of GO:0007186 (G protein-coupled receptor signaling pathway) |
2010-06-14 | Deleted | RELATION | part of GO:0007186 (G protein-coupled receptor signaling pathway) |
2010-06-08 | Added | RELATION | part of GO:0007186 (G protein-coupled receptor signaling pathway) |
2008-04-01 | Updated | RELATION | is a GO:0004888 (transmembrane signaling receptor activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-06 | Added | XREF | Reactome:R-HSA-381706 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-11-03 | Added | XREF | Reactome:R-HSA-381706 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-11-01 | Added | XREF | Reactome:R-HSA-381706 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-10-09 | Added | XREF | Reactome:R-HSA-381706 |
2024-10-08 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-09-21 | Added | XREF | Reactome:R-HSA-381706 |
2024-09-20 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-09-19 | Added | XREF | Reactome:R-HSA-381706 |
2024-09-13 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-09-10 | Added | XREF | Reactome:R-HSA-381706 |
2024-09-08 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-09-07 | Added | XREF | Reactome:R-HSA-381706 |
2024-09-06 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-09-05 | Added | XREF | Reactome:R-HSA-381706 |
2024-09-02 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-08-20 | Added | XREF | Reactome:R-HSA-381706 |
2024-08-16 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-08-15 | Added | XREF | Reactome:R-HSA-381706 |
2024-08-08 | Added | XREF | Reactome:R-HSA-381706 |
2024-08-08 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-08-06 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-08-05 | Added | XREF | Reactome:R-HSA-381706 |
2024-07-28 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-07-27 | Added | XREF | Reactome:R-HSA-381706 |
2024-07-26 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-07-25 | Added | XREF | Reactome:R-HSA-381706 |
2024-07-20 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-07-19 | Added | XREF | Reactome:R-HSA-381706 |
2024-07-18 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-07-14 | Added | XREF | Reactome:R-HSA-381706 |
2024-07-11 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-07-10 | Added | XREF | Reactome:R-HSA-381706 |
2024-07-09 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-07-06 | Added | XREF | Reactome:R-HSA-381706 |
2024-07-04 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-07-03 | Added | XREF | Reactome:R-HSA-381706 |
2024-06-30 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-06-29 | Added | XREF | Reactome:R-HSA-381706 |
2024-06-28 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-06-27 | Added | XREF | Reactome:R-HSA-381706 |
2024-06-26 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-06-23 | Added | XREF | Reactome:R-HSA-381706 |
2024-06-20 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-06-19 | Added | XREF | Reactome:R-HSA-381706 |
2024-06-14 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-06-13 | Added | XREF | Reactome:R-HSA-381706 |
2024-06-12 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-06-11 | Added | XREF | Reactome:R-HSA-381706 |
2024-06-07 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-06-01 | Added | XREF | Reactome:R-HSA-381706 |
2024-05-31 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-05-30 | Added | XREF | Reactome:R-HSA-381706 |
2024-05-29 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-05-25 | Added | XREF | Reactome:R-HSA-381706 |
2024-05-24 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-05-23 | Added | XREF | Reactome:R-HSA-381706 |
2024-05-22 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-05-16 | Added | XREF | Reactome:R-HSA-381706 |
2024-05-15 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-05-14 | Added | XREF | Reactome:R-HSA-381706 |
2024-05-11 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-05-09 | Added | XREF | Reactome:R-HSA-381706 |
2024-05-09 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-05-08 | Added | XREF | Reactome:R-HSA-381706 |
2024-05-05 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-05-03 | Added | XREF | Reactome:R-HSA-381706 |
2024-05-02 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-05-01 | Added | XREF | Reactome:R-HSA-381706 |
2024-04-25 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-04-24 | Added | XREF | Reactome:R-HSA-381706 |
2024-04-21 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-04-19 | Added | XREF | Reactome:R-HSA-381706 |
2024-04-18 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-04-14 | Added | XREF | Reactome:R-HSA-381706 |
2024-04-13 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-04-12 | Added | XREF | Reactome:R-HSA-381706 |
2024-04-11 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-04-09 | Added | XREF | Reactome:R-HSA-381706 |
2024-04-07 | Deleted | XREF | Reactome:R-HSA-381706 |
2024-04-06 | Added | XREF | Reactome:R-HSA-381706 |
2019-04-01 | Added | XREF | Reactome:R-HSA-114558 |
2019-04-01 | Added | XREF | Reactome:R-HSA-114552 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-114552 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-114558 |
2019-04-01 | Added | XREF | Reactome:R-HSA-167408 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-167408 |
2018-12-11 | Added | XREF | reactome:R-HSA-114552 |
2018-12-11 | Added | XREF | reactome:R-HSA-114558 |
2018-12-11 | Added | XREF | reactome:R-HSA-167408 |
2011-10-24 | Added | XREF | Wikipedia:GPCR |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
2010-10-07 | Added | SECONDARY | GO:0001625 (Epstein-Barr Virus-induced receptor activity) |
2010-10-07 | Added | SECONDARY | GO:0001623 (Mas proto-oncogene receptor activity) |
2010-10-07 | Added | SECONDARY | GO:0001624 (RDC1 receptor activity) |
2010-10-07 | Added | SECONDARY | GO:0001622 (super conserved receptor expressed in brain receptor activity) |
2006-11-02 | Added | SECONDARY | GO:0016526 (G-protein coupled receptor activity, unknown ligand) |
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