This term is obsolete.
Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'.

GO:0005102 JSON

signaling receptor binding

Molecular Function

Definition (GO:0005102 GONUTS page)

Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

Comments

Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'.

1,448,039 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
receptor-associated protein activity related
receptor ligand narrow
receptor binding broad

Ancestor Chart

Ancestor chart for GO:0005102
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005102

Child Term Relationship to
GO:0005102
growth factor receptor binding
is_a
wishful thinking binding
is_a
receptor tyrosine kinase-like orphan receptor binding
is_a
patched binding
is_a
peroxisome proliferator activated receptor binding
is_a
negative regulation of receptor binding
negatively_regulates
semaphorin receptor binding
is_a
netrin receptor binding
is_a
CD8 receptor binding
is_a
CD70 receptor binding
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A8XY28 6238 A8XY28_CAEBR GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PL19 6945 B7PL19_IXOSC GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PVH4 6945 B7PVH4_IXOSC GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein O16262 6239 NIPI4_CAEEL GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein O95970 9606 LGI1_HUMAN GO:0005102 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20463223
NOT-qualified manual protein P21333-1 9606 FLNA_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684
NOT-qualified manual protein P63026 9913 VAMP2_BOVIN GO:0005515 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699
NOT-qualified manual protein Q86V48 9606 LUZP1_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684
NOT-qualified manual protein Q8K4Y5 10116 LGI1_RAT GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR001178 Pesticidal crystal protein, domain II
InterPro IPR002072 Nerve growth factor-related
InterPro IPR003060 Pyocin S killer protein
InterPro IPR005817 Wnt
InterPro IPR008065 Pro-FMRFamide-related neuropeptide FF
InterPro IPR009139 Wnt-1 protein
InterPro IPR009140 Wnt-2 protein
InterPro IPR009141 Wnt-3 protein
InterPro IPR009142 Wnt-4 protein
InterPro IPR009143 Wnt-6 protein

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0004384 obsolete membrane-associated guanylate kinase consider GO:0005102
GO:0004973 obsolete N-methyl-D-aspartate receptor-associated protein activity consider GO:0005102
GO:0005194 obsolete cell adhesion molecule activity consider GO:0005102
GO:0008337 obsolete selectin consider GO:0005102
GO:0008648 obsolete tachykinin consider GO:0005102
GO:0015468 obsolete colicin consider GO:0005102
GO:0015470 obsolete bacteriocin activity consider GO:0005102
GO:0016086 obsolete allatostatin consider GO:0005102
GO:0016088 obsolete insulin consider GO:0005102
GO:0016962 obsolete receptor-associated protein activity consider GO:0005102

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0005102 based on ALL annotations
The top 100 of 6,493 co-occurring terms
Co-occurring Term PR S% #Together #Compared
signaling receptor binding
1,074.33 100.00 181,451 181,451
frizzled binding
937.12 26.67 50,362 57,736
cell fate commitment
683.11 23.77 49,939 78,540
canonical Wnt signaling pathway
539.37 21.97 50,962 101,507
neuron differentiation
411.89 19.18 50,318 131,246
Wnt signaling pathway
363.19 18.90 54,431 161,009
cytokine activity
348.26 18.46 54,444 167,953
extracellular space
88.95 7.75 99,723 1,204,410
animal organ development
288.15 7.63 17,473 65,145
T cell receptor signaling pathway
538.58 7.49 14,689 29,301
Totals 1299286 12809348
No co-occurrence statistics for GO:0005102 based on MANUAL annotations
The top 100 of 5,560 co-occurring terms
Co-occurring Term PR S% #Together #Compared
signaling receptor binding
380.39 100.00 3,396 3,396
T cell receptor signaling pathway
154.78 9.05 354 870
regulation of cytokine production
144.22 8.16 320 844
non-membrane spanning protein tyrosine kinase activity
175.84 7.87 294 636
external side of plasma membrane
36.27 6.43 559 5,862
cell surface receptor protein tyrosine kinase signaling pathway
59.67 6.36 328 2,091
innate immune response
37.36 5.50 377 3,838
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
268.07 5.16 179 254
positive regulation of T cell mediated cytotoxicity
178.61 5.13 185 394
antigen processing and presentation of endogenous peptide antigen via MHC class Ib
261.61 5.01 174 253
Totals 15703 188234

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_plant 97
goslim_chembl 296
goslim_mouse 45
goslim_agr 53
goslim_flybase_ribbon 44

Change Log

Timestamp Action Category Detail
2022-03-18 Added RELATION has part GO:0005186 (pheromone activity)
2021-05-24 Added DEFINITION Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2020-07-19 Added RELATION has part GO:0030159 (signaling receptor complex adaptor activity)
2018-09-22 Added SUBSET goslim_flybase_ribbon
2018-03-05 Added SYNONYM receptor binding
2018-03-05 Updated TERM signaling receptor binding
2017-03-04 Added SUBSET goslim_agr
2016-12-17 Added SUBSET goslim_mouse
2016-07-23 Deleted SUBSET goslim_metagenomics
Timestamp Action Category Detail
2018-03-05 Updated TERM signaling receptor binding
2003-06-10 Updated TERM receptor binding
2003-03-19 Updated TERM receptor binding activity
2002-07-23 Updated TERM receptor binding
2002-02-06 Updated TERM ligand
2001-04-03 Updated TERM ligand
2001-03-30 Added TERM ligand
Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2018-03-05 Added SYNONYM receptor binding
2009-07-03 Deleted DEFINITION Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2008-11-02 Deleted SYNONYM adrenocorticotropin
2008-11-02 Deleted SYNONYM allatostatin
2008-11-02 Deleted SYNONYM insulin
2008-05-13 Added DEFINITION Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2008-05-12 Deleted DEFINITION Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2007-10-16 Deleted SYNONYM cell adhesion receptor regulator activity
2007-10-16 Deleted SYNONYM transmembrane receptor protein serine/threonine kinase related_receptor-associated protein activity
2007-10-16 Deleted SYNONYM cell adhesion receptor inhibitor activity
2007-10-08 Deleted SYNONYM bacteriocin activity
2007-10-06 Deleted SYNONYM alpha-2 macroglobulin receptor-associated protein activity
2007-10-06 Deleted SYNONYM N-methyl-D-aspartate receptor-associated protein activity
2007-10-06 Deleted SYNONYM membrane-associated guanylate kinase
2007-10-06 Deleted SYNONYM nicotinic acetylcholine receptor-associated protein activity
2007-09-10 Deleted SYNONYM tachykinin
2007-09-10 Deleted SYNONYM selectin
2007-09-10 Deleted SYNONYM cell adhesion molecule activity
2007-09-10 Deleted SYNONYM colicin
2007-08-09 Added SYNONYM receptor-associated protein activity
2007-08-09 Added SYNONYM selectin
2007-08-09 Added SYNONYM tachykinin
2007-08-09 Added SYNONYM transmembrane receptor protein serine/threonine kinase related_receptor-associated protein activity
2007-08-09 Deleted SYNONYM N-methyl-D-aspartate receptor-associated protein activity
2007-08-09 Deleted SYNONYM adrenocorticotropin
2007-08-09 Deleted SYNONYM allatostatin
2007-08-09 Deleted SYNONYM alpha-2 macroglobulin receptor-associated protein activity
2007-08-09 Deleted SYNONYM bacteriocin activity
2007-08-09 Deleted SYNONYM cell adhesion molecule activity
2007-08-09 Deleted SYNONYM cell adhesion receptor inhibitor activity
2007-08-09 Deleted SYNONYM cell adhesion receptor regulator activity
2007-08-09 Deleted SYNONYM colicin
2007-08-09 Deleted SYNONYM insulin
2007-08-09 Deleted SYNONYM membrane-associated guanylate kinase
2007-08-09 Deleted SYNONYM nicotinic acetylcholine receptor-associated protein activity
2007-08-09 Deleted SYNONYM receptor ligand
2007-08-09 Added SYNONYM N-methyl-D-aspartate receptor-associated protein activity
2007-08-09 Added SYNONYM adrenocorticotropin
2007-08-09 Added SYNONYM allatostatin
2007-08-09 Added SYNONYM alpha-2 macroglobulin receptor-associated protein activity
2007-08-09 Added SYNONYM bacteriocin activity
2007-08-09 Added SYNONYM cell adhesion molecule activity
2007-08-09 Added SYNONYM cell adhesion receptor inhibitor activity
2007-08-09 Added SYNONYM cell adhesion receptor regulator activity
2007-08-09 Added SYNONYM colicin
2007-08-09 Added SYNONYM insulin
2007-08-09 Added SYNONYM membrane-associated guanylate kinase
2007-08-09 Deleted SYNONYM receptor-associated protein activity
2007-08-09 Deleted SYNONYM selectin
2007-08-09 Deleted SYNONYM tachykinin
2007-08-09 Deleted SYNONYM transmembrane receptor protein serine/threonine kinase related_receptor-associated protein activity
2007-08-09 Added SYNONYM nicotinic acetylcholine receptor-associated protein activity
2007-08-09 Added SYNONYM receptor ligand
2005-11-01 Deleted SYNONYM cell adhesion receptor activity
2005-08-10 Added SYNONYM transmembrane receptor protein serine/threonine kinase related_receptor-associated protein activity
2005-08-10 Added SYNONYM membrane-associated guanylate kinase
2005-08-10 Added SYNONYM insulin
2005-08-10 Added SYNONYM colicin
2005-08-10 Added SYNONYM cell adhesion receptor regulator activity
2005-08-10 Added SYNONYM cell adhesion receptor inhibitor activity
2005-08-10 Added SYNONYM cell adhesion receptor activity
2005-08-10 Added SYNONYM cell adhesion molecule activity
2005-08-10 Added SYNONYM bacteriocin activity
2005-08-10 Added SYNONYM alpha-2 macroglobulin receptor-associated protein activity
2005-08-10 Added SYNONYM nicotinic acetylcholine receptor-associated protein activity
2005-08-10 Added SYNONYM receptor-associated protein activity
2005-08-10 Added SYNONYM selectin
2005-08-10 Added SYNONYM tachykinin
2005-08-10 Added SYNONYM N-methyl-D-aspartate receptor-associated protein activity
2005-08-10 Added SYNONYM adrenocorticotropin
2005-08-10 Added SYNONYM allatostatin
2003-07-26 Updated DEFINITION Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2003-03-26 Updated DEFINITION Interacting selectively with one or more specific sites on another molecule.
2002-11-27 Added DEFINITION Interacting selectively and stoichiometrically with one or more specific sites on another molecule.
2002-07-25 Added SYNONYM receptor ligand
Timestamp Action Category Detail
2022-03-18 Added RELATION has part GO:0005186 (pheromone activity)
2020-07-19 Added RELATION has part GO:0030159 (signaling receptor complex adaptor activity)
2015-10-23 Added RELATION has part GO:0061684 (chaperone-mediated autophagy)
2015-10-23 Added RELATION has part GO:0061740 (protein targeting to lysosome involved in chaperone-mediated autophagy)
2013-11-27 Added RELATION has part GO:0046813 (receptor-mediated virion attachment to host cell)
2008-04-01 Updated RELATION is a GO:0005515 (protein binding)
Timestamp Action Category Detail
2009-02-25 Added XREF Wikipedia:Ligand_(biochemistry)
Timestamp Action Category Detail
2018-09-22 Added SUBSET goslim_flybase_ribbon
2017-03-04 Added SUBSET goslim_agr
2016-12-17 Added SUBSET goslim_mouse
2016-07-23 Deleted SUBSET goslim_metagenomics
2015-05-19 Added SUBSET goslim_chembl
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-11 Added SUBSET goslim_ChEMBL
2013-04-18 Updated SUBSET goslim_metagenomics
2013-04-18 Updated SUBSET goslim_plant
2012-02-17 Added SUBSET goslim_metagenomics
2010-12-05 Deleted SUBSET goslim_generic
2008-06-09 Added SUBSET goslim_generic
2008-06-09 Added SUBSET goslim_plant
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