Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'.
GO:0005102
JSON
signaling receptor binding
Molecular Function
Definition (GO:0005102 GONUTS page)
Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
Comments
Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
receptor-associated protein activity | related |
receptor ligand | narrow |
receptor binding | broad |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0005102
Child Term | Relationship to GO:0005102 |
---|---|
growth factor receptor binding
|
is_a |
wishful thinking binding
|
is_a |
receptor tyrosine kinase-like orphan receptor binding
|
is_a |
patched binding
|
is_a |
peroxisome proliferator activated receptor binding
|
is_a |
negative regulation of receptor binding
|
negatively_regulates |
semaphorin receptor binding
|
is_a |
netrin receptor binding
|
is_a |
CD8 receptor binding
|
is_a |
CD70 receptor binding
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Binding term considerations | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A8XY28 | 6238 | A8XY28_CAEBR | GO:0005102 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | B7PL19 | 6945 | B7PL19_IXOSC | GO:0005102 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | B7PVH4 | 6945 | B7PVH4_IXOSC | GO:0005102 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | O16262 | 6239 | NIPI4_CAEEL | GO:0005102 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | O95970 | 9606 | LGI1_HUMAN | GO:0005102 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20463223 | |
NOT-qualified manual | protein | P21333-1 | 9606 | FLNA_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 | |
NOT-qualified manual | protein | P63026 | 9913 | VAMP2_BOVIN | GO:0005515 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699 | |
NOT-qualified manual | protein | Q86V48 | 9606 | LUZP1_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 | |
NOT-qualified manual | protein | Q8K4Y5 | 10116 | LGI1_RAT | GO:0005102 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR001178 | Pesticidal crystal protein, domain II |
InterPro | IPR002072 | Nerve growth factor-related |
InterPro | IPR003060 | Pyocin S killer protein |
InterPro | IPR005817 | Wnt |
InterPro | IPR008065 | Pro-FMRFamide-related neuropeptide FF |
InterPro | IPR009139 | Wnt-1 protein |
InterPro | IPR009140 | Wnt-2 protein |
InterPro | IPR009141 | Wnt-3 protein |
InterPro | IPR009142 | Wnt-4 protein |
InterPro | IPR009143 | Wnt-6 protein |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0004384 | obsolete membrane-associated guanylate kinase | consider GO:0005102 |
GO:0004973 | obsolete N-methyl-D-aspartate receptor-associated protein activity | consider GO:0005102 |
GO:0005194 | obsolete cell adhesion molecule activity | consider GO:0005102 |
GO:0008337 | obsolete selectin | consider GO:0005102 |
GO:0008648 | obsolete tachykinin | consider GO:0005102 |
GO:0015468 | obsolete colicin | consider GO:0005102 |
GO:0015470 | obsolete bacteriocin activity | consider GO:0005102 |
GO:0016086 | obsolete allatostatin | consider GO:0005102 |
GO:0016088 | obsolete insulin | consider GO:0005102 |
GO:0016962 | obsolete receptor-associated protein activity | consider GO:0005102 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0005102 based on ALL annotations
The top 100 of 6,493 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
signaling receptor binding
|
1,074.33 | 100.00 | 181,451 | 181,451 |
frizzled binding
|
937.12 | 26.67 | 50,362 | 57,736 |
cell fate commitment
|
683.11 | 23.77 | 49,939 | 78,540 |
canonical Wnt signaling pathway
|
539.37 | 21.97 | 50,962 | 101,507 |
neuron differentiation
|
411.89 | 19.18 | 50,318 | 131,246 |
Wnt signaling pathway
|
363.19 | 18.90 | 54,431 | 161,009 |
cytokine activity
|
348.26 | 18.46 | 54,444 | 167,953 |
extracellular space
|
88.95 | 7.75 | 99,723 | 1,204,410 |
animal organ development
|
288.15 | 7.63 | 17,473 | 65,145 |
T cell receptor signaling pathway
|
538.58 | 7.49 | 14,689 | 29,301 |
Totals | 1299286 | 12809348 |
No co-occurrence statistics for GO:0005102 based on MANUAL annotations
The top 100 of 5,560 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
signaling receptor binding
|
380.39 | 100.00 | 3,396 | 3,396 |
T cell receptor signaling pathway
|
154.78 | 9.05 | 354 | 870 |
regulation of cytokine production
|
144.22 | 8.16 | 320 | 844 |
non-membrane spanning protein tyrosine kinase activity
|
175.84 | 7.87 | 294 | 636 |
external side of plasma membrane
|
36.27 | 6.43 | 559 | 5,862 |
cell surface receptor protein tyrosine kinase signaling pathway
|
59.67 | 6.36 | 328 | 2,091 |
innate immune response
|
37.36 | 5.50 | 377 | 3,838 |
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
|
268.07 | 5.16 | 179 | 254 |
positive regulation of T cell mediated cytotoxicity
|
178.61 | 5.13 | 185 | 394 |
antigen processing and presentation of endogenous peptide antigen via MHC class Ib
|
261.61 | 5.01 | 174 | 253 |
Totals | 15703 | 188234 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_plant | 97 |
goslim_chembl | 296 |
goslim_mouse | 45 |
goslim_agr | 53 |
goslim_flybase_ribbon | 44 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-03-18 | Added | RELATION | has part GO:0005186 (pheromone activity) |
2021-05-24 | Added | DEFINITION | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
2020-07-19 | Added | RELATION | has part GO:0030159 (signaling receptor complex adaptor activity) |
2018-09-22 | Added | SUBSET | goslim_flybase_ribbon |
2018-03-05 | Added | SYNONYM | receptor binding |
2018-03-05 | Updated | TERM | signaling receptor binding |
2017-03-04 | Added | SUBSET | goslim_agr |
2016-12-17 | Added | SUBSET | goslim_mouse |
2016-07-23 | Deleted | SUBSET | goslim_metagenomics |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-03-05 | Updated | TERM | signaling receptor binding |
2003-06-10 | Updated | TERM | receptor binding |
2003-03-19 | Updated | TERM | receptor binding activity |
2002-07-23 | Updated | TERM | receptor binding |
2002-02-06 | Updated | TERM | ligand |
2001-04-03 | Updated | TERM | ligand |
2001-03-30 | Added | TERM | ligand |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Added | DEFINITION | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
2018-03-05 | Added | SYNONYM | receptor binding |
2009-07-03 | Deleted | DEFINITION | Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
2009-07-03 | Added | DEFINITION | Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
2008-11-02 | Deleted | SYNONYM | adrenocorticotropin |
2008-11-02 | Deleted | SYNONYM | allatostatin |
2008-11-02 | Deleted | SYNONYM | insulin |
2008-05-13 | Added | DEFINITION | Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
2008-05-12 | Deleted | DEFINITION | Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
2007-10-16 | Deleted | SYNONYM | cell adhesion receptor regulator activity |
2007-10-16 | Deleted | SYNONYM | transmembrane receptor protein serine/threonine kinase related_receptor-associated protein activity |
2007-10-16 | Deleted | SYNONYM | cell adhesion receptor inhibitor activity |
2007-10-08 | Deleted | SYNONYM | bacteriocin activity |
2007-10-06 | Deleted | SYNONYM | alpha-2 macroglobulin receptor-associated protein activity |
2007-10-06 | Deleted | SYNONYM | N-methyl-D-aspartate receptor-associated protein activity |
2007-10-06 | Deleted | SYNONYM | membrane-associated guanylate kinase |
2007-10-06 | Deleted | SYNONYM | nicotinic acetylcholine receptor-associated protein activity |
2007-09-10 | Deleted | SYNONYM | tachykinin |
2007-09-10 | Deleted | SYNONYM | selectin |
2007-09-10 | Deleted | SYNONYM | cell adhesion molecule activity |
2007-09-10 | Deleted | SYNONYM | colicin |
2007-08-09 | Added | SYNONYM | receptor-associated protein activity |
2007-08-09 | Added | SYNONYM | selectin |
2007-08-09 | Added | SYNONYM | tachykinin |
2007-08-09 | Added | SYNONYM | transmembrane receptor protein serine/threonine kinase related_receptor-associated protein activity |
2007-08-09 | Deleted | SYNONYM | N-methyl-D-aspartate receptor-associated protein activity |
2007-08-09 | Deleted | SYNONYM | adrenocorticotropin |
2007-08-09 | Deleted | SYNONYM | allatostatin |
2007-08-09 | Deleted | SYNONYM | alpha-2 macroglobulin receptor-associated protein activity |
2007-08-09 | Deleted | SYNONYM | bacteriocin activity |
2007-08-09 | Deleted | SYNONYM | cell adhesion molecule activity |
2007-08-09 | Deleted | SYNONYM | cell adhesion receptor inhibitor activity |
2007-08-09 | Deleted | SYNONYM | cell adhesion receptor regulator activity |
2007-08-09 | Deleted | SYNONYM | colicin |
2007-08-09 | Deleted | SYNONYM | insulin |
2007-08-09 | Deleted | SYNONYM | membrane-associated guanylate kinase |
2007-08-09 | Deleted | SYNONYM | nicotinic acetylcholine receptor-associated protein activity |
2007-08-09 | Deleted | SYNONYM | receptor ligand |
2007-08-09 | Added | SYNONYM | N-methyl-D-aspartate receptor-associated protein activity |
2007-08-09 | Added | SYNONYM | adrenocorticotropin |
2007-08-09 | Added | SYNONYM | allatostatin |
2007-08-09 | Added | SYNONYM | alpha-2 macroglobulin receptor-associated protein activity |
2007-08-09 | Added | SYNONYM | bacteriocin activity |
2007-08-09 | Added | SYNONYM | cell adhesion molecule activity |
2007-08-09 | Added | SYNONYM | cell adhesion receptor inhibitor activity |
2007-08-09 | Added | SYNONYM | cell adhesion receptor regulator activity |
2007-08-09 | Added | SYNONYM | colicin |
2007-08-09 | Added | SYNONYM | insulin |
2007-08-09 | Added | SYNONYM | membrane-associated guanylate kinase |
2007-08-09 | Deleted | SYNONYM | receptor-associated protein activity |
2007-08-09 | Deleted | SYNONYM | selectin |
2007-08-09 | Deleted | SYNONYM | tachykinin |
2007-08-09 | Deleted | SYNONYM | transmembrane receptor protein serine/threonine kinase related_receptor-associated protein activity |
2007-08-09 | Added | SYNONYM | nicotinic acetylcholine receptor-associated protein activity |
2007-08-09 | Added | SYNONYM | receptor ligand |
2005-11-01 | Deleted | SYNONYM | cell adhesion receptor activity |
2005-08-10 | Added | SYNONYM | transmembrane receptor protein serine/threonine kinase related_receptor-associated protein activity |
2005-08-10 | Added | SYNONYM | membrane-associated guanylate kinase |
2005-08-10 | Added | SYNONYM | insulin |
2005-08-10 | Added | SYNONYM | colicin |
2005-08-10 | Added | SYNONYM | cell adhesion receptor regulator activity |
2005-08-10 | Added | SYNONYM | cell adhesion receptor inhibitor activity |
2005-08-10 | Added | SYNONYM | cell adhesion receptor activity |
2005-08-10 | Added | SYNONYM | cell adhesion molecule activity |
2005-08-10 | Added | SYNONYM | bacteriocin activity |
2005-08-10 | Added | SYNONYM | alpha-2 macroglobulin receptor-associated protein activity |
2005-08-10 | Added | SYNONYM | nicotinic acetylcholine receptor-associated protein activity |
2005-08-10 | Added | SYNONYM | receptor-associated protein activity |
2005-08-10 | Added | SYNONYM | selectin |
2005-08-10 | Added | SYNONYM | tachykinin |
2005-08-10 | Added | SYNONYM | N-methyl-D-aspartate receptor-associated protein activity |
2005-08-10 | Added | SYNONYM | adrenocorticotropin |
2005-08-10 | Added | SYNONYM | allatostatin |
2003-07-26 | Updated | DEFINITION | Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
2003-03-26 | Updated | DEFINITION | Interacting selectively with one or more specific sites on another molecule. |
2002-11-27 | Added | DEFINITION | Interacting selectively and stoichiometrically with one or more specific sites on another molecule. |
2002-07-25 | Added | SYNONYM | receptor ligand |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-03-18 | Added | RELATION | has part GO:0005186 (pheromone activity) |
2020-07-19 | Added | RELATION | has part GO:0030159 (signaling receptor complex adaptor activity) |
2015-10-23 | Added | RELATION | has part GO:0061684 (chaperone-mediated autophagy) |
2015-10-23 | Added | RELATION | has part GO:0061740 (protein targeting to lysosome involved in chaperone-mediated autophagy) |
2013-11-27 | Added | RELATION | has part GO:0046813 (receptor-mediated virion attachment to host cell) |
2008-04-01 | Updated | RELATION | is a GO:0005515 (protein binding) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-02-25 | Added | XREF | Wikipedia:Ligand_(biochemistry) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-09-22 | Added | SUBSET | goslim_flybase_ribbon |
2017-03-04 | Added | SUBSET | goslim_agr |
2016-12-17 | Added | SUBSET | goslim_mouse |
2016-07-23 | Deleted | SUBSET | goslim_metagenomics |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
2013-04-18 | Updated | SUBSET | goslim_metagenomics |
2013-04-18 | Updated | SUBSET | goslim_plant |
2012-02-17 | Added | SUBSET | goslim_metagenomics |
2010-12-05 | Deleted | SUBSET | goslim_generic |
2008-06-09 | Added | SUBSET | goslim_generic |
2008-06-09 | Added | SUBSET | goslim_plant |
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