GO:0005221
JSON
intracellularly cyclic nucleotide-activated monoatomic cation channel activity
Molecular Function
Definition (GO:0005221 GONUTS page)
Enables the transmembrane transfer of a monoatomic cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
| Synonym | Type |
|---|---|
| intracellular cyclic nucleotide activated monoatomic cation channel activity | exact |
| intracellular cyclic nucleotide-activated monoatomic cation channel activity | exact |
| intracellular cyclic nucleotide activated cation channel activity | broad |
Ancestor Chart
Ancestor chart for GO:0005221
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0005221
| Child Term | Relationship to GO:0005221 |
|---|---|
|
intracellularly cAMP-activated cation channel activity
|
is_a |
|
intracellularly cGMP-activated cation channel activity
|
is_a |
|
intracellular cyclic nucleotide activated cation channel complex
|
capable_of |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
| Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
|---|---|---|---|---|---|---|---|
| NOT-qualified manual | protein | A0A8I5ZLE9 | 10116 | A0A8I5ZLE9_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | A0A8I5ZST4 | 10116 | A0A8I5ZST4_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | A0A8I6AI08 | 10116 | A0A8I6AI08_RAT | GO:0015267 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | A0PK00 | 9606 | T120B_HUMAN | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
| NOT-qualified manual | protein | A6HVQ8 | 10116 | A6HVQ8_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | A6J168 | 10116 | A6J168_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | A6J4P5 | 10116 | A6J4P5_RAT | GO:0015267 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | A6K7I4 | 10116 | A6K7I4_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | A6K7I4 | 10116 | A6K7I4_RAT | GO:0034220 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | A6QPF8 | 9913 | T120B_BOVIN | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 |
Cross-references
| Database | ID | Description |
|---|---|---|
| InterPro | IPR050866 | Cyclic nucleotide-gated cation channel |
| Reactome | R-HSA-2514867 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0005221 based on ALL annotations
The top 100 of 309 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
intracellularly cyclic nucleotide-activated monoatomic cation channel activity
|
10,914.62 | 100.00 | 18,155 | 18,155 |
|
intracellular cyclic nucleotide activated cation channel complex
|
10,913.43 | 50.80 | 9,223 | 9,224 |
|
intracellularly cGMP-activated cation channel activity
|
10,793.30 | 50.68 | 9,253 | 9,357 |
|
intracellularly cAMP-activated cation channel activity
|
10,641.64 | 50.02 | 9,200 | 9,436 |
|
cGMP binding
|
4,814.63 | 31.06 | 9,297 | 21,076 |
|
protein-containing complex binding
|
1,941.53 | 17.72 | 17,785 | 99,981 |
|
retina homeostasis
|
5,191.90 | 6.83 | 1,340 | 2,817 |
|
photoreceptor outer segment
|
1,372.00 | 6.70 | 2,279 | 18,130 |
|
cAMP binding
|
788.01 | 4.68 | 2,132 | 29,530 |
|
monoatomic cation transmembrane transport
|
353.42 | 3.24 | 18,096 | 558,863 |
| Totals | 164974 | 92812801 | ||
No co-occurrence statistics for GO:0005221 based on MANUAL annotations
The top 74 of 74 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
intracellularly cyclic nucleotide-activated monoatomic cation channel activity
|
67,215.86 | 100.00 | 21 | 21 |
|
intracellular cyclic nucleotide activated cation channel complex
|
6,647.72 | 9.73 | 18 | 182 |
|
non-motile cilium membrane
|
11,202.64 | 6.45 | 2 | 12 |
|
intracellularly cAMP-activated cation channel activity
|
4,245.21 | 6.03 | 12 | 190 |
|
intracellularly cGMP-activated cation channel activity
|
3,932.84 | 5.56 | 11 | 188 |
|
cGMP binding
|
3,407.26 | 4.85 | 11 | 217 |
|
cyclic nucleotide-activated monoatomic ion channel activity
|
33,607.93 | 4.55 | 1 | 2 |
|
inorganic cation import across plasma membrane
|
8,401.98 | 3.57 | 1 | 8 |
|
peroxisome targeting sequence binding
|
6,110.53 | 3.23 | 1 | 11 |
|
positive regulation of corticotropin secretion
|
5,601.32 | 3.13 | 1 | 12 |
| Totals | 213 | 607726 | ||
Change Log
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- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-01-30 | Added | SYNONYM | intracellular cyclic nucleotide-activated monoatomic cation channel activity |
| 2024-01-30 | Updated | TERM | intracellularly cyclic nucleotide-activated monoatomic cation channel activity |
| 2023-10-10 | Updated | TERM | intracellular cyclic nucleotide-activated monoatomic cation channel activity |
| 2023-10-10 | Added | SYNONYM | intracellular cyclic nucleotide activated monoatomic cation channel activity |
| 2022-12-18 | Added | DEFINITION | Enables the transmembrane transfer of a monoatomic cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts. |
| 2022-12-18 | Deleted | DEFINITION | Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts. |
| 2022-12-02 | Added | SYNONYM | intracellular cyclic nucleotide activated cation channel activity |
| 2022-12-02 | Updated | TERM | intracellular cyclic nucleotide activated monoatomic cation channel activity |
| 2019-04-01 | Deleted | XREF | reactome:R-HSA-2514867 |
| 2019-04-01 | Added | XREF | Reactome:R-HSA-2514867 |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-01-30 | Updated | TERM | intracellularly cyclic nucleotide-activated monoatomic cation channel activity |
| 2023-10-10 | Updated | TERM | intracellular cyclic nucleotide-activated monoatomic cation channel activity |
| 2022-12-02 | Updated | TERM | intracellular cyclic nucleotide activated monoatomic cation channel activity |
| 2010-06-09 | Updated | TERM | intracellular cyclic nucleotide activated cation channel activity |
| 2010-06-08 | Updated | TERM | intracellular cyclic nucleotide activated cation channel activity |
| 2003-03-19 | Updated | TERM | intracellular cyclic nucleotide activated cation channel activity |
| 2002-02-06 | Updated | TERM | intracellular cyclic nucleotide activated cation channel |
| 2001-04-03 | Updated | TERM | intracellular cyclic nucleotide activated cation channel |
| 2001-03-30 | Added | TERM | intracellular cyclic nucleotide activated cation channel |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-01-30 | Added | SYNONYM | intracellular cyclic nucleotide-activated monoatomic cation channel activity |
| 2023-10-10 | Added | SYNONYM | intracellular cyclic nucleotide activated monoatomic cation channel activity |
| 2022-12-18 | Added | DEFINITION | Enables the transmembrane transfer of a monoatomic cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts. |
| 2022-12-18 | Deleted | DEFINITION | Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts. |
| 2022-12-02 | Added | SYNONYM | intracellular cyclic nucleotide activated cation channel activity |
| 2015-05-11 | Deleted | DEFINITION | Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts. |
| 2015-05-11 | Added | DEFINITION | Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts. |
| 2008-05-13 | Added | DEFINITION | Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts. |
| 2008-05-12 | Deleted | DEFINITION | Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts. |
| 2007-07-27 | Added | DEFINITION | Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2018-02-09 | Deleted | RELATION | is a GO:0140135 (mechanosensitive monoatomic cation channel activity) |
| 2018-02-09 | Added | RELATION | is a GO:0099094 (ligand-gated monoatomic cation channel activity) |
| 2017-11-19 | Added | RELATION | is a GO:0140135 (mechanosensitive monoatomic cation channel activity) |
| 2017-11-19 | Deleted | RELATION | is a GO:0005261 (monoatomic cation channel activity) |
| 2008-04-01 | Updated | RELATION | is a GO:0005217 (intracellularly ligand-gated monoatomic ion channel activity) |
| 2008-04-01 | Updated | RELATION | is a GO:0043855 (cyclic nucleotide-activated monoatomic ion channel activity) |
| 2008-04-01 | Updated | RELATION | is a GO:0005261 (monoatomic cation channel activity) |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2019-04-01 | Deleted | XREF | reactome:R-HSA-2514867 |
| 2019-04-01 | Added | XREF | Reactome:R-HSA-2514867 |
| 2018-12-11 | Added | XREF | reactome:R-HSA-2514867 |
| Timestamp | Action | Category | Detail |
|---|
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