This term is obsolete.
Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term.

GO:0005615 JSON

extracellular space

Cellular Component

Definition (GO:0005615 GONUTS page)

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

Comments

Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term.

1,340,216 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
intercellular space related

Ancestor Chart

Ancestor chart for GO:0005615
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005615

Child Term Relationship to
GO:0005615
immunoglobulin complex, circulating
part_of
extracellular exosome
part_of
plasma lipoprotein particle
part_of
insulin-like growth factor binding protein complex
part_of
interleukin-27 complex
part_of
interleukin-23 complex
part_of
reelin complex
part_of
classical-complement-pathway C3/C5 convertase complex
part_of
interleukin-35 complex
part_of
blood microparticle
part_of

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q99470 9606 SDF2_HUMAN GO:0005576 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A0G2JY81 10116 A0A0G2JY81_RAT GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A7U3L4H9 10116 A0A7U3L4H9_RAT GO:0005576 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AAN5 10116 A0A8I6AAN5_RAT GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A1Z7L0 7227 A1Z7L0_DROME GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:35714143
NOT-qualified manual protein A4QNU9 7955 A4QNU9_DANRE GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:22292055
NOT-qualified manual protein A6HTD8 10116 A6HTD8_RAT GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6HWX9 10116 A6HWX9_RAT GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6K8X7 10116 A6K8X7_RAT GO:0005576 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein B1WC21 10116 B1WC21_RAT GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR000213 Vitamin D-binding protein
InterPro IPR000215 Serpin family
InterPro IPR000264 ALB/AFP/VDB
InterPro IPR000512 Diphtheria toxin (NAD+-dipthamide ADP-ribosyltransferase)
InterPro IPR000975 Interleukin-1 family
InterPro IPR001144 Heat-labile enterotoxin, A chain
InterPro IPR001219 Scorpion alpha long chain toxin
InterPro IPR001363 Proteinase inhibitor I25C, fetuin, conserved site
InterPro IPR001489 Heat-stable enterotoxin, STa
InterPro IPR001500 Alpha-1-acid glycoprotein

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0005615 based on ALL annotations
The top 100 of 10,199 co-occurring terms
Co-occurring Term PR S% #Together #Compared
extracellular space
161.85 100.00 1,204,410 1,204,410
extracellular region
36.49 18.18 583,406 2,587,694
cytokine activity
154.57 13.23 160,396 167,953
signaling receptor binding
88.95 7.75 99,723 181,451
extracellular matrix
84.58 7.60 98,335 188,172
growth factor activity
108.41 7.26 90,689 135,396
immune response
61.30 7.17 97,820 258,287
serine-type endopeptidase inhibitor activity
94.44 6.29 79,323 135,952
collagen-containing extracellular matrix
84.29 5.63 71,460 137,216
metallopeptidase activity
16.05 5.49 131,790 1,329,122
Totals 5446310 33930540
No co-occurrence statistics for GO:0005615 based on MANUAL annotations
The top 100 of 8,977 co-occurring terms
Co-occurring Term PR S% #Together #Compared
extracellular space
42.21 100.00 30,602 30,602
proteolysis involved in protein catabolic process
29.25 7.87 2,494 3,599
cysteine-type endopeptidase activity
27.16 7.82 2,500 3,886
collagen-containing extracellular matrix
29.09 7.25 2,293 3,327
cytokine activity
38.18 6.30 1,942 2,147
serine-type endopeptidase activity
16.29 6.28 2,135 5,533
proteolysis
12.40 6.09 2,182 7,427
extracellular matrix
19.47 5.33 1,738 3,769
extracellular matrix organization
21.68 4.62 1,478 2,878
extracellular region
7.23 4.37 1,698 9,908
Totals 97158 703306

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_generic 141
goslim_chembl 296
goslim_drosophila 173

Change Log

Timestamp Action Category Detail
2024-02-24 Deleted SUBSET goslim_prokaryote
2023-12-15 Added SUBSET goslim_prokaryote
2019-11-09 Added SUBSET goslim_drosophila
2019-09-12 Deleted RELATION is a GO:0044421 (obsolete extracellular region part)
2019-09-12 Added RELATION part of GO:0005576 (extracellular region)
2019-09-12 Added RELATION is a GO:0110165 (cellular anatomical structure)
2019-05-17 Deleted SUBSET goslim_plant
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-19 Added SUBSET goslim_chembl
2015-05-11 Added SUBSET goslim_ChEMBL
Timestamp Action Category Detail
2004-09-29 Updated TERM extracellular space
2002-02-06 Updated TERM extracellular space
2001-04-03 Updated TERM extracellular space
2001-03-30 Added TERM extracellular space
Timestamp Action Category Detail
2008-05-13 Added DEFINITION That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2008-05-12 Deleted DEFINITION That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2007-08-09 Added SYNONYM intercellular space
2007-08-09 Deleted SYNONYM intercellular space
2004-11-12 Added SYNONYM intercellular space
2002-11-27 Updated DEFINITION That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2001-08-06 Added DEFINITION That part of a multicellular organism outside the cells proper - usually taken to be outside the plasma membranes - and occupied by fluid.
Timestamp Action Category Detail
2019-09-12 Deleted RELATION is a GO:0044421 (obsolete extracellular region part)
2019-09-12 Added RELATION part of GO:0005576 (extracellular region)
2019-09-12 Added RELATION is a GO:0110165 (cellular anatomical structure)
2008-04-01 Updated RELATION is a GO:0044421 (obsolete extracellular region part)
Timestamp Action Category Detail
2010-02-04 Added XREF NIF_Subcellular:sao1425028079
Timestamp Action Category Detail
2024-02-24 Deleted SUBSET goslim_prokaryote
2023-12-15 Added SUBSET goslim_prokaryote
2019-11-09 Added SUBSET goslim_drosophila
2019-05-17 Deleted SUBSET goslim_plant
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-19 Added SUBSET goslim_chembl
2015-05-11 Added SUBSET goslim_ChEMBL
2013-04-18 Updated SUBSET goslim_generic
2013-04-18 Updated SUBSET goslim_plant
2011-03-18 Deleted SUBSET goslim_goa
2008-06-09 Added SUBSET goslim_goa
2008-06-09 Added SUBSET goslim_plant
2008-06-09 Added SUBSET goslim_generic
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