Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term.
GO:0005615
JSON
extracellular space
Cellular Component
Definition (GO:0005615 GONUTS page)
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
Comments
Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
intercellular space | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0005615
Child Term | Relationship to GO:0005615 |
---|---|
immunoglobulin complex, circulating
|
part_of |
extracellular exosome
|
part_of |
plasma lipoprotein particle
|
part_of |
insulin-like growth factor binding protein complex
|
part_of |
interleukin-27 complex
|
part_of |
interleukin-23 complex
|
part_of |
reelin complex
|
part_of |
classical-complement-pathway C3/C5 convertase complex
|
part_of |
interleukin-35 complex
|
part_of |
blood microparticle
|
part_of |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q99470 | 9606 | SDF2_HUMAN | GO:0005576 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A0G2JY81 | 10116 | A0A0G2JY81_RAT | GO:0005615 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A7U3L4H9 | 10116 | A0A7U3L4H9_RAT | GO:0005576 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AAN5 | 10116 | A0A8I6AAN5_RAT | GO:0005615 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A1Z7L0 | 7227 | A1Z7L0_DROME | GO:0005615 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:35714143 | |
NOT-qualified manual | protein | A4QNU9 | 7955 | A4QNU9_DANRE | GO:0005615 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:22292055 | |
NOT-qualified manual | protein | A6HTD8 | 10116 | A6HTD8_RAT | GO:0005615 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6HWX9 | 10116 | A6HWX9_RAT | GO:0005615 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K8X7 | 10116 | A6K8X7_RAT | GO:0005576 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | B1WC21 | 10116 | B1WC21_RAT | GO:0005615 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR000213 | Vitamin D-binding protein |
InterPro | IPR000215 | Serpin family |
InterPro | IPR000264 | ALB/AFP/VDB |
InterPro | IPR000512 | Diphtheria toxin (NAD+-dipthamide ADP-ribosyltransferase) |
InterPro | IPR000975 | Interleukin-1 family |
InterPro | IPR001144 | Heat-labile enterotoxin, A chain |
InterPro | IPR001219 | Scorpion alpha long chain toxin |
InterPro | IPR001363 | Proteinase inhibitor I25C, fetuin, conserved site |
InterPro | IPR001489 | Heat-stable enterotoxin, STa |
InterPro | IPR001500 | Alpha-1-acid glycoprotein |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0005615 based on ALL annotations
The top 100 of 10,199 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
extracellular space
|
161.85 | 100.00 | 1,204,410 | 1,204,410 |
extracellular region
|
36.49 | 18.18 | 583,406 | 2,587,694 |
cytokine activity
|
154.57 | 13.23 | 160,396 | 167,953 |
signaling receptor binding
|
88.95 | 7.75 | 99,723 | 181,451 |
extracellular matrix
|
84.58 | 7.60 | 98,335 | 188,172 |
growth factor activity
|
108.41 | 7.26 | 90,689 | 135,396 |
immune response
|
61.30 | 7.17 | 97,820 | 258,287 |
serine-type endopeptidase inhibitor activity
|
94.44 | 6.29 | 79,323 | 135,952 |
collagen-containing extracellular matrix
|
84.29 | 5.63 | 71,460 | 137,216 |
metallopeptidase activity
|
16.05 | 5.49 | 131,790 | 1,329,122 |
Totals | 5446310 | 33930540 |
No co-occurrence statistics for GO:0005615 based on MANUAL annotations
The top 100 of 8,977 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
extracellular space
|
42.21 | 100.00 | 30,602 | 30,602 |
proteolysis involved in protein catabolic process
|
29.25 | 7.87 | 2,494 | 3,599 |
cysteine-type endopeptidase activity
|
27.16 | 7.82 | 2,500 | 3,886 |
collagen-containing extracellular matrix
|
29.09 | 7.25 | 2,293 | 3,327 |
cytokine activity
|
38.18 | 6.30 | 1,942 | 2,147 |
serine-type endopeptidase activity
|
16.29 | 6.28 | 2,135 | 5,533 |
proteolysis
|
12.40 | 6.09 | 2,182 | 7,427 |
extracellular matrix
|
19.47 | 5.33 | 1,738 | 3,769 |
extracellular matrix organization
|
21.68 | 4.62 | 1,478 | 2,878 |
extracellular region
|
7.23 | 4.37 | 1,698 | 9,908 |
Totals | 97158 | 703306 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_generic | 141 |
goslim_chembl | 296 |
goslim_drosophila | 173 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-02-24 | Deleted | SUBSET | goslim_prokaryote |
2023-12-15 | Added | SUBSET | goslim_prokaryote |
2019-11-09 | Added | SUBSET | goslim_drosophila |
2019-09-12 | Deleted | RELATION | is a GO:0044421 (obsolete extracellular region part) |
2019-09-12 | Added | RELATION | part of GO:0005576 (extracellular region) |
2019-09-12 | Added | RELATION | is a GO:0110165 (cellular anatomical structure) |
2019-05-17 | Deleted | SUBSET | goslim_plant |
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
Timestamp | Action | Category | Detail |
---|---|---|---|
2004-09-29 | Updated | TERM | extracellular space |
2002-02-06 | Updated | TERM | extracellular space |
2001-04-03 | Updated | TERM | extracellular space |
2001-03-30 | Added | TERM | extracellular space |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
2008-05-12 | Deleted | DEFINITION | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
2007-08-09 | Added | SYNONYM | intercellular space |
2007-08-09 | Deleted | SYNONYM | intercellular space |
2004-11-12 | Added | SYNONYM | intercellular space |
2002-11-27 | Updated | DEFINITION | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
2001-08-06 | Added | DEFINITION | That part of a multicellular organism outside the cells proper - usually taken to be outside the plasma membranes - and occupied by fluid. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-09-12 | Deleted | RELATION | is a GO:0044421 (obsolete extracellular region part) |
2019-09-12 | Added | RELATION | part of GO:0005576 (extracellular region) |
2019-09-12 | Added | RELATION | is a GO:0110165 (cellular anatomical structure) |
2008-04-01 | Updated | RELATION | is a GO:0044421 (obsolete extracellular region part) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-02-04 | Added | XREF | NIF_Subcellular:sao1425028079 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-02-24 | Deleted | SUBSET | goslim_prokaryote |
2023-12-15 | Added | SUBSET | goslim_prokaryote |
2019-11-09 | Added | SUBSET | goslim_drosophila |
2019-05-17 | Deleted | SUBSET | goslim_plant |
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
2013-04-18 | Updated | SUBSET | goslim_generic |
2013-04-18 | Updated | SUBSET | goslim_plant |
2011-03-18 | Deleted | SUBSET | goslim_goa |
2008-06-09 | Added | SUBSET | goslim_goa |
2008-06-09 | Added | SUBSET | goslim_plant |
2008-06-09 | Added | SUBSET | goslim_generic |
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link