This term is obsolete.

GO:0005885 JSON

Arp2/3 protein complex

Cellular Component

Definition (GO:0005885 GONUTS page)

A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments. PMID:12479800

26,649 annotations

Ancestor Chart

Ancestor chart for GO:0005885
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Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0005885 Arp2/3 protein complex Only in Taxon 131567 cellular organisms

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5ZRZ8 10116 A0A8I5ZRZ8_RAT GO:0005856 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZT22 10116 A0A8I5ZT22_RAT GO:0005856 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6IVM5 10116 A6IVM5_RAT GO:0005856 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6IVM6 10116 A6IVM6_RAT GO:0005856 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZJL1 10116 D3ZJL1_RAT GO:0005856 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q03001-7 9606 DYST_HUMAN GO:0015629 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10428034
NOT-qualified manual protein Q99P55 10116 SGPP1_RAT GO:0015629 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q9JI99 10090 SGPP1_MOUSE GO:0015629 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12235122
NOT-qualified manual protein Q9Y4C4 9606 MFHA1_HUMAN GO:0005856 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:24286120

Cross-references

Database ID Description
InterPro IPR006789 Actin-related protein 2/3 complex subunit 5
InterPro IPR007188 Actin-related protein 2/3 complex subunit 2
InterPro IPR007204 Actin-related protein 2/3 complex subunit 3
InterPro IPR008384 Actin-related protein 2/3 complex subunit 4
InterPro IPR017383 Actin-related protein 2/3 complex subunit 1
InterPro IPR034666 Arp2/3 complex subunit 2/4
InterPro IPR036743 Actin-related protein 2/3 complex subunit 5 superfamily
InterPro IPR036753 Actin-related protein 2/3 complex subunit 3 superfamily

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0005885 based on ALL annotations
The top 100 of 792 co-occurring terms
Co-occurring Term PR S% #Together #Compared
Arp2/3 protein complex
7,542.61 100.00 25,845 25,845
Arp2/3 complex-mediated actin nucleation
6,428.63 85.21 25,836 30,313
actin filament polymerization
1,973.15 18.78 10,328 39,480
regulation of actin filament polymerization
1,451.40 14.06 8,872 46,106
actin cytoskeleton
736.75 9.55 20,882 213,783
actin cortical patch
720.29 5.68 3,180 33,300
actin cortical patch organization
4,788.35 5.12 1,363 2,147
actin filament binding
331.37 4.29 16,653 379,052
actin binding
300.17 3.95 22,192 557,639
structural constituent of cytoskeleton
291.19 3.35 5,231 135,499
Totals 207526 42901012
No co-occurrence statistics for GO:0005885 based on MANUAL annotations
The top 100 of 248 co-occurring terms
Co-occurring Term PR S% #Together #Compared
Arp2/3 protein complex
1,481.42 100.00 872 872
Arp2/3 complex-mediated actin nucleation
1,286.14 84.30 843 971
actin filament binding
156.52 10.52 835 7,903
structural constituent of cytoskeleton
105.27 5.46 166 2,336
cell cortex
66.50 3.38 105 2,339
site of double-strand break
43.99 2.00 50 1,684
actin cortical patch
103.35 1.82 21 301
actin nucleation
364.28 1.63 15 61
positive regulation of lamellipodium assembly
99.78 1.24 13 193
regulation of double-strand break repair via nonhomologous end joining
428.83 1.22 11 38
Totals 3398 97564

Change Log

Timestamp Action Category Detail
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2019-09-12 Deleted RELATION is a GO:0044430 (obsolete cytoskeletal part)
2018-02-18 Added RELATION is a GO:0032991 (protein-containing complex)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2008-10-21 Deleted DEFINITION A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5)., and functions in the nucleation of branched actin filaments.
2008-10-21 Added DEFINITION A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments.
2008-10-06 Added DEFINITION A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5)., and functions in the nucleation of branched actin filaments.
2008-10-06 Deleted DEFINITION A stable complex of seven subunits, two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). Functions in the nucleation of actin filaments.
2008-05-13 Added DEFINITION A stable complex of seven subunits, two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). Functions in the nucleation of actin filaments.
2008-05-12 Deleted DEFINITION A stable complex of seven subunits, two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). Functions in the nucleation of actin filaments.
Timestamp Action Category Detail
2002-02-06 Updated TERM Arp2/3 protein complex
2001-04-03 Updated TERM Arp2/3 protein complex
2001-03-30 Added TERM Arp2/3 protein complex
Timestamp Action Category Detail
2008-10-21 Deleted DEFINITION A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5)., and functions in the nucleation of branched actin filaments.
2008-10-21 Added DEFINITION A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments.
2008-10-06 Added DEFINITION A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5)., and functions in the nucleation of branched actin filaments.
2008-10-06 Deleted DEFINITION A stable complex of seven subunits, two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). Functions in the nucleation of actin filaments.
2008-05-13 Added DEFINITION A stable complex of seven subunits, two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). Functions in the nucleation of actin filaments.
2008-05-12 Deleted DEFINITION A stable complex of seven subunits, two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). Functions in the nucleation of actin filaments.
2003-03-26 Added DEFINITION A stable complex of seven subunits, two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). Functions in the nucleation of actin filaments.
Timestamp Action Category Detail
2019-09-12 Deleted RELATION is a GO:0044430 (obsolete cytoskeletal part)
2018-02-18 Added RELATION is a GO:0032991 (protein-containing complex)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0044430 (obsolete cytoskeletal part)
2008-04-01 Updated RELATION part of GO:0015629 (actin cytoskeleton)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
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