GO:0005885
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Arp2/3 protein complex
Cellular Component
Definition (GO:0005885 GONUTS page)
A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments. PMID:12479800
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0005885 | Arp2/3 protein complex | Only in Taxon | 131567 | cellular organisms |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5ZRZ8 | 10116 | A0A8I5ZRZ8_RAT | GO:0005856 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZT22 | 10116 | A0A8I5ZT22_RAT | GO:0005856 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6IVM5 | 10116 | A6IVM5_RAT | GO:0005856 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6IVM6 | 10116 | A6IVM6_RAT | GO:0005856 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D3ZJL1 | 10116 | D3ZJL1_RAT | GO:0005856 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q03001-7 | 9606 | DYST_HUMAN | GO:0015629 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10428034 | |
NOT-qualified manual | protein | Q99P55 | 10116 | SGPP1_RAT | GO:0015629 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q9JI99 | 10090 | SGPP1_MOUSE | GO:0015629 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12235122 | |
NOT-qualified manual | protein | Q9Y4C4 | 9606 | MFHA1_HUMAN | GO:0005856 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:24286120 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR006789 | Actin-related protein 2/3 complex subunit 5 |
InterPro | IPR007188 | Actin-related protein 2/3 complex subunit 2 |
InterPro | IPR007204 | Actin-related protein 2/3 complex subunit 3 |
InterPro | IPR008384 | Actin-related protein 2/3 complex subunit 4 |
InterPro | IPR017383 | Actin-related protein 2/3 complex subunit 1 |
InterPro | IPR034666 | Arp2/3 complex subunit 2/4 |
InterPro | IPR036743 | Actin-related protein 2/3 complex subunit 5 superfamily |
InterPro | IPR036753 | Actin-related protein 2/3 complex subunit 3 superfamily |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0005885 based on ALL annotations
The top 100 of 792 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
Arp2/3 protein complex
|
7,542.61 | 100.00 | 25,845 | 25,845 |
Arp2/3 complex-mediated actin nucleation
|
6,428.63 | 85.21 | 25,836 | 30,313 |
actin filament polymerization
|
1,973.15 | 18.78 | 10,328 | 39,480 |
regulation of actin filament polymerization
|
1,451.40 | 14.06 | 8,872 | 46,106 |
actin cytoskeleton
|
736.75 | 9.55 | 20,882 | 213,783 |
actin cortical patch
|
720.29 | 5.68 | 3,180 | 33,300 |
actin cortical patch organization
|
4,788.35 | 5.12 | 1,363 | 2,147 |
actin filament binding
|
331.37 | 4.29 | 16,653 | 379,052 |
actin binding
|
300.17 | 3.95 | 22,192 | 557,639 |
structural constituent of cytoskeleton
|
291.19 | 3.35 | 5,231 | 135,499 |
Totals | 207526 | 42901012 |
No co-occurrence statistics for GO:0005885 based on MANUAL annotations
The top 100 of 248 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
Arp2/3 protein complex
|
1,481.42 | 100.00 | 872 | 872 |
Arp2/3 complex-mediated actin nucleation
|
1,286.14 | 84.30 | 843 | 971 |
actin filament binding
|
156.52 | 10.52 | 835 | 7,903 |
structural constituent of cytoskeleton
|
105.27 | 5.46 | 166 | 2,336 |
cell cortex
|
66.50 | 3.38 | 105 | 2,339 |
site of double-strand break
|
43.99 | 2.00 | 50 | 1,684 |
actin cortical patch
|
103.35 | 1.82 | 21 | 301 |
actin nucleation
|
364.28 | 1.63 | 15 | 61 |
positive regulation of lamellipodium assembly
|
99.78 | 1.24 | 13 | 193 |
regulation of double-strand break repair via nonhomologous end joining
|
428.83 | 1.22 | 11 | 38 |
Totals | 3398 | 97564 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
2019-09-12 | Deleted | RELATION | is a GO:0044430 (obsolete cytoskeletal part) |
2018-02-18 | Added | RELATION | is a GO:0032991 (protein-containing complex) |
2018-02-18 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2008-10-21 | Deleted | DEFINITION | A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5)., and functions in the nucleation of branched actin filaments. |
2008-10-21 | Added | DEFINITION | A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments. |
2008-10-06 | Added | DEFINITION | A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5)., and functions in the nucleation of branched actin filaments. |
2008-10-06 | Deleted | DEFINITION | A stable complex of seven subunits, two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). Functions in the nucleation of actin filaments. |
2008-05-13 | Added | DEFINITION | A stable complex of seven subunits, two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). Functions in the nucleation of actin filaments. |
2008-05-12 | Deleted | DEFINITION | A stable complex of seven subunits, two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). Functions in the nucleation of actin filaments. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2002-02-06 | Updated | TERM | Arp2/3 protein complex |
2001-04-03 | Updated | TERM | Arp2/3 protein complex |
2001-03-30 | Added | TERM | Arp2/3 protein complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-10-21 | Deleted | DEFINITION | A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5)., and functions in the nucleation of branched actin filaments. |
2008-10-21 | Added | DEFINITION | A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments. |
2008-10-06 | Added | DEFINITION | A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5)., and functions in the nucleation of branched actin filaments. |
2008-10-06 | Deleted | DEFINITION | A stable complex of seven subunits, two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). Functions in the nucleation of actin filaments. |
2008-05-13 | Added | DEFINITION | A stable complex of seven subunits, two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). Functions in the nucleation of actin filaments. |
2008-05-12 | Deleted | DEFINITION | A stable complex of seven subunits, two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). Functions in the nucleation of actin filaments. |
2003-03-26 | Added | DEFINITION | A stable complex of seven subunits, two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). Functions in the nucleation of actin filaments. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-09-12 | Deleted | RELATION | is a GO:0044430 (obsolete cytoskeletal part) |
2018-02-18 | Added | RELATION | is a GO:0032991 (protein-containing complex) |
2018-02-18 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2008-04-01 | Updated | RELATION | is a GO:0043234 (protein complex) |
2008-04-01 | Updated | RELATION | is a GO:0044430 (obsolete cytoskeletal part) |
2008-04-01 | Updated | RELATION | part of GO:0015629 (actin cytoskeleton) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
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