This term is obsolete.

GO:0005921 JSON

gap junction

Cellular Component

Definition (GO:0005921 GONUTS page)

A cell-cell junction composed of pannexins or innexins and connexins, two different families of channel-forming proteins. PMID:22366062

54,510 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
gap junction plaque exact
communicating junction exact
electrotonic synapse related
electrical synapse related
macula communicans exact
zonula communicans exact
intercellular gap junction channel related
gap junction macula exact

Ancestor Chart

Ancestor chart for GO:0005921
Chart options
Apply Download Chart
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005921

Child Term Relationship to
GO:0005921
GO:0005922
connexin complex
part_of

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0005921 gap junction Only in Taxon 6072 Eumetazoa

More information on taxon constraints in GO is available here

Cross-references

Database ID Description
InterPro IPR002262 Gap junction alpha-3 protein (Cx46)
NIF_Subcellular sao118541872
UniProtKB-KW KW-0303 Gap junction
UniProtKB-SubCell SL-0124 Gap junction
Wikipedia Gap_junction

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0005921 based on ALL annotations
The top 100 of 892 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0005921
gap junction
5,816.62 100.00 34,067 34,067
GO:0005243
gap junction channel activity
5,512.85 70.26 24,899 26,271
GO:0005922
connexin complex
5,392.27 51.19 18,171 19,601
GO:0007267
cell-cell signaling
3,044.81 38.34 20,065 38,331
GO:0007154
cell communication
1,109.83 16.12 17,343 90,895
GO:1990349
gap junction-mediated intercellular transport
5,538.44 7.05 2,409 2,530
GO:0032732
positive regulation of interleukin-1 production
3,487.69 6.85 2,447 4,081
GO:0022829
wide pore channel activity
1,935.33 6.09 2,363 7,102
GO:0010644
cell communication by electrical coupling
5,701.56 4.21 1,437 1,466
GO:0007602
phototransduction
285.13 3.00 2,451 50,000
Totals 165814 2943165
No co-occurrence statistics for GO:0005921 based on MANUAL annotations
The top 100 of 525 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0005921
gap junction
6,819.00 100.00 207 207
GO:0005243
gap junction channel activity
1,976.35 27.32 171 590
GO:0055077
gap junction hemi-channel activity
4,507.47 17.18 39 59
GO:0016264
gap junction assembly
3,182.20 9.09 21 45
GO:0005922
connexin complex
527.74 5.76 38 491
GO:0010644
cell communication by electrical coupling
1,528.40 5.16 13 58
GO:1903763
gap junction channel activity involved in cell communication by electrical coupling
6,819.00 4.83 10 10
GO:0086053
AV node cell to bundle of His cell communication by electrical coupling
5,579.18 4.31 9 11
GO:0086077
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
2,479.64 3.62 8 22
GO:0010496
intercellular transport
1,076.68 3.53 9 57
Totals 917 10055

Change Log

Timestamp Action Category Detail
2016-08-06 Added DEFINITION A cell-cell junction composed of pannexins or innexins and connexins, two different families of channel-forming proteins.
2016-08-06 Deleted DEFINITION A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons.
2016-08-06 Added CONSTRAINT in_taxon NCBITaxon:6072 (Eumetazoa)
2014-08-07 Added SYNONYM intercellular gap junction channel
2013-02-23 Added SYNONYM electrical synapse
2013-02-23 Added SYNONYM electrotonic synapse
2013-02-22 Added SYNONYM gap junction plaque
2013-02-22 Added SYNONYM gap junction macula
2010-02-04 Added XREF NIF_Subcellular:sao118541872
2009-02-08 Added XREF Wikipedia:Gap_junction
Timestamp Action Category Detail
2002-02-06 Updated TERM gap junction
2001-04-03 Updated TERM gap junction
2001-03-30 Added TERM gap junction
Timestamp Action Category Detail
2016-08-06 Added DEFINITION A cell-cell junction composed of pannexins or innexins and connexins, two different families of channel-forming proteins.
2016-08-06 Deleted DEFINITION A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons.
2014-08-07 Added SYNONYM intercellular gap junction channel
2013-02-23 Added SYNONYM electrical synapse
2013-02-23 Added SYNONYM electrotonic synapse
2013-02-22 Added SYNONYM gap junction plaque
2013-02-22 Added SYNONYM gap junction macula
2008-11-28 Deleted DEFINITION A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2P4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons.
2008-11-28 Added DEFINITION A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons.
2008-11-27 Added DEFINITION A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2P4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons.
2008-11-27 Deleted DEFINITION Any specialized areas of the plasma membranes of adjacent cells where the membranes are 2-4 nm apart and penetrated by a connexon. This gap junction allows passage of small molecules and electric current. The variety in the properties of gap junctions is reflected in the number of connexins, the family of proteins which form the junction.
2008-05-13 Added DEFINITION Any specialized areas of the plasma membranes of adjacent cells where the membranes are 2-4 nm apart and penetrated by a connexon. This gap junction allows passage of small molecules and electric current. The variety in the properties of gap junctions is reflected in the number of connexins, the family of proteins which form the junction.
2008-05-12 Deleted DEFINITION Any specialized areas of the plasma membranes of adjacent cells where the membranes are 2-4 nm apart and penetrated by a connexon. This gap junction allows passage of small molecules and electric current. The variety in the properties of gap junctions is reflected in the number of connexins, the family of proteins which form the junction.
2007-11-27 Updated DEFINITION Any specialized areas of the plasma membranes of adjacent cells where the membranes are 2-4 nm apart and penetrated by a connexon. This gap junction allows passage of small molecules and electric current. The variety in the properties of gap junctions is reflected in the number of connexins, the family of proteins which form the junction.
2007-08-09 Deleted SYNONYM communicating junction
2007-08-09 Deleted SYNONYM zonula communicans
2007-08-09 Added SYNONYM zonula communicans
2007-08-09 Deleted SYNONYM macula communicans
2007-08-09 Added SYNONYM communicating junction
2007-08-09 Added SYNONYM macula communicans
2004-04-19 Added SYNONYM macula communicans
2004-04-19 Added SYNONYM communicating junction
2004-04-19 Added SYNONYM zonula communicans
2004-04-16 Deleted SYNONYM zonula communicans
2004-04-16 Deleted SYNONYM communicating junction
2004-04-16 Deleted SYNONYM macula communicans
2002-11-27 Updated DEFINITION Any specialized areas of the plasma membranes of adjacent cells where the membranes are 2-4 nm apart and penetrated by a connexon.
2001-08-06 Added DEFINITION ny specialised areas of the plasma membranes of adjacent cells where the membranes are 2-4nm apart and penetrated by a connexon.
2001-03-30 Added SYNONYM communicating junction
2001-03-30 Added SYNONYM macula communicans
2001-03-30 Added SYNONYM zonula communicans
Timestamp Action Category Detail
2008-11-27 Deleted RELATION part of GO:0014704 (intercalated disc)
2008-04-01 Updated RELATION part of GO:0014704 (intercalated disc)
2008-04-01 Updated RELATION is a GO:0005911 (cell-cell junction)
Timestamp Action Category Detail
2010-02-04 Added XREF NIF_Subcellular:sao118541872
2009-02-08 Added XREF Wikipedia:Gap_junction
Timestamp Action Category Detail
2016-08-06 Added CONSTRAINT in_taxon NCBITaxon:6072 (Eumetazoa)
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.
I agree, dismiss this banner