This term is obsolete.

GO:0005960 JSON

glycine cleavage complex

Cellular Component

Definition (GO:0005960 GONUTS page)

A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T.

Secondary IDs

GO:0005961, GO:0070015

128,565 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
glycine dehydrogenase complex (decarboxylating) related
glycine synthase complex exact
glycine cleavage system exact
glycine dehydrogenase (decarboxylating) complex exact
glycine decarboxylase complex exact

Ancestor Chart

Ancestor chart for GO:0005960
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Ancestor chart

Cross-references

Database ID Description
InterPro IPR002930 Glycine cleavage system H-protein
InterPro IPR006223 Glycine cleavage system T protein
InterPro IPR017453 Glycine cleavage system H-protein, subgroup
Wikipedia Glycine_decarboxylase_complex

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0005960 based on ALL annotations
The top 100 of 461 co-occurring terms
Co-occurring Term PR S% #Together #Compared
glycine cleavage complex
1,544.21 100.00 128,321 128,321
glycine decarboxylation via glycine cleavage system
1,423.58 81.90 112,934 122,504
glycine catabolic process
1,376.41 54.16 74,408 83,479
glycine binding
1,332.64 32.20 43,550 50,464
glycine dehydrogenase (decarboxylating) activity
1,161.22 30.66 43,772 58,209
aminomethyltransferase activity
1,466.94 28.49 37,116 39,071
transaminase activity
47.29 2.85 36,794 1,201,488
pyridoxal phosphate binding
38.43 2.37 43,815 1,760,728
cytosol
10.62 0.69 96,200 13,989,509
chloroplast envelope
59.68 0.61 914 23,648
Totals 767137 92242537
No co-occurrence statistics for GO:0005960 based on MANUAL annotations
The top 67 of 67 co-occurring terms
Co-occurring Term PR S% #Together #Compared
glycine cleavage complex
3,610.06 100.00 391 391
glycine decarboxylation via glycine cleavage system
3,510.78 96.77 389 400
glycine dehydrogenase (decarboxylating) activity
3,522.54 40.76 161 165
glycine binding
2,285.40 32.57 157 248
pyridoxal phosphate binding
238.74 6.02 157 2,374
glycine catabolic process
1,805.03 3.69 15 30
aminomethyltransferase activity
1,263.52 1.73 7 20
one-carbon metabolic process
252.70 1.45 7 100
protein lipoylation
416.55 0.72 3 26
mitochondrion
26.10 0.72 354 48,955
Totals 1789 794094

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_pir 438

Change Log

Timestamp Action Category Detail
2024-09-07 Deleted RELATION part of GO:0005737 (cytoplasm)
2024-09-07 Deleted CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2019-09-20 Added RELATION is a GO:1990204 (oxidoreductase complex)
2019-09-20 Deleted RELATION is a GO:1902494 (catalytic complex)
2019-09-12 Added RELATION part of GO:0005737 (cytoplasm)
2019-09-12 Deleted RELATION is a GO:0044444 (obsolete cytoplasmic part)
2019-08-30 Deleted RELATION is a GO:1990204 (oxidoreductase complex)
2019-08-30 Added RELATION is a GO:1902494 (catalytic complex)
2015-06-18 Added RELATION capable of GO:0004375 (glycine dehydrogenase (decarboxylating) activity)
Timestamp Action Category Detail
2003-05-24 Updated TERM glycine cleavage complex
2002-06-12 Updated TERM glycine cleavage system complex
2002-02-06 Updated TERM glycine cleavage system
2001-04-03 Updated TERM glycine cleavage system
2001-03-30 Added TERM glycine cleavage system
Timestamp Action Category Detail
2009-02-25 Added SYNONYM glycine dehydrogenase (decarboxylating) complex
2009-02-25 Added SYNONYM glycine decarboxylase complex
2009-02-25 Added DEFINITION A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T.
2009-02-25 Deleted DEFINITION A multienzyme complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase.
2008-05-13 Added DEFINITION A multienzyme complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase.
2008-05-12 Deleted DEFINITION A multienzyme complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase.
2008-02-22 Added SYNONYM glycine dehydrogenase complex (decarboxylating)
2007-08-09 Added SYNONYM glycine cleavage system
2007-08-09 Deleted SYNONYM glycine synthase complex
2007-08-09 Deleted SYNONYM glycine cleavage system
2007-08-09 Added SYNONYM glycine synthase complex
2004-04-19 Added SYNONYM glycine cleavage system
2004-04-19 Added SYNONYM glycine synthase complex
2004-04-16 Deleted SYNONYM glycine synthase complex
2004-04-16 Deleted SYNONYM glycine cleavage system
2003-05-24 Added SYNONYM glycine synthase complex
2003-05-24 Added SYNONYM glycine cleavage system
2003-05-24 Deleted SYNONYM glycine synthase
2003-04-17 Updated DEFINITION A multienzyme complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase.
2003-04-09 Updated DEFINITION A multi-enzyme complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase.
2002-11-27 Added DEFINITION An enzyme complex composed of aminomethyltransferase and glycine dehydrogenase (decarboxylating). It catalyzes the cleavage of glycine, forming dihydrolipoylprotein, methylenetetrahydrofolate and ammonia.
2001-03-30 Added SYNONYM glycine synthase
Timestamp Action Category Detail
2024-09-07 Deleted RELATION part of GO:0005737 (cytoplasm)
2019-09-20 Added RELATION is a GO:1990204 (oxidoreductase complex)
2019-09-20 Deleted RELATION is a GO:1902494 (catalytic complex)
2019-09-12 Added RELATION part of GO:0005737 (cytoplasm)
2019-09-12 Deleted RELATION is a GO:0044444 (obsolete cytoplasmic part)
2019-08-30 Deleted RELATION is a GO:1990204 (oxidoreductase complex)
2019-08-30 Added RELATION is a GO:1902494 (catalytic complex)
2015-06-18 Added RELATION capable of GO:0004375 (glycine dehydrogenase (decarboxylating) activity)
2013-10-24 Added RELATION is a GO:1990204 (oxidoreductase complex)
2013-10-24 Deleted RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0044444 (obsolete cytoplasmic part)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
Timestamp Action Category Detail
2009-02-08 Added XREF Wikipedia:Glycine_decarboxylase_complex
Timestamp Action Category Detail
2024-09-07 Deleted CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2013-04-18 Updated SUBSET goslim_pir
2009-02-25 Added SECONDARY GO:0070015 (glycine decarboxylase complex)
2008-06-09 Added SUBSET goslim_pir
2008-02-22 Added SECONDARY GO:0005961 (glycine dehydrogenase complex (decarboxylating))
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