This term is obsolete.

GO:0006103 JSON

2-oxoglutarate metabolic process

Biological Process

Definition (GO:0006103 GONUTS page)

The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.

89,183 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
2-ketoglutarate metabolic process exact
2-ketoglutarate metabolism exact
alpha-oxoglutarate metabolism exact
alpha-oxoglutarate metabolic process exact
alpha-ketoglutarate metabolism exact
alpha-ketoglutarate metabolic process exact
2-oxoglutarate metabolism exact

Ancestor Chart

Ancestor chart for GO:0006103
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006103

Child Term Relationship to
GO:0006103
mixed acid fermentation
is_a
L-histidine catabolic process to 2-oxoglutarate
is_a
proline catabolic process to 2-oxoglutarate
is_a
L-arabinose catabolic process to 2-oxoglutarate
is_a
acetyl-CoA assimilation pathway
is_a

Cross-references

Database ID Description
InterPro IPR020373 Alpha-ketoglutarate dehydrogenase component 4/YMR-31
Reactome R-HSA-2978092
Reactome R-HSA-880009

Cross-Ontology Relations

Relation Other Ontology ID Term
has_primary_input_or_output CHEBI CHEBI:16810 2-oxoglutarate(2-)

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0006100 obsolete tricarboxylic acid cycle intermediate metabolic process consider GO:0006103

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0006103 based on ALL annotations
The top 100 of 591 co-occurring terms
Co-occurring Term PR S% #Together #Compared
2-oxoglutarate metabolic process
2,187.99 100.00 89,095 89,095
dihydrolipoyl dehydrogenase activity
2,126.05 93.32 85,464 87,954
pyruvate metabolic process
704.56 31.77 85,464 265,404
oxoglutarate dehydrogenase complex
258.26 5.48 8,278 70,132
NAD(P)+ transhydrogenase (Si-specific) activity
2,137.27 5.43 4,846 4,961
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
315.80 5.29 6,871 47,605
flavin adenine dinucleotide binding
112.61 5.14 85,463 1,660,475
nucleotide binding
81.15 3.67 68,305 1,841,736
NADP metabolic process
378.15 3.02 3,140 18,168
oxoglutarate dehydrogenase (succinyl-transferring) activity
120.54 1.79 2,309 41,912
Totals 569369 63312635
No co-occurrence statistics for GO:0006103 based on MANUAL annotations
The top 100 of 335 co-occurring terms
Co-occurring Term PR S% #Together #Compared
2-oxoglutarate metabolic process
3,018.22 100.00 428 428
dihydrolipoyl dehydrogenase activity
2,855.08 63.06 280 296
oxoglutarate dehydrogenase complex
1,096.00 29.41 260 716
pyruvate metabolic process
818.90 23.73 280 1,032
glutamate metabolic process
909.60 8.30 44 146
flavin adenine dinucleotide binding
242.05 7.69 279 3,479
aspartate metabolic process
1,411.12 7.68 36 77
L-aspartate:2-oxoglutarate aminotransferase activity
288.56 4.76 37 387
oxoglutarate dehydrogenase (succinyl-transferring) activity
301.82 3.51 22 220
aspartate biosynthetic process
545.46 3.02 15 83
Totals 2498 75582

Change Log

Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-2978092
2024-12-05 Added XREF Reactome:R-HSA-880009
2019-07-06 Deleted RELATION is a GO:0051186 (obsolete cofactor metabolic process)
2017-11-29 Added RELATION is a GO:0051186 (obsolete cofactor metabolic process)
2009-07-03 Deleted RELATION is a GO:0042180 (ketone metabolic process)
2008-05-13 Added DEFINITION The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
2008-05-12 Deleted DEFINITION The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
2008-04-01 Updated RELATION is a GO:0042180 (ketone metabolic process)
2008-04-01 Updated RELATION is a GO:0043648 (dicarboxylic acid metabolic process)
2007-08-09 Deleted SYNONYM 2-ketoglutarate metabolic process
Timestamp Action Category Detail
2007-01-15 Updated TERM 2-oxoglutarate metabolic process
2002-10-03 Updated TERM 2-oxoglutarate metabolism
2002-02-06 Updated TERM 2-oxo-glutarate metabolism
2001-10-15 Updated TERM 2-oxo-glutarate metabolism
2001-04-03 Updated TERM 2-oxoglutarate metabolism
2001-03-30 Added TERM 2-oxoglutarate metabolism
Timestamp Action Category Detail
2008-05-13 Added DEFINITION The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
2008-05-12 Deleted DEFINITION The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
2007-08-09 Deleted SYNONYM 2-ketoglutarate metabolic process
2007-08-09 Deleted SYNONYM alpha-ketoglutarate metabolic process
2007-08-09 Deleted SYNONYM alpha-oxoglutarate metabolic process
2007-08-09 Deleted SYNONYM alpha-oxoglutarate metabolism
2007-08-09 Deleted SYNONYM 2-oxoglutarate metabolism
2007-08-09 Added SYNONYM alpha-oxoglutarate metabolic process
2007-08-09 Added SYNONYM 2-ketoglutarate metabolic process
2007-08-09 Added SYNONYM 2-ketoglutarate metabolism
2007-08-09 Added SYNONYM 2-oxoglutarate metabolism
2007-08-09 Deleted SYNONYM alpha-ketoglutarate metabolism
2007-08-09 Deleted SYNONYM 2-ketoglutarate metabolism
2007-08-09 Added SYNONYM alpha-ketoglutarate metabolism
2007-08-09 Added SYNONYM alpha-ketoglutarate metabolic process
2007-08-09 Added SYNONYM alpha-oxoglutarate metabolism
2007-01-29 Added SYNONYM 2-oxoglutarate metabolism
2007-01-15 Added SYNONYM alpha-ketoglutarate metabolic process
2007-01-15 Added SYNONYM 2-ketoglutarate metabolic process
2007-01-15 Added SYNONYM alpha-oxoglutarate metabolic process
2006-05-04 Updated DEFINITION The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
2005-07-09 Deleted SYNONYM ketoglutarate metabolism
2005-07-09 Added SYNONYM 2-ketoglutarate metabolism
2005-07-09 Added SYNONYM alpha-ketoglutarate metabolism
2005-07-09 Added SYNONYM alpha-oxoglutarate metabolism
2005-01-21 Updated DEFINITION The chemical reactions involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
2004-04-19 Added SYNONYM ketoglutarate metabolism
2004-04-16 Deleted SYNONYM ketoglutarate metabolism
2002-11-27 Added DEFINITION The chemical reactions and physical changes involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
2002-10-03 Added SYNONYM ketoglutarate metabolism
Timestamp Action Category Detail
2019-07-06 Deleted RELATION is a GO:0051186 (obsolete cofactor metabolic process)
2017-11-29 Added RELATION is a GO:0051186 (obsolete cofactor metabolic process)
2009-07-03 Deleted RELATION is a GO:0042180 (ketone metabolic process)
2008-04-01 Updated RELATION is a GO:0042180 (ketone metabolic process)
2008-04-01 Updated RELATION is a GO:0043648 (dicarboxylic acid metabolic process)
Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-2978092
2024-12-05 Added XREF Reactome:R-HSA-880009
Timestamp Action Category Detail
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