This term is obsolete.
Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'.

GO:0006268 JSON

DNA unwinding involved in DNA replication

Biological Process

Definition (GO:0006268 GONUTS page)

The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.

Comments

Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'.

187,644 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
DNA unwinding during replication related
DNA unwinding factor related

Ancestor Chart

Ancestor chart for GO:0006268
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006268

Child Term Relationship to
GO:0006268
cell cycle DNA replication DNA unwinding
is_a

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein D3ZVK1 10116 MCM8_RAT GO:0006260 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F1M5F3 10116 MCM9_RAT GO:0006260 3 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein F1N2W9 9913 MCM9_BOVIN GO:0006260 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein O61847 6239 CDK2_CAEEL GO:0006260 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:10207147
NOT-qualified manual protein Q2KHI9 10090 MCM9_MOUSE GO:0006260 2 NOT-qualified manual annotations exist with evidence code ECO:0000315 from these references: PMID:21987787, PMID:23401855
NOT-qualified manual protein Q41188 3702 CSP2_ARATH GO:0032508 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17169986
NOT-qualified manual protein Q9NXL9 9606 MCM9_HUMAN GO:0006260 1 NOT-qualified manual annotation exists with evidence code ECO:0000316 from this reference: PMID:23401855
NOT-qualified manual protein Q9UJA3 9606 MCM8_HUMAN GO:0006260 1 NOT-qualified manual annotation exists with evidence code ECO:0000316 from this reference: PMID:23401855

Cross-references

Database ID Description
InterPro IPR003176 Adenovirus DNA-binding, all-alpha domain
InterPro IPR005751 ATP-dependent DNA helicase PcrA
InterPro IPR005752 ATP-dependent DNA helicase Rep
InterPro IPR005753 DNA helicase, ATP-dependent, UvrD type
InterPro IPR037540 DNA-binding protein, Adenovirus

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0030039 obsolete DNA unwinding factor replaced_by GO:0006268

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0006268 based on ALL annotations
The top 100 of 965 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA unwinding involved in DNA replication
1,041.17 100.00 187,230 187,230
primosome complex
600.46 33.03 81,636 141,554
DNA replication, synthesis of primer
482.99 29.17 82,386 177,597
3'-5' DNA helicase activity
297.25 22.83 99,673 349,121
DNA helicase activity
256.99 22.62 136,694 553,794
DNA replication initiation
357.72 22.25 72,449 210,868
four-way junction helicase activity
209.94 16.96 96,590 479,025
single-stranded 3'-5' DNA helicase activity
206.03 15.64 80,073 404,658
forked DNA-dependent helicase activity
200.95 15.21 78,194 405,142
double-stranded DNA helicase activity
200.77 15.19 78,156 405,312
Totals 3060154 158303858
No co-occurrence statistics for GO:0006268 based on MANUAL annotations
The top 100 of 412 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA unwinding involved in DNA replication
1,021.19 100.00 1,265 1,265
four-way junction helicase activity
846.68 46.79 655 790
3'-5' DNA helicase activity
522.33 39.46 801 1,566
MCM complex
533.00 26.38 440 843
chromosome
351.56 26.19 661 1,920
double-strand break repair via break-induced replication
366.09 21.35 437 1,219
single-stranded DNA helicase activity
366.61 17.83 331 922
mitotic DNA replication initiation
394.81 13.04 208 538
DNA strand elongation involved in DNA replication
359.81 12.72 210 596
double-strand break repair via homologous recombination
137.66 12.03 667 4,948
Totals 9423 433705

Change Log

Timestamp Action Category Detail
2016-02-04 Deleted SYNONYM DNA unwinding involved in DNA replication
2014-11-07 Added SYNONYM DNA unwinding involved in DNA replication
2013-07-27 Deleted RELATION has part GO:0033260 (nuclear DNA replication)
2013-07-12 Updated TERM DNA unwinding involved in DNA replication
2010-11-24 Deleted DEFINITION The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
2010-11-24 Added DEFINITION The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
2010-10-31 Added RELATION has part GO:0033260 (nuclear DNA replication)
2010-04-16 Added SYNONYM DNA unwinding during replication
2010-04-16 Updated TERM DNA unwinding involved in replication
2008-05-13 Added DEFINITION The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
Timestamp Action Category Detail
2013-07-12 Updated TERM DNA unwinding involved in DNA replication
2010-04-16 Updated TERM DNA unwinding involved in replication
2005-10-05 Updated TERM DNA unwinding during replication
2002-02-06 Updated TERM DNA unwinding
2001-04-03 Updated TERM DNA unwinding
2001-03-30 Added TERM DNA unwinding
Timestamp Action Category Detail
2016-02-04 Deleted SYNONYM DNA unwinding involved in DNA replication
2014-11-07 Added SYNONYM DNA unwinding involved in DNA replication
2010-11-24 Deleted DEFINITION The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
2010-11-24 Added DEFINITION The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
2010-04-16 Added SYNONYM DNA unwinding during replication
2008-05-13 Added DEFINITION The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
2008-05-12 Deleted DEFINITION The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
2007-08-09 Added SYNONYM DNA unwinding factor
2007-08-09 Deleted SYNONYM DNA unwinding factor
2007-01-15 Deleted SYNONYM duplex DNA melting
2005-08-10 Added SYNONYM DNA unwinding factor
2004-04-26 Added SYNONYM duplex DNA melting
2004-04-24 Added DEFINITION The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
Timestamp Action Category Detail
2013-07-27 Deleted RELATION has part GO:0033260 (nuclear DNA replication)
2010-10-31 Added RELATION has part GO:0033260 (nuclear DNA replication)
2008-04-01 Updated RELATION is a GO:0032508 (DNA duplex unwinding)
2008-04-01 Updated RELATION part of GO:0006261 (DNA-templated DNA replication)
Timestamp Action Category Detail
Timestamp Action Category Detail
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