Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'.
GO:0006268
JSON
DNA unwinding involved in DNA replication
Biological Process
Definition (GO:0006268 GONUTS page)
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
Comments
Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
DNA unwinding during replication | related |
DNA unwinding factor | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0006268
Child Term | Relationship to GO:0006268 |
---|---|
cell cycle DNA replication DNA unwinding
|
is_a |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | D3ZVK1 | 10116 | MCM8_RAT | GO:0006260 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F1M5F3 | 10116 | MCM9_RAT | GO:0006260 | 3 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | F1N2W9 | 9913 | MCM9_BOVIN | GO:0006260 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | O61847 | 6239 | CDK2_CAEEL | GO:0006260 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:10207147 | |
NOT-qualified manual | protein | Q2KHI9 | 10090 | MCM9_MOUSE | GO:0006260 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000315 from these references: PMID:21987787, PMID:23401855 | |
NOT-qualified manual | protein | Q41188 | 3702 | CSP2_ARATH | GO:0032508 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17169986 | |
NOT-qualified manual | protein | Q9NXL9 | 9606 | MCM9_HUMAN | GO:0006260 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000316 from this reference: PMID:23401855 | |
NOT-qualified manual | protein | Q9UJA3 | 9606 | MCM8_HUMAN | GO:0006260 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000316 from this reference: PMID:23401855 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR003176 | Adenovirus DNA-binding, all-alpha domain |
InterPro | IPR005751 | ATP-dependent DNA helicase PcrA |
InterPro | IPR005752 | ATP-dependent DNA helicase Rep |
InterPro | IPR005753 | DNA helicase, ATP-dependent, UvrD type |
InterPro | IPR037540 | DNA-binding protein, Adenovirus |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0030039 | obsolete DNA unwinding factor | replaced_by GO:0006268 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0006268 based on ALL annotations
The top 100 of 965 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA unwinding involved in DNA replication
|
1,041.17 | 100.00 | 187,230 | 187,230 |
primosome complex
|
600.46 | 33.03 | 81,636 | 141,554 |
DNA replication, synthesis of primer
|
482.99 | 29.17 | 82,386 | 177,597 |
3'-5' DNA helicase activity
|
297.25 | 22.83 | 99,673 | 349,121 |
DNA helicase activity
|
256.99 | 22.62 | 136,694 | 553,794 |
DNA replication initiation
|
357.72 | 22.25 | 72,449 | 210,868 |
four-way junction helicase activity
|
209.94 | 16.96 | 96,590 | 479,025 |
single-stranded 3'-5' DNA helicase activity
|
206.03 | 15.64 | 80,073 | 404,658 |
forked DNA-dependent helicase activity
|
200.95 | 15.21 | 78,194 | 405,142 |
double-stranded DNA helicase activity
|
200.77 | 15.19 | 78,156 | 405,312 |
Totals | 3060154 | 158303858 |
No co-occurrence statistics for GO:0006268 based on MANUAL annotations
The top 100 of 412 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA unwinding involved in DNA replication
|
1,021.19 | 100.00 | 1,265 | 1,265 |
four-way junction helicase activity
|
846.68 | 46.79 | 655 | 790 |
3'-5' DNA helicase activity
|
522.33 | 39.46 | 801 | 1,566 |
MCM complex
|
533.00 | 26.38 | 440 | 843 |
chromosome
|
351.56 | 26.19 | 661 | 1,920 |
double-strand break repair via break-induced replication
|
366.09 | 21.35 | 437 | 1,219 |
single-stranded DNA helicase activity
|
366.61 | 17.83 | 331 | 922 |
mitotic DNA replication initiation
|
394.81 | 13.04 | 208 | 538 |
DNA strand elongation involved in DNA replication
|
359.81 | 12.72 | 210 | 596 |
double-strand break repair via homologous recombination
|
137.66 | 12.03 | 667 | 4,948 |
Totals | 9423 | 433705 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2016-02-04 | Deleted | SYNONYM | DNA unwinding involved in DNA replication |
2014-11-07 | Added | SYNONYM | DNA unwinding involved in DNA replication |
2013-07-27 | Deleted | RELATION | has part GO:0033260 (nuclear DNA replication) |
2013-07-12 | Updated | TERM | DNA unwinding involved in DNA replication |
2010-11-24 | Deleted | DEFINITION | The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. |
2010-11-24 | Added | DEFINITION | The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. |
2010-10-31 | Added | RELATION | has part GO:0033260 (nuclear DNA replication) |
2010-04-16 | Added | SYNONYM | DNA unwinding during replication |
2010-04-16 | Updated | TERM | DNA unwinding involved in replication |
2008-05-13 | Added | DEFINITION | The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2013-07-12 | Updated | TERM | DNA unwinding involved in DNA replication |
2010-04-16 | Updated | TERM | DNA unwinding involved in replication |
2005-10-05 | Updated | TERM | DNA unwinding during replication |
2002-02-06 | Updated | TERM | DNA unwinding |
2001-04-03 | Updated | TERM | DNA unwinding |
2001-03-30 | Added | TERM | DNA unwinding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-02-04 | Deleted | SYNONYM | DNA unwinding involved in DNA replication |
2014-11-07 | Added | SYNONYM | DNA unwinding involved in DNA replication |
2010-11-24 | Deleted | DEFINITION | The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. |
2010-11-24 | Added | DEFINITION | The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. |
2010-04-16 | Added | SYNONYM | DNA unwinding during replication |
2008-05-13 | Added | DEFINITION | The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. |
2008-05-12 | Deleted | DEFINITION | The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. |
2007-08-09 | Added | SYNONYM | DNA unwinding factor |
2007-08-09 | Deleted | SYNONYM | DNA unwinding factor |
2007-01-15 | Deleted | SYNONYM | duplex DNA melting |
2005-08-10 | Added | SYNONYM | DNA unwinding factor |
2004-04-26 | Added | SYNONYM | duplex DNA melting |
2004-04-24 | Added | DEFINITION | The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2013-07-27 | Deleted | RELATION | has part GO:0033260 (nuclear DNA replication) |
2010-10-31 | Added | RELATION | has part GO:0033260 (nuclear DNA replication) |
2008-04-01 | Updated | RELATION | is a GO:0032508 (DNA duplex unwinding) |
2008-04-01 | Updated | RELATION | part of GO:0006261 (DNA-templated DNA replication) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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