This term is obsolete.
Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation.

GO:0006352 JSON

DNA-templated transcription initiation

Biological Process

Definition (GO:0006352 GONUTS page)

The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place. PMID:18280161

Comments

Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation.

Secondary IDs

GO:0001123

1,052,049 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
DNA-templated transcription, initiation exact
transcription initiation factor activity related
transcription initiation from bacterial-type RNA polymerase promoter narrow
initiation of DNA-dependent transcription exact
transcription initiation, DNA-dependent related
DNA-dependent transcription, initiation exact
initiation of transcription, DNA-dependent exact
DNA-dependent RNA polymerase complex assembly at promoter exact

Ancestor Chart

Ancestor chart for GO:0006352
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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006352

Child Term Relationship to
GO:0006352
GO:0006367
transcription initiation at RNA polymerase II promoter
is_a
GO:0070897
transcription preinitiation complex assembly
part_of
GO:2000143
negative regulation of DNA-templated transcription initiation
negatively_regulates
GO:0001112
DNA-templated transcription open complex formation
part_of
GO:2000142
regulation of DNA-templated transcription initiation
regulates
GO:0006361
transcription initiation at RNA polymerase I promoter
is_a
GO:0006384
transcription initiation at RNA polymerase III promoter
is_a
GO:0001173
DNA-templated transcriptional start site selection
part_of
GO:2000144
positive regulation of DNA-templated transcription initiation
positively_regulates
GO:0006391
transcription initiation at mitochondrial promoter
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to transcription processes Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein Q96327 3702 EBP1_ARATH GO:0006351 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15689342

Cross-references

Database ID Description
InterPro IPR000812 Transcription factor TFIIB
InterPro IPR000814 TATA-box binding protein
InterPro IPR000838 RNA polymerase sigma factor 70, ECF, conserved site
InterPro IPR000943 RNA polymerase sigma-70
InterPro IPR003162 Transcription initiation factor TAFII31
InterPro IPR003228 Transcription initiation factor TFIID subunit 12 domain
InterPro IPR003923 Transcription initiation factor TFIID, subunit 10
InterPro IPR005574 RNA polymerase subunit Rpb4/RPC9
InterPro IPR007046 RNA polymerase sigma factor 54, core-binding domain
InterPro IPR007624 RNA polymerase sigma-70 region 3

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0006352 based on ALL annotations
The top 100 of 2,128 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0006352
DNA-templated transcription initiation
245.27 100.00 807,914 807,914
GO:0016987
sigma factor activity
243.51 83.28 676,925 681,801
GO:2000142
regulation of DNA-templated transcription initiation
238.35 81.81 677,017 696,666
GO:0006355
regulation of DNA-templated transcription
18.66 7.55 732,723 9,631,576
GO:0010468
regulation of gene expression
30.01 4.75 58,156 475,274
GO:0003677
DNA binding
10.69 4.32 679,921 15,603,631
GO:0000428
DNA-directed RNA polymerase complex
21.88 4.03 55,423 621,248
GO:0001216
DNA-binding transcription activator activity
212.69 3.54 28,742 33,145
GO:0017025
TBP-class protein binding
150.98 3.53 29,163 47,374
GO:0070897
transcription preinitiation complex assembly
244.25 2.98 24,071 24,171
Totals 4615680 102603320
No co-occurrence statistics for GO:0006352 based on MANUAL annotations
The top 100 of 441 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0006352
DNA-templated transcription initiation
1,594.95 100.00 885 885
GO:0097550
transcription preinitiation complex
1,154.80 45.56 488 674
GO:0000995
RNA polymerase III general transcription initiation factor activity
1,242.58 21.34 201 258
GO:0016251
RNA polymerase II general transcription initiation factor activity
372.34 20.18 529 2,266
GO:0017025
TBP-class protein binding
529.79 19.55 285 858
GO:0000126
transcription factor TFIIIB complex
932.43 18.63 190 325
GO:0001006
RNA polymerase III type 3 promoter sequence-specific DNA binding
789.08 17.46 188 380
GO:0006383
transcription by RNA polymerase III
446.23 14.38 202 722
GO:0001174
transcriptional start site selection at RNA polymerase II promoter
1,408.53 7.61 68 77
GO:0140223
general transcription initiation factor activity
1,571.15 7.45 66 67
Totals 4339 69784

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_yeast 163

Change Log

Timestamp Action Category Detail
2022-06-12 Added DEFINITION The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.
2022-06-12 Updated TERM DNA-templated transcription initiation
2022-06-12 Added SYNONYM DNA-templated transcription, initiation
2022-06-12 Deleted DEFINITION Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription.
2021-09-14 Added SECONDARY GO:0001123 (transcription initiation from bacterial-type RNA polymerase promoter)
2021-09-14 Added SYNONYM transcription initiation from bacterial-type RNA polymerase promoter
2020-02-28 Deleted XREF MIPS_funcat:11.02.03.01.01
2019-05-04 Added XREF MIPS_funcat:11.02.03.01.01
2013-12-14 Added SYNONYM DNA-dependent transcription, initiation
2013-12-14 Updated TERM DNA-templated transcription, initiation
Timestamp Action Category Detail
2022-06-12 Updated TERM DNA-templated transcription initiation
2013-12-14 Updated TERM DNA-templated transcription, initiation
2012-07-10 Updated TERM DNA-dependent transcription, initiation
2010-12-16 Updated TERM transcription initiation, DNA-dependent
2002-02-06 Updated TERM transcription initiation
2001-04-03 Updated TERM transcription initiation
2001-03-30 Added TERM transcription initiation
Timestamp Action Category Detail
2022-06-12 Added DEFINITION The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.
2022-06-12 Added SYNONYM DNA-templated transcription, initiation
2022-06-12 Deleted DEFINITION Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription.
2021-09-14 Added SYNONYM transcription initiation from bacterial-type RNA polymerase promoter
2013-12-14 Added SYNONYM DNA-dependent transcription, initiation
2012-07-10 Added SYNONYM transcription initiation, DNA-dependent
2012-07-10 Added SYNONYM initiation of DNA-dependent transcription
2011-11-17 Added SYNONYM transcription initiation factor activity
2010-12-16 Deleted SYNONYM initiation of transcription
2010-12-16 Deleted SYNONYM RNA polymerase complex assembly at promoter
2010-12-16 Added SYNONYM DNA-dependent RNA polymerase complex assembly at promoter
2010-12-16 Added SYNONYM initiation of transcription, DNA-dependent
2010-12-05 Deleted DEFINITION Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
2010-12-05 Added DEFINITION Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription.
2010-10-06 Added SYNONYM initiation of transcription
2010-09-03 Deleted DEFINITION Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter.
2010-09-03 Added DEFINITION Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
2008-05-16 Deleted DEFINITION Processes involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template resulting in the subsequent synthesis of RNA from that promoter.
2008-05-16 Added DEFINITION Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter.
2008-05-13 Added DEFINITION Processes involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template resulting in the subsequent synthesis of RNA from that promoter.
2008-05-12 Deleted DEFINITION Processes involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template resulting in the subsequent synthesis of RNA from that promoter.
2007-08-09 Added SYNONYM RNA polymerase complex assembly at promoter
2007-08-09 Deleted SYNONYM RNA polymerase complex assembly at promoter
2007-01-15 Added SYNONYM RNA polymerase complex assembly at promoter
2007-01-09 Updated DEFINITION Processes involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template resulting in the subsequent synthesis of RNA from that promoter.
2003-10-25 Added DEFINITION Processes involved in starting transcription, which is the synthesis of RNA by RNA polymerases using a DNA template.
Timestamp Action Category Detail
2010-12-05 Added RELATION is a GO:0032774 (RNA biosynthetic process)
2010-12-05 Deleted RELATION is a GO:0006461 (protein complex assembly)
2009-10-29 Added RELATION is a GO:0006461 (protein complex assembly)
2009-10-29 Deleted RELATION is a GO:0032774 (RNA biosynthetic process)
2009-08-31 Added RELATION is a GO:0032774 (RNA biosynthetic process)
2009-08-31 Deleted RELATION is a GO:0065004 (protein-DNA complex assembly)
2008-04-01 Updated RELATION part of GO:0006351 (DNA-templated transcription)
2008-04-01 Updated RELATION is a GO:0065004 (protein-DNA complex assembly)
Timestamp Action Category Detail
2020-02-28 Deleted XREF MIPS_funcat:11.02.03.01.01
2019-05-04 Added XREF MIPS_funcat:11.02.03.01.01
Timestamp Action Category Detail
2021-09-14 Added SECONDARY GO:0001123 (transcription initiation from bacterial-type RNA polymerase promoter)
2013-04-18 Updated SUBSET goslim_yeast
2011-08-14 Added SUBSET goslim_yeast
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