GO:0006457
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protein folding
Biological Process
Definition (GO:0006457 GONUTS page)
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
Secondary IDs
GO:0007022, GO:0007024, GO:0007025
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
chaperonin-mediated tubulin folding | narrow |
beta-tubulin folding | narrow |
alpha-tubulin folding | narrow |
chaperone activity | related |
protein complex assembly, multichaperone pathway | related |
chaperonin ATPase activity | related |
co-chaperone activity | related |
co-chaperonin activity | related |
glycoprotein-specific chaperone activity | related |
non-chaperonin molecular chaperone ATPase activity | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0006457
Child Term | Relationship to GO:0006457 |
---|---|
protein refolding
|
is_a |
protein maturation by protein folding
|
is_a |
'de novo' protein folding
|
is_a |
regulation of protein folding
|
regulates |
post-chaperonin tubulin folding pathway
|
is_a |
mitochondrial disulfide relay system
|
is_a |
protein folding chaperone
|
part_of |
chaperone-mediated protein folding
|
is_a |
negative regulation of protein folding
|
negatively_regulates |
protein folding in endoplasmic reticulum
|
is_a |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR000397 | Heat shock protein Hsp33 |
InterPro | IPR000740 | GrpE nucleotide exchange factor |
InterPro | IPR000774 | Peptidyl-prolyl cis-trans isomerase, FKBP-type, N-terminal |
InterPro | IPR001404 | Heat shock protein Hsp90 family |
InterPro | IPR001580 | Calreticulin/calnexin |
InterPro | IPR002194 | Chaperonin TCP-1, conserved site |
InterPro | IPR002777 | Prefoldin beta-like |
InterPro | IPR003752 | Disulphide bond formation protein DsbB/BdbC |
InterPro | IPR004487 | Clp protease, ATP-binding subunit ClpX |
InterPro | IPR004961 | Lipase chaperone |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0003754 | obsolete chaperone activity | consider GO:0006457 |
GO:0003759 | obsolete glycoprotein-specific chaperone activity | consider GO:0006457 |
GO:0003763 | obsolete chaperonin ATPase activity | consider GO:0006457 |
GO:0003767 | obsolete co-chaperone activity | consider GO:0006457 |
GO:0003772 | obsolete co-chaperonin activity | consider GO:0006457 |
GO:0006462 | obsolete protein complex assembly, multichaperone pathway | consider GO:0006457 |
GO:0008571 | obsolete non-chaperonin molecular chaperone ATPase activity | consider GO:0006457 |
GO:0010538 | obsolete Hsp27 protein regulator activity | consider GO:0006457 |
GO:0010539 | obsolete Hsp27 protein inhibitor activity | consider GO:0006457 |
GO:0010545 | obsolete Hsp90 protein regulator activity | consider GO:0006457 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0006457 based on ALL annotations
The top 100 of 4,287 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein folding
|
196.50 | 100.00 | 992,035 | 992,035 |
unfolded protein binding
|
148.43 | 45.58 | 530,454 | 702,277 |
ATP-dependent protein folding chaperone
|
152.58 | 29.56 | 320,472 | 412,733 |
peptidyl-prolyl cis-trans isomerase activity
|
88.07 | 16.46 | 204,748 | 456,863 |
protein-folding chaperone binding
|
135.81 | 14.69 | 155,985 | 225,689 |
chaperone cofactor-dependent protein refolding
|
169.03 | 14.40 | 146,270 | 170,040 |
protein folding chaperone
|
186.95 | 14.22 | 142,125 | 149,386 |
RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
|
110.66 | 11.71 | 127,776 | 226,896 |
RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
|
110.66 | 11.71 | 127,776 | 226,896 |
protein refolding
|
73.95 | 8.80 | 102,209 | 271,606 |
Totals | 5926806 | 146725118 |
No co-occurrence statistics for GO:0006457 based on MANUAL annotations
The top 100 of 1,596 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein folding
|
141.18 | 100.00 | 9,150 | 9,150 |
unfolded protein binding
|
70.30 | 26.94 | 3,384 | 6,796 |
peptidyl-prolyl cis-trans isomerase activity
|
74.57 | 14.84 | 1,565 | 2,963 |
cyclosporin A binding
|
140.94 | 12.80 | 1,171 | 1,173 |
chaperonin-containing T-complex
|
137.60 | 11.31 | 1,038 | 1,065 |
protein complex oligomerization
|
126.24 | 11.30 | 1,048 | 1,172 |
response to hydrogen peroxide
|
90.66 | 10.77 | 1,048 | 1,632 |
response to heat
|
60.16 | 10.55 | 1,125 | 2,640 |
protein disulfide isomerase activity
|
121.01 | 10.25 | 954 | 1,113 |
response to salt stress
|
68.76 | 10.25 | 1,051 | 2,158 |
Totals | 41376 | 990904 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_candida | 86 |
goslim_pir | 439 |
goslim_yeast | 163 |
goslim_generic | 141 |
goslim_pombe | 61 |
goslim_prokaryote | 97 |
goslim_chembl | 296 |
goslim_metagenomics | 111 |
goslim_drosophila | 173 |
goslim_prokaryote_ribbon | 49 |
goslim_euk_cellular_processes_ribbon | 61 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-22 | Added | SUBSET | goslim_euk_cellular_processes_ribbon |
2024-02-24 | Added | SUBSET | goslim_prokaryote_ribbon |
2023-12-15 | Added | SUBSET | goslim_prokaryote |
2023-07-06 | Added | RELATION | part of GO:0051604 (protein maturation) |
2022-04-08 | Deleted | SUBSET | goslim_aspergillus |
2020-02-28 | Deleted | XREF | MIPS_funcat:14.01 |
2020-02-28 | Deleted | XREF | MIPS_funcat:14 |
2019-11-09 | Added | SUBSET | goslim_drosophila |
2019-05-04 | Added | XREF | MIPS_funcat:14.01 |
2019-05-04 | Added | XREF | MIPS_funcat:14 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2002-02-06 | Updated | TERM | protein folding |
2001-04-03 | Updated | TERM | protein folding |
2001-03-30 | Added | TERM | protein folding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-04-29 | Added | SYNONYM | beta-tubulin folding |
2009-04-29 | Added | SYNONYM | chaperonin-mediated tubulin folding |
2009-04-29 | Added | SYNONYM | alpha-tubulin folding |
2008-05-13 | Added | DEFINITION | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
2008-05-12 | Deleted | DEFINITION | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
2007-08-09 | Added | SYNONYM | co-chaperone activity |
2007-08-09 | Added | SYNONYM | co-chaperonin activity |
2007-08-09 | Added | SYNONYM | glycoprotein-specific chaperone activity |
2007-08-09 | Added | SYNONYM | non-chaperonin molecular chaperone ATPase activity |
2007-08-09 | Added | SYNONYM | protein complex assembly, multichaperone pathway |
2007-08-09 | Deleted | SYNONYM | chaperonin ATPase activity |
2007-08-09 | Deleted | SYNONYM | co-chaperone activity |
2007-08-09 | Deleted | SYNONYM | co-chaperonin activity |
2007-08-09 | Deleted | SYNONYM | glycoprotein-specific chaperone activity |
2007-08-09 | Deleted | SYNONYM | non-chaperonin molecular chaperone ATPase activity |
2007-08-09 | Deleted | SYNONYM | protein complex assembly, multichaperone pathway |
2007-08-09 | Deleted | SYNONYM | chaperone activity |
2007-08-09 | Added | SYNONYM | chaperone activity |
2007-08-09 | Added | SYNONYM | chaperonin ATPase activity |
2005-08-10 | Added | SYNONYM | co-chaperone activity |
2005-08-10 | Added | SYNONYM | chaperonin ATPase activity |
2005-08-10 | Added | SYNONYM | glycoprotein-specific chaperone activity |
2005-08-10 | Added | SYNONYM | non-chaperonin molecular chaperone ATPase activity |
2005-08-10 | Added | SYNONYM | protein complex assembly, multichaperone pathway |
2005-08-10 | Added | SYNONYM | co-chaperonin activity |
2005-04-27 | Updated | DEFINITION | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
2004-07-26 | Added | SYNONYM | chaperone activity |
2004-07-22 | Updated | DEFINITION | The process of assisting in the noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
2004-07-16 | Added | DEFINITION | Processes that assist in the noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-07-06 | Added | RELATION | part of GO:0051604 (protein maturation) |
2015-10-08 | Deleted | RELATION | is a GO:0044267 (cellular protein metabolic process) |
2015-10-08 | Added | RELATION | is a GO:0009987 (cellular process) |
2008-04-01 | Updated | RELATION | is a GO:0044267 (cellular protein metabolic process) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-02-28 | Deleted | XREF | MIPS_funcat:14.01 |
2020-02-28 | Deleted | XREF | MIPS_funcat:14 |
2019-05-04 | Added | XREF | MIPS_funcat:14.01 |
2019-05-04 | Added | XREF | MIPS_funcat:14 |
2009-03-02 | Added | XREF | Wikipedia:Protein_folding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-22 | Added | SUBSET | goslim_euk_cellular_processes_ribbon |
2024-02-24 | Added | SUBSET | goslim_prokaryote_ribbon |
2023-12-15 | Added | SUBSET | goslim_prokaryote |
2022-04-08 | Deleted | SUBSET | goslim_aspergillus |
2019-11-09 | Added | SUBSET | goslim_drosophila |
2016-07-23 | Added | SUBSET | goslim_metagenomics |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
2013-04-18 | Updated | SUBSET | goslim_aspergillus |
2013-04-18 | Updated | SUBSET | goslim_pombe |
2013-04-18 | Updated | SUBSET | goslim_generic |
2013-04-18 | Updated | SUBSET | goslim_yeast |
2013-04-18 | Updated | SUBSET | goslim_pir |
2013-04-18 | Updated | SUBSET | goslim_candida |
2011-11-05 | Added | SUBSET | goslim_aspergillus |
2010-12-05 | Added | SUBSET | goslim_generic |
2009-05-11 | Added | SUBSET | goslim_pombe |
2009-04-29 | Added | SECONDARY | GO:0007025 (beta-tubulin folding) |
2009-04-29 | Added | SECONDARY | GO:0007024 (alpha-tubulin folding) |
2009-04-29 | Added | SECONDARY | GO:0007022 (chaperonin-mediated tubulin folding) |
2008-06-09 | Added | SUBSET | goslim_pir |
2008-06-09 | Added | SUBSET | goslim_candida |
2008-06-09 | Added | SUBSET | goslim_yeast |
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