This term is obsolete.

GO:0006457 JSON

protein folding

Biological Process

Definition (GO:0006457 GONUTS page)

The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

Secondary IDs

GO:0007022, GO:0007024, GO:0007025

2,262,831 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
chaperonin-mediated tubulin folding narrow
beta-tubulin folding narrow
alpha-tubulin folding narrow
chaperone activity related
protein complex assembly, multichaperone pathway related
chaperonin ATPase activity related
co-chaperone activity related
co-chaperonin activity related
glycoprotein-specific chaperone activity related
non-chaperonin molecular chaperone ATPase activity related

Ancestor Chart

Ancestor chart for GO:0006457
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006457

Child Term Relationship to
GO:0006457
protein refolding
is_a
protein maturation by protein folding
is_a
'de novo' protein folding
is_a
regulation of protein folding
regulates
post-chaperonin tubulin folding pathway
is_a
mitochondrial disulfide relay system
is_a
protein folding chaperone
part_of
chaperone-mediated protein folding
is_a
negative regulation of protein folding
negatively_regulates
protein folding in endoplasmic reticulum
is_a

Cross-references

Database ID Description
InterPro IPR000397 Heat shock protein Hsp33
InterPro IPR000740 GrpE nucleotide exchange factor
InterPro IPR000774 Peptidyl-prolyl cis-trans isomerase, FKBP-type, N-terminal
InterPro IPR001404 Heat shock protein Hsp90 family
InterPro IPR001580 Calreticulin/calnexin
InterPro IPR002194 Chaperonin TCP-1, conserved site
InterPro IPR002777 Prefoldin beta-like
InterPro IPR003752 Disulphide bond formation protein DsbB/BdbC
InterPro IPR004487 Clp protease, ATP-binding subunit ClpX
InterPro IPR004961 Lipase chaperone

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0003754 obsolete chaperone activity consider GO:0006457
GO:0003759 obsolete glycoprotein-specific chaperone activity consider GO:0006457
GO:0003763 obsolete chaperonin ATPase activity consider GO:0006457
GO:0003767 obsolete co-chaperone activity consider GO:0006457
GO:0003772 obsolete co-chaperonin activity consider GO:0006457
GO:0006462 obsolete protein complex assembly, multichaperone pathway consider GO:0006457
GO:0008571 obsolete non-chaperonin molecular chaperone ATPase activity consider GO:0006457
GO:0010538 obsolete Hsp27 protein regulator activity consider GO:0006457
GO:0010539 obsolete Hsp27 protein inhibitor activity consider GO:0006457
GO:0010545 obsolete Hsp90 protein regulator activity consider GO:0006457

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0006457 based on ALL annotations
The top 100 of 4,287 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein folding
196.50 100.00 992,035 992,035
unfolded protein binding
148.43 45.58 530,454 702,277
ATP-dependent protein folding chaperone
152.58 29.56 320,472 412,733
peptidyl-prolyl cis-trans isomerase activity
88.07 16.46 204,748 456,863
protein-folding chaperone binding
135.81 14.69 155,985 225,689
chaperone cofactor-dependent protein refolding
169.03 14.40 146,270 170,040
protein folding chaperone
186.95 14.22 142,125 149,386
RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
110.66 11.71 127,776 226,896
RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
110.66 11.71 127,776 226,896
protein refolding
73.95 8.80 102,209 271,606
Totals 5926806 146725118
No co-occurrence statistics for GO:0006457 based on MANUAL annotations
The top 100 of 1,596 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein folding
141.18 100.00 9,150 9,150
unfolded protein binding
70.30 26.94 3,384 6,796
peptidyl-prolyl cis-trans isomerase activity
74.57 14.84 1,565 2,963
cyclosporin A binding
140.94 12.80 1,171 1,173
chaperonin-containing T-complex
137.60 11.31 1,038 1,065
protein complex oligomerization
126.24 11.30 1,048 1,172
response to hydrogen peroxide
90.66 10.77 1,048 1,632
response to heat
60.16 10.55 1,125 2,640
protein disulfide isomerase activity
121.01 10.25 954 1,113
response to salt stress
68.76 10.25 1,051 2,158
Totals 41376 990904

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_candida 86
goslim_pir 439
goslim_yeast 163
goslim_generic 141
goslim_pombe 61
goslim_prokaryote 97
goslim_chembl 296
goslim_metagenomics 111
goslim_drosophila 173
goslim_prokaryote_ribbon 49
goslim_euk_cellular_processes_ribbon 61

Change Log

Timestamp Action Category Detail
2024-03-22 Added SUBSET goslim_euk_cellular_processes_ribbon
2024-02-24 Added SUBSET goslim_prokaryote_ribbon
2023-12-15 Added SUBSET goslim_prokaryote
2023-07-06 Added RELATION part of GO:0051604 (protein maturation)
2022-04-08 Deleted SUBSET goslim_aspergillus
2020-02-28 Deleted XREF MIPS_funcat:14.01
2020-02-28 Deleted XREF MIPS_funcat:14
2019-11-09 Added SUBSET goslim_drosophila
2019-05-04 Added XREF MIPS_funcat:14.01
2019-05-04 Added XREF MIPS_funcat:14
Timestamp Action Category Detail
2002-02-06 Updated TERM protein folding
2001-04-03 Updated TERM protein folding
2001-03-30 Added TERM protein folding
Timestamp Action Category Detail
2009-04-29 Added SYNONYM beta-tubulin folding
2009-04-29 Added SYNONYM chaperonin-mediated tubulin folding
2009-04-29 Added SYNONYM alpha-tubulin folding
2008-05-13 Added DEFINITION The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
2008-05-12 Deleted DEFINITION The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
2007-08-09 Added SYNONYM co-chaperone activity
2007-08-09 Added SYNONYM co-chaperonin activity
2007-08-09 Added SYNONYM glycoprotein-specific chaperone activity
2007-08-09 Added SYNONYM non-chaperonin molecular chaperone ATPase activity
2007-08-09 Added SYNONYM protein complex assembly, multichaperone pathway
2007-08-09 Deleted SYNONYM chaperonin ATPase activity
2007-08-09 Deleted SYNONYM co-chaperone activity
2007-08-09 Deleted SYNONYM co-chaperonin activity
2007-08-09 Deleted SYNONYM glycoprotein-specific chaperone activity
2007-08-09 Deleted SYNONYM non-chaperonin molecular chaperone ATPase activity
2007-08-09 Deleted SYNONYM protein complex assembly, multichaperone pathway
2007-08-09 Deleted SYNONYM chaperone activity
2007-08-09 Added SYNONYM chaperone activity
2007-08-09 Added SYNONYM chaperonin ATPase activity
2005-08-10 Added SYNONYM co-chaperone activity
2005-08-10 Added SYNONYM chaperonin ATPase activity
2005-08-10 Added SYNONYM glycoprotein-specific chaperone activity
2005-08-10 Added SYNONYM non-chaperonin molecular chaperone ATPase activity
2005-08-10 Added SYNONYM protein complex assembly, multichaperone pathway
2005-08-10 Added SYNONYM co-chaperonin activity
2005-04-27 Updated DEFINITION The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
2004-07-26 Added SYNONYM chaperone activity
2004-07-22 Updated DEFINITION The process of assisting in the noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
2004-07-16 Added DEFINITION Processes that assist in the noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
Timestamp Action Category Detail
2023-07-06 Added RELATION part of GO:0051604 (protein maturation)
2015-10-08 Deleted RELATION is a GO:0044267 (cellular protein metabolic process)
2015-10-08 Added RELATION is a GO:0009987 (cellular process)
2008-04-01 Updated RELATION is a GO:0044267 (cellular protein metabolic process)
Timestamp Action Category Detail
2020-02-28 Deleted XREF MIPS_funcat:14.01
2020-02-28 Deleted XREF MIPS_funcat:14
2019-05-04 Added XREF MIPS_funcat:14.01
2019-05-04 Added XREF MIPS_funcat:14
2009-03-02 Added XREF Wikipedia:Protein_folding
Timestamp Action Category Detail
2024-03-22 Added SUBSET goslim_euk_cellular_processes_ribbon
2024-02-24 Added SUBSET goslim_prokaryote_ribbon
2023-12-15 Added SUBSET goslim_prokaryote
2022-04-08 Deleted SUBSET goslim_aspergillus
2019-11-09 Added SUBSET goslim_drosophila
2016-07-23 Added SUBSET goslim_metagenomics
2015-05-19 Added SUBSET goslim_chembl
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-11 Added SUBSET goslim_ChEMBL
2013-04-18 Updated SUBSET goslim_aspergillus
2013-04-18 Updated SUBSET goslim_pombe
2013-04-18 Updated SUBSET goslim_generic
2013-04-18 Updated SUBSET goslim_yeast
2013-04-18 Updated SUBSET goslim_pir
2013-04-18 Updated SUBSET goslim_candida
2011-11-05 Added SUBSET goslim_aspergillus
2010-12-05 Added SUBSET goslim_generic
2009-05-11 Added SUBSET goslim_pombe
2009-04-29 Added SECONDARY GO:0007025 (beta-tubulin folding)
2009-04-29 Added SECONDARY GO:0007024 (alpha-tubulin folding)
2009-04-29 Added SECONDARY GO:0007022 (chaperonin-mediated tubulin folding)
2008-06-09 Added SUBSET goslim_pir
2008-06-09 Added SUBSET goslim_candida
2008-06-09 Added SUBSET goslim_yeast
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