GO:0007229
JSON
integrin-mediated signaling pathway
Biological Process
Definition (GO:0007229 GONUTS page)
The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
integrin-mediated signalling pathway | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0007229
Child Term | Relationship to GO:0007229 |
---|---|
positive regulation of integrin-mediated signaling pathway
|
positively_regulates |
negative regulation of integrin-mediated signaling pathway
|
negatively_regulates |
regulation of integrin-mediated signaling pathway
|
regulates |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
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signalling | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0G2JY81 | 10116 | A0A0G2JY81_RAT | GO:0007229 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AAN5 | 10116 | A0A8I6AAN5_RAT | GO:0007229 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6HTD8 | 10116 | A6HTD8_RAT | GO:0007229 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | B1WC21 | 10116 | B1WC21_RAT | GO:0007229 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D3ZQ25 | 10116 | D3ZQ25_RAT | GO:0007229 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | O88797 | 10116 | DAB2_RAT | GO:0007229 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P23142 | 9606 | FBLN1_HUMAN | GO:0007229 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:11792823 | |
NOT-qualified manual | protein | P98082 | 9606 | DAB2_HUMAN | GO:0007229 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:19581412 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR012013 | Integrin beta-4 subunit |
InterPro | IPR037413 | Mucosal addressin cell adhesion molecule 1 |
InterPro | IPR037837 | Kindlin/fermitin, PH domain |
InterPro | IPR037843 | Kindlin/fermitin |
InterPro | IPR043443 | FYN-binding protein 1/2-like |
UniProtKB-KW | KW-0401 | Integrin |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0007229 based on ALL annotations
The top 100 of 2,844 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
integrin-mediated signaling pathway
|
2,680.34 | 100.00 | 72,729 | 72,729 |
cell adhesion mediated by integrin
|
2,551.08 | 53.82 | 40,241 | 42,280 |
integrin complex
|
2,382.54 | 52.72 | 41,050 | 46,181 |
integrin binding
|
1,564.90 | 46.17 | 50,053 | 85,730 |
cell-matrix adhesion
|
1,643.19 | 45.73 | 46,760 | 76,274 |
cell-cell adhesion
|
492.09 | 15.70 | 37,810 | 205,947 |
focal adhesion
|
552.08 | 14.14 | 22,619 | 109,815 |
external side of plasma membrane
|
349.68 | 10.78 | 27,862 | 213,567 |
cell adhesion
|
207.93 | 7.40 | 45,066 | 580,935 |
leukocyte migration
|
1,994.51 | 7.22 | 5,383 | 7,234 |
Totals | 552651 | 6456623 |
No co-occurrence statistics for GO:0007229 based on MANUAL annotations
The top 100 of 2,036 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
integrin-mediated signaling pathway
|
1,275.22 | 100.00 | 1,013 | 1,013 |
integrin complex
|
1,261.58 | 54.47 | 555 | 561 |
integrin binding
|
528.05 | 34.79 | 694 | 1,676 |
cell adhesion mediated by integrin
|
964.43 | 34.33 | 391 | 517 |
cell-matrix adhesion
|
585.16 | 31.28 | 502 | 1,094 |
cell-cell adhesion
|
236.53 | 16.25 | 575 | 3,100 |
focal adhesion
|
185.54 | 11.45 | 354 | 2,433 |
leukocyte migration
|
612.11 | 7.61 | 84 | 175 |
external side of plasma membrane
|
94.85 | 6.77 | 436 | 5,862 |
fibronectin binding
|
361.96 | 5.52 | 65 | 229 |
Totals | 7776 | 74179 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-03-14 | Added | DEFINITION | The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
2022-03-14 | Deleted | DEFINITION | A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
2020-02-28 | Deleted | XREF | MIPS_funcat:30.05.02.26 |
2019-05-04 | Added | XREF | MIPS_funcat:30.05.02.26 |
2012-01-18 | Deleted | DEFINITION | Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. |
2012-01-18 | Added | DEFINITION | A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
2010-04-14 | Deleted | RELATION | is a GO:0023034 (intracellular signaling pathway) |
2010-02-20 | Added | RELATION | is a GO:0023034 (intracellular signaling pathway) |
2008-05-13 | Added | DEFINITION | Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. |
2008-05-12 | Deleted | DEFINITION | Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2002-02-14 | Updated | TERM | integrin-mediated signaling pathway |
2002-02-06 | Updated | TERM | integrin receptor signal signaling pathway |
2001-04-03 | Updated | TERM | integrin receptor signal signaling pathway |
2001-03-30 | Added | TERM | integrin receptor signal signaling pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-03-14 | Added | DEFINITION | The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
2022-03-14 | Deleted | DEFINITION | A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
2012-01-18 | Deleted | DEFINITION | Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. |
2012-01-18 | Added | DEFINITION | A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
2008-05-13 | Added | DEFINITION | Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. |
2008-05-12 | Deleted | DEFINITION | Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. |
2007-08-09 | Deleted | SYNONYM | integrin-mediated signalling pathway |
2007-08-09 | Added | SYNONYM | integrin-mediated signalling pathway |
2004-07-15 | Added | DEFINITION | Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. |
2004-04-19 | Added | SYNONYM | integrin-mediated signalling pathway |
2004-04-16 | Deleted | SYNONYM | integrin-mediated signalling pathway |
2003-11-13 | Added | SYNONYM | integrin-mediated signalling pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-04-14 | Deleted | RELATION | is a GO:0023034 (intracellular signaling pathway) |
2010-02-20 | Added | RELATION | is a GO:0023034 (intracellular signaling pathway) |
2008-04-01 | Updated | RELATION | is a GO:0007166 (cell surface receptor signaling pathway) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-02-28 | Deleted | XREF | MIPS_funcat:30.05.02.26 |
2019-05-04 | Added | XREF | MIPS_funcat:30.05.02.26 |
Timestamp | Action | Category | Detail |
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