This term is obsolete.

GO:0007229 JSON

integrin-mediated signaling pathway

Biological Process

Definition (GO:0007229 GONUTS page)

The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

73,615 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
integrin-mediated signalling pathway exact

Ancestor Chart

Ancestor chart for GO:0007229
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0007229

Child Term Relationship to
GO:0007229
positive regulation of integrin-mediated signaling pathway
positively_regulates
negative regulation of integrin-mediated signaling pathway
negatively_regulates
regulation of integrin-mediated signaling pathway
regulates

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0G2JY81 10116 A0A0G2JY81_RAT GO:0007229 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AAN5 10116 A0A8I6AAN5_RAT GO:0007229 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6HTD8 10116 A6HTD8_RAT GO:0007229 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein B1WC21 10116 B1WC21_RAT GO:0007229 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZQ25 10116 D3ZQ25_RAT GO:0007229 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein O88797 10116 DAB2_RAT GO:0007229 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P23142 9606 FBLN1_HUMAN GO:0007229 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:11792823
NOT-qualified manual protein P98082 9606 DAB2_HUMAN GO:0007229 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:19581412

Cross-references

Database ID Description
InterPro IPR012013 Integrin beta-4 subunit
InterPro IPR037413 Mucosal addressin cell adhesion molecule 1
InterPro IPR037837 Kindlin/fermitin, PH domain
InterPro IPR037843 Kindlin/fermitin
InterPro IPR043443 FYN-binding protein 1/2-like
UniProtKB-KW KW-0401 Integrin

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0007229 based on ALL annotations
The top 100 of 2,844 co-occurring terms
Co-occurring Term PR S% #Together #Compared
integrin-mediated signaling pathway
2,680.34 100.00 72,729 72,729
cell adhesion mediated by integrin
2,551.08 53.82 40,241 42,280
integrin complex
2,382.54 52.72 41,050 46,181
integrin binding
1,564.90 46.17 50,053 85,730
cell-matrix adhesion
1,643.19 45.73 46,760 76,274
cell-cell adhesion
492.09 15.70 37,810 205,947
focal adhesion
552.08 14.14 22,619 109,815
external side of plasma membrane
349.68 10.78 27,862 213,567
cell adhesion
207.93 7.40 45,066 580,935
leukocyte migration
1,994.51 7.22 5,383 7,234
Totals 552651 6456623
No co-occurrence statistics for GO:0007229 based on MANUAL annotations
The top 100 of 2,036 co-occurring terms
Co-occurring Term PR S% #Together #Compared
integrin-mediated signaling pathway
1,275.22 100.00 1,013 1,013
integrin complex
1,261.58 54.47 555 561
integrin binding
528.05 34.79 694 1,676
cell adhesion mediated by integrin
964.43 34.33 391 517
cell-matrix adhesion
585.16 31.28 502 1,094
cell-cell adhesion
236.53 16.25 575 3,100
focal adhesion
185.54 11.45 354 2,433
leukocyte migration
612.11 7.61 84 175
external side of plasma membrane
94.85 6.77 436 5,862
fibronectin binding
361.96 5.52 65 229
Totals 7776 74179

Change Log

Timestamp Action Category Detail
2022-03-14 Added DEFINITION The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
2022-03-14 Deleted DEFINITION A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2020-02-28 Deleted XREF MIPS_funcat:30.05.02.26
2019-05-04 Added XREF MIPS_funcat:30.05.02.26
2012-01-18 Deleted DEFINITION Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands.
2012-01-18 Added DEFINITION A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2010-04-14 Deleted RELATION is a GO:0023034 (intracellular signaling pathway)
2010-02-20 Added RELATION is a GO:0023034 (intracellular signaling pathway)
2008-05-13 Added DEFINITION Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands.
2008-05-12 Deleted DEFINITION Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands.
Timestamp Action Category Detail
2002-02-14 Updated TERM integrin-mediated signaling pathway
2002-02-06 Updated TERM integrin receptor signal signaling pathway
2001-04-03 Updated TERM integrin receptor signal signaling pathway
2001-03-30 Added TERM integrin receptor signal signaling pathway
Timestamp Action Category Detail
2022-03-14 Added DEFINITION The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
2022-03-14 Deleted DEFINITION A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-01-18 Deleted DEFINITION Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands.
2012-01-18 Added DEFINITION A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2008-05-13 Added DEFINITION Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands.
2008-05-12 Deleted DEFINITION Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands.
2007-08-09 Deleted SYNONYM integrin-mediated signalling pathway
2007-08-09 Added SYNONYM integrin-mediated signalling pathway
2004-07-15 Added DEFINITION Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands.
2004-04-19 Added SYNONYM integrin-mediated signalling pathway
2004-04-16 Deleted SYNONYM integrin-mediated signalling pathway
2003-11-13 Added SYNONYM integrin-mediated signalling pathway
Timestamp Action Category Detail
2010-04-14 Deleted RELATION is a GO:0023034 (intracellular signaling pathway)
2010-02-20 Added RELATION is a GO:0023034 (intracellular signaling pathway)
2008-04-01 Updated RELATION is a GO:0007166 (cell surface receptor signaling pathway)
Timestamp Action Category Detail
2020-02-28 Deleted XREF MIPS_funcat:30.05.02.26
2019-05-04 Added XREF MIPS_funcat:30.05.02.26
Timestamp Action Category Detail
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