This term is obsolete.

GO:0007267 JSON

cell-cell signaling

Biological Process

Definition (GO:0007267 GONUTS page)

Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.

521,195 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
cell-cell signalling exact

Ancestor Chart

Ancestor chart for GO:0007267
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0007267

Child Term Relationship to
GO:0007267
endodermal-mesodermal cell signaling
is_a
cerebellar Purkinje cell-granule cell precursor cell signaling
is_a
synaptic signaling
is_a
regulation of pre-tubular aggregate formation by cell-cell signaling
is_a
c-di-GMP signaling
is_a
visceral mesoderm-endoderm interaction involved in midgut development
is_a
cell-cell signaling involved in placenta development
is_a
epiblast cell-extraembryonic ectoderm cell signaling
is_a
mesenchymal-epithelial cell signaling
is_a
ectoderm and mesoderm interaction
is_a

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Cross-references

Database ID Description
InterPro IPR000320 Hedgehog, N-terminal signalling domain
InterPro IPR001657 Hedgehog protein
InterPro IPR002261 Gap junction alpha-1 protein (Cx43)
InterPro IPR017289 SH2 protein 1A

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0003001 obsolete generation of a signal involved in cell-cell signaling consider GO:0007267
GO:0023017 obsolete signal transmission via diffusible molecule consider GO:0007267

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0007267 based on ALL annotations
The top 100 of 3,526 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cell-cell signaling
5,169.57 100.00 38,331 38,331
connexin complex
5,026.36 49.03 19,058 19,601
gap junction
3,044.81 38.34 20,065 34,067
gap junction channel activity
3,466.85 37.50 17,618 26,271
cell communication
1,040.34 16.49 18,292 90,895
patched binding
2,941.93 11.11 4,650 8,171
positive regulation of interleukin-1 production
4,622.34 9.41 3,649 4,081
wide pore channel activity
2,653.94 8.73 3,646 7,102
alpha1-adrenergic receptor activity
4,994.46 8.68 3,337 3,454
protein autoprocessing
1,321.31 8.62 4,409 17,250
Totals 227256 3077708
No co-occurrence statistics for GO:0007267 based on MANUAL annotations
The top 100 of 2,809 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cell-cell signaling
1,268.22 100.00 1,113 1,113
connexin complex
1,242.39 42.83 481 491
gap junction channel activity
967.29 35.91 450 590
alpha1-adrenergic receptor activity
1,217.49 6.45 72 75
gap junction-mediated intercellular transport
1,152.93 6.25 70 77
wide pore channel activity
584.57 4.99 59 128
adenylate cyclase-activating adrenergic receptor signaling pathway
209.43 4.87 72 436
growth factor binding
238.88 4.07 55 292
phospholipase C-activating G protein-coupled receptor signaling pathway
112.16 4.07 78 882
positive regulation of MAPK cascade
71.07 3.85 122 2,177
Totals 5507 37726

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_plant 97
goslim_chembl 296

Change Log

Timestamp Action Category Detail
2022-11-08 Deleted DEFINITION Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
2022-11-08 Added DEFINITION Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
2021-11-15 Deleted SUBSET goslim_generic
2017-08-13 Deleted RELATION is a GO:0044700 (single organism signaling)
2017-08-13 Deleted RELATION is a GO:0044763 (single-organism cellular process)
2017-08-13 Added RELATION is a GO:0023052 (signaling)
2016-12-17 Added RELATION is a GO:0044763 (single-organism cellular process)
2016-05-21 Deleted DEFINITION Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the recieving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
2016-05-21 Added DEFINITION Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
2016-05-20 Deleted DEFINITION Any process that mediates the transfer of information from one cell to another.
Timestamp Action Category Detail
2002-02-06 Updated TERM cell-cell signaling
2001-04-03 Updated TERM cell-cell signaling
2001-03-30 Added TERM cell-cell signaling
Timestamp Action Category Detail
2022-11-08 Deleted DEFINITION Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
2022-11-08 Added DEFINITION Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
2016-05-21 Deleted DEFINITION Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the recieving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
2016-05-21 Added DEFINITION Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
2016-05-20 Deleted DEFINITION Any process that mediates the transfer of information from one cell to another.
2016-05-20 Added DEFINITION Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the recieving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
2011-02-27 Deleted SYNONYM paracrine signaling
2010-04-30 Added SYNONYM paracrine signaling
2010-04-30 Deleted SYNONYM paracrine signaling
2010-03-31 Added SYNONYM paracrine signaling
2008-05-13 Added DEFINITION Any process that mediates the transfer of information from one cell to another.
2008-05-12 Deleted DEFINITION Any process that mediates the transfer of information from one cell to another.
2007-08-09 Added SYNONYM cell-cell signalling
2007-08-09 Deleted SYNONYM cell-cell signalling
2004-04-19 Added SYNONYM cell-cell signalling
2004-04-16 Deleted SYNONYM cell-cell signalling
2003-11-13 Added SYNONYM cell-cell signalling
2001-08-06 Added DEFINITION Any process that mediates the transfer of information from one cell to another.
Timestamp Action Category Detail
2017-08-13 Deleted RELATION is a GO:0044700 (single organism signaling)
2017-08-13 Deleted RELATION is a GO:0044763 (single-organism cellular process)
2017-08-13 Added RELATION is a GO:0023052 (signaling)
2016-12-17 Added RELATION is a GO:0044763 (single-organism cellular process)
2012-09-29 Deleted RELATION is a GO:0023052 (signaling)
2012-09-29 Added RELATION is a GO:0044700 (single organism signaling)
2010-04-15 Deleted RELATION is a GO:0023060 (obsolete signal transmission)
2010-03-31 Added RELATION is a GO:0023052 (signaling)
2010-02-20 Added RELATION is a GO:0023060 (obsolete signal transmission)
2008-04-01 Updated RELATION is a GO:0007154 (cell communication)
Timestamp Action Category Detail
Timestamp Action Category Detail
2021-11-15 Deleted SUBSET goslim_generic
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-19 Added SUBSET goslim_chembl
2015-05-11 Added SUBSET goslim_ChEMBL
2013-04-18 Updated SUBSET goslim_plant
2013-04-18 Updated SUBSET goslim_generic
2008-06-09 Added SUBSET goslim_generic
2008-06-09 Added SUBSET goslim_plant
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