GO:0008017
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microtubule binding
Molecular Function
Definition (GO:0008017 GONUTS page)
Binding to a microtubule, a filament composed of tubulin monomers.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
microtubule severing activity | related |
microtubule/chromatin interaction | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0008017
Child Term | Relationship to GO:0008017 |
---|---|
S100A9 complex
|
capable_of |
negative regulation of microtubule binding
|
negatively_regulates |
positive regulation of microtubule binding
|
positively_regulates |
microtubule lateral binding
|
is_a |
regulation of microtubule binding
|
regulates |
microtubule minus-end binding
|
is_a |
microtubule plus-end binding
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Binding term considerations | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | P21333-1 | 9606 | FLNA_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 | |
NOT-qualified manual | protein | P63026 | 9913 | VAMP2_BOVIN | GO:0005515 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699 | |
NOT-qualified manual | protein | Q00535 | 9606 | CDK5_HUMAN | GO:0008017 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:17491008 | |
NOT-qualified manual | protein | Q2HIK4 | 3702 | PFD6_ARATH | GO:0008017 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:19004800 | |
NOT-qualified manual | protein | Q86V48 | 9606 | LUZP1_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR001265 | Formin homology family, Cappuccino subfamily |
InterPro | IPR001752 | Kinesin motor domain |
InterPro | IPR002955 | Microtubule-associated protein Tau |
InterPro | IPR003108 | GAR domain |
InterPro | IPR004953 | EB1, C-terminal |
InterPro | IPR007145 | Microtubule-associated protein, MAP65/Ase1/PRC1 |
InterPro | IPR007882 | Microtubule-associated protein 6 |
InterPro | IPR008636 | Hook, C-terminal |
InterPro | IPR009234 | Adenomatous polyposis coli protein basic domain |
InterPro | IPR009768 | Microtubule-associated protein 70 |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0008351 | obsolete microtubule severing activity | consider GO:0008017 |
GO:0008546 | obsolete microtubule/chromatin interaction | consider GO:0008017 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0008017 based on ALL annotations
The top 100 of 5,088 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
microtubule binding
|
453.67 | 100.00 | 429,694 | 429,694 |
microtubule
|
208.84 | 33.92 | 241,981 | 525,653 |
microtubule motor activity
|
446.43 | 33.70 | 145,621 | 147,982 |
microtubule-based movement
|
267.67 | 27.43 | 145,638 | 246,841 |
cytoskeletal motor activity
|
156.51 | 18.65 | 124,077 | 359,662 |
cytoskeleton
|
74.31 | 13.78 | 199,552 | 1,218,329 |
microtubule cytoskeleton organization
|
161.62 | 10.14 | 53,342 | 149,732 |
microtubule cytoskeleton
|
172.36 | 7.88 | 38,842 | 102,238 |
spindle
|
147.59 | 7.83 | 40,167 | 123,469 |
spindle elongation
|
429.45 | 7.70 | 33,251 | 35,126 |
Totals | 2547942 | 15863400 |
No co-occurrence statistics for GO:0008017 based on MANUAL annotations
The top 100 of 3,133 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
microtubule binding
|
150.82 | 100.00 | 8,565 | 8,565 |
microtubule
|
89.31 | 30.94 | 3,367 | 5,686 |
kinesin complex
|
149.04 | 25.28 | 2,172 | 2,198 |
microtubule-based movement
|
108.47 | 19.40 | 1,798 | 2,500 |
microtubule motor activity
|
112.75 | 16.31 | 1,478 | 1,977 |
ATP hydrolysis activity
|
31.51 | 12.77 | 2,118 | 10,138 |
microtubule cytoskeleton organization
|
39.78 | 10.58 | 1,286 | 4,876 |
plus-end-directed microtubule motor activity
|
107.52 | 8.08 | 715 | 1,003 |
microtubule cytoskeleton
|
39.89 | 7.00 | 744 | 2,813 |
cytoplasmic microtubule
|
74.27 | 6.74 | 620 | 1,259 |
Totals | 46645 | 454844 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers. |
2021-05-24 | Added | DEFINITION | Binding to a microtubule, a filament composed of tubulin monomers. |
2020-07-19 | Added | XREF | Reactome:R-HSA-9614343 |
2016-06-22 | Deleted | RELATION | is a GO:0032403 (protein complex binding) |
2016-02-04 | Added | RELATION | has part GO:0008608 (attachment of spindle microtubules to kinetochore) |
2013-09-27 | Added | RELATION | is a GO:0032403 (protein complex binding) |
2009-07-03 | Deleted | DEFINITION | Interacting selectively with microtubules, filaments composed of tubulin monomers. |
2009-07-03 | Added | DEFINITION | Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers. |
2008-05-13 | Added | DEFINITION | Interacting selectively with microtubules, filaments composed of tubulin monomers. |
2008-05-12 | Deleted | DEFINITION | Interacting selectively with microtubules, filaments composed of tubulin monomers. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-06-10 | Updated | TERM | microtubule binding |
2003-03-19 | Updated | TERM | microtubule binding activity |
2002-02-06 | Updated | TERM | microtubule binding |
2001-04-03 | Updated | TERM | microtubule binding |
2001-03-30 | Added | TERM | microtubule binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers. |
2021-05-24 | Added | DEFINITION | Binding to a microtubule, a filament composed of tubulin monomers. |
2009-07-03 | Deleted | DEFINITION | Interacting selectively with microtubules, filaments composed of tubulin monomers. |
2009-07-03 | Added | DEFINITION | Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers. |
2008-05-13 | Added | DEFINITION | Interacting selectively with microtubules, filaments composed of tubulin monomers. |
2008-05-12 | Deleted | DEFINITION | Interacting selectively with microtubules, filaments composed of tubulin monomers. |
2007-08-09 | Deleted | SYNONYM | microtubule severing activity |
2007-08-09 | Added | SYNONYM | microtubule/chromatin interaction |
2007-08-09 | Added | SYNONYM | microtubule severing activity |
2007-08-09 | Deleted | SYNONYM | microtubule/chromatin interaction |
2005-08-10 | Added | SYNONYM | microtubule/chromatin interaction |
2005-08-10 | Added | SYNONYM | microtubule severing activity |
2003-03-26 | Added | DEFINITION | Interacting selectively with microtubules, filaments composed of tubulin monomers. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-06-22 | Deleted | RELATION | is a GO:0032403 (protein complex binding) |
2016-02-04 | Added | RELATION | has part GO:0008608 (attachment of spindle microtubules to kinetochore) |
2013-09-27 | Added | RELATION | is a GO:0032403 (protein complex binding) |
2008-04-01 | Updated | RELATION | is a GO:0015631 (tubulin binding) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-07-19 | Added | XREF | Reactome:R-HSA-9614343 |
Timestamp | Action | Category | Detail |
---|
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