This term is obsolete.

GO:0008137 JSON

NADH dehydrogenase (ubiquinone) activity

Molecular Function

Definition (GO:0008137 GONUTS page)

Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out).

855,814 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
complex 1 dehydrogenase activity related
complex I (NADH:Q1 oxidoreductase) activity related
complex I (electron transport chain) activity related
complex I (mitochondrial electron transport) activity related
electron transfer complex I activity related
mitochondrial electron transport complex 1 activity narrow
mitochondrial electron transport complex I activity narrow
type 1 dehydrogenase activity related
NADH-Q6 oxidoreductase activity related
NADH-ubiquinone-1 reductase activity related

Ancestor Chart

Ancestor chart for GO:0008137
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008137

Child Term Relationship to
GO:0008137
respiratory chain complex I
capable_of

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0009055 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0009055 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0009055 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0009055 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0009055 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.

Cross-references

Database ID Description
EC 7.1.1.2
InterPro IPR000283 NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site
InterPro IPR000440 NADH:ubiquinone/plastoquinone oxidoreductase, chain 3
InterPro IPR001268 NADH:ubiquinone oxidoreductase, 30kDa subunit
InterPro IPR001457 NADH:ubiquinone/plastoquinone oxidoreductase, chain 6
InterPro IPR001949 NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site
InterPro IPR003917 NADH:ubiquinone oxidoreductase, chain 2
InterPro IPR003918 NADH:ubiquinone oxidoreductase
InterPro IPR003945 NADH-quinone oxidoreductase, chain 5-like
InterPro IPR004497 NAD(P)H-quinone oxidoreductase subunit I

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:57945 NADH(2-)
has_participant CHEBI CHEBI:16389 ubiquinones
has_participant CHEBI CHEBI:57540 NAD(1-)
has_participant CHEBI CHEBI:17976 ubiquinol
has_participant CHEBI CHEBI:15378 hydron

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008137 based on ALL annotations
The top 100 of 810 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NADH dehydrogenase (ubiquinone) activity
231.88 100.00 854,540 854,540
ATP synthesis coupled electron transport
159.60 36.67 375,714 545,890
NADH dehydrogenase activity
148.38 30.49 314,555 491,581
quinone binding
127.74 30.22 342,666 622,018
proton transmembrane transport
51.70 19.93 557,254 2,499,177
ubiquinone binding
188.47 12.66 111,450 137,123
NADH:ubiquinone reductase (non-electrogenic) activity
131.37 12.38 116,848 206,254
mitochondrial membrane
90.50 11.56 120,497 308,745
mitochondrial electron transport, NADH to ubiquinone
169.78 11.31 100,844 137,731
electron transport coupled proton transport
32.80 11.18 297,306 2,101,926
Totals 6118402 177994580
No co-occurrence statistics for GO:0008137 based on MANUAL annotations
The top 100 of 120 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NADH dehydrogenase (ubiquinone) activity
1,180.21 100.00 1,196 1,196
mitochondrial electron transport, NADH to ubiquinone
467.17 25.33 494 1,248
mitochondrial respiratory chain complex I assembly
309.95 18.55 463 1,763
respiratory chain complex I
229.53 17.55 768 3,949
electron transport coupled proton transport
512.80 17.05 262 603
aerobic respiration
288.74 14.65 320 1,308
NADH dehydrogenase complex
537.92 9.88 134 294
mitochondrial inner membrane
111.44 8.86 703 7,445
NADH dehydrogenase activity
148.10 5.18 97 773
proton motive force-driven mitochondrial ATP synthesis
98.77 3.20 59 705
Totals 5011 255294

Change Log

Timestamp Action Category Detail
2025-01-31 Added RELATION is a GO:0003954 (NADH dehydrogenase activity)
2024-04-19 Added RELATION is a GO:0015078 (proton transmembrane transporter activity)
2024-04-19 Added RELATION is a GO:0022853 (active monoatomic ion transmembrane transporter activity)
2024-04-19 Added RELATION is a GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor)
2024-04-18 Deleted RELATION is a GO:0050136 (NADH:ubiquinone reductase (non-electrogenic) activity)
2023-09-23 Deleted DEFINITION Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) <=> NAD+ + ubiquinol + 4 H+(out).
2023-09-23 Added DEFINITION Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out).
2023-08-04 Deleted XREF MetaCyc:RXN0-5330
2022-09-01 Added DEFINITION Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) <=> NAD+ + ubiquinol + 4 H+(out).
2022-09-01 Deleted DEFINITION Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out).
Timestamp Action Category Detail
2003-03-19 Updated TERM NADH dehydrogenase (ubiquinone) activity
2002-05-21 Updated TERM NADH dehydrogenase (ubiquinone)
2002-03-31 Updated TERM NADH2 dehydrogenase (ubiquinone)
2002-02-06 Updated TERM NADH dehydrogenase (ubiquinone)
2001-04-03 Updated TERM NADH dehydrogenase (ubiquinone)
2001-03-30 Added TERM NADH dehydrogenase (ubiquinone)
Timestamp Action Category Detail
2023-09-23 Deleted DEFINITION Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) <=> NAD+ + ubiquinol + 4 H+(out).
2023-09-23 Added DEFINITION Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out).
2022-09-01 Added DEFINITION Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) <=> NAD+ + ubiquinol + 4 H+(out).
2022-09-01 Deleted DEFINITION Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out).
2020-10-08 Added SYNONYM NADH coenzyme Q1 reductase activity
2020-10-08 Added SYNONYM NADH-CoQ oxidoreductase activity
2020-10-08 Added SYNONYM NADH-coenzyme Q reductase activity
2020-10-08 Added SYNONYM DPNH-ubiquinone reductase activity
2020-10-08 Added SYNONYM dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity
2020-10-08 Added SYNONYM NADH-ubiquinone reductase activity
2020-10-08 Added SYNONYM NADH:ubiquinone oxidoreductase activity
2020-10-08 Added SYNONYM DPNH-coenzyme Q reductase activity
2020-10-08 Added SYNONYM reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity
2020-10-08 Added SYNONYM NADH-CoQ reductase activity
2020-10-08 Added SYNONYM NADH-ubiquinone-1 reductase activity
2020-10-08 Added SYNONYM NADH-ubiquinone oxidoreductase activity
2020-10-08 Added SYNONYM coenzyme Q reductase activity
2020-10-08 Added SYNONYM NADH-Q6 oxidoreductase activity
2020-10-08 Deleted SYNONYM NADH coenzyme Q1 reductase activity
2020-10-08 Deleted SYNONYM NADH-CoQ oxidoreductase activity
2020-10-08 Deleted SYNONYM NADH-CoQ reductase activity
2020-10-08 Deleted SYNONYM NADH-Q6 oxidoreductase activity
2020-10-08 Deleted SYNONYM NADH-coenzyme Q oxidoreductase activity
2020-10-08 Deleted SYNONYM NADH-coenzyme Q reductase activity
2020-10-08 Deleted SYNONYM NADH-ubiquinone oxidoreductase activity
2020-10-08 Deleted SYNONYM NADH-ubiquinone reductase activity
2020-10-08 Deleted SYNONYM NADH-ubiquinone-1 reductase activity
2020-10-08 Deleted SYNONYM coenzyme Q reductase activity
2020-10-08 Deleted SYNONYM dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity
2020-10-08 Deleted SYNONYM reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity
2020-10-08 Deleted SYNONYM DPNH-coenzyme Q reductase activity
2020-10-08 Deleted SYNONYM DPNH-ubiquinone reductase activity
2020-10-08 Deleted SYNONYM NADH:ubiquinone oxidoreductase activity
2020-10-08 Added SYNONYM NADH-coenzyme Q oxidoreductase activity
2019-05-31 Deleted DEFINITION Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol.
2019-05-31 Added DEFINITION Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out).
2008-05-13 Added DEFINITION Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol.
2007-11-08 Added SYNONYM NADH:ubiquinone oxidoreductase activity
2007-09-06 Added SYNONYM complex I (mitochondrial electron transport) activity
2007-09-06 Added SYNONYM NADH-coenzyme Q oxidoreductase activity
2007-09-06 Added SYNONYM NADH-Q6 oxidoreductase activity
2007-09-06 Added SYNONYM NADH-CoQ reductase activity
2007-09-06 Added SYNONYM NADH-CoQ oxidoreductase activity
2007-09-06 Deleted SYNONYM NADH:ubiquinone oxidoreductase
2007-09-06 Deleted SYNONYM NADH-ubiquinone oxidoreductase
2007-09-06 Added SYNONYM NADH coenzyme Q1 reductase activity
2007-09-06 Added SYNONYM DPNH-ubiquinone reductase activity
2007-09-06 Added SYNONYM DPNH-coenzyme Q reductase activity
2007-09-06 Added SYNONYM type 1 dehydrogenase activity
2007-09-06 Added SYNONYM reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity
2007-09-06 Added SYNONYM mitochondrial electron transport complex I activity
2007-09-06 Added SYNONYM mitochondrial electron transport complex 1 activity
2007-09-06 Added SYNONYM electron transfer complex I activity
2007-09-06 Added SYNONYM dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity
2007-09-06 Added SYNONYM NADH-coenzyme Q reductase activity
2007-09-06 Added SYNONYM complex I (electron transport chain) activity
2007-09-06 Added SYNONYM complex I (NADH:Q1 oxidoreductase) activity
2007-09-06 Added SYNONYM complex 1 dehydrogenase activity
2007-09-06 Added SYNONYM coenzyme Q reductase activity
2007-09-06 Added SYNONYM NADH:ubiquinone oxidoreductase complex activity
2007-09-06 Added SYNONYM NADH-ubiquinone-1 reductase activity
2007-09-06 Added SYNONYM NADH-ubiquinone reductase activity
2007-09-06 Added SYNONYM NADH-ubiquinone oxidoreductase activity
2007-08-21 Added SYNONYM NADH:ubiquinone oxidoreductase
2007-08-21 Added SYNONYM NADH-ubiquinone oxidoreductase
2007-08-09 Added SYNONYM ubiquinone reductase activity
2007-08-09 Deleted SYNONYM ubiquinone reductase activity
2005-07-09 Added SYNONYM ubiquinone reductase activity
2005-07-09 Deleted SYNONYM ubiquinone reductase
2004-04-19 Added SYNONYM ubiquinone reductase
2004-04-16 Deleted SYNONYM ubiquinone reductase
2003-10-27 Added SYNONYM ubiquinone reductase
2003-09-19 Deleted SYNONYM ubiquinone reductase
2002-11-27 Added DEFINITION Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol.
2002-05-21 Added SYNONYM ubiquinone reductase
Timestamp Action Category Detail
2025-01-31 Added RELATION is a GO:0003954 (NADH dehydrogenase activity)
2024-04-19 Added RELATION is a GO:0015078 (proton transmembrane transporter activity)
2024-04-19 Added RELATION is a GO:0022853 (active monoatomic ion transmembrane transporter activity)
2024-04-19 Added RELATION is a GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor)
2024-04-18 Deleted RELATION is a GO:0050136 (NADH:ubiquinone reductase (non-electrogenic) activity)
2021-05-22 Added RELATION is a GO:0015453 (oxidoreduction-driven active transmembrane transporter activity)
2021-01-04 Added RELATION is a GO:0009055 (electron transfer activity)
2008-04-01 Updated RELATION is a GO:0050136 (NADH:ubiquinone reductase (non-electrogenic) activity)
Timestamp Action Category Detail
2023-08-04 Deleted XREF MetaCyc:RXN0-5330
2019-05-31 Deleted XREF EC:1.6.5.3
2019-05-31 Added XREF EC:7.1.1.2
2019-05-31 Added XREF RHEA:29091
2019-05-31 Deleted XREF RHEA:23152
2019-04-01 Added XREF Reactome:R-HSA-163217
2019-04-01 Deleted XREF reactome:R-HSA-163217
2018-12-11 Added XREF reactome:R-HSA-163217
2018-07-13 Added XREF RHEA:23152
2018-07-13 Deleted XREF RHEA:23155
2011-09-16 Added XREF RHEA:23155
2009-05-21 Added XREF MetaCyc:RXN0-5330
2009-05-21 Deleted XREF MetaCyc:NADH-DEHYDROG-RXN
2009-05-21 Added XREF MetaCyc:NADH-DEHYDROG-A-RXN
2007-07-11 Deleted XREF TC:3.D.1.-.-
2003-10-27 Added XREF MetaCyc:NADH-DEHYDROG-RXN
2003-10-27 Added XREF TC:3.D.1.-.-
2003-09-19 Deleted XREF TC:3.D.1.-.-
2001-03-30 Added XREF EC:1.6.5.3
2001-03-30 Added XREF TC:3.D.1.-.-
Timestamp Action Category Detail
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