GO:0008137
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NADH dehydrogenase (ubiquinone) activity
Molecular Function
Definition (GO:0008137 GONUTS page)
Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out).
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
complex 1 dehydrogenase activity | related |
complex I (NADH:Q1 oxidoreductase) activity | related |
complex I (electron transport chain) activity | related |
complex I (mitochondrial electron transport) activity | related |
electron transfer complex I activity | related |
mitochondrial electron transport complex 1 activity | narrow |
mitochondrial electron transport complex I activity | narrow |
type 1 dehydrogenase activity | related |
NADH-Q6 oxidoreductase activity | related |
NADH-ubiquinone-1 reductase activity | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0008137
Child Term | Relationship to GO:0008137 |
---|---|
respiratory chain complex I
|
capable_of |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0009055 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0009055 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0009055 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0009055 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 5270 | BI1_MYCMD | GO:0009055 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 5270 | BI1_MYCMD | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. |
Cross-references
Database | ID | Description |
---|---|---|
EC | 7.1.1.2 | |
InterPro | IPR000283 | NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site |
InterPro | IPR000440 | NADH:ubiquinone/plastoquinone oxidoreductase, chain 3 |
InterPro | IPR001268 | NADH:ubiquinone oxidoreductase, 30kDa subunit |
InterPro | IPR001457 | NADH:ubiquinone/plastoquinone oxidoreductase, chain 6 |
InterPro | IPR001949 | NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site |
InterPro | IPR003917 | NADH:ubiquinone oxidoreductase, chain 2 |
InterPro | IPR003918 | NADH:ubiquinone oxidoreductase |
InterPro | IPR003945 | NADH-quinone oxidoreductase, chain 5-like |
InterPro | IPR004497 | NAD(P)H-quinone oxidoreductase subunit I |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:57945 | NADH(2-) |
has_participant | CHEBI | CHEBI:16389 | ubiquinones |
has_participant | CHEBI | CHEBI:57540 | NAD(1-) |
has_participant | CHEBI | CHEBI:17976 | ubiquinol |
has_participant | CHEBI | CHEBI:15378 | hydron |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0008137 based on ALL annotations
The top 100 of 810 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NADH dehydrogenase (ubiquinone) activity
|
231.88 | 100.00 | 854,540 | 854,540 |
ATP synthesis coupled electron transport
|
159.60 | 36.67 | 375,714 | 545,890 |
NADH dehydrogenase activity
|
148.38 | 30.49 | 314,555 | 491,581 |
quinone binding
|
127.74 | 30.22 | 342,666 | 622,018 |
proton transmembrane transport
|
51.70 | 19.93 | 557,254 | 2,499,177 |
ubiquinone binding
|
188.47 | 12.66 | 111,450 | 137,123 |
NADH:ubiquinone reductase (non-electrogenic) activity
|
131.37 | 12.38 | 116,848 | 206,254 |
mitochondrial membrane
|
90.50 | 11.56 | 120,497 | 308,745 |
mitochondrial electron transport, NADH to ubiquinone
|
169.78 | 11.31 | 100,844 | 137,731 |
electron transport coupled proton transport
|
32.80 | 11.18 | 297,306 | 2,101,926 |
Totals | 6118402 | 177994580 |
No co-occurrence statistics for GO:0008137 based on MANUAL annotations
The top 100 of 120 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NADH dehydrogenase (ubiquinone) activity
|
1,180.21 | 100.00 | 1,196 | 1,196 |
mitochondrial electron transport, NADH to ubiquinone
|
467.17 | 25.33 | 494 | 1,248 |
mitochondrial respiratory chain complex I assembly
|
309.95 | 18.55 | 463 | 1,763 |
respiratory chain complex I
|
229.53 | 17.55 | 768 | 3,949 |
electron transport coupled proton transport
|
512.80 | 17.05 | 262 | 603 |
aerobic respiration
|
288.74 | 14.65 | 320 | 1,308 |
NADH dehydrogenase complex
|
537.92 | 9.88 | 134 | 294 |
mitochondrial inner membrane
|
111.44 | 8.86 | 703 | 7,445 |
NADH dehydrogenase activity
|
148.10 | 5.18 | 97 | 773 |
proton motive force-driven mitochondrial ATP synthesis
|
98.77 | 3.20 | 59 | 705 |
Totals | 5011 | 255294 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2025-01-31 | Added | RELATION | is a GO:0003954 (NADH dehydrogenase activity) |
2024-04-19 | Added | RELATION | is a GO:0015078 (proton transmembrane transporter activity) |
2024-04-19 | Added | RELATION | is a GO:0022853 (active monoatomic ion transmembrane transporter activity) |
2024-04-19 | Added | RELATION | is a GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor) |
2024-04-18 | Deleted | RELATION | is a GO:0050136 (NADH:ubiquinone reductase (non-electrogenic) activity) |
2023-09-23 | Deleted | DEFINITION | Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) <=> NAD+ + ubiquinol + 4 H+(out). |
2023-09-23 | Added | DEFINITION | Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). |
2023-08-04 | Deleted | XREF | MetaCyc:RXN0-5330 |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) <=> NAD+ + ubiquinol + 4 H+(out). |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out). |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | NADH dehydrogenase (ubiquinone) activity |
2002-05-21 | Updated | TERM | NADH dehydrogenase (ubiquinone) |
2002-03-31 | Updated | TERM | NADH2 dehydrogenase (ubiquinone) |
2002-02-06 | Updated | TERM | NADH dehydrogenase (ubiquinone) |
2001-04-03 | Updated | TERM | NADH dehydrogenase (ubiquinone) |
2001-03-30 | Added | TERM | NADH dehydrogenase (ubiquinone) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-09-23 | Deleted | DEFINITION | Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) <=> NAD+ + ubiquinol + 4 H+(out). |
2023-09-23 | Added | DEFINITION | Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) <=> NAD+ + ubiquinol + 4 H+(out). |
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out). |
2020-10-08 | Added | SYNONYM | NADH coenzyme Q1 reductase activity |
2020-10-08 | Added | SYNONYM | NADH-CoQ oxidoreductase activity |
2020-10-08 | Added | SYNONYM | NADH-coenzyme Q reductase activity |
2020-10-08 | Added | SYNONYM | DPNH-ubiquinone reductase activity |
2020-10-08 | Added | SYNONYM | dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity |
2020-10-08 | Added | SYNONYM | NADH-ubiquinone reductase activity |
2020-10-08 | Added | SYNONYM | NADH:ubiquinone oxidoreductase activity |
2020-10-08 | Added | SYNONYM | DPNH-coenzyme Q reductase activity |
2020-10-08 | Added | SYNONYM | reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity |
2020-10-08 | Added | SYNONYM | NADH-CoQ reductase activity |
2020-10-08 | Added | SYNONYM | NADH-ubiquinone-1 reductase activity |
2020-10-08 | Added | SYNONYM | NADH-ubiquinone oxidoreductase activity |
2020-10-08 | Added | SYNONYM | coenzyme Q reductase activity |
2020-10-08 | Added | SYNONYM | NADH-Q6 oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | NADH coenzyme Q1 reductase activity |
2020-10-08 | Deleted | SYNONYM | NADH-CoQ oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | NADH-CoQ reductase activity |
2020-10-08 | Deleted | SYNONYM | NADH-Q6 oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | NADH-coenzyme Q oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | NADH-coenzyme Q reductase activity |
2020-10-08 | Deleted | SYNONYM | NADH-ubiquinone oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | NADH-ubiquinone reductase activity |
2020-10-08 | Deleted | SYNONYM | NADH-ubiquinone-1 reductase activity |
2020-10-08 | Deleted | SYNONYM | coenzyme Q reductase activity |
2020-10-08 | Deleted | SYNONYM | dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity |
2020-10-08 | Deleted | SYNONYM | reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity |
2020-10-08 | Deleted | SYNONYM | DPNH-coenzyme Q reductase activity |
2020-10-08 | Deleted | SYNONYM | DPNH-ubiquinone reductase activity |
2020-10-08 | Deleted | SYNONYM | NADH:ubiquinone oxidoreductase activity |
2020-10-08 | Added | SYNONYM | NADH-coenzyme Q oxidoreductase activity |
2019-05-31 | Deleted | DEFINITION | Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. |
2019-05-31 | Added | DEFINITION | Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out). |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. |
2007-11-08 | Added | SYNONYM | NADH:ubiquinone oxidoreductase activity |
2007-09-06 | Added | SYNONYM | complex I (mitochondrial electron transport) activity |
2007-09-06 | Added | SYNONYM | NADH-coenzyme Q oxidoreductase activity |
2007-09-06 | Added | SYNONYM | NADH-Q6 oxidoreductase activity |
2007-09-06 | Added | SYNONYM | NADH-CoQ reductase activity |
2007-09-06 | Added | SYNONYM | NADH-CoQ oxidoreductase activity |
2007-09-06 | Deleted | SYNONYM | NADH:ubiquinone oxidoreductase |
2007-09-06 | Deleted | SYNONYM | NADH-ubiquinone oxidoreductase |
2007-09-06 | Added | SYNONYM | NADH coenzyme Q1 reductase activity |
2007-09-06 | Added | SYNONYM | DPNH-ubiquinone reductase activity |
2007-09-06 | Added | SYNONYM | DPNH-coenzyme Q reductase activity |
2007-09-06 | Added | SYNONYM | type 1 dehydrogenase activity |
2007-09-06 | Added | SYNONYM | reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity |
2007-09-06 | Added | SYNONYM | mitochondrial electron transport complex I activity |
2007-09-06 | Added | SYNONYM | mitochondrial electron transport complex 1 activity |
2007-09-06 | Added | SYNONYM | electron transfer complex I activity |
2007-09-06 | Added | SYNONYM | dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity |
2007-09-06 | Added | SYNONYM | NADH-coenzyme Q reductase activity |
2007-09-06 | Added | SYNONYM | complex I (electron transport chain) activity |
2007-09-06 | Added | SYNONYM | complex I (NADH:Q1 oxidoreductase) activity |
2007-09-06 | Added | SYNONYM | complex 1 dehydrogenase activity |
2007-09-06 | Added | SYNONYM | coenzyme Q reductase activity |
2007-09-06 | Added | SYNONYM | NADH:ubiquinone oxidoreductase complex activity |
2007-09-06 | Added | SYNONYM | NADH-ubiquinone-1 reductase activity |
2007-09-06 | Added | SYNONYM | NADH-ubiquinone reductase activity |
2007-09-06 | Added | SYNONYM | NADH-ubiquinone oxidoreductase activity |
2007-08-21 | Added | SYNONYM | NADH:ubiquinone oxidoreductase |
2007-08-21 | Added | SYNONYM | NADH-ubiquinone oxidoreductase |
2007-08-09 | Added | SYNONYM | ubiquinone reductase activity |
2007-08-09 | Deleted | SYNONYM | ubiquinone reductase activity |
2005-07-09 | Added | SYNONYM | ubiquinone reductase activity |
2005-07-09 | Deleted | SYNONYM | ubiquinone reductase |
2004-04-19 | Added | SYNONYM | ubiquinone reductase |
2004-04-16 | Deleted | SYNONYM | ubiquinone reductase |
2003-10-27 | Added | SYNONYM | ubiquinone reductase |
2003-09-19 | Deleted | SYNONYM | ubiquinone reductase |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. |
2002-05-21 | Added | SYNONYM | ubiquinone reductase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2025-01-31 | Added | RELATION | is a GO:0003954 (NADH dehydrogenase activity) |
2024-04-19 | Added | RELATION | is a GO:0015078 (proton transmembrane transporter activity) |
2024-04-19 | Added | RELATION | is a GO:0022853 (active monoatomic ion transmembrane transporter activity) |
2024-04-19 | Added | RELATION | is a GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor) |
2024-04-18 | Deleted | RELATION | is a GO:0050136 (NADH:ubiquinone reductase (non-electrogenic) activity) |
2021-05-22 | Added | RELATION | is a GO:0015453 (oxidoreduction-driven active transmembrane transporter activity) |
2021-01-04 | Added | RELATION | is a GO:0009055 (electron transfer activity) |
2008-04-01 | Updated | RELATION | is a GO:0050136 (NADH:ubiquinone reductase (non-electrogenic) activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-08-04 | Deleted | XREF | MetaCyc:RXN0-5330 |
2019-05-31 | Deleted | XREF | EC:1.6.5.3 |
2019-05-31 | Added | XREF | EC:7.1.1.2 |
2019-05-31 | Added | XREF | RHEA:29091 |
2019-05-31 | Deleted | XREF | RHEA:23152 |
2019-04-01 | Added | XREF | Reactome:R-HSA-163217 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-163217 |
2018-12-11 | Added | XREF | reactome:R-HSA-163217 |
2018-07-13 | Added | XREF | RHEA:23152 |
2018-07-13 | Deleted | XREF | RHEA:23155 |
2011-09-16 | Added | XREF | RHEA:23155 |
2009-05-21 | Added | XREF | MetaCyc:RXN0-5330 |
2009-05-21 | Deleted | XREF | MetaCyc:NADH-DEHYDROG-RXN |
2009-05-21 | Added | XREF | MetaCyc:NADH-DEHYDROG-A-RXN |
2007-07-11 | Deleted | XREF | TC:3.D.1.-.- |
2003-10-27 | Added | XREF | MetaCyc:NADH-DEHYDROG-RXN |
2003-10-27 | Added | XREF | TC:3.D.1.-.- |
2003-09-19 | Deleted | XREF | TC:3.D.1.-.- |
2001-03-30 | Added | XREF | EC:1.6.5.3 |
2001-03-30 | Added | XREF | TC:3.D.1.-.- |
Timestamp | Action | Category | Detail |
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