This term is obsolete.

GO:0008146 JSON

sulfotransferase activity

Molecular Function

Definition (GO:0008146 GONUTS page)

Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.

227,124 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
sulphotransferase activity exact

Ancestor Chart

Ancestor chart for GO:0008146
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008146

Child Term Relationship to
GO:0008146
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity
is_a
choline sulfotransferase activity
is_a
proteoglycan sulfotransferase activity
is_a
galactose 3-O-sulfotransferase activity
is_a
HNK-1 sulfotransferase activity
is_a
brassinosteroid sulfotransferase activity
is_a
psychosine sulfotransferase activity
is_a
hydroxyjasmonate sulfotransferase activity
is_a
Renilla-luciferin sulfotransferase activity
is_a
aliphatic desulfoglucosinolate sulfotransferase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I940 7227 Q8I940_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
EC 2.8.2.-
InterPro IPR000863 Sulfotransferase domain
InterPro IPR005331 Sulfotransferase
InterPro IPR007734 Heparan sulphate 2-O-sulfotransferase
InterPro IPR010635 Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase
InterPro IPR016469 Carbohydrate sulfotransferase
InterPro IPR018011 Carbohydrate sulfotransferase 8-10
InterPro IPR037359 Heparan sulfate sulfotransferase
Reactome R-HSA-176588
Reactome R-HSA-176604

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008146 based on ALL annotations
The top 100 of 1,262 co-occurring terms
Co-occurring Term PR S% #Together #Compared
sulfotransferase activity
1,308.89 100.00 151,392 151,392
ubiquitin-like modifier activating enzyme activity
400.92 15.53 36,276 118,431
thiosulfate sulfurtransferase activity
360.45 14.71 36,333 131,934
protein-tyrosine sulfotransferase activity
1,000.66 8.81 13,707 17,929
catalytic activity, acting on a protein
640.65 7.95 13,126 26,817
carbohydrate biosynthetic process
371.23 7.51 14,029 49,463
[heparan sulfate]-glucosamine 3-sulfotransferase activity
1,308.38 5.15 7,797 7,800
heparan sulfate proteoglycan biosynthetic process, enzymatic modification
1,293.88 4.56 6,900 6,980
N-acetylglucosamine 6-O-sulfotransferase activity
879.80 3.95 6,104 9,081
galactosylceramide sulfotransferase activity
1,241.47 3.86 5,856 6,174
Totals 668430 131444372
No co-occurrence statistics for GO:0008146 based on MANUAL annotations
The top 100 of 204 co-occurring terms
Co-occurring Term PR S% #Together #Compared
sulfotransferase activity
2,168.25 100.00 651 651
proteoglycan biosynthetic process
679.45 14.33 136 434
thiosulfate sulfurtransferase activity
187.50 3.67 39 451
nucleotidyltransferase activity
138.17 3.19 39 612
dermatan sulfate proteoglycan metabolic process
2,054.13 2.76 18 19
aryl sulfotransferase activity
297.02 2.57 20 146
sulfation
69.07 2.24 46 1,444
3'-phosphoadenosine 5'-phosphosulfate binding
1,084.13 2.11 14 28
3'-phosphoadenosine 5'-phosphosulfate metabolic process
740.38 2.06 14 41
dermatan 4-sulfotransferase activity
1,658.08 1.98 13 17
Totals 1376 28319

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_chembl 296

Change Log

Timestamp Action Category Detail
2023-04-02 Added XREF Reactome:R-HSA-9753277
2021-04-30 Added XREF EC:2.8.2.-
2021-04-20 Deleted XREF EC:2.8.2.-
2021-04-20 Deleted XREF RHEA:51064
2021-01-04 Added XREF EC:2.8.2.-
2021-01-04 Deleted XREF EC:2.8.2
2020-06-22 Added XREF RHEA:51064
2019-04-01 Added XREF Reactome:R-HSA-176604
2019-04-01 Added XREF Reactome:R-HSA-176669
2019-04-01 Deleted XREF reactome:R-HSA-176604
Timestamp Action Category Detail
2003-03-19 Updated TERM sulfotransferase activity
2002-02-06 Updated TERM sulfotransferase
2001-04-03 Updated TERM sulfotransferase
2001-03-30 Added TERM sulfotransferase
Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.
2008-05-12 Deleted DEFINITION Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.
2007-08-09 Deleted SYNONYM sulphotransferase activity
2007-08-09 Added SYNONYM sulphotransferase activity
2006-02-04 Updated DEFINITION Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.
2004-04-19 Added SYNONYM sulphotransferase activity
2004-04-16 Deleted SYNONYM sulphotransferase activity
2003-11-13 Added SYNONYM sulphotransferase activity
2003-09-25 Added DEFINITION Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016782 (transferase activity, transferring sulphur-containing groups)
Timestamp Action Category Detail
2023-04-02 Added XREF Reactome:R-HSA-9753277
2021-04-30 Added XREF EC:2.8.2.-
2021-04-20 Deleted XREF EC:2.8.2.-
2021-04-20 Deleted XREF RHEA:51064
2021-01-04 Added XREF EC:2.8.2.-
2021-01-04 Deleted XREF EC:2.8.2
2020-06-22 Added XREF RHEA:51064
2019-04-01 Added XREF Reactome:R-HSA-176604
2019-04-01 Added XREF Reactome:R-HSA-176669
2019-04-01 Deleted XREF reactome:R-HSA-176604
2019-04-01 Added XREF Reactome:R-HSA-176588
2019-04-01 Deleted XREF reactome:R-HSA-176669
2019-04-01 Added XREF Reactome:R-HSA-2022061
2019-04-01 Deleted XREF reactome:R-HSA-176588
2019-04-01 Deleted XREF reactome:R-HSA-2022061
2018-12-11 Added XREF reactome:R-HSA-2022061
2018-12-11 Added XREF reactome:R-HSA-176588
2018-12-11 Added XREF reactome:R-HSA-176604
2018-12-11 Added XREF reactome:R-HSA-176669
2006-02-09 Deleted XREF EC:2.8.2.-
2006-02-09 Added XREF EC:2.8.2
2001-03-30 Added XREF EC:2.8.2.-
Timestamp Action Category Detail
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-19 Added SUBSET goslim_chembl
2015-05-11 Added SUBSET goslim_ChEMBL
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