GO:0008146
JSON
sulfotransferase activity
Molecular Function
Definition (GO:0008146 GONUTS page)
Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
sulphotransferase activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0008146
Child Term | Relationship to GO:0008146 |
---|---|
psychosine sulfotransferase activity
|
is_a |
aliphatic desulfoglucosinolate sulfotransferase activity
|
is_a |
brassinosteroid sulfotransferase activity
|
is_a |
cortisol sulfotransferase activity
|
is_a |
UDP-N-acetylgalactosamine-4-sulfate sulfotransferase activity
|
is_a |
bile-salt sulfotransferase activity
|
is_a |
chondroitin sulfotransferase activity
|
is_a |
quercetin-3,3'-bissulfate 7-sulfotransferase activity
|
is_a |
alcohol sulfotransferase activity
|
is_a |
quercetin-3-sulfate 4'-sulfotransferase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I940 | 7227 | Q8I940_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.8.2.- | |
InterPro | IPR000863 | Sulfotransferase domain |
InterPro | IPR005331 | Sulfotransferase |
InterPro | IPR007734 | Heparan sulphate 2-O-sulfotransferase |
InterPro | IPR010635 | Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase |
InterPro | IPR016469 | Carbohydrate sulfotransferase |
InterPro | IPR018011 | Carbohydrate sulfotransferase 8-10 |
InterPro | IPR037359 | Heparan sulfate sulfotransferase |
Reactome | R-HSA-176588 | |
Reactome | R-HSA-176604 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0008146 based on ALL annotations
The top 100 of 1,235 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
sulfotransferase activity
|
1,322.26 | 100.00 | 147,429 | 147,429 |
ubiquitin-like modifier activating enzyme activity
|
407.05 | 15.69 | 35,736 | 116,083 |
thiosulfate sulfurtransferase activity
|
365.68 | 14.85 | 35,785 | 129,396 |
protein-tyrosine sulfotransferase activity
|
1,011.10 | 8.88 | 13,466 | 17,610 |
catalytic activity, acting on a protein
|
554.71 | 7.71 | 12,729 | 30,342 |
carbohydrate biosynthetic process
|
368.81 | 7.42 | 13,540 | 48,543 |
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
|
1,321.90 | 5.06 | 7,457 | 7,459 |
heparan sulfate proteoglycan biosynthetic process, enzymatic modification
|
1,307.08 | 4.50 | 6,633 | 6,710 |
N-acetylglucosamine 6-O-sulfotransferase activity
|
897.37 | 3.95 | 5,937 | 8,748 |
galactosylceramide sulfotransferase activity
|
1,251.83 | 3.81 | 5,635 | 5,952 |
Totals | 669199 | 129671258 |
No co-occurrence statistics for GO:0008146 based on MANUAL annotations
The top 100 of 206 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
sulfotransferase activity
|
770.30 | 100.00 | 1,677 | 1,677 |
sulfation
|
671.26 | 61.04 | 1,125 | 1,291 |
proteoglycan biosynthetic process
|
206.86 | 5.35 | 105 | 391 |
thiosulfate sulfurtransferase activity
|
69.40 | 1.92 | 40 | 444 |
nucleotidyltransferase activity
|
63.53 | 1.89 | 40 | 485 |
aryl sulfotransferase activity
|
145.22 | 1.30 | 23 | 122 |
3'-phosphoadenosine 5'-phosphosulfate metabolic process
|
288.86 | 0.88 | 15 | 40 |
dermatan 4-sulfotransferase
|
634.37 | 0.83 | 14 | 17 |
3'-phosphoadenosine 5'-phosphosulfate binding
|
355.52 | 0.71 | 12 | 26 |
xenobiotic metabolic process
|
13.00 | 0.68 | 19 | 1,126 |
Totals | 4638 | 239685 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_chembl | 296 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-04-02 | Added | XREF | Reactome:R-HSA-9753277 |
2021-04-30 | Added | XREF | EC:2.8.2.- |
2021-04-20 | Deleted | XREF | EC:2.8.2.- |
2021-04-20 | Deleted | XREF | RHEA:51064 |
2021-01-04 | Added | XREF | EC:2.8.2.- |
2021-01-04 | Deleted | XREF | EC:2.8.2 |
2020-06-22 | Added | XREF | RHEA:51064 |
2019-04-01 | Added | XREF | Reactome:R-HSA-176604 |
2019-04-01 | Added | XREF | Reactome:R-HSA-176669 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-176604 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | sulfotransferase activity |
2002-02-06 | Updated | TERM | sulfotransferase |
2001-04-03 | Updated | TERM | sulfotransferase |
2001-03-30 | Added | TERM | sulfotransferase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. |
2007-08-09 | Deleted | SYNONYM | sulphotransferase activity |
2007-08-09 | Added | SYNONYM | sulphotransferase activity |
2006-02-04 | Updated | DEFINITION | Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. |
2004-04-19 | Added | SYNONYM | sulphotransferase activity |
2004-04-16 | Deleted | SYNONYM | sulphotransferase activity |
2003-11-13 | Added | SYNONYM | sulphotransferase activity |
2003-09-25 | Added | DEFINITION | Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016782 (transferase activity, transferring sulphur-containing groups) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-04-02 | Added | XREF | Reactome:R-HSA-9753277 |
2021-04-30 | Added | XREF | EC:2.8.2.- |
2021-04-20 | Deleted | XREF | EC:2.8.2.- |
2021-04-20 | Deleted | XREF | RHEA:51064 |
2021-01-04 | Added | XREF | EC:2.8.2.- |
2021-01-04 | Deleted | XREF | EC:2.8.2 |
2020-06-22 | Added | XREF | RHEA:51064 |
2019-04-01 | Added | XREF | Reactome:R-HSA-176604 |
2019-04-01 | Added | XREF | Reactome:R-HSA-176669 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-176604 |
2019-04-01 | Added | XREF | Reactome:R-HSA-176588 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-176669 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2022061 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-176588 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2022061 |
2018-12-11 | Added | XREF | reactome:R-HSA-2022061 |
2018-12-11 | Added | XREF | reactome:R-HSA-176588 |
2018-12-11 | Added | XREF | reactome:R-HSA-176604 |
2018-12-11 | Added | XREF | reactome:R-HSA-176669 |
2006-02-09 | Deleted | XREF | EC:2.8.2.- |
2006-02-09 | Added | XREF | EC:2.8.2 |
2001-03-30 | Added | XREF | EC:2.8.2.- |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
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