GO:0008203
JSON
cholesterol metabolic process
Biological Process
Definition (GO:0008203 GONUTS page)
The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
cholesterol metabolism | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0008203
Child Term | Relationship to GO:0008203 |
---|---|
cholesterol biosynthetic process
|
is_a |
regulation of cholesterol metabolic process
|
regulates |
cholesterol catabolic process
|
is_a |
positive regulation of cholesterol metabolic process
|
positively_regulates |
cholesterol ester hydrolysis involved in cholesterol transport
|
is_a |
negative regulation of cholesterol metabolic process
|
negatively_regulates |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0008203 | cholesterol metabolic process | Never in Taxon | 4895 | Schizosaccharomyces | |
GO:0008203 | cholesterol metabolic process | Never in Taxon | 4930 | Saccharomyces |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0008202 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0008202 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | Q0UV92 | 321614 | Q0UV92_PHANO | GO:0008202 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | Q4WKE9 | 330879 | Q4WKE9_ASPFU | GO:0008202 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | Q5BGM7 | 227321 | Q5BGM7_EMENI | GO:0008202 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | Q6C017 | 284591 | Q6C017_YARLI | GO:0008202 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | Q7SGR1 | 367110 | Q7SGR1_NEUCR | GO:0008202 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR010468 | Hormone-sensitive lipase, N-terminal |
InterPro | IPR045605 | 3-ketosteroid-9-alpha-monooxygenase, oxygenase component-like, C-terminal domain |
UniProtKB-KW | KW-0153 | Cholesterol metabolism |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_primary_input_or_output | CHEBI | CHEBI:16113 | cholesterol |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0010872 | obsolete regulation of cholesterol esterification | consider GO:0008203 |
GO:0010873 | obsolete positive regulation of cholesterol esterification | consider GO:0008203 |
GO:0034434 | obsolete sterol esterification | consider GO:0008203 |
GO:0034435 | obsolete cholesterol esterification | consider GO:0008203 |
GO:0150110 | obsolete negative regulation of cholesterol esterification | consider GO:0008203 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0008203 based on ALL annotations
The top 100 of 2,282 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
cholesterol metabolic process
|
3,382.12 | 100.00 | 57,638 | 57,638 |
cholesterol transfer activity
|
1,625.81 | 13.18 | 8,857 | 18,425 |
cholesterol homeostasis
|
1,136.52 | 12.09 | 9,151 | 27,232 |
low-density lipoprotein particle
|
2,792.47 | 12.00 | 7,099 | 8,598 |
cortisol metabolic process
|
3,313.28 | 11.66 | 6,738 | 6,878 |
glucocorticoid biosynthetic process
|
3,297.46 | 11.66 | 6,738 | 6,911 |
cellular response to peptide hormone stimulus
|
3,149.44 | 11.57 | 6,727 | 7,224 |
chylomicron
|
2,407.86 | 11.27 | 6,804 | 9,557 |
very-low-density lipoprotein particle
|
2,083.53 | 11.07 | 6,851 | 11,121 |
C21-steroid hormone biosynthetic process
|
3,379.95 | 10.77 | 6,210 | 6,214 |
Totals | 415724 | 10863691 |
No co-occurrence statistics for GO:0008203 based on MANUAL annotations
The top 100 of 1,570 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
cholesterol metabolic process
|
2,680.08 | 100.00 | 482 | 482 |
cholesterol efflux
|
1,162.74 | 21.17 | 141 | 325 |
phospholipid efflux
|
1,732.03 | 17.79 | 95 | 147 |
acylglycerol homeostasis
|
2,526.05 | 16.84 | 82 | 87 |
high-density lipoprotein particle
|
1,430.38 | 16.81 | 95 | 178 |
phosphatidylcholine-sterol O-acyltransferase activator activity
|
2,613.91 | 16.32 | 79 | 81 |
chylomicron
|
2,010.06 | 15.91 | 81 | 108 |
cholesterol transfer activity
|
927.72 | 14.80 | 99 | 286 |
very-low-density lipoprotein particle
|
1,140.75 | 13.97 | 83 | 195 |
low-density lipoprotein particle
|
1,270.43 | 12.97 | 73 | 154 |
Totals | 3154 | 18028 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-12-09 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4930 (Saccharomyces) |
2015-12-09 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4895 (Schizosaccharomyces) |
2015-09-16 | Added | RELATION | is a GO:1902652 (secondary alcohol metabolic process) |
2008-05-13 | Added | DEFINITION | The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. |
2008-05-12 | Deleted | DEFINITION | The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. |
2008-04-01 | Updated | RELATION | is a GO:0016125 (sterol metabolic process) |
2007-08-09 | Added | SYNONYM | cholesterol metabolism |
2007-08-09 | Deleted | SYNONYM | cholesterol metabolism |
2007-01-29 | Added | SYNONYM | cholesterol metabolism |
2007-01-15 | Updated | TERM | cholesterol metabolic process |
Timestamp | Action | Category | Detail |
---|---|---|---|
2007-01-15 | Updated | TERM | cholesterol metabolic process |
2002-02-06 | Updated | TERM | cholesterol metabolism |
2001-04-03 | Updated | TERM | cholesterol metabolism |
2001-03-30 | Added | TERM | cholesterol metabolism |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. |
2008-05-12 | Deleted | DEFINITION | The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. |
2007-08-09 | Added | SYNONYM | cholesterol metabolism |
2007-08-09 | Deleted | SYNONYM | cholesterol metabolism |
2007-01-29 | Added | SYNONYM | cholesterol metabolism |
2006-05-04 | Updated | DEFINITION | The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. |
2005-01-21 | Updated | DEFINITION | The chemical reactions involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. |
2002-11-27 | Added | DEFINITION | The chemical reactions and physical changes involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-09-16 | Added | RELATION | is a GO:1902652 (secondary alcohol metabolic process) |
2008-04-01 | Updated | RELATION | is a GO:0016125 (sterol metabolic process) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-12-09 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4930 (Saccharomyces) |
2015-12-09 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4895 (Schizosaccharomyces) |
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link