This term is obsolete.

GO:0008203 JSON

cholesterol metabolic process

Biological Process

Definition (GO:0008203 GONUTS page)

The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.

108,141 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
cholesterol metabolism exact

Ancestor Chart

Ancestor chart for GO:0008203
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008203

Child Term Relationship to
GO:0008203
cholesterol biosynthetic process
is_a
regulation of cholesterol metabolic process
regulates
cholesterol catabolic process
is_a
positive regulation of cholesterol metabolic process
positively_regulates
cholesterol ester hydrolysis involved in cholesterol transport
is_a
negative regulation of cholesterol metabolic process
negatively_regulates

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0008203 cholesterol metabolic process Never in Taxon 4895 Schizosaccharomyces
GO:0008203 cholesterol metabolic process Never in Taxon 4930 Saccharomyces

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0008202 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0008202 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein Q0UV92 321614 Q0UV92_PHANO GO:0008202 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein Q4WKE9 330879 Q4WKE9_ASPFU GO:0008202 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein Q5BGM7 227321 Q5BGM7_EMENI GO:0008202 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein Q6C017 284591 Q6C017_YARLI GO:0008202 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein Q7SGR1 367110 Q7SGR1_NEUCR GO:0008202 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
InterPro IPR010468 Hormone-sensitive lipase, N-terminal
InterPro IPR045605 3-ketosteroid-9-alpha-monooxygenase, oxygenase component-like, C-terminal domain
UniProtKB-KW KW-0153 Cholesterol metabolism

Cross-Ontology Relations

Relation Other Ontology ID Term
has_primary_input_or_output CHEBI CHEBI:16113 cholesterol

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0010872 obsolete regulation of cholesterol esterification consider GO:0008203
GO:0010873 obsolete positive regulation of cholesterol esterification consider GO:0008203
GO:0034434 obsolete sterol esterification consider GO:0008203
GO:0034435 obsolete cholesterol esterification consider GO:0008203
GO:0150110 obsolete negative regulation of cholesterol esterification consider GO:0008203

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008203 based on ALL annotations
The top 100 of 2,282 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cholesterol metabolic process
3,382.12 100.00 57,638 57,638
cholesterol transfer activity
1,625.81 13.18 8,857 18,425
cholesterol homeostasis
1,136.52 12.09 9,151 27,232
low-density lipoprotein particle
2,792.47 12.00 7,099 8,598
cortisol metabolic process
3,313.28 11.66 6,738 6,878
glucocorticoid biosynthetic process
3,297.46 11.66 6,738 6,911
cellular response to peptide hormone stimulus
3,149.44 11.57 6,727 7,224
chylomicron
2,407.86 11.27 6,804 9,557
very-low-density lipoprotein particle
2,083.53 11.07 6,851 11,121
C21-steroid hormone biosynthetic process
3,379.95 10.77 6,210 6,214
Totals 415724 10863691
No co-occurrence statistics for GO:0008203 based on MANUAL annotations
The top 100 of 1,570 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cholesterol metabolic process
2,680.08 100.00 482 482
cholesterol efflux
1,162.74 21.17 141 325
phospholipid efflux
1,732.03 17.79 95 147
acylglycerol homeostasis
2,526.05 16.84 82 87
high-density lipoprotein particle
1,430.38 16.81 95 178
phosphatidylcholine-sterol O-acyltransferase activator activity
2,613.91 16.32 79 81
chylomicron
2,010.06 15.91 81 108
cholesterol transfer activity
927.72 14.80 99 286
very-low-density lipoprotein particle
1,140.75 13.97 83 195
low-density lipoprotein particle
1,270.43 12.97 73 154
Totals 3154 18028

Change Log

Timestamp Action Category Detail
2015-12-09 Added CONSTRAINT never_in_taxon NCBITaxon:4930 (Saccharomyces)
2015-12-09 Added CONSTRAINT never_in_taxon NCBITaxon:4895 (Schizosaccharomyces)
2015-09-16 Added RELATION is a GO:1902652 (secondary alcohol metabolic process)
2008-05-13 Added DEFINITION The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
2008-05-12 Deleted DEFINITION The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
2008-04-01 Updated RELATION is a GO:0016125 (sterol metabolic process)
2007-08-09 Added SYNONYM cholesterol metabolism
2007-08-09 Deleted SYNONYM cholesterol metabolism
2007-01-29 Added SYNONYM cholesterol metabolism
2007-01-15 Updated TERM cholesterol metabolic process
Timestamp Action Category Detail
2007-01-15 Updated TERM cholesterol metabolic process
2002-02-06 Updated TERM cholesterol metabolism
2001-04-03 Updated TERM cholesterol metabolism
2001-03-30 Added TERM cholesterol metabolism
Timestamp Action Category Detail
2008-05-13 Added DEFINITION The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
2008-05-12 Deleted DEFINITION The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
2007-08-09 Added SYNONYM cholesterol metabolism
2007-08-09 Deleted SYNONYM cholesterol metabolism
2007-01-29 Added SYNONYM cholesterol metabolism
2006-05-04 Updated DEFINITION The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
2005-01-21 Updated DEFINITION The chemical reactions involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
2002-11-27 Added DEFINITION The chemical reactions and physical changes involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
Timestamp Action Category Detail
2015-09-16 Added RELATION is a GO:1902652 (secondary alcohol metabolic process)
2008-04-01 Updated RELATION is a GO:0016125 (sterol metabolic process)
Timestamp Action Category Detail
Timestamp Action Category Detail
2015-12-09 Added CONSTRAINT never_in_taxon NCBITaxon:4930 (Saccharomyces)
2015-12-09 Added CONSTRAINT never_in_taxon NCBITaxon:4895 (Schizosaccharomyces)
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