This term is obsolete.

GO:0008658 JSON

penicillin binding

Molecular Function

Definition (GO:0008658 GONUTS page)

Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system.

228,785 annotations

Ancestor Chart

Ancestor chart for GO:0008658
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Cross-references

Database ID Description
InterPro IPR001460 Penicillin-binding protein, transpeptidase
InterPro IPR005311 Penicillin-binding protein, dimerisation domain
InterPro IPR017790 Penicillin-binding protein 2
InterPro IPR036138 Penicillin-binding protein, dimerisation domain superfamily
InterPro IPR037532 Peptidoglycan D,D-transpeptidase FtsI

Cross-Ontology Relations

Relation Other Ontology ID Term
has_primary_input CHEBI CHEBI:51356 penicillinate anion

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008658 based on ALL annotations
The top 100 of 360 co-occurring terms
Co-occurring Term PR S% #Together #Compared
penicillin binding
866.55 100.00 228,670 228,670
peptidoglycan glycosyltransferase activity
600.20 39.29 108,809 157,097
serine-type D-Ala-D-Ala carboxypeptidase activity
393.56 21.62 66,808 147,100
peptidoglycan L,D-transpeptidase activity
379.72 20.53 63,735 145,447
carboxypeptidase activity
206.84 20.20 129,932 544,350
peptidoglycan biosynthetic process
112.31 12.13 149,404 1,152,754
cell wall organization
103.49 11.52 174,920 1,464,669
outer membrane-bounded periplasmic space
92.99 9.35 96,331 897,720
regulation of cell shape
71.53 7.47 100,702 1,219,943
response to antibiotic
89.75 7.07 41,699 402,608
Totals 1781477 178249954
No co-occurrence statistics for GO:0008658 based on MANUAL annotations
The top 33 of 33 co-occurring terms
Co-occurring Term PR S% #Together #Compared
penicillin binding
12,949.85 100.00 109 109
peptidoglycan L,D-transpeptidase activity
5,326.15 28.02 51 124
cell wall organization
1,755.30 13.35 98 723
serine-type D-Ala-D-Ala carboxypeptidase activity
8,633.23 7.08 8 12
peptidoglycan glycosyltransferase activity
754.36 2.91 6 103
peptidoglycan biosynthetic process
380.88 2.14 8 272
peptidoglycan metabolic process
289.92 1.25 3 134
beta-lactamase activity
304.70 1.04 2 85
carboxypeptidase activity
166.45 1.01 5 389
positive regulation of bipolar cell growth
12,949.84 0.92 1 1
Totals 449 369169

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_metagenomics 111

Change Log

Timestamp Action Category Detail
2024-12-23 Deleted RELATION is a GO:0097159 (obsolete organic cyclic compound binding)
2022-12-24 Deleted RELATION is a GO:0043177 (organic acid binding)
2021-07-10 Deleted RELATION is a GO:0008144 (obsolete drug binding)
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system.
2021-05-24 Added DEFINITION Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system.
2020-11-03 Added RELATION is a GO:0043177 (organic acid binding)
2016-11-28 Added RELATION is a GO:0033293 (monocarboxylic acid binding)
2016-11-28 Deleted RELATION is a GO:0043177 (organic acid binding)
2016-07-23 Added SUBSET goslim_metagenomics
2016-06-22 Added RELATION is a GO:0043177 (organic acid binding)
Timestamp Action Category Detail
2003-06-10 Updated TERM penicillin binding
2003-03-19 Updated TERM penicillin binding activity
2002-02-06 Updated TERM penicillin binding
2001-04-03 Updated TERM penicillin binding
2001-03-30 Added TERM penicillin binding
Timestamp Action Category Detail
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system.
2021-05-24 Added DEFINITION Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system.
2009-07-03 Deleted DEFINITION Interacting selectively with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system.
2008-05-13 Added DEFINITION Interacting selectively with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system.
2008-05-12 Deleted DEFINITION Interacting selectively with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system.
2003-03-26 Updated DEFINITION Interacting selectively with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system.
2002-11-27 Added DEFINITION Interacting selectively and stoichiometrically with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system.
Timestamp Action Category Detail
2024-12-23 Deleted RELATION is a GO:0097159 (obsolete organic cyclic compound binding)
2022-12-24 Deleted RELATION is a GO:0043177 (organic acid binding)
2021-07-10 Deleted RELATION is a GO:0008144 (obsolete drug binding)
2020-11-03 Added RELATION is a GO:0043177 (organic acid binding)
2016-11-28 Added RELATION is a GO:0033293 (monocarboxylic acid binding)
2016-11-28 Deleted RELATION is a GO:0043177 (organic acid binding)
2016-06-22 Added RELATION is a GO:0043177 (organic acid binding)
2016-06-22 Deleted RELATION is a GO:0033293 (monocarboxylic acid binding)
2012-12-05 Added RELATION is a GO:1901681 (sulfur compound binding)
2012-11-15 Added RELATION is a GO:0033293 (monocarboxylic acid binding)
2012-11-15 Deleted RELATION is a GO:0031406 (carboxylic acid binding)
2012-09-19 Added RELATION is a GO:0097159 (obsolete organic cyclic compound binding)
2012-09-19 Added RELATION is a GO:1901363 (heterocyclic compound binding)
2012-09-19 Added RELATION is a GO:0033218 (amide binding)
2009-07-03 Added RELATION is a GO:0031406 (carboxylic acid binding)
2008-04-01 Updated RELATION is a GO:0008144 (obsolete drug binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
2016-07-23 Added SUBSET goslim_metagenomics
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