This term is obsolete.
While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).

GO:0008922 JSON

long-chain fatty acid [acyl-carrier-protein] ligase activity

Molecular Function

Definition (GO:0008922 GONUTS page)

Catalysis of the reaction: a long-chain fatty acid + ATP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.

Comments

While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).

Secondary IDs

GO:0010300

3,517 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
acyl-acyl-carrier-protein synthetase activity related
long-chain-fatty-acid-[acyl-carrier protein] ligase activity exact
long-chain-fatty-acid-ACP ligase activity exact
stearoyl-ACP synthetase activity related
long-chain-fatty-acid-[acyl-carrier-protein] ligase activity exact
long-chain fatty acid-[acyl-carrier-protein] ligase activity exact
acyl-acyl carrier protein synthetase broad
acyl-ACP synthetase activity exact
acyl-acyl-carrier-proteinsynthetase activity related
long-chain-fatty-acid-acyl-carrier-protein ligase activity related

Ancestor Chart

Ancestor chart for GO:0008922
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5Y5Z6 10116 A0A8I5Y5Z6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A2T0 10116 A0A8I6A2T0_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6I4N6 10116 A6I4N6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F7EEB9 10116 F7EEB9_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q13426 9606 XRCC4_HUMAN GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 6.2.1.20
InterPro IPR023775 Bifunctional protein Aas
KEGG_REACTION R07325
MetaCyc ACYLACPSYNTH-RXN
RHEA 45588

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:30616 ATP(4-)
has_participant CHEBI CHEBI:64479 O-(pantetheine-4'-phosphoryl)serine(1-) residue
has_participant CHEBI CHEBI:456215 adenosine 5'-monophosphate(2-)
has_participant CHEBI CHEBI:33019 diphosphate(3-)
has_participant CHEBI CHEBI:57560 long-chain fatty acid anion
has_participant CHEBI CHEBI:133243 O-[S-(long-chain fatty acyl)pantetheine-4'-phosphoryl]serine(1-) residue

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0103062 obsolete cis-keto-C60-meroacyl-AMP ligase activity replaced_by GO:0008922

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008922 based on ALL annotations
The top 75 of 75 co-occurring terms
Co-occurring Term PR S% #Together #Compared
long-chain fatty acid [acyl-carrier-protein] ligase activity
55,474.90 100.00 3,514 3,514
acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity
49,418.83 39.97 1,477 1,658
fatty acid elongation
1,443.29 2.52 1,590 61,114
4-coumarate-CoA ligase activity
1,024.54 1.25 130 7,039
medium-chain fatty acid-CoA ligase activity
703.66 1.25 1,484 116,995
trans-cinnamate-CoA ligase activity
1,201.62 1.22 96 4,432
phenylpropanoid metabolic process
809.78 1.12 164 11,235
erythronolide synthase activity
2,129.10 0.82 36 938
ligase activity, forming carbon-sulfur bonds
405.32 0.72 995 136,184
lovastatin nonaketide synthase activity
19,097.91 0.59 21 61
Totals 22874 230815933
No co-occurrence statistics for GO:0008922 based on MANUAL annotations
The top 15 of 15 co-occurring terms
Co-occurring Term PR S% #Together #Compared
long-chain fatty acid [acyl-carrier-protein] ligase activity
430,599.70 100.00 3 3
acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity
430,599.66 33.33 1 1
adenylyltransferase activity
17,941.65 3.85 1 24
biological process involved in interaction with host
2,405.58 0.55 1 179
phospholipid biosynthetic process
1,537.86 0.35 1 280
fatty acid elongation
758.10 0.18 1 568
fatty acid biosynthetic process
490.99 0.11 2 1,754
long-chain fatty acid-CoA ligase activity
459.55 0.11 1 937
chloroplast envelope
428.03 0.10 1 1,006
plastid
267.12 0.06 1 1,612
Totals 18 216799

Change Log

Timestamp Action Category Detail
2023-12-15 Deleted DEFINITION Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons.
2023-12-15 Added DEFINITION Catalysis of the reaction: a long-chain fatty acid + ATP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
2023-01-18 Added DEFINITION Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons.
2023-01-18 Deleted DEFINITION Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is fatty acid with a chain length between C13 and C22.
2020-10-08 Deleted SYNONYM acyl-acyl-carrier-proteinsynthetase activity
2020-10-08 Deleted SYNONYM acyl-acyl-carrier-protein synthetase activity
2020-10-08 Added SYNONYM acyl-acyl-carrier-protein synthetase activity
2020-10-08 Added SYNONYM long-chain-fatty-acid-acyl-carrier-protein ligase activity
2020-10-08 Deleted SYNONYM long-chain-fatty-acid-acyl-carrier-protein ligase activity
2020-10-08 Deleted SYNONYM long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity
Timestamp Action Category Detail
2010-05-13 Updated TERM long-chain fatty acid [acyl-carrier-protein] ligase activity
2006-11-25 Updated TERM long-chain-fatty-acid-[acyl-carrier-protein] ligase activity
2003-09-06 Updated TERM long-chain-fatty-acid-[acyl-carrier protein] ligase activity
2003-03-19 Updated TERM long-chain-fatty-acid-acyl-carrier protein ligase activity
2002-02-06 Updated TERM long-chain-fatty-acid-acyl-carrier protein ligase
2001-11-07 Updated TERM long-chain-fatty-acid-acyl-carrier protein ligase
2001-04-03 Updated TERM long-chain-fatty-acid--acyl-carrier protein ligase
2001-03-30 Added TERM long-chain-fatty-acid--acyl-carrier protein ligase
Timestamp Action Category Detail
2023-12-15 Deleted DEFINITION Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons.
2023-12-15 Added DEFINITION Catalysis of the reaction: a long-chain fatty acid + ATP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
2023-01-18 Added DEFINITION Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons.
2023-01-18 Deleted DEFINITION Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is fatty acid with a chain length between C13 and C22.
2020-10-08 Deleted SYNONYM acyl-acyl-carrier-proteinsynthetase activity
2020-10-08 Deleted SYNONYM acyl-acyl-carrier-protein synthetase activity
2020-10-08 Added SYNONYM acyl-acyl-carrier-protein synthetase activity
2020-10-08 Added SYNONYM long-chain-fatty-acid-acyl-carrier-protein ligase activity
2020-10-08 Deleted SYNONYM long-chain-fatty-acid-acyl-carrier-protein ligase activity
2020-10-08 Deleted SYNONYM long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity
2020-10-08 Deleted SYNONYM stearoyl-ACP synthetase activity
2020-10-08 Deleted SYNONYM acyl-[acyl-carrier-protein] synthetase activity
2020-10-08 Added SYNONYM acyl-acyl-carrier-proteinsynthetase activity
2020-10-08 Added SYNONYM acyl-[acyl-carrier-protein] synthetase activity
2020-10-08 Added SYNONYM stearoyl-ACP synthetase activity
2020-10-08 Added SYNONYM long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity
2012-06-20 Deleted DEFINITION Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
2012-06-20 Added DEFINITION Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is fatty acid with a chain length between C13 and C22.
2012-02-04 Deleted DEFINITION Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein].
2012-02-04 Added DEFINITION Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
2010-05-13 Added SYNONYM long-chain-fatty-acid-[acyl-carrier-protein] ligase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein].
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein].
2008-01-07 Added SYNONYM long-chain fatty acid-[acyl-carrier-protein] ligase activity
2007-12-14 Added SYNONYM acyl-acyl-carrier-protein synthetase activity
2007-12-14 Added SYNONYM acyl-acyl carrier protein synthetase
2007-12-14 Added SYNONYM long-chain-fatty-acid-acyl-carrier-protein ligase activity
2007-12-14 Added SYNONYM acyl-ACP synthetase activity
2007-12-14 Added SYNONYM acyl-acyl-carrier-proteinsynthetase activity
2007-12-14 Added SYNONYM stearoyl-ACP synthetase activity
2007-12-14 Added SYNONYM long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity
2007-09-06 Added SYNONYM acyl-[acyl-carrier-protein] synthetase activity
2007-08-09 Added SYNONYM long-chain-fatty-acid-ACP ligase activity
2007-08-09 Added SYNONYM long-chain-fatty-acid-[acyl-carrier protein] ligase activity
2007-08-09 Deleted SYNONYM long-chain-fatty-acid-[acyl-carrier protein] ligase activity
2007-08-09 Deleted SYNONYM long-chain-fatty-acid-ACP ligase activity
2006-11-25 Added SYNONYM long-chain-fatty-acid-[acyl-carrier protein] ligase activity
2004-04-19 Added SYNONYM long-chain-fatty-acid-ACP ligase activity
2004-04-16 Deleted SYNONYM long-chain-fatty-acid-ACP ligase activity
2003-10-27 Added SYNONYM long-chain-fatty-acid-ACP ligase activity
2003-10-24 Updated DEFINITION Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein].
2003-04-24 Updated DEFINITION Catalysis of the reaction: ATP + an acid + (acyl-carrier protein) = AMP + diphosphate + acyl-(acyl-carrier protein).
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein].
Timestamp Action Category Detail
2018-03-05 Deleted RELATION is a GO:0016878 (acid-thiol ligase activity)
2008-04-01 Updated RELATION is a GO:0016878 (acid-thiol ligase activity)
2008-04-01 Updated RELATION is a GO:0015645 (fatty acid ligase activity)
Timestamp Action Category Detail
2020-06-22 Added XREF RHEA:45588
2019-06-20 Deleted XREF KEGG:R07325
2019-06-20 Added XREF KEGG_REACTION:R07325
2011-05-03 Added XREF KEGG:R07325
2003-10-27 Added XREF MetaCyc:ACYLACPSYNTH-RXN
2001-03-30 Added XREF EC:6.2.1.20
Timestamp Action Category Detail
2007-12-14 Added SECONDARY GO:0010300 (acyl-ACP synthetase activity)
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