While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
GO:0008922
JSON
long-chain fatty acid [acyl-carrier-protein] ligase activity
Molecular Function
Definition (GO:0008922 GONUTS page)
Catalysis of the reaction: a long-chain fatty acid + ATP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.
Comments
While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).
Secondary IDs
GO:0010300
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
acyl-acyl-carrier-protein synthetase activity | related |
long-chain-fatty-acid-[acyl-carrier protein] ligase activity | exact |
long-chain-fatty-acid-ACP ligase activity | exact |
stearoyl-ACP synthetase activity | related |
long-chain-fatty-acid-[acyl-carrier-protein] ligase activity | exact |
long-chain fatty acid-[acyl-carrier-protein] ligase activity | exact |
acyl-acyl carrier protein synthetase | broad |
acyl-ACP synthetase activity | exact |
acyl-acyl-carrier-proteinsynthetase activity | related |
long-chain-fatty-acid-acyl-carrier-protein ligase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5Y5Z6 | 10116 | A0A8I5Y5Z6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A2T0 | 10116 | A0A8I6A2T0_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6I4N6 | 10116 | A6I4N6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F7EEB9 | 10116 | F7EEB9_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q13426 | 9606 | XRCC4_HUMAN | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 6.2.1.20 | |
InterPro | IPR023775 | Bifunctional protein Aas |
KEGG_REACTION | R07325 | |
MetaCyc | ACYLACPSYNTH-RXN | |
RHEA | 45588 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:30616 | ATP(4-) |
has_participant | CHEBI | CHEBI:64479 | O-(pantetheine-4'-phosphoryl)serine(1-) residue |
has_participant | CHEBI | CHEBI:456215 | adenosine 5'-monophosphate(2-) |
has_participant | CHEBI | CHEBI:33019 | diphosphate(3-) |
has_participant | CHEBI | CHEBI:57560 | long-chain fatty acid anion |
has_participant | CHEBI | CHEBI:133243 | O-[S-(long-chain fatty acyl)pantetheine-4'-phosphoryl]serine(1-) residue |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0103062 | obsolete cis-keto-C60-meroacyl-AMP ligase activity | replaced_by GO:0008922 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0008922 based on ALL annotations
The top 75 of 75 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
long-chain fatty acid [acyl-carrier-protein] ligase activity
|
55,474.90 | 100.00 | 3,514 | 3,514 |
acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity
|
49,418.83 | 39.97 | 1,477 | 1,658 |
fatty acid elongation
|
1,443.29 | 2.52 | 1,590 | 61,114 |
4-coumarate-CoA ligase activity
|
1,024.54 | 1.25 | 130 | 7,039 |
medium-chain fatty acid-CoA ligase activity
|
703.66 | 1.25 | 1,484 | 116,995 |
trans-cinnamate-CoA ligase activity
|
1,201.62 | 1.22 | 96 | 4,432 |
phenylpropanoid metabolic process
|
809.78 | 1.12 | 164 | 11,235 |
erythronolide synthase activity
|
2,129.10 | 0.82 | 36 | 938 |
ligase activity, forming carbon-sulfur bonds
|
405.32 | 0.72 | 995 | 136,184 |
lovastatin nonaketide synthase activity
|
19,097.91 | 0.59 | 21 | 61 |
Totals | 22874 | 230815933 |
No co-occurrence statistics for GO:0008922 based on MANUAL annotations
The top 15 of 15 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
long-chain fatty acid [acyl-carrier-protein] ligase activity
|
430,599.70 | 100.00 | 3 | 3 |
acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity
|
430,599.66 | 33.33 | 1 | 1 |
adenylyltransferase activity
|
17,941.65 | 3.85 | 1 | 24 |
biological process involved in interaction with host
|
2,405.58 | 0.55 | 1 | 179 |
phospholipid biosynthetic process
|
1,537.86 | 0.35 | 1 | 280 |
fatty acid elongation
|
758.10 | 0.18 | 1 | 568 |
fatty acid biosynthetic process
|
490.99 | 0.11 | 2 | 1,754 |
long-chain fatty acid-CoA ligase activity
|
459.55 | 0.11 | 1 | 937 |
chloroplast envelope
|
428.03 | 0.10 | 1 | 1,006 |
plastid
|
267.12 | 0.06 | 1 | 1,612 |
Totals | 18 | 216799 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-15 | Deleted | DEFINITION | Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons. |
2023-12-15 | Added | DEFINITION | Catalysis of the reaction: a long-chain fatty acid + ATP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. |
2023-01-18 | Added | DEFINITION | Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons. |
2023-01-18 | Deleted | DEFINITION | Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is fatty acid with a chain length between C13 and C22. |
2020-10-08 | Deleted | SYNONYM | acyl-acyl-carrier-proteinsynthetase activity |
2020-10-08 | Deleted | SYNONYM | acyl-acyl-carrier-protein synthetase activity |
2020-10-08 | Added | SYNONYM | acyl-acyl-carrier-protein synthetase activity |
2020-10-08 | Added | SYNONYM | long-chain-fatty-acid-acyl-carrier-protein ligase activity |
2020-10-08 | Deleted | SYNONYM | long-chain-fatty-acid-acyl-carrier-protein ligase activity |
2020-10-08 | Deleted | SYNONYM | long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-05-13 | Updated | TERM | long-chain fatty acid [acyl-carrier-protein] ligase activity |
2006-11-25 | Updated | TERM | long-chain-fatty-acid-[acyl-carrier-protein] ligase activity |
2003-09-06 | Updated | TERM | long-chain-fatty-acid-[acyl-carrier protein] ligase activity |
2003-03-19 | Updated | TERM | long-chain-fatty-acid-acyl-carrier protein ligase activity |
2002-02-06 | Updated | TERM | long-chain-fatty-acid-acyl-carrier protein ligase |
2001-11-07 | Updated | TERM | long-chain-fatty-acid-acyl-carrier protein ligase |
2001-04-03 | Updated | TERM | long-chain-fatty-acid--acyl-carrier protein ligase |
2001-03-30 | Added | TERM | long-chain-fatty-acid--acyl-carrier protein ligase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-15 | Deleted | DEFINITION | Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons. |
2023-12-15 | Added | DEFINITION | Catalysis of the reaction: a long-chain fatty acid + ATP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. |
2023-01-18 | Added | DEFINITION | Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons. |
2023-01-18 | Deleted | DEFINITION | Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is fatty acid with a chain length between C13 and C22. |
2020-10-08 | Deleted | SYNONYM | acyl-acyl-carrier-proteinsynthetase activity |
2020-10-08 | Deleted | SYNONYM | acyl-acyl-carrier-protein synthetase activity |
2020-10-08 | Added | SYNONYM | acyl-acyl-carrier-protein synthetase activity |
2020-10-08 | Added | SYNONYM | long-chain-fatty-acid-acyl-carrier-protein ligase activity |
2020-10-08 | Deleted | SYNONYM | long-chain-fatty-acid-acyl-carrier-protein ligase activity |
2020-10-08 | Deleted | SYNONYM | long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity |
2020-10-08 | Deleted | SYNONYM | stearoyl-ACP synthetase activity |
2020-10-08 | Deleted | SYNONYM | acyl-[acyl-carrier-protein] synthetase activity |
2020-10-08 | Added | SYNONYM | acyl-acyl-carrier-proteinsynthetase activity |
2020-10-08 | Added | SYNONYM | acyl-[acyl-carrier-protein] synthetase activity |
2020-10-08 | Added | SYNONYM | stearoyl-ACP synthetase activity |
2020-10-08 | Added | SYNONYM | long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity |
2012-06-20 | Deleted | DEFINITION | Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18. |
2012-06-20 | Added | DEFINITION | Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is fatty acid with a chain length between C13 and C22. |
2012-02-04 | Deleted | DEFINITION | Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. |
2012-02-04 | Added | DEFINITION | Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18. |
2010-05-13 | Added | SYNONYM | long-chain-fatty-acid-[acyl-carrier-protein] ligase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. |
2008-01-07 | Added | SYNONYM | long-chain fatty acid-[acyl-carrier-protein] ligase activity |
2007-12-14 | Added | SYNONYM | acyl-acyl-carrier-protein synthetase activity |
2007-12-14 | Added | SYNONYM | acyl-acyl carrier protein synthetase |
2007-12-14 | Added | SYNONYM | long-chain-fatty-acid-acyl-carrier-protein ligase activity |
2007-12-14 | Added | SYNONYM | acyl-ACP synthetase activity |
2007-12-14 | Added | SYNONYM | acyl-acyl-carrier-proteinsynthetase activity |
2007-12-14 | Added | SYNONYM | stearoyl-ACP synthetase activity |
2007-12-14 | Added | SYNONYM | long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity |
2007-09-06 | Added | SYNONYM | acyl-[acyl-carrier-protein] synthetase activity |
2007-08-09 | Added | SYNONYM | long-chain-fatty-acid-ACP ligase activity |
2007-08-09 | Added | SYNONYM | long-chain-fatty-acid-[acyl-carrier protein] ligase activity |
2007-08-09 | Deleted | SYNONYM | long-chain-fatty-acid-[acyl-carrier protein] ligase activity |
2007-08-09 | Deleted | SYNONYM | long-chain-fatty-acid-ACP ligase activity |
2006-11-25 | Added | SYNONYM | long-chain-fatty-acid-[acyl-carrier protein] ligase activity |
2004-04-19 | Added | SYNONYM | long-chain-fatty-acid-ACP ligase activity |
2004-04-16 | Deleted | SYNONYM | long-chain-fatty-acid-ACP ligase activity |
2003-10-27 | Added | SYNONYM | long-chain-fatty-acid-ACP ligase activity |
2003-10-24 | Updated | DEFINITION | Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. |
2003-04-24 | Updated | DEFINITION | Catalysis of the reaction: ATP + an acid + (acyl-carrier protein) = AMP + diphosphate + acyl-(acyl-carrier protein). |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-03-05 | Deleted | RELATION | is a GO:0016878 (acid-thiol ligase activity) |
2008-04-01 | Updated | RELATION | is a GO:0016878 (acid-thiol ligase activity) |
2008-04-01 | Updated | RELATION | is a GO:0015645 (fatty acid ligase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-06-22 | Added | XREF | RHEA:45588 |
2019-06-20 | Deleted | XREF | KEGG:R07325 |
2019-06-20 | Added | XREF | KEGG_REACTION:R07325 |
2011-05-03 | Added | XREF | KEGG:R07325 |
2003-10-27 | Added | XREF | MetaCyc:ACYLACPSYNTH-RXN |
2001-03-30 | Added | XREF | EC:6.2.1.20 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2007-12-14 | Added | SECONDARY | GO:0010300 (acyl-ACP synthetase activity) |
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link