This term is obsolete.

GO:0008982 JSON

protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

Molecular Function

Definition (GO:0008982 GONUTS page)

Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.

Secondary IDs

GO:0015455, GO:0015456

172,847 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
phosphohistidinoprotein-hexose phosphotransferase activity related
phosphoprotein factor-hexose phosophotransferase activity related
protein-Np-phosphohistidine-sugar phosphotransferase activity exact
PTS permease activity related
enzyme II of the phosphotransferase system related
PEP--sugar phosphotransferase enzyme II activity exact
phosphoenolpyruvate-sugar phosphotransferase enzyme II related
PEP-dependent phosphotransferase enzyme II related
phosphotransfer-driven group translocator broad
PTS transporter related

Ancestor Chart

Ancestor chart for GO:0008982
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008982

Child Term Relationship to
GO:0008982
protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity
is_a
protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity
is_a
protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity
is_a
protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity
is_a
protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity
is_a
protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity
is_a
protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity
is_a
protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity
is_a
protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity
is_a
protein-N(PI)-phosphohistidine-N-acetyl-mannosamine phosphotransferase system transporter activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A1L8END5 8355 A0A1L8END5_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8EV37 8355 A0A1L8EV37_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I3Q0M1 9615 A0A8I3Q0M1_CANLF GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8J0TR01 8355 A0A8J0TR01_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8J0TZJ2 8355 A0A8J0TZJ2_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8M2B232 7955 A0A8M2B232_DANRE GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8V1ACT6 9031 A0A8V1ACT6_CHICK GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B3DI75 7955 B3DI75_DANRE GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein F1MJW4 9913 F1MJW4_BOVIN GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
InterPro IPR001996 Phosphotransferase system, IIB component, type 1
InterPro IPR003352 Phosphotransferase system, EIIC
InterPro IPR003501 Phosphotransferase system, EIIB component, type 2/3
InterPro IPR004501 Phosphotransferase system, EIIC component, type 3
InterPro IPR004702 Phosphotransferease, sorbitol phosphotransferase enzyme II
InterPro IPR004715 Phosphotransferase system, IIA component fructose subfamily
InterPro IPR004716 Phosphotransferase system, glucitol/sorbitol-specific IIA component
InterPro IPR004718 Phosphotransferase system, mannitol-specific enzyme IIC
InterPro IPR004719 Phosphotransferase system, maltose/glucose-specific subfamily IIC component
InterPro IPR004720 Phosphotransferase system, sorbose subfamily IIB component

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008982 based on ALL annotations
The top 100 of 261 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
1,348.22 100.00 146,975 146,975
phosphoenolpyruvate-dependent sugar phosphotransferase system
547.02 40.57 146,963 362,212
protein-phosphocysteine-sugar phosphotransferase activity
638.72 15.62 27,769 58,615
protein-phosphocysteine-trehalose phosphotransferase system transporter activity
1,329.48 13.25 19,510 19,785
trehalose transport
1,323.73 13.25 19,515 19,876
N-acetylglucosamine transport
1,339.05 7.94 11,678 11,758
carbohydrate derivative transport
727.86 5.63 8,694 16,104
N-acetylglucosamine transmembrane transporter activity
1,347.99 3.88 5,708 5,709
organelle inner membrane
1,109.36 3.85 5,708 6,937
D-glucose transmembrane transport
315.59 3.23 5,308 22,676
Totals 742458 225411945
No co-occurrence statistics for GO:0008982 based on MANUAL annotations
The top 17 of 17 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
56,461.32 100.00 25 25
phosphoenolpyruvate-dependent sugar phosphotransferase system
3,754.08 6.65 25 376
transmembrane transporter complex
2,566.42 4.54 24 528
protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity
14,115.33 3.57 1 4
protein-phosphocysteine-N,N'-diacetylchitobiose phosphotransferase system transporter activity
9,410.22 3.33 1 6
mannose transmembrane transport
9,410.22 3.33 1 6
N,N'-diacetylchitobiose import
4,705.11 2.78 1 12
D-glucose import across plasma membrane
2,823.07 2.27 1 20
fructose import across plasma membrane
2,566.42 2.17 1 22
N-acetylglucosamine transport
925.60 1.18 1 61
Totals 88 547157

Change Log

Timestamp Action Category Detail
2022-08-26 Added SYNONYM PEP--sugar phosphotransferase enzyme II activity
2022-08-26 Added XREF TC:4.A
2022-08-26 Deleted SYNONYM protein-Npi-phosphohistidine-sugar phosphotransferase activity
2022-08-26 Deleted SYNONYM phosphohistidinoprotein-hexose phosphoribosyltransferase activity
2022-08-26 Deleted SYNONYM protein-Npi-phosphohistidine:sugar N-pros-phosphotransferase activity
2022-08-26 Added SYNONYM phosphotransfer-driven group translocator
2022-08-26 Deleted SYNONYM protein-Npi-phospho-L-histidine:sugar N-pros-phosphotransferase activity
2022-08-26 Deleted SYNONYM enzyme IIl4ac
2022-08-26 Deleted SYNONYM gene bglC RNA formation factors
2022-08-26 Deleted SYNONYM gene glC proteins
Timestamp Action Category Detail
2003-03-19 Updated TERM protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
2002-02-06 Updated TERM protein-N(PI)-phosphohistidine-sugar phosphotransferase
2001-04-03 Updated TERM protein-N(PI)-phosphohistidine-sugar phosphotransferase
2001-03-30 Added TERM protein-N(PI)-phosphohistidine-sugar phosphotransferase
Timestamp Action Category Detail
2022-08-26 Added SYNONYM PEP--sugar phosphotransferase enzyme II activity
2022-08-26 Deleted SYNONYM protein-Npi-phosphohistidine-sugar phosphotransferase activity
2022-08-26 Deleted SYNONYM phosphohistidinoprotein-hexose phosphoribosyltransferase activity
2022-08-26 Deleted SYNONYM protein-Npi-phosphohistidine:sugar N-pros-phosphotransferase activity
2022-08-26 Added SYNONYM phosphotransfer-driven group translocator
2022-08-26 Deleted SYNONYM protein-Npi-phospho-L-histidine:sugar N-pros-phosphotransferase activity
2022-08-26 Deleted SYNONYM enzyme IIl4ac
2022-08-26 Deleted SYNONYM gene bglC RNA formation factors
2022-08-26 Deleted SYNONYM gene glC proteins
2022-08-26 Deleted SYNONYM protein, specific or class, gene bglC
2022-08-26 Deleted SYNONYM ribonucleic acid formation factor, gene glC
2022-08-26 Deleted SYNONYM sucrose phosphotransferase system II
2022-08-26 Deleted SYNONYM PEP--sugar phosphotransferase enzyme II activity
2022-08-26 Deleted SYNONYM enzyme II of the phosphotransferase system
2022-08-26 Deleted SYNONYM group translocator activity
2022-08-26 Deleted SYNONYM phosphotransfer-driven group translocator
2022-08-26 Deleted SYNONYM protein-Npi-phospho-L-histidine:sugar Npi-phosphotransferase activity
2022-08-26 Deleted SYNONYM phosphotransferase, phosphohistidinoprotein-hexose activity
2022-08-26 Added SYNONYM enzyme II of the phosphotransferase system
2020-10-08 Added SYNONYM protein-Npi-phosphohistidine:sugar N-pros-phosphotransferase activity
2020-10-08 Added SYNONYM phosphohistidinoprotein-hexose phosphoribosyltransferase activity
2020-10-08 Added SYNONYM phosphoprotein factor-hexose phosophotransferase activity
2020-10-08 Added SYNONYM phosphohistidinoprotein-hexose phosphotransferase activity
2020-10-08 Added SYNONYM protein-Npi-phospho-L-histidine:sugar N-pros-phosphotransferase activity
2020-10-08 Added SYNONYM PTS permease activity
2020-10-08 Added SYNONYM protein-Npi-phospho-L-histidine:sugar Npi-phosphotransferase activity
2020-10-08 Deleted SYNONYM PTS permease activity
2020-10-08 Deleted SYNONYM phosphohistidinoprotein-hexose phosphoribosyltransferase activity
2020-10-08 Deleted SYNONYM phosphohistidinoprotein-hexose phosphotransferase activity
2020-10-08 Deleted SYNONYM phosphoprotein factor-hexose phosophotransferase activity
2020-10-08 Deleted SYNONYM phosphotransferase, phosphohistidinoprotein-hexose activity
2020-10-08 Deleted SYNONYM protein-Npi-phospho-L-histidine:sugar N-pros-phosphotransferase activity
2020-10-08 Deleted SYNONYM protein-Npi-phospho-L-histidine:sugar Npi-phosphotransferase activity
2020-10-08 Deleted SYNONYM protein-Npi-phosphohistidine-sugar phosphotransferase activity
2020-10-08 Deleted SYNONYM protein-Npi-phosphohistidine:sugar N-pros-phosphotransferase activity
2020-10-08 Added SYNONYM phosphotransferase, phosphohistidinoprotein-hexose activity
2020-10-08 Added SYNONYM protein-Npi-phosphohistidine-sugar phosphotransferase activity
2008-05-13 Added DEFINITION Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
2008-05-12 Deleted DEFINITION Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
2007-12-14 Added SYNONYM phosphoprotein factor-hexose phosophotransferase activity
2007-12-14 Added SYNONYM ribonucleic acid formation factor, gene glC
2007-12-14 Added SYNONYM sucrose phosphotransferase system II
2007-12-14 Added SYNONYM PEP-dependent phosphotransferase enzyme II
2007-12-14 Added SYNONYM enzyme IIl4ac
2007-12-14 Added SYNONYM gene bglC RNA formation factors
2007-12-14 Added SYNONYM gene glC proteins
2007-12-14 Added SYNONYM phosphoenolpyruvate-sugar phosphotransferase enzyme II
2007-12-14 Added SYNONYM phosphohistidinoprotein-hexose phosphoribosyltransferase activity
2007-12-14 Added SYNONYM phosphohistidinoprotein-hexose phosphotransferase activity
2007-12-14 Added SYNONYM protein-Npi-phosphohistidine-sugar phosphotransferase activity
2007-12-14 Added SYNONYM protein-Npi-phospho-L-histidine:sugar Npi-phosphotransferase activity
2007-12-14 Added SYNONYM protein-Npi-phospho-L-histidine:sugar N-pros-phosphotransferase activity
2007-12-14 Added SYNONYM protein, specific or class, gene bglC
2007-12-14 Added SYNONYM phosphotransferase, phosphohistidinoprotein-hexose activity
2007-12-14 Added SYNONYM protein-Npi-phosphohistidine:sugar N-pros-phosphotransferase activity
2007-09-06 Added SYNONYM group translocator activity
2007-09-06 Deleted SYNONYM PTS transporter
2007-09-06 Deleted SYNONYM group translocator activity
2007-09-06 Added SYNONYM PEP--sugar phosphotransferase enzyme II activity
2007-09-06 Added SYNONYM PTS permease activity
2007-09-06 Added SYNONYM PTS transporter
2007-09-06 Added SYNONYM enzyme II of the phosphotransferase system
2007-08-09 Deleted SYNONYM phosphotransfer-driven group translocator
2007-08-09 Deleted SYNONYM group translocator activity
2007-08-09 Deleted SYNONYM PTS transporter
2007-08-09 Deleted SYNONYM protein-Np-phosphohistidine-sugar phosphotransferase activity
2007-08-09 Added SYNONYM PTS transporter
2007-08-09 Added SYNONYM group translocator activity
2007-08-09 Added SYNONYM phosphotransfer-driven group translocator
2007-08-09 Added SYNONYM protein-Np-phosphohistidine-sugar phosphotransferase activity
2007-07-27 Updated DEFINITION Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
2007-07-11 Added SYNONYM group translocator activity
2004-04-19 Added SYNONYM protein-Np-phosphohistidine-sugar phosphotransferase activity
2004-04-19 Added SYNONYM PTS transporter
2004-04-19 Added SYNONYM phosphotransfer-driven group translocator
2004-04-16 Deleted SYNONYM phosphotransfer-driven group translocator
2004-04-16 Deleted SYNONYM PTS transporter
2004-04-16 Deleted SYNONYM protein-Np-phosphohistidine-sugar phosphotransferase activity
2003-10-27 Added SYNONYM phosphotransfer-driven group translocator
2003-10-27 Added SYNONYM protein-Np-phosphohistidine-sugar phosphotransferase activity
2003-10-27 Added SYNONYM PTS transporter
2003-08-22 Deleted SYNONYM phosphotransfer-driven group translocator
2003-08-22 Deleted SYNONYM PTS transporter
2003-03-26 Updated DEFINITION Catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in).
2002-11-27 Added DEFINITION Catalysis of the reaction: protein N-phosphohistidine + sugar (outside cell) = protein histidine + sugar phosphate (inside cell).
2002-10-24 Added SYNONYM phosphotransfer-driven group translocator
2002-10-24 Added SYNONYM PTS transporter
Timestamp Action Category Detail
2021-03-12 Deleted RELATION is a GO:0022853 (active monoatomic ion transmembrane transporter activity)
2021-03-12 Added RELATION is a GO:0022804 (active transmembrane transporter activity)
2020-11-03 Added RELATION is a GO:0022853 (active monoatomic ion transmembrane transporter activity)
2020-11-03 Deleted RELATION is a GO:0022804 (active transmembrane transporter activity)
2008-04-01 Updated RELATION is a GO:0016773 (phosphotransferase activity, alcohol group as acceptor)
2008-04-01 Updated RELATION is a GO:0015144 (carbohydrate transmembrane transporter activity)
2008-04-01 Updated RELATION is a GO:0022804 (active transmembrane transporter activity)
Timestamp Action Category Detail
2022-08-26 Added XREF TC:4.A
2022-08-26 Deleted XREF MetaCyc:2.7.1.69-RXN
2022-08-26 Deleted XREF EC:2.7.1.69
2007-07-11 Deleted XREF TC:4.A.-.-.-
2003-10-27 Added XREF TC:4.A.-.-.-
2003-10-27 Added XREF MetaCyc:2.7.1.69-RXN
2003-08-22 Deleted XREF TC:4.A.-.-.-
2002-10-24 Added XREF TC:4.A.-.-.-
2001-03-30 Added XREF EC:2.7.1.69
Timestamp Action Category Detail
2007-07-11 Added SECONDARY GO:0015455 (group translocator activity)
2002-10-24 Added SECONDARY GO:0015456 (phosphotransfer-driven group translocator)
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