This term is obsolete.

GO:0009002 JSON

serine-type D-Ala-D-Ala carboxypeptidase activity

Molecular Function

Definition (GO:0009002 GONUTS page)

Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine.

147,124 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
D-alanyl-D-alanine carboxypeptidase activity related
DD-transpeptidase activity related
DD-carboxypeptidase broad
DD-peptidase activity related
D-alanyl-D-alanine-cleaving-peptidase activity related
D-alanyl-D-alanine-carboxypeptidase activity related
D-alanyl-D-alanine-cleaving peptidase activity related
D-alanyl carboxypeptidase activity related
D-alanine carboxypeptidase broad

Ancestor Chart

Ancestor chart for GO:0009002
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein P52708 4558 HNLS_SORBI GO:0004185 To remove over-annotation from InterPro entries. Swiss-Prot entry has been shown not to have carboxypeptidase activity (PMID: 12356304). Reported by InterPro on 15th January 2016. IPR001563|IPR018202
NOT-qualified manual protein A0A0B4JCV5 7227 A0A0B4JCV5_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4JD89 7227 A0A0B4JD89_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4K6V8 7227 A0A0B4K6V8_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4K7A7 7227 A0A0B4K7A7_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4K7P3 7227 A0A0B4K7P3_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4KFB1 7227 A0A0B4KFB1_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4KFH4 7227 A0A0B4KFH4_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4KGE6 7227 A0A0B4KGE6_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4LEH6 7227 A0A0B4LEH6_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10913309

Cross-references

Database ID Description
EC 3.4.16.4
InterPro IPR001967 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, N-terminal
InterPro IPR012907 Peptidase S11, D-Ala-D-Ala carboxypeptidase A, C-terminal
InterPro IPR017790 Penicillin-binding protein 2
InterPro IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A
InterPro IPR037167 D-Ala-D-Ala carboxypeptidase, C-terminal domain superfamily
MetaCyc 3.4.16.4-RXN

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0009002 based on ALL annotations
The top 100 of 317 co-occurring terms
Co-occurring Term PR S% #Together #Compared
serine-type D-Ala-D-Ala carboxypeptidase activity
1,347.08 100.00 147,100 147,100
penicillin binding
393.56 21.62 66,808 228,670
carboxypeptidase activity
297.02 21.00 120,024 544,350
peptidoglycan glycosyltransferase activity
305.07 13.24 35,578 157,097
peptidoglycan L,D-transpeptidase activity
274.50 11.27 29,638 145,447
peptidoglycan biosynthetic process
152.55 11.16 130,542 1,152,754
regulation of cell shape
136.82 9.97 123,909 1,219,943
cell wall organization
116.70 8.55 126,891 1,464,669
peptidase activity
65.91 4.64 69,122 1,412,747
response to antibiotic
68.83 3.89 20,573 402,608
Totals 1246591 170365495
No co-occurrence statistics for GO:0009002 based on MANUAL annotations
The top 27 of 27 co-occurring terms
Co-occurring Term PR S% #Together #Compared
serine-type D-Ala-D-Ala carboxypeptidase activity
117,627.75 100.00 12 12
positive regulation of bipolar cell growth
117,627.76 8.33 1 1
cell wall repair
58,813.88 7.69 1 2
penicillin binding
8,633.23 7.08 8 109
peptidoglycan glycosyltransferase activity
3,426.05 2.68 3 103
beta-lactamase activity
2,767.71 2.11 2 85
peptidoglycan metabolic process
2,633.46 2.10 3 134
peptidoglycan biosynthetic process
2,162.27 1.79 5 272
FtsZ-dependent cytokinesis
1,729.82 1.37 2 136
division septum assembly
1,434.48 1.08 1 82
Totals 83 277390

Change Log

Timestamp Action Category Detail
2020-10-08 Added SYNONYM D-alanyl-D-alanine-cleaving-peptidase activity
2020-10-08 Deleted SYNONYM DD-transpeptidase activity
2020-10-08 Deleted SYNONYM DD-peptidase activity
2020-10-08 Deleted SYNONYM D-alanyl-D-alanine carboxypeptidase activity
2020-10-08 Deleted SYNONYM D-alanyl-D-alanine-cleaving-peptidase activity
2020-10-08 Deleted SYNONYM D-alanyl-D-alanine-cleaving peptidase activity
2020-10-08 Deleted SYNONYM D-alanyl-D-alanine-carboxypeptidase activity
2020-10-08 Deleted SYNONYM D-alanyl carboxypeptidase activity
2020-10-08 Added SYNONYM D-alanyl-D-alanine-cleaving peptidase activity
2020-10-08 Added SYNONYM D-alanyl-D-alanine-carboxypeptidase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM serine-type D-Ala-D-Ala carboxypeptidase activity
2002-02-06 Updated TERM serine-type D-Ala-D-Ala carboxypeptidase
2001-04-03 Updated TERM serine-type D-Ala-D-Ala carboxypeptidase
2001-03-30 Added TERM serine-type D-Ala-D-Ala carboxypeptidase
Timestamp Action Category Detail
2020-10-08 Added SYNONYM D-alanyl-D-alanine-cleaving-peptidase activity
2020-10-08 Deleted SYNONYM DD-transpeptidase activity
2020-10-08 Deleted SYNONYM DD-peptidase activity
2020-10-08 Deleted SYNONYM D-alanyl-D-alanine carboxypeptidase activity
2020-10-08 Deleted SYNONYM D-alanyl-D-alanine-cleaving-peptidase activity
2020-10-08 Deleted SYNONYM D-alanyl-D-alanine-cleaving peptidase activity
2020-10-08 Deleted SYNONYM D-alanyl-D-alanine-carboxypeptidase activity
2020-10-08 Deleted SYNONYM D-alanyl carboxypeptidase activity
2020-10-08 Added SYNONYM D-alanyl-D-alanine-cleaving peptidase activity
2020-10-08 Added SYNONYM D-alanyl-D-alanine-carboxypeptidase activity
2020-10-08 Added SYNONYM D-alanyl carboxypeptidase activity
2020-10-08 Added SYNONYM DD-transpeptidase activity
2020-10-08 Added SYNONYM D-alanyl-D-alanine carboxypeptidase activity
2020-10-08 Added SYNONYM DD-peptidase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine.
2007-11-08 Added SYNONYM D-alanyl carboxypeptidase activity
2007-11-08 Added SYNONYM D-alanine carboxypeptidase
2007-11-08 Added SYNONYM DD-carboxypeptidase
2007-11-08 Added SYNONYM D-alanyl-D-alanine-cleaving-peptidase activity
2007-11-08 Added SYNONYM D-alanyl-D-alanine-carboxypeptidase activity
2007-11-08 Added SYNONYM D-alanyl-D-alanine-cleaving peptidase activity
2007-09-06 Added SYNONYM DD-peptidase activity
2007-09-06 Added SYNONYM DD-transpeptidase activity
2007-09-06 Added SYNONYM D-alanyl-D-alanine carboxypeptidase activity
2003-07-31 Updated DEFINITION Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine.
2002-11-27 Added DEFINITION Catalysis of the reaction: D-alanyl-D-alanine + H2O = 2 D-alanine.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0004185 (serine-type carboxypeptidase activity)
Timestamp Action Category Detail
2003-10-27 Added XREF MetaCyc:3.4.16.4-RXN
2001-03-30 Added XREF EC:3.4.16.4
Timestamp Action Category Detail
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