GO:0009002
JSON
serine-type D-Ala-D-Ala carboxypeptidase activity
Molecular Function
Definition (GO:0009002 GONUTS page)
Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
D-alanyl carboxypeptidase activity | related |
D-alanine carboxypeptidase | broad |
DD-peptidase activity | related |
D-alanyl-D-alanine carboxypeptidase activity | related |
D-alanyl-D-alanine-cleaving-peptidase activity | related |
D-alanyl-D-alanine-carboxypeptidase activity | related |
D-alanyl-D-alanine-cleaving peptidase activity | related |
DD-transpeptidase activity | related |
DD-carboxypeptidase | broad |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | P52708 | 4558 | HNLS_SORBI | GO:0004185 | To remove over-annotation from InterPro entries. Swiss-Prot entry has been shown not to have carboxypeptidase activity (PMID: 12356304). Reported by InterPro on 15th January 2016. | IPR001563|IPR018202 |
NOT-qualified manual | protein | A0A0B4JCV5 | 7227 | A0A0B4JCV5_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4JD89 | 7227 | A0A0B4JD89_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4K6V8 | 7227 | A0A0B4K6V8_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4K7A7 | 7227 | A0A0B4K7A7_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4K7P3 | 7227 | A0A0B4K7P3_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4KFB1 | 7227 | A0A0B4KFB1_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4KFH4 | 7227 | A0A0B4KFH4_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4KGE6 | 7227 | A0A0B4KGE6_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4LEH6 | 7227 | A0A0B4LEH6_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10913309 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.4.16.4 | |
InterPro | IPR001967 | Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, N-terminal |
InterPro | IPR012907 | Peptidase S11, D-Ala-D-Ala carboxypeptidase A, C-terminal |
InterPro | IPR017790 | Penicillin-binding protein 2 |
InterPro | IPR018044 | Peptidase S11, D-alanyl-D-alanine carboxypeptidase A |
InterPro | IPR037167 | D-Ala-D-Ala carboxypeptidase, C-terminal domain superfamily |
MetaCyc | 3.4.16.4-RXN |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0009002 based on ALL annotations
The top 100 of 322 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
serine-type D-Ala-D-Ala carboxypeptidase activity
|
1,338.45 | 100.00 | 145,645 | 145,645 |
penicillin binding
|
397.20 | 21.96 | 66,693 | 224,735 |
carboxypeptidase activity
|
294.18 | 20.94 | 118,917 | 541,050 |
peptidoglycan glycosyltransferase activity
|
309.74 | 13.53 | 35,779 | 154,609 |
peptidoglycan L,D-transpeptidase activity
|
276.76 | 11.36 | 29,313 | 141,760 |
peptidoglycan biosynthetic process
|
151.96 | 11.19 | 129,332 | 1,139,148 |
regulation of cell shape
|
133.02 | 9.72 | 118,822 | 1,195,633 |
cell wall organization
|
114.83 | 8.44 | 121,529 | 1,416,592 |
peptidase activity
|
67.27 | 4.75 | 68,038 | 1,353,802 |
response to antibiotic
|
70.25 | 3.99 | 20,703 | 394,460 |
Totals | 1225179 | 143230301 |
No co-occurrence statistics for GO:0009002 based on MANUAL annotations
The top 27 of 27 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
serine-type D-Ala-D-Ala carboxypeptidase activity
|
107,649.92 | 100.00 | 12 | 12 |
positive regulation of bipolar cell growth
|
107,649.91 | 8.33 | 1 | 1 |
cell wall repair
|
53,824.96 | 7.69 | 1 | 2 |
penicillin binding
|
7,974.07 | 7.14 | 8 | 108 |
peptidoglycan metabolic process
|
4,820.15 | 3.95 | 3 | 67 |
beta-lactamase activity
|
3,987.03 | 3.13 | 2 | 54 |
peptidoglycan glycosyltransferase activity
|
3,588.33 | 3.03 | 3 | 90 |
peptidoglycan biosynthetic process
|
2,078.18 | 1.88 | 5 | 259 |
FtsZ-dependent cytokinesis
|
1,722.40 | 1.48 | 2 | 125 |
division septum assembly
|
1,516.20 | 1.22 | 1 | 71 |
Totals | 83 | 257890 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | D-alanyl-D-alanine-cleaving-peptidase activity |
2020-10-08 | Deleted | SYNONYM | D-alanyl-D-alanine-carboxypeptidase activity |
2020-10-08 | Deleted | SYNONYM | D-alanyl carboxypeptidase activity |
2020-10-08 | Added | SYNONYM | DD-peptidase activity |
2020-10-08 | Deleted | SYNONYM | DD-transpeptidase activity |
2020-10-08 | Deleted | SYNONYM | DD-peptidase activity |
2020-10-08 | Deleted | SYNONYM | D-alanyl-D-alanine carboxypeptidase activity |
2020-10-08 | Deleted | SYNONYM | D-alanyl-D-alanine-cleaving-peptidase activity |
2020-10-08 | Deleted | SYNONYM | D-alanyl-D-alanine-cleaving peptidase activity |
2020-10-08 | Added | SYNONYM | D-alanyl-D-alanine-cleaving peptidase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | serine-type D-Ala-D-Ala carboxypeptidase activity |
2002-02-06 | Updated | TERM | serine-type D-Ala-D-Ala carboxypeptidase |
2001-04-03 | Updated | TERM | serine-type D-Ala-D-Ala carboxypeptidase |
2001-03-30 | Added | TERM | serine-type D-Ala-D-Ala carboxypeptidase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | D-alanyl-D-alanine-cleaving-peptidase activity |
2020-10-08 | Deleted | SYNONYM | D-alanyl-D-alanine-carboxypeptidase activity |
2020-10-08 | Deleted | SYNONYM | D-alanyl carboxypeptidase activity |
2020-10-08 | Added | SYNONYM | DD-peptidase activity |
2020-10-08 | Deleted | SYNONYM | DD-transpeptidase activity |
2020-10-08 | Deleted | SYNONYM | DD-peptidase activity |
2020-10-08 | Deleted | SYNONYM | D-alanyl-D-alanine carboxypeptidase activity |
2020-10-08 | Deleted | SYNONYM | D-alanyl-D-alanine-cleaving-peptidase activity |
2020-10-08 | Deleted | SYNONYM | D-alanyl-D-alanine-cleaving peptidase activity |
2020-10-08 | Added | SYNONYM | D-alanyl-D-alanine-cleaving peptidase activity |
2020-10-08 | Added | SYNONYM | D-alanyl-D-alanine-carboxypeptidase activity |
2020-10-08 | Added | SYNONYM | D-alanyl carboxypeptidase activity |
2020-10-08 | Added | SYNONYM | DD-transpeptidase activity |
2020-10-08 | Added | SYNONYM | D-alanyl-D-alanine carboxypeptidase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine. |
2007-11-08 | Added | SYNONYM | D-alanyl carboxypeptidase activity |
2007-11-08 | Added | SYNONYM | D-alanine carboxypeptidase |
2007-11-08 | Added | SYNONYM | D-alanyl-D-alanine-carboxypeptidase activity |
2007-11-08 | Added | SYNONYM | D-alanyl-D-alanine-cleaving peptidase activity |
2007-11-08 | Added | SYNONYM | D-alanyl-D-alanine-cleaving-peptidase activity |
2007-11-08 | Added | SYNONYM | DD-carboxypeptidase |
2007-09-06 | Added | SYNONYM | D-alanyl-D-alanine carboxypeptidase activity |
2007-09-06 | Added | SYNONYM | DD-transpeptidase activity |
2007-09-06 | Added | SYNONYM | DD-peptidase activity |
2003-07-31 | Updated | DEFINITION | Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine. |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: D-alanyl-D-alanine + H2O = 2 D-alanine. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0004185 (serine-type carboxypeptidase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-10-27 | Added | XREF | MetaCyc:3.4.16.4-RXN |
2001-03-30 | Added | XREF | EC:3.4.16.4 |
Timestamp | Action | Category | Detail |
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