This term is obsolete.

GO:0009378 JSON

four-way junction helicase activity

Molecular Function

Definition (GO:0009378 GONUTS page)

Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis. PMID:22723423 PMID:9442895

Secondary IDs

GO:1990163

479,478 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
ATP-dependent four-way junction helicase activity exact
ATP-dependent four-way junction DNA helicase activity exact
ATP-dependent Holliday junction helicase activity narrow
Holliday junction helicase activity narrow

Ancestor Chart

Ancestor chart for GO:0009378
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0G2JTU1 10116 A0A0G2JTU1_RAT GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6IBW5 10116 A6IBW5_RAT GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6KC96 10116 A6KC96_RAT GO:0004386 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6KFV6 10116 A6KFV6_RAT GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein B5DFJ3 10116 B5DFJ3_RAT GO:0004386 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZDS8 10116 D3ZDS8_RAT GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZG52 10116 DNA2_RAT GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein D3ZS47 10116 D3ZS47_RAT GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein E1BB03 9913 ZRAB3_BOVIN GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein E1BMP7 9913 DNA2_BOVIN GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024

Cross-references

Database ID Description
EC 3.6.4.12
InterPro IPR004605 Holliday junction branch migration complex subunit RuvB
InterPro IPR008823 RuvB C-terminal winged helix domain
InterPro IPR008824 RuvB-like P-loop domain
InterPro IPR011114 Holliday junction DNA helicase RuvA, C-terminal
InterPro IPR013849 DNA helicase, Holliday junction RuvA type, domain I, bacterial

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0009378 based on ALL annotations
The top 100 of 2,063 co-occurring terms
Co-occurring Term PR S% #Together #Compared
four-way junction helicase activity
406.95 100.00 479,025 479,025
single-stranded 3'-5' DNA helicase activity
404.81 83.66 402,535 404,658
forked DNA-dependent helicase activity
404.39 83.60 402,598 405,142
double-stranded DNA helicase activity
404.18 83.55 402,552 405,312
DNA duplex unwinding
198.51 44.48 399,736 819,479
3'-5' DNA helicase activity
255.47 35.99 219,169 349,121
DNA helicase activity
199.94 35.77 272,090 553,794
chromatin extrusion motor activity
277.77 30.36 169,346 248,104
ATP-dependent H3-H4 histone complex chaperone activity
277.76 30.36 169,346 248,109
cohesin loader activity
277.54 30.35 169,346 248,310
Totals 8242631 134161801
No co-occurrence statistics for GO:0009378 based on MANUAL annotations
The top 100 of 235 co-occurring terms
Co-occurring Term PR S% #Together #Compared
four-way junction helicase activity
1,635.19 100.00 790 790
3'-5' DNA helicase activity
811.33 49.21 777 1,566
DNA unwinding involved in DNA replication
846.68 46.79 655 1,265
chromosome
588.50 34.22 691 1,920
double-strand break repair via homologous recombination
217.45 12.95 658 4,948
double-strand break repair via synthesis-dependent strand annealing
511.00 8.28 80 256
four-way junction DNA binding
234.66 7.00 95 662
G-quadruplex DNA unwinding
824.96 6.63 56 111
interstrand cross-link repair
138.61 4.81 79 932
replisome
975.84 4.54 37 62
Totals 5407 246308

Change Log

Timestamp Action Category Detail
2024-08-16 Added XREF EC:3.6.4.12
2021-07-04 Deleted DEFINITION Catalysis of the reaction: ATP + H2O = ADP + phosphate, where this reaction drives the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions.
2021-07-04 Added DEFINITION Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis.
2019-05-25 Deleted DEFINITION Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions.
2019-05-25 Added SYNONYM ATP-dependent four-way junction helicase activity
2019-05-25 Added SYNONYM ATP-dependent Holliday junction helicase activity
2019-05-25 Added SYNONYM ATP-dependent four-way junction DNA helicase activity
2019-05-25 Added SECONDARY GO:1990163 (ATP-dependent four-way junction helicase activity)
2019-05-25 Added DEFINITION Catalysis of the reaction: ATP + H2O = ADP + phosphate, where this reaction drives the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions.
2008-05-13 Added DEFINITION Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions.
Timestamp Action Category Detail
2008-01-21 Updated TERM four-way junction helicase activity
2003-03-19 Updated TERM Holliday junction helicase activity
2002-02-06 Updated TERM Holliday junction helicase
2001-04-03 Updated TERM Holliday junction helicase
2001-03-30 Added TERM Holliday junction helicase
Timestamp Action Category Detail
2021-07-04 Deleted DEFINITION Catalysis of the reaction: ATP + H2O = ADP + phosphate, where this reaction drives the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions.
2021-07-04 Added DEFINITION Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis.
2019-05-25 Deleted DEFINITION Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions.
2019-05-25 Added SYNONYM ATP-dependent four-way junction helicase activity
2019-05-25 Added SYNONYM ATP-dependent Holliday junction helicase activity
2019-05-25 Added SYNONYM ATP-dependent four-way junction DNA helicase activity
2019-05-25 Added DEFINITION Catalysis of the reaction: ATP + H2O = ADP + phosphate, where this reaction drives the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions.
2008-05-13 Added DEFINITION Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions.
2008-05-12 Deleted DEFINITION Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions.
2008-01-27 Updated DEFINITION Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions.
2008-01-21 Added SYNONYM Holliday junction helicase activity
2004-04-18 Added DEFINITION Catalysis of the unwinding of the DNA helix of a Holliday junction.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0003678 (DNA helicase activity)
Timestamp Action Category Detail
2024-08-16 Added XREF EC:3.6.4.12
Timestamp Action Category Detail
2019-05-25 Added SECONDARY GO:1990163 (ATP-dependent four-way junction helicase activity)
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