GO:0009378
JSON
four-way junction helicase activity
Molecular Function
Definition (GO:0009378 GONUTS page)
Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis. PMID:22723423 PMID:9442895
Secondary IDs
GO:1990163
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
ATP-dependent four-way junction helicase activity | exact |
ATP-dependent four-way junction DNA helicase activity | exact |
ATP-dependent Holliday junction helicase activity | narrow |
Holliday junction helicase activity | narrow |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0G2JTU1 | 10116 | A0A0G2JTU1_RAT | GO:0003678 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6IBW5 | 10116 | A6IBW5_RAT | GO:0003678 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6KC96 | 10116 | A6KC96_RAT | GO:0004386 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6KFV6 | 10116 | A6KFV6_RAT | GO:0003678 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | B5DFJ3 | 10116 | B5DFJ3_RAT | GO:0004386 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D3ZDS8 | 10116 | D3ZDS8_RAT | GO:0003678 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D3ZG52 | 10116 | DNA2_RAT | GO:0003678 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | D3ZS47 | 10116 | D3ZS47_RAT | GO:0003678 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | E1BB03 | 9913 | ZRAB3_BOVIN | GO:0003678 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | E1BMP7 | 9913 | DNA2_BOVIN | GO:0003678 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.6.4.12 | |
InterPro | IPR004605 | Holliday junction branch migration complex subunit RuvB |
InterPro | IPR008823 | RuvB C-terminal winged helix domain |
InterPro | IPR008824 | RuvB-like P-loop domain |
InterPro | IPR011114 | Holliday junction DNA helicase RuvA, C-terminal |
InterPro | IPR013849 | DNA helicase, Holliday junction RuvA type, domain I, bacterial |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0009378 based on ALL annotations
The top 100 of 2,063 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
four-way junction helicase activity
|
406.95 | 100.00 | 479,025 | 479,025 |
single-stranded 3'-5' DNA helicase activity
|
404.81 | 83.66 | 402,535 | 404,658 |
forked DNA-dependent helicase activity
|
404.39 | 83.60 | 402,598 | 405,142 |
double-stranded DNA helicase activity
|
404.18 | 83.55 | 402,552 | 405,312 |
DNA duplex unwinding
|
198.51 | 44.48 | 399,736 | 819,479 |
3'-5' DNA helicase activity
|
255.47 | 35.99 | 219,169 | 349,121 |
DNA helicase activity
|
199.94 | 35.77 | 272,090 | 553,794 |
chromatin extrusion motor activity
|
277.77 | 30.36 | 169,346 | 248,104 |
ATP-dependent H3-H4 histone complex chaperone activity
|
277.76 | 30.36 | 169,346 | 248,109 |
cohesin loader activity
|
277.54 | 30.35 | 169,346 | 248,310 |
Totals | 8242631 | 134161801 |
No co-occurrence statistics for GO:0009378 based on MANUAL annotations
The top 100 of 235 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
four-way junction helicase activity
|
1,635.19 | 100.00 | 790 | 790 |
3'-5' DNA helicase activity
|
811.33 | 49.21 | 777 | 1,566 |
DNA unwinding involved in DNA replication
|
846.68 | 46.79 | 655 | 1,265 |
chromosome
|
588.50 | 34.22 | 691 | 1,920 |
double-strand break repair via homologous recombination
|
217.45 | 12.95 | 658 | 4,948 |
double-strand break repair via synthesis-dependent strand annealing
|
511.00 | 8.28 | 80 | 256 |
four-way junction DNA binding
|
234.66 | 7.00 | 95 | 662 |
G-quadruplex DNA unwinding
|
824.96 | 6.63 | 56 | 111 |
interstrand cross-link repair
|
138.61 | 4.81 | 79 | 932 |
replisome
|
975.84 | 4.54 | 37 | 62 |
Totals | 5407 | 246308 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-08-16 | Added | XREF | EC:3.6.4.12 |
2021-07-04 | Deleted | DEFINITION | Catalysis of the reaction: ATP + H2O = ADP + phosphate, where this reaction drives the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions. |
2021-07-04 | Added | DEFINITION | Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis. |
2019-05-25 | Deleted | DEFINITION | Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions. |
2019-05-25 | Added | SYNONYM | ATP-dependent four-way junction helicase activity |
2019-05-25 | Added | SYNONYM | ATP-dependent Holliday junction helicase activity |
2019-05-25 | Added | SYNONYM | ATP-dependent four-way junction DNA helicase activity |
2019-05-25 | Added | SECONDARY | GO:1990163 (ATP-dependent four-way junction helicase activity) |
2019-05-25 | Added | DEFINITION | Catalysis of the reaction: ATP + H2O = ADP + phosphate, where this reaction drives the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions. |
2008-05-13 | Added | DEFINITION | Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-01-21 | Updated | TERM | four-way junction helicase activity |
2003-03-19 | Updated | TERM | Holliday junction helicase activity |
2002-02-06 | Updated | TERM | Holliday junction helicase |
2001-04-03 | Updated | TERM | Holliday junction helicase |
2001-03-30 | Added | TERM | Holliday junction helicase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-07-04 | Deleted | DEFINITION | Catalysis of the reaction: ATP + H2O = ADP + phosphate, where this reaction drives the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions. |
2021-07-04 | Added | DEFINITION | Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis. |
2019-05-25 | Deleted | DEFINITION | Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions. |
2019-05-25 | Added | SYNONYM | ATP-dependent four-way junction helicase activity |
2019-05-25 | Added | SYNONYM | ATP-dependent Holliday junction helicase activity |
2019-05-25 | Added | SYNONYM | ATP-dependent four-way junction DNA helicase activity |
2019-05-25 | Added | DEFINITION | Catalysis of the reaction: ATP + H2O = ADP + phosphate, where this reaction drives the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions. |
2008-05-13 | Added | DEFINITION | Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions. |
2008-01-27 | Updated | DEFINITION | Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions. |
2008-01-21 | Added | SYNONYM | Holliday junction helicase activity |
2004-04-18 | Added | DEFINITION | Catalysis of the unwinding of the DNA helix of a Holliday junction. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0003678 (DNA helicase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-08-16 | Added | XREF | EC:3.6.4.12 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-05-25 | Added | SECONDARY | GO:1990163 (ATP-dependent four-way junction helicase activity) |
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