GO:0010459
JSON
negative regulation of heart rate
Biological Process
Definition (GO:0010459 GONUTS page)
Any process that stops, prevents or reduces the frequency or rate of heart contraction.
Ancestor Chart
Ancestor chart for GO:0010459
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0010459
| Child Term | Relationship to GO:0010459 |
|---|---|
|
G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
|
part_of |
|
negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
|
is_a |
|
negative regulation of heart rate by acetylcholine
|
is_a |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
| Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
|---|---|---|---|---|---|---|---|
| NOT-qualified manual | protein | P04897 | 10116 | GNAI2_RAT | GO:0008016 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | P08752 | 10090 | GNAI2_MOUSE | GO:0008016 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11158953 | |
| NOT-qualified manual | protein | P08753 | 10116 | GNAI3_RAT | GO:0008016 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | Q9DC51 | 10090 | GNAI3_MOUSE | GO:0008016 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11158953 | |
| NOT-qualified manual | protein | Q9ERZ8 | 10116 | TRPV4_RAT | GO:0002027 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:23136043 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0010459 based on ALL annotations
The top 100 of 704 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
negative regulation of heart rate
|
170,747.38 | 100.00 | 1,166 | 1,166 |
|
negative regulation of calcium ion import into sarcoplasmic reticulum
|
165,658.03 | 54.89 | 651 | 671 |
|
regulation of relaxation of muscle
|
161,164.61 | 15.72 | 185 | 196 |
|
regulation of cardiac muscle cell contraction
|
53,875.22 | 11.99 | 189 | 599 |
|
regulation of calcium ion transport
|
23,723.82 | 10.70 | 370 | 2,663 |
|
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
|
23,345.43 | 9.23 | 258 | 1,887 |
|
phospholamban complex
|
170,747.38 | 8.23 | 96 | 96 |
|
calcium ion-transporting ATPase complex
|
168,987.10 | 8.23 | 96 | 97 |
|
negative regulation of heart contraction
|
52,223.27 | 8.06 | 115 | 376 |
|
adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
|
168,911.38 | 7.88 | 92 | 93 |
| Totals | 11021 | 318058 | ||
No co-occurrence statistics for GO:0010459 based on MANUAL annotations
The top 100 of 643 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
negative regulation of heart rate
|
20,154.44 | 100.00 | 70 | 70 |
|
negative regulation of calcium ion import into sarcoplasmic reticulum
|
11,604.07 | 22.62 | 19 | 33 |
|
cell body fiber
|
6,158.30 | 11.58 | 11 | 36 |
|
axon hillock
|
6,158.30 | 11.58 | 11 | 36 |
|
regulation of relaxation of muscle
|
12,402.73 | 10.67 | 8 | 13 |
|
clustering of voltage-gated sodium channels
|
4,347.04 | 10.00 | 11 | 51 |
|
ATPase inhibitor activity
|
2,470.54 | 9.22 | 19 | 155 |
|
regulation of cardiac muscle cell contraction
|
3,627.80 | 8.11 | 9 | 50 |
|
dendritic spine neck
|
8,637.62 | 7.69 | 6 | 14 |
|
regulation of cell communication by electrical coupling involved in cardiac conduction
|
4,551.00 | 7.45 | 7 | 31 |
| Totals | 644 | 8781 | ||
Change Log
- All changes
- All changes
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- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2008-05-13 | Added | DEFINITION | Any process that stops, prevents or reduces the frequency or rate of heart contraction. |
| 2008-05-12 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency or rate of heart contraction. |
| 2008-04-01 | Updated | RELATION | is a GO:0045822 (negative regulation of heart contraction) |
| 2008-04-01 | Updated | RELATION | is a GO:0002027 (regulation of heart rate) |
| 2007-11-27 | Added | DEFINITION | Any process that stops, prevents or reduces the frequency or rate of heart contraction. |
| 2007-11-09 | Added | TERM | negative regulation of heart rate |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2007-11-09 | Added | TERM | negative regulation of heart rate |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2008-05-13 | Added | DEFINITION | Any process that stops, prevents or reduces the frequency or rate of heart contraction. |
| 2008-05-12 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency or rate of heart contraction. |
| 2007-11-27 | Added | DEFINITION | Any process that stops, prevents or reduces the frequency or rate of heart contraction. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2008-04-01 | Updated | RELATION | is a GO:0045822 (negative regulation of heart contraction) |
| 2008-04-01 | Updated | RELATION | is a GO:0002027 (regulation of heart rate) |
| Timestamp | Action | Category | Detail |
|---|
| Timestamp | Action | Category | Detail |
|---|
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