This term is obsolete.

GO:0016579 JSON

protein deubiquitination

Biological Process

Definition (GO:0016579 GONUTS page)

The removal of one or more ubiquitin groups from a protein.

Secondary IDs

GO:0006514

267,621 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
deubiquitination exact
protein deubiquitinylation exact
protein deubiquitylation exact

Ancestor Chart

Ancestor chart for GO:0016579
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0016579

Child Term Relationship to
GO:0016579
protein K63-linked deubiquitination
is_a
protein linear deubiquitination
is_a
regulation of protein deubiquitination
regulates
protein K48-linked deubiquitination
is_a
monoubiquitinated protein deubiquitination
is_a
protein K29-linked deubiquitination
is_a
protein K27-linked deubiquitination
is_a
negative regulation of protein deubiquitination
negatively_regulates
protein K6-linked deubiquitination
is_a
protein K33-linked deubiquitination
is_a

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein D3ZYY9 10116 D3ZYY9_RAT GO:0016579 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P15975 10090 UBP53_MOUSE GO:0016579 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:26609154
NOT-qualified manual protein Q3B7D8 10116 OTULL_RAT GO:0016579 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein Q3TVP5 10090 OTULL_MOUSE GO:0016579 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q9NUU6 9606 OTULL_HUMAN GO:0016579 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:31056421

Cross-references

Database ID Description
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
InterPro IPR006155 Josephin domain
InterPro IPR016615 Ubiquitin thioesterase Otubain
InterPro IPR016652 Ubiquitinyl hydrolase
InterPro IPR017390 Ubiquitinyl hydrolase, UCH37 type
InterPro IPR033815 Ubiquitin specific peptidase 1
InterPro IPR033837 Ubiquitinyl hydrolase-L5
InterPro IPR033865 Machado-Joseph disease protein
InterPro IPR039138 Ubiquitin thioesterase OTU1/2/3
InterPro IPR043934 SidE, DUB domain

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0016579 based on ALL annotations
The top 100 of 2,595 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein deubiquitination
966.89 100.00 204,941 204,941
cysteine-type deubiquitinase activity
811.06 78.85 190,443 227,033
cysteine-type peptidase activity
205.54 18.53 121,057 569,466
deubiquitinase activity
944.16 15.27 31,409 32,165
regulation of protein stability
506.55 4.29 9,142 17,450
proteasome binding
189.73 3.83 9,297 47,378
regulation of proteasomal protein catabolic process
441.98 3.73 8,005 17,512
K63-linked deubiquitinase activity
619.96 3.22 6,719 10,479
ubiquitin-dependent protein catabolic process
44.84 3.02 16,325 352,009
endoplasmic reticulum unfolded protein response
111.34 2.55 6,484 56,307
Totals 1153489 91863060
No co-occurrence statistics for GO:0016579 based on MANUAL annotations
The top 100 of 772 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein deubiquitination
4,356.58 100.00 324 324
protein K48-linked deubiquitination
2,861.04 23.78 88 134
protein K63-linked deubiquitination
1,720.29 17.42 77 195
protein K11-linked deubiquitination
2,693.16 9.86 34 55
monoubiquitinated protein deubiquitination
2,532.90 7.31 25 43
cysteine-type deubiquitinase activity
287.20 6.55 296 4,490
K63-linked deubiquitinase activity
544.57 6.53 39 312
K48-linked deubiquitinase activity
481.01 5.78 35 317
protein deubiquitination involved in ubiquitin-dependent protein catabolic process
701.48 4.49 19 118
deubiquitinase activity
269.66 4.47 45 727
Totals 1852 26890

Change Log

Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-5688426
2024-04-27 Deleted SUBSET gocheck_do_not_annotate
2023-06-13 Added SUBSET gocheck_do_not_annotate
2020-02-28 Deleted XREF MIPS_funcat:14.07.05
2019-05-04 Added XREF MIPS_funcat:14.07.05
2010-10-17 Deleted RELATION is a GO:0006464 (cellular protein modification process)
2010-10-15 Deleted RELATION is a GO:0043687 (post-translational protein modification)
2010-10-15 Added RELATION is a GO:0006464 (cellular protein modification process)
2010-10-11 Deleted DEFINITION The removal of one or more ubiquitin moieties from a protein.
2010-10-11 Added DEFINITION The removal of one or more ubiquitin groups from a protein.
Timestamp Action Category Detail
2002-06-12 Updated TERM protein deubiquitination
2002-02-06 Updated TERM protein deubiquitylation
2001-04-03 Updated TERM protein deubiquitylation
2001-03-30 Added TERM protein deubiquitylation
Timestamp Action Category Detail
2010-10-11 Deleted DEFINITION The removal of one or more ubiquitin moieties from a protein.
2010-10-11 Added DEFINITION The removal of one or more ubiquitin groups from a protein.
2008-05-13 Added DEFINITION The removal of one or more ubiquitin moieties from a protein.
2008-05-12 Deleted DEFINITION The removal of one or more ubiquitin moieties from a protein.
2007-08-09 Added SYNONYM deubiquitination
2007-08-09 Deleted SYNONYM protein deubiquitylation
2007-08-09 Deleted SYNONYM protein deubiquitinylation
2007-08-09 Deleted SYNONYM deubiquitination
2007-08-09 Added SYNONYM protein deubiquitylation
2007-08-09 Added SYNONYM protein deubiquitinylation
2004-04-19 Added SYNONYM deubiquitination
2004-04-19 Added SYNONYM protein deubiquitinylation
2004-04-19 Added SYNONYM protein deubiquitylation
2004-04-16 Deleted SYNONYM protein deubiquitylation
2004-04-16 Deleted SYNONYM deubiquitination
2004-04-16 Deleted SYNONYM protein deubiquitinylation
2003-08-18 Added SYNONYM protein deubiquitinylation
2003-08-12 Added SYNONYM protein deubiquitylation
2003-03-26 Added DEFINITION The removal of one or more ubiquitin moieties from a protein.
2003-01-11 Added SYNONYM deubiquitination
Timestamp Action Category Detail
2010-10-17 Deleted RELATION is a GO:0006464 (cellular protein modification process)
2010-10-15 Deleted RELATION is a GO:0043687 (post-translational protein modification)
2010-10-15 Added RELATION is a GO:0006464 (cellular protein modification process)
2009-05-21 Added RELATION is a GO:0070646 (protein modification by small protein removal)
2008-07-20 Deleted RELATION is a GO:0006512 (obsolete ubiquitin cycle)
2008-07-20 Added RELATION is a GO:0043687 (post-translational protein modification)
2008-04-01 Updated RELATION is a GO:0006512 (obsolete ubiquitin cycle)
Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-5688426
2020-02-28 Deleted XREF MIPS_funcat:14.07.05
2019-05-04 Added XREF MIPS_funcat:14.07.05
Timestamp Action Category Detail
2024-04-27 Deleted SUBSET gocheck_do_not_annotate
2023-06-13 Added SUBSET gocheck_do_not_annotate
2003-01-11 Added SECONDARY GO:0006514 (deubiquitination)
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