GO:0016579
JSON
protein deubiquitination
Biological Process
Definition (GO:0016579 GONUTS page)
The removal of one or more ubiquitin groups from a protein.
Secondary IDs
GO:0006514
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
deubiquitination | exact |
protein deubiquitinylation | exact |
protein deubiquitylation | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0016579
Child Term | Relationship to GO:0016579 |
---|---|
protein K63-linked deubiquitination
|
is_a |
protein linear deubiquitination
|
is_a |
regulation of protein deubiquitination
|
regulates |
protein K48-linked deubiquitination
|
is_a |
monoubiquitinated protein deubiquitination
|
is_a |
protein K29-linked deubiquitination
|
is_a |
protein K27-linked deubiquitination
|
is_a |
negative regulation of protein deubiquitination
|
negatively_regulates |
protein K6-linked deubiquitination
|
is_a |
protein K33-linked deubiquitination
|
is_a |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | D3ZYY9 | 10116 | D3ZYY9_RAT | GO:0016579 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P15975 | 10090 | UBP53_MOUSE | GO:0016579 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:26609154 | |
NOT-qualified manual | protein | Q3B7D8 | 10116 | OTULL_RAT | GO:0016579 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | Q3TVP5 | 10090 | OTULL_MOUSE | GO:0016579 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q9NUU6 | 9606 | OTULL_HUMAN | GO:0016579 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:31056421 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR001394 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase |
InterPro | IPR006155 | Josephin domain |
InterPro | IPR016615 | Ubiquitin thioesterase Otubain |
InterPro | IPR016652 | Ubiquitinyl hydrolase |
InterPro | IPR017390 | Ubiquitinyl hydrolase, UCH37 type |
InterPro | IPR033815 | Ubiquitin specific peptidase 1 |
InterPro | IPR033837 | Ubiquitinyl hydrolase-L5 |
InterPro | IPR033865 | Machado-Joseph disease protein |
InterPro | IPR039138 | Ubiquitin thioesterase OTU1/2/3 |
InterPro | IPR043934 | SidE, DUB domain |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0016579 based on ALL annotations
The top 100 of 2,595 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein deubiquitination
|
966.89 | 100.00 | 204,941 | 204,941 |
cysteine-type deubiquitinase activity
|
811.06 | 78.85 | 190,443 | 227,033 |
cysteine-type peptidase activity
|
205.54 | 18.53 | 121,057 | 569,466 |
deubiquitinase activity
|
944.16 | 15.27 | 31,409 | 32,165 |
regulation of protein stability
|
506.55 | 4.29 | 9,142 | 17,450 |
proteasome binding
|
189.73 | 3.83 | 9,297 | 47,378 |
regulation of proteasomal protein catabolic process
|
441.98 | 3.73 | 8,005 | 17,512 |
K63-linked deubiquitinase activity
|
619.96 | 3.22 | 6,719 | 10,479 |
ubiquitin-dependent protein catabolic process
|
44.84 | 3.02 | 16,325 | 352,009 |
endoplasmic reticulum unfolded protein response
|
111.34 | 2.55 | 6,484 | 56,307 |
Totals | 1153489 | 91863060 |
No co-occurrence statistics for GO:0016579 based on MANUAL annotations
The top 100 of 772 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein deubiquitination
|
4,356.58 | 100.00 | 324 | 324 |
protein K48-linked deubiquitination
|
2,861.04 | 23.78 | 88 | 134 |
protein K63-linked deubiquitination
|
1,720.29 | 17.42 | 77 | 195 |
protein K11-linked deubiquitination
|
2,693.16 | 9.86 | 34 | 55 |
monoubiquitinated protein deubiquitination
|
2,532.90 | 7.31 | 25 | 43 |
cysteine-type deubiquitinase activity
|
287.20 | 6.55 | 296 | 4,490 |
K63-linked deubiquitinase activity
|
544.57 | 6.53 | 39 | 312 |
K48-linked deubiquitinase activity
|
481.01 | 5.78 | 35 | 317 |
protein deubiquitination involved in ubiquitin-dependent protein catabolic process
|
701.48 | 4.49 | 19 | 118 |
deubiquitinase activity
|
269.66 | 4.47 | 45 | 727 |
Totals | 1852 | 26890 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-12-05 | Added | XREF | Reactome:R-HSA-5688426 |
2024-04-27 | Deleted | SUBSET | gocheck_do_not_annotate |
2023-06-13 | Added | SUBSET | gocheck_do_not_annotate |
2020-02-28 | Deleted | XREF | MIPS_funcat:14.07.05 |
2019-05-04 | Added | XREF | MIPS_funcat:14.07.05 |
2010-10-17 | Deleted | RELATION | is a GO:0006464 (cellular protein modification process) |
2010-10-15 | Deleted | RELATION | is a GO:0043687 (post-translational protein modification) |
2010-10-15 | Added | RELATION | is a GO:0006464 (cellular protein modification process) |
2010-10-11 | Deleted | DEFINITION | The removal of one or more ubiquitin moieties from a protein. |
2010-10-11 | Added | DEFINITION | The removal of one or more ubiquitin groups from a protein. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2002-06-12 | Updated | TERM | protein deubiquitination |
2002-02-06 | Updated | TERM | protein deubiquitylation |
2001-04-03 | Updated | TERM | protein deubiquitylation |
2001-03-30 | Added | TERM | protein deubiquitylation |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-10-11 | Deleted | DEFINITION | The removal of one or more ubiquitin moieties from a protein. |
2010-10-11 | Added | DEFINITION | The removal of one or more ubiquitin groups from a protein. |
2008-05-13 | Added | DEFINITION | The removal of one or more ubiquitin moieties from a protein. |
2008-05-12 | Deleted | DEFINITION | The removal of one or more ubiquitin moieties from a protein. |
2007-08-09 | Added | SYNONYM | deubiquitination |
2007-08-09 | Deleted | SYNONYM | protein deubiquitylation |
2007-08-09 | Deleted | SYNONYM | protein deubiquitinylation |
2007-08-09 | Deleted | SYNONYM | deubiquitination |
2007-08-09 | Added | SYNONYM | protein deubiquitylation |
2007-08-09 | Added | SYNONYM | protein deubiquitinylation |
2004-04-19 | Added | SYNONYM | deubiquitination |
2004-04-19 | Added | SYNONYM | protein deubiquitinylation |
2004-04-19 | Added | SYNONYM | protein deubiquitylation |
2004-04-16 | Deleted | SYNONYM | protein deubiquitylation |
2004-04-16 | Deleted | SYNONYM | deubiquitination |
2004-04-16 | Deleted | SYNONYM | protein deubiquitinylation |
2003-08-18 | Added | SYNONYM | protein deubiquitinylation |
2003-08-12 | Added | SYNONYM | protein deubiquitylation |
2003-03-26 | Added | DEFINITION | The removal of one or more ubiquitin moieties from a protein. |
2003-01-11 | Added | SYNONYM | deubiquitination |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-10-17 | Deleted | RELATION | is a GO:0006464 (cellular protein modification process) |
2010-10-15 | Deleted | RELATION | is a GO:0043687 (post-translational protein modification) |
2010-10-15 | Added | RELATION | is a GO:0006464 (cellular protein modification process) |
2009-05-21 | Added | RELATION | is a GO:0070646 (protein modification by small protein removal) |
2008-07-20 | Deleted | RELATION | is a GO:0006512 (obsolete ubiquitin cycle) |
2008-07-20 | Added | RELATION | is a GO:0043687 (post-translational protein modification) |
2008-04-01 | Updated | RELATION | is a GO:0006512 (obsolete ubiquitin cycle) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-12-05 | Added | XREF | Reactome:R-HSA-5688426 |
2020-02-28 | Deleted | XREF | MIPS_funcat:14.07.05 |
2019-05-04 | Added | XREF | MIPS_funcat:14.07.05 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-04-27 | Deleted | SUBSET | gocheck_do_not_annotate |
2023-06-13 | Added | SUBSET | gocheck_do_not_annotate |
2003-01-11 | Added | SECONDARY | GO:0006514 (deubiquitination) |
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