This term is obsolete.

GO:0016592 JSON

mediator complex

Cellular Component

Definition (GO:0016592 GONUTS page)

A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. PMID:11454195 PMID:16168358 PMID:17870225

Secondary IDs

GO:0000119

119,411 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
TRAP complex narrow
L mediator complex exact
CDK8-containing TRAP/mediator complex related
Srb-mediator complex exact

Ancestor Chart

Ancestor chart for GO:0016592
Chart options
Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0016592 mediator complex Only in Taxon 2759 Eukaryota

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A096MJ18 10116 A0A096MJ18_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A096MK97 10116 A0A096MK97_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2JW23 10116 A0A0G2JW23_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2K8T1 10116 A0A0G2K8T1_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A1B0GR71 10090 A0A1B0GR71_MOUSE GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636
NOT-qualified manual protein A0A1B0GRK6 10090 A0A1B0GRK6_MOUSE GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636
NOT-qualified manual protein A0A1D8PHF8 237561 A0A1D8PHF8_CANAL GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8760936
NOT-qualified manual protein A0A1W2Q633 10116 A0A1W2Q633_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5Y8H4 10116 A0A8I5Y8H4_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A0E5 10116 A0A8I6A0E5_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR007018 Mediator complex, subunit Med6
InterPro IPR008626 Mediator complex, subunit Med15, fungi
InterPro IPR008831 Mediator complex, subunit Med31
InterPro IPR009244 Mediator complex, subunit Med7
InterPro IPR009332 Mediator of RNA polymerase II transcription subunit 22
InterPro IPR009401 Mediator complex subunit Med13, C-terminal
InterPro IPR011425 Mediator of RNA polymerase II transcription subunit 9
InterPro IPR013921 Mediator complex, subunit Med20
InterPro IPR013942 Mediator complex, subunit Med19, fungi
InterPro IPR013947 Mediator complex, subunit Med14

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0016592 based on ALL annotations
The top 100 of 2,011 co-occurring terms
Co-occurring Term PR S% #Together #Compared
mediator complex
1,692.36 100.00 117,088 117,088
transcription coregulator activity
758.89 38.38 85,110 189,800
core mediator complex
1,682.73 21.46 25,157 25,301
transcription coactivator activity
192.99 7.35 20,031 175,653
positive regulation of transcription by RNA polymerase II
79.44 4.13 29,853 635,978
regulation of transcription by RNA polymerase II
57.81 3.36 79,074 2,314,777
positive regulation of transcription initiation by RNA polymerase II
448.57 2.74 3,473 13,103
positive regulation of gene expression
123.33 2.73 4,884 67,017
termination of RNA polymerase II transcription
308.00 2.14 2,772 15,231
transcription regulator complex
54.76 2.10 6,585 203,495
Totals 526994 22574173
No co-occurrence statistics for GO:0016592 based on MANUAL annotations
The top 100 of 506 co-occurring terms
Co-occurring Term PR S% #Together #Compared
mediator complex
511.61 100.00 2,759 2,759
core mediator complex
424.36 28.07 822 991
transcription coregulator activity
81.13 11.16 755 4,761
transcription coactivator activity
61.87 8.65 643 5,317
positive regulation of transcription initiation by RNA polymerase II
286.78 8.46 250 446
positive regulation of transcription by RNA polymerase II
24.70 4.26 738 15,284
transcription regulator complex
27.24 3.19 203 3,812
nuclear thyroid hormone receptor binding
204.64 2.38 68 170
regulation of transcription by RNA polymerase II
12.23 2.31 1,142 47,787
positive regulation of gene expression
20.86 2.25 132 3,237
Totals 10206 554404

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
2020-11-03 Deleted RELATION is a GO:0032991 (protein-containing complex)
2020-11-03 Added RELATION is a GO:0140513 (nuclear protein-containing complex)
2020-11-03 Deleted RELATION part of GO:0005654 (nucleoplasm)
2019-09-12 Added RELATION part of GO:0005654 (nucleoplasm)
2019-09-12 Deleted RELATION is a GO:0044451 (obsolete nucleoplasm part)
2018-02-18 Added RELATION is a GO:0032991 (protein-containing complex)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2012-03-17 Added RELATION has part GO:0002929 (MECO complex)
2009-08-06 Deleted DEFINITION A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.
Timestamp Action Category Detail
2009-08-06 Updated TERM mediator complex
2002-02-06 Updated TERM Srb-mediator complex
2001-04-03 Updated TERM Srb-mediator complex
2001-03-30 Added TERM Srb-mediator complex
Timestamp Action Category Detail
2009-08-06 Deleted DEFINITION A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.
2009-08-06 Added DEFINITION A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
2009-08-06 Added SYNONYM CDK8-containing TRAP/mediator complex
2009-08-06 Added SYNONYM TRAP complex
2009-08-06 Added SYNONYM Srb-mediator complex
2009-08-06 Deleted SYNONYM CDK8-containing TRAP/mediator complex
2008-06-07 Deleted DEFINITION A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.
2008-06-07 Added DEFINITION A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.
2008-05-13 Added DEFINITION A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.
2008-05-12 Deleted DEFINITION A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.
2007-08-09 Deleted SYNONYM L mediator complex
2007-08-09 Deleted SYNONYM CDK8-containing TRAP/mediator complex
2007-08-09 Added SYNONYM L mediator complex
2007-08-09 Added SYNONYM CDK8-containing TRAP/mediator complex
2007-07-23 Added SYNONYM L mediator complex
2007-07-23 Added SYNONYM CDK8-containing TRAP/mediator complex
2004-12-01 Updated DEFINITION A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.
2004-11-26 Added DEFINITION A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16�polypeptides: Srb2, -4,�-5,�-6,�and -7, Med1, -2,�-4,�-6,�-7,�and -8,�Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.
Timestamp Action Category Detail
2020-11-03 Deleted RELATION is a GO:0032991 (protein-containing complex)
2020-11-03 Added RELATION is a GO:0140513 (nuclear protein-containing complex)
2020-11-03 Deleted RELATION part of GO:0005654 (nucleoplasm)
2019-09-12 Added RELATION part of GO:0005654 (nucleoplasm)
2019-09-12 Deleted RELATION is a GO:0044451 (obsolete nucleoplasm part)
2018-02-18 Added RELATION is a GO:0032991 (protein-containing complex)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2012-03-17 Added RELATION has part GO:0002929 (MECO complex)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0044451 (obsolete nucleoplasm part)
Timestamp Action Category Detail
2009-08-06 Added XREF Wikipedia:Mediator_(coactivator)
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
2009-08-06 Added SECONDARY GO:0000119 (mediator complex)
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