GO:0016592
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mediator complex
Cellular Component
Definition (GO:0016592 GONUTS page)
A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. PMID:11454195 PMID:16168358 PMID:17870225
Secondary IDs
GO:0000119
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
TRAP complex | narrow |
L mediator complex | exact |
CDK8-containing TRAP/mediator complex | related |
Srb-mediator complex | exact |
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0016592 | mediator complex | Only in Taxon | 2759 | Eukaryota |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A096MJ18 | 10116 | A0A096MJ18_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A096MK97 | 10116 | A0A096MK97_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2JW23 | 10116 | A0A0G2JW23_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2K8T1 | 10116 | A0A0G2K8T1_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A1B0GR71 | 10090 | A0A1B0GR71_MOUSE | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636 | |
NOT-qualified manual | protein | A0A1B0GRK6 | 10090 | A0A1B0GRK6_MOUSE | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636 | |
NOT-qualified manual | protein | A0A1D8PHF8 | 237561 | A0A1D8PHF8_CANAL | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8760936 | |
NOT-qualified manual | protein | A0A1W2Q633 | 10116 | A0A1W2Q633_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5Y8H4 | 10116 | A0A8I5Y8H4_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A0E5 | 10116 | A0A8I6A0E5_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR007018 | Mediator complex, subunit Med6 |
InterPro | IPR008626 | Mediator complex, subunit Med15, fungi |
InterPro | IPR008831 | Mediator complex, subunit Med31 |
InterPro | IPR009244 | Mediator complex, subunit Med7 |
InterPro | IPR009332 | Mediator of RNA polymerase II transcription subunit 22 |
InterPro | IPR009401 | Mediator complex subunit Med13, C-terminal |
InterPro | IPR011425 | Mediator of RNA polymerase II transcription subunit 9 |
InterPro | IPR013921 | Mediator complex, subunit Med20 |
InterPro | IPR013942 | Mediator complex, subunit Med19, fungi |
InterPro | IPR013947 | Mediator complex, subunit Med14 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0016592 based on ALL annotations
The top 100 of 2,011 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
mediator complex
|
1,692.36 | 100.00 | 117,088 | 117,088 |
transcription coregulator activity
|
758.89 | 38.38 | 85,110 | 189,800 |
core mediator complex
|
1,682.73 | 21.46 | 25,157 | 25,301 |
transcription coactivator activity
|
192.99 | 7.35 | 20,031 | 175,653 |
positive regulation of transcription by RNA polymerase II
|
79.44 | 4.13 | 29,853 | 635,978 |
regulation of transcription by RNA polymerase II
|
57.81 | 3.36 | 79,074 | 2,314,777 |
positive regulation of transcription initiation by RNA polymerase II
|
448.57 | 2.74 | 3,473 | 13,103 |
positive regulation of gene expression
|
123.33 | 2.73 | 4,884 | 67,017 |
termination of RNA polymerase II transcription
|
308.00 | 2.14 | 2,772 | 15,231 |
transcription regulator complex
|
54.76 | 2.10 | 6,585 | 203,495 |
Totals | 526994 | 22574173 |
No co-occurrence statistics for GO:0016592 based on MANUAL annotations
The top 100 of 506 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
mediator complex
|
511.61 | 100.00 | 2,759 | 2,759 |
core mediator complex
|
424.36 | 28.07 | 822 | 991 |
transcription coregulator activity
|
81.13 | 11.16 | 755 | 4,761 |
transcription coactivator activity
|
61.87 | 8.65 | 643 | 5,317 |
positive regulation of transcription initiation by RNA polymerase II
|
286.78 | 8.46 | 250 | 446 |
positive regulation of transcription by RNA polymerase II
|
24.70 | 4.26 | 738 | 15,284 |
transcription regulator complex
|
27.24 | 3.19 | 203 | 3,812 |
nuclear thyroid hormone receptor binding
|
204.64 | 2.38 | 68 | 170 |
regulation of transcription by RNA polymerase II
|
12.23 | 2.31 | 1,142 | 47,787 |
positive regulation of gene expression
|
20.86 | 2.25 | 132 | 3,237 |
Totals | 10206 | 554404 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
2020-11-03 | Deleted | RELATION | is a GO:0032991 (protein-containing complex) |
2020-11-03 | Added | RELATION | is a GO:0140513 (nuclear protein-containing complex) |
2020-11-03 | Deleted | RELATION | part of GO:0005654 (nucleoplasm) |
2019-09-12 | Added | RELATION | part of GO:0005654 (nucleoplasm) |
2019-09-12 | Deleted | RELATION | is a GO:0044451 (obsolete nucleoplasm part) |
2018-02-18 | Added | RELATION | is a GO:0032991 (protein-containing complex) |
2018-02-18 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2012-03-17 | Added | RELATION | has part GO:0002929 (MECO complex) |
2009-08-06 | Deleted | DEFINITION | A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-08-06 | Updated | TERM | mediator complex |
2002-02-06 | Updated | TERM | Srb-mediator complex |
2001-04-03 | Updated | TERM | Srb-mediator complex |
2001-03-30 | Added | TERM | Srb-mediator complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-08-06 | Deleted | DEFINITION | A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins. |
2009-08-06 | Added | DEFINITION | A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. |
2009-08-06 | Added | SYNONYM | CDK8-containing TRAP/mediator complex |
2009-08-06 | Added | SYNONYM | TRAP complex |
2009-08-06 | Added | SYNONYM | Srb-mediator complex |
2009-08-06 | Deleted | SYNONYM | CDK8-containing TRAP/mediator complex |
2008-06-07 | Deleted | DEFINITION | A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins. |
2008-06-07 | Added | DEFINITION | A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins. |
2008-05-13 | Added | DEFINITION | A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins. |
2008-05-12 | Deleted | DEFINITION | A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins. |
2007-08-09 | Deleted | SYNONYM | L mediator complex |
2007-08-09 | Deleted | SYNONYM | CDK8-containing TRAP/mediator complex |
2007-08-09 | Added | SYNONYM | L mediator complex |
2007-08-09 | Added | SYNONYM | CDK8-containing TRAP/mediator complex |
2007-07-23 | Added | SYNONYM | L mediator complex |
2007-07-23 | Added | SYNONYM | CDK8-containing TRAP/mediator complex |
2004-12-01 | Updated | DEFINITION | A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins. |
2004-11-26 | Added | DEFINITION | A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16�polypeptides: Srb2, -4,�-5,�-6,�and -7, Med1, -2,�-4,�-6,�-7,�and -8,�Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-11-03 | Deleted | RELATION | is a GO:0032991 (protein-containing complex) |
2020-11-03 | Added | RELATION | is a GO:0140513 (nuclear protein-containing complex) |
2020-11-03 | Deleted | RELATION | part of GO:0005654 (nucleoplasm) |
2019-09-12 | Added | RELATION | part of GO:0005654 (nucleoplasm) |
2019-09-12 | Deleted | RELATION | is a GO:0044451 (obsolete nucleoplasm part) |
2018-02-18 | Added | RELATION | is a GO:0032991 (protein-containing complex) |
2018-02-18 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2012-03-17 | Added | RELATION | has part GO:0002929 (MECO complex) |
2008-04-01 | Updated | RELATION | is a GO:0043234 (protein complex) |
2008-04-01 | Updated | RELATION | is a GO:0044451 (obsolete nucleoplasm part) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-08-06 | Added | XREF | Wikipedia:Mediator_(coactivator) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
2009-08-06 | Added | SECONDARY | GO:0000119 (mediator complex) |
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