GO:0016702
JSON
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Molecular Function
Definition (GO:0016702 GONUTS page)
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0016702
Child Term | Relationship to GO:0016702 |
---|---|
gentisate 1,2-dioxygenase activity
|
is_a |
2,3-dihydroxybiphenyl 1,2-dioxygenase activity
|
is_a |
arachidonate 8(S)-lipoxygenase activity
|
is_a |
fatty acid alpha-dioxygenase activity
|
is_a |
indole 2,3-dioxygenase activity
|
is_a |
tryptophan 2,3-dioxygenase activity
|
is_a |
homogentisate 1,2-dioxygenase activity
|
is_a |
hydroxyquinol 1,2-dioxygenase activity
|
is_a |
gallate dioxygenase activity
|
is_a |
biphenyl-2,3-diol 1,2-dioxygenase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | D3ZKX9 | 10116 | LOXE3_RAT | GO:0016702 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.13.11.- | |
InterPro | IPR000907 | Lipoxygenase |
InterPro | IPR001885 | Lipoxygenase, mammalian |
InterPro | IPR004294 | Carotenoid oxygenase |
InterPro | IPR010300 | Cysteine dioxygenase type I |
InterPro | IPR012864 | Cysteine oxygenase/2-aminoethanethiol dioxygenase |
InterPro | IPR013819 | Lipoxygenase, C-terminal |
InterPro | IPR015889 | Intradiol ring-cleavage dioxygenase, core |
InterPro | IPR020833 | Lipoxygenase, iron binding site |
InterPro | IPR020834 | Lipoxygenase, conserved site |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0034887 | obsolete 1,4-dihydroisonicotinate 2,3-dioxygenase activity | consider GO:0016702 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0016702 based on ALL annotations
The top 100 of 1,341 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
|
2,060.90 | 100.00 | 94,589 | 94,589 |
carotene catabolic process
|
2,060.60 | 28.34 | 26,807 | 26,811 |
carotenoid dioxygenase activity
|
2,060.75 | 27.83 | 26,329 | 26,331 |
lipid oxidation
|
2,048.65 | 17.12 | 16,212 | 16,309 |
dioxygenase activity
|
206.99 | 9.69 | 69,282 | 689,815 |
oxylipin biosynthetic process
|
1,675.61 | 8.13 | 7,841 | 9,644 |
beta-carotene 15,15'-dioxygenase activity
|
2,052.69 | 7.66 | 7,251 | 7,280 |
cysteine dioxygenase activity
|
2,039.86 | 6.76 | 6,397 | 6,463 |
retinal metabolic process
|
1,627.66 | 6.06 | 5,827 | 7,378 |
ferric iron binding
|
181.85 | 5.52 | 12,128 | 137,445 |
Totals | 525915 | 40784142 |
No co-occurrence statistics for GO:0016702 based on MANUAL annotations
The top 100 of 198 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
|
1,586.98 | 100.00 | 814 | 814 |
lipid oxidation
|
1,405.73 | 70.98 | 636 | 718 |
prostaglandin-endoperoxide synthase activity
|
1,407.32 | 5.73 | 47 | 53 |
cyclooxygenase pathway
|
1,130.12 | 5.64 | 47 | 66 |
lipoxygenase pathway
|
444.76 | 4.75 | 44 | 157 |
arachidonate metabolic process
|
157.27 | 3.62 | 44 | 444 |
xanthophyll catabolic process
|
1,154.16 | 0.98 | 8 | 11 |
carotene metabolic process
|
1,234.32 | 0.86 | 7 | 9 |
beta,beta-carotene-9',10'-cleaving oxygenase activity
|
1,234.32 | 0.86 | 7 | 9 |
prostaglandin biosynthetic process
|
74.24 | 0.82 | 8 | 171 |
Totals | 1969 | 25750 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-06 | Added | XREF | Reactome:R-HSA-9916401 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-9916401 |
2024-11-03 | Added | XREF | Reactome:R-HSA-9916401 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-9916401 |
2024-11-01 | Added | XREF | Reactome:R-HSA-9916401 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-9916401 |
2024-10-09 | Added | XREF | Reactome:R-HSA-9916401 |
2021-01-04 | Deleted | XREF | EC:1.13.11 |
2021-01-04 | Added | XREF | EC:1.13.11.- |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2161775 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-25 | Updated | TERM | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
2003-03-19 | Updated | TERM | oxidoreductase, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen activity |
2002-02-06 | Updated | TERM | oxidoreductase, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
2001-04-03 | Updated | TERM | oxidoreductase, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
2001-03-30 | Added | TERM | oxidoreductase, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. |
2008-05-12 | Deleted | DEFINITION | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. |
2007-10-06 | Deleted | SYNONYM | dioxygenase activity |
2007-08-09 | Deleted | SYNONYM | dioxygenase activity |
2007-08-09 | Added | SYNONYM | dioxygenase activity |
2006-11-28 | Added | DEFINITION | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. |
2004-02-26 | Added | SYNONYM | dioxygenase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016701 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen) |
2008-04-01 | Updated | RELATION | is a GO:0051213 (dioxygenase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-06 | Added | XREF | Reactome:R-HSA-9916401 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-9916401 |
2024-11-03 | Added | XREF | Reactome:R-HSA-9916401 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-9916401 |
2024-11-01 | Added | XREF | Reactome:R-HSA-9916401 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-9916401 |
2024-10-09 | Added | XREF | Reactome:R-HSA-9916401 |
2021-01-04 | Deleted | XREF | EC:1.13.11 |
2021-01-04 | Added | XREF | EC:1.13.11.- |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2161775 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5164399 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2161917 |
2019-04-01 | Added | XREF | Reactome:R-HSA-9020274 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5164399 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-9026918 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2161917 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2161907 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-9026408 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-9018880 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2161907 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2161775 |
2019-04-01 | Added | XREF | Reactome:R-HSA-9026918 |
2019-04-01 | Added | XREF | Reactome:R-HSA-9026408 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-9020274 |
2019-04-01 | Added | XREF | Reactome:R-HSA-9018880 |
2018-12-11 | Added | XREF | reactome:R-HSA-9018880 |
2018-12-11 | Added | XREF | reactome:R-HSA-2161775 |
2018-12-11 | Added | XREF | reactome:R-HSA-9026408 |
2018-12-11 | Added | XREF | reactome:R-HSA-9020274 |
2018-12-11 | Added | XREF | reactome:R-HSA-5164399 |
2018-12-11 | Added | XREF | reactome:R-HSA-2161907 |
2018-12-11 | Added | XREF | reactome:R-HSA-9026918 |
2018-12-11 | Added | XREF | reactome:R-HSA-2161917 |
2006-02-09 | Added | XREF | EC:1.13.11 |
2006-02-09 | Deleted | XREF | EC:1.13.11.- |
2001-03-30 | Added | XREF | EC:1.13.11.- |
Timestamp | Action | Category | Detail |
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