This term is obsolete.

GO:0016702 JSON

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

Molecular Function

Definition (GO:0016702 GONUTS page)

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.

311,920 annotations

Ancestor Chart

Ancestor chart for GO:0016702
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0016702

Child Term Relationship to
GO:0016702
gentisate 1,2-dioxygenase activity
is_a
2,3-dihydroxybiphenyl 1,2-dioxygenase activity
is_a
arachidonate 8(S)-lipoxygenase activity
is_a
fatty acid alpha-dioxygenase activity
is_a
indole 2,3-dioxygenase activity
is_a
tryptophan 2,3-dioxygenase activity
is_a
homogentisate 1,2-dioxygenase activity
is_a
hydroxyquinol 1,2-dioxygenase activity
is_a
gallate dioxygenase activity
is_a
biphenyl-2,3-diol 1,2-dioxygenase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein D3ZKX9 10116 LOXE3_RAT GO:0016702 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
EC 1.13.11.-
InterPro IPR000907 Lipoxygenase
InterPro IPR001885 Lipoxygenase, mammalian
InterPro IPR004294 Carotenoid oxygenase
InterPro IPR010300 Cysteine dioxygenase type I
InterPro IPR012864 Cysteine oxygenase/2-aminoethanethiol dioxygenase
InterPro IPR013819 Lipoxygenase, C-terminal
InterPro IPR015889 Intradiol ring-cleavage dioxygenase, core
InterPro IPR020833 Lipoxygenase, iron binding site
InterPro IPR020834 Lipoxygenase, conserved site

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0034887 obsolete 1,4-dihydroisonicotinate 2,3-dioxygenase activity consider GO:0016702

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0016702 based on ALL annotations
The top 100 of 1,341 co-occurring terms
Co-occurring Term PR S% #Together #Compared
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
2,060.90 100.00 94,589 94,589
carotene catabolic process
2,060.60 28.34 26,807 26,811
carotenoid dioxygenase activity
2,060.75 27.83 26,329 26,331
lipid oxidation
2,048.65 17.12 16,212 16,309
dioxygenase activity
206.99 9.69 69,282 689,815
oxylipin biosynthetic process
1,675.61 8.13 7,841 9,644
beta-carotene 15,15'-dioxygenase activity
2,052.69 7.66 7,251 7,280
cysteine dioxygenase activity
2,039.86 6.76 6,397 6,463
retinal metabolic process
1,627.66 6.06 5,827 7,378
ferric iron binding
181.85 5.52 12,128 137,445
Totals 525915 40784142
No co-occurrence statistics for GO:0016702 based on MANUAL annotations
The top 100 of 198 co-occurring terms
Co-occurring Term PR S% #Together #Compared
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
1,586.98 100.00 814 814
lipid oxidation
1,405.73 70.98 636 718
prostaglandin-endoperoxide synthase activity
1,407.32 5.73 47 53
cyclooxygenase pathway
1,130.12 5.64 47 66
lipoxygenase pathway
444.76 4.75 44 157
arachidonate metabolic process
157.27 3.62 44 444
xanthophyll catabolic process
1,154.16 0.98 8 11
carotene metabolic process
1,234.32 0.86 7 9
beta,beta-carotene-9',10'-cleaving oxygenase activity
1,234.32 0.86 7 9
prostaglandin biosynthetic process
74.24 0.82 8 171
Totals 1969 25750

Change Log

Timestamp Action Category Detail
2024-11-06 Added XREF Reactome:R-HSA-9916401
2024-11-05 Deleted XREF Reactome:R-HSA-9916401
2024-11-03 Added XREF Reactome:R-HSA-9916401
2024-11-02 Deleted XREF Reactome:R-HSA-9916401
2024-11-01 Added XREF Reactome:R-HSA-9916401
2024-10-26 Deleted XREF Reactome:R-HSA-9916401
2024-10-09 Added XREF Reactome:R-HSA-9916401
2021-01-04 Deleted XREF EC:1.13.11
2021-01-04 Added XREF EC:1.13.11.-
2019-04-01 Deleted XREF reactome:R-HSA-2161775
Timestamp Action Category Detail
2003-03-25 Updated TERM oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
2003-03-19 Updated TERM oxidoreductase, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen activity
2002-02-06 Updated TERM oxidoreductase, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
2001-04-03 Updated TERM oxidoreductase, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
2001-03-30 Added TERM oxidoreductase, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.
2008-05-12 Deleted DEFINITION Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.
2007-10-06 Deleted SYNONYM dioxygenase activity
2007-08-09 Deleted SYNONYM dioxygenase activity
2007-08-09 Added SYNONYM dioxygenase activity
2006-11-28 Added DEFINITION Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.
2004-02-26 Added SYNONYM dioxygenase activity
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016701 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen)
2008-04-01 Updated RELATION is a GO:0051213 (dioxygenase activity)
Timestamp Action Category Detail
2024-11-06 Added XREF Reactome:R-HSA-9916401
2024-11-05 Deleted XREF Reactome:R-HSA-9916401
2024-11-03 Added XREF Reactome:R-HSA-9916401
2024-11-02 Deleted XREF Reactome:R-HSA-9916401
2024-11-01 Added XREF Reactome:R-HSA-9916401
2024-10-26 Deleted XREF Reactome:R-HSA-9916401
2024-10-09 Added XREF Reactome:R-HSA-9916401
2021-01-04 Deleted XREF EC:1.13.11
2021-01-04 Added XREF EC:1.13.11.-
2019-04-01 Deleted XREF reactome:R-HSA-2161775
2019-04-01 Added XREF Reactome:R-HSA-5164399
2019-04-01 Added XREF Reactome:R-HSA-2161917
2019-04-01 Added XREF Reactome:R-HSA-9020274
2019-04-01 Deleted XREF reactome:R-HSA-5164399
2019-04-01 Deleted XREF reactome:R-HSA-9026918
2019-04-01 Deleted XREF reactome:R-HSA-2161917
2019-04-01 Deleted XREF reactome:R-HSA-2161907
2019-04-01 Deleted XREF reactome:R-HSA-9026408
2019-04-01 Deleted XREF reactome:R-HSA-9018880
2019-04-01 Added XREF Reactome:R-HSA-2161907
2019-04-01 Added XREF Reactome:R-HSA-2161775
2019-04-01 Added XREF Reactome:R-HSA-9026918
2019-04-01 Added XREF Reactome:R-HSA-9026408
2019-04-01 Deleted XREF reactome:R-HSA-9020274
2019-04-01 Added XREF Reactome:R-HSA-9018880
2018-12-11 Added XREF reactome:R-HSA-9018880
2018-12-11 Added XREF reactome:R-HSA-2161775
2018-12-11 Added XREF reactome:R-HSA-9026408
2018-12-11 Added XREF reactome:R-HSA-9020274
2018-12-11 Added XREF reactome:R-HSA-5164399
2018-12-11 Added XREF reactome:R-HSA-2161907
2018-12-11 Added XREF reactome:R-HSA-9026918
2018-12-11 Added XREF reactome:R-HSA-2161917
2006-02-09 Added XREF EC:1.13.11
2006-02-09 Deleted XREF EC:1.13.11.-
2001-03-30 Added XREF EC:1.13.11.-
Timestamp Action Category Detail
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