GO:0017054
JSON
negative cofactor 2 complex
Cellular Component
Definition (GO:0017054 GONUTS page)
A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini. PMID:15574413
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0017054 | negative cofactor 2 complex | Only in Taxon | 2759 | Eukaryota |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A096MJ18 | 10116 | A0A096MJ18_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A096MK97 | 10116 | A0A096MK97_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2JW23 | 10116 | A0A0G2JW23_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2K8T1 | 10116 | A0A0G2K8T1_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A1B0GR71 | 10090 | A0A1B0GR71_MOUSE | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636 | |
NOT-qualified manual | protein | A0A1B0GRK6 | 10090 | A0A1B0GRK6_MOUSE | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636 | |
NOT-qualified manual | protein | A0A1D8PHF8 | 237561 | A0A1D8PHF8_CANAL | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8760936 | |
NOT-qualified manual | protein | A0A1W2Q633 | 10116 | A0A1W2Q633_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5Y8H4 | 10116 | A0A8I5Y8H4_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A0E5 | 10116 | A0A8I6A0E5_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR042225 | Negative cofactor 2 complex subunit beta |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0017054 based on ALL annotations
The top 74 of 74 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative cofactor 2 complex
|
33,523.44 | 100.00 | 5,815 | 5,815 |
general transcription initiation factor activity
|
32,832.56 | 52.53 | 3,089 | 3,154 |
core promoter sequence-specific DNA binding
|
6,355.31 | 15.97 | 2,925 | 15,429 |
RNA polymerase II general transcription initiation factor activity
|
3,069.36 | 9.15 | 5,793 | 63,271 |
RNA polymerase II preinitiation complex assembly
|
2,644.97 | 7.38 | 3,105 | 39,354 |
TBP-class protein binding
|
2,317.84 | 6.54 | 3,182 | 46,022 |
negative regulation of RNA polymerase II transcription preinitiation complex assembly
|
23,200.67 | 3.84 | 227 | 328 |
regulation of RNA polymerase II transcription preinitiation complex assembly
|
17,719.53 | 3.09 | 185 | 350 |
protein heterodimerization activity
|
757.43 | 2.26 | 5,782 | 255,908 |
negative regulation of transcription by RNA polymerase III
|
1,276.89 | 1.76 | 185 | 4,857 |
Totals | 44621 | 187838345 |
No co-occurrence statistics for GO:0017054 based on MANUAL annotations
The top 44 of 44 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative cofactor 2 complex
|
13,317.52 | 100.00 | 97 | 97 |
core promoter sequence-specific DNA binding
|
1,568.65 | 10.56 | 49 | 416 |
TBP-class protein binding
|
904.91 | 6.43 | 53 | 780 |
RNA polymerase II general transcription initiation factor activity
|
631.07 | 4.74 | 97 | 2,047 |
RNA polymerase II preinitiation complex assembly
|
562.71 | 4.07 | 51 | 1,207 |
transcription by RNA polymerase II
|
257.58 | 1.90 | 47 | 2,430 |
negative regulation of RNA polymerase II transcription preinitiation complex assembly
|
2,219.59 | 1.87 | 2 | 12 |
RNA polymerase II general transcription initiation factor binding
|
739.86 | 1.53 | 2 | 36 |
ATAC complex
|
298.15 | 1.32 | 3 | 134 |
regulation of tubulin deacetylation
|
422.78 | 1.27 | 2 | 63 |
Totals | 531 | 595899 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
2014-05-11 | Added | RELATION | is a GO:0090571 (RNA polymerase II transcription repressor complex) |
2014-05-11 | Deleted | RELATION | is a GO:0017053 (transcription repressor complex) |
2008-05-13 | Added | DEFINITION | A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini. |
2008-05-12 | Deleted | DEFINITION | A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini. |
2008-04-01 | Updated | RELATION | is a GO:0017053 (transcription repressor complex) |
2007-06-27 | Added | DEFINITION | A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini. |
2002-05-21 | Updated | TERM | negative cofactor 2 complex |
2001-05-16 | Added | TERM | negative co-factor 2 complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2002-05-21 | Updated | TERM | negative cofactor 2 complex |
2001-05-16 | Added | TERM | negative co-factor 2 complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini. |
2008-05-12 | Deleted | DEFINITION | A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini. |
2007-06-27 | Added | DEFINITION | A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2014-05-11 | Added | RELATION | is a GO:0090571 (RNA polymerase II transcription repressor complex) |
2014-05-11 | Deleted | RELATION | is a GO:0017053 (transcription repressor complex) |
2008-04-01 | Updated | RELATION | is a GO:0017053 (transcription repressor complex) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
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