This term is obsolete.

GO:0017054 JSON

negative cofactor 2 complex

Cellular Component

Definition (GO:0017054 GONUTS page)

A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini. PMID:15574413

5,873 annotations

Ancestor Chart

Ancestor chart for GO:0017054
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Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0017054 negative cofactor 2 complex Only in Taxon 2759 Eukaryota

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A096MJ18 10116 A0A096MJ18_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A096MK97 10116 A0A096MK97_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2JW23 10116 A0A0G2JW23_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2K8T1 10116 A0A0G2K8T1_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A1B0GR71 10090 A0A1B0GR71_MOUSE GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636
NOT-qualified manual protein A0A1B0GRK6 10090 A0A1B0GRK6_MOUSE GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636
NOT-qualified manual protein A0A1D8PHF8 237561 A0A1D8PHF8_CANAL GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8760936
NOT-qualified manual protein A0A1W2Q633 10116 A0A1W2Q633_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5Y8H4 10116 A0A8I5Y8H4_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A0E5 10116 A0A8I6A0E5_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR042225 Negative cofactor 2 complex subunit beta

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0017054 based on ALL annotations
The top 74 of 74 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative cofactor 2 complex
33,523.44 100.00 5,815 5,815
general transcription initiation factor activity
32,832.56 52.53 3,089 3,154
core promoter sequence-specific DNA binding
6,355.31 15.97 2,925 15,429
RNA polymerase II general transcription initiation factor activity
3,069.36 9.15 5,793 63,271
RNA polymerase II preinitiation complex assembly
2,644.97 7.38 3,105 39,354
TBP-class protein binding
2,317.84 6.54 3,182 46,022
negative regulation of RNA polymerase II transcription preinitiation complex assembly
23,200.67 3.84 227 328
regulation of RNA polymerase II transcription preinitiation complex assembly
17,719.53 3.09 185 350
protein heterodimerization activity
757.43 2.26 5,782 255,908
negative regulation of transcription by RNA polymerase III
1,276.89 1.76 185 4,857
Totals 44621 187838345
No co-occurrence statistics for GO:0017054 based on MANUAL annotations
The top 44 of 44 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative cofactor 2 complex
13,317.52 100.00 97 97
core promoter sequence-specific DNA binding
1,568.65 10.56 49 416
TBP-class protein binding
904.91 6.43 53 780
RNA polymerase II general transcription initiation factor activity
631.07 4.74 97 2,047
RNA polymerase II preinitiation complex assembly
562.71 4.07 51 1,207
transcription by RNA polymerase II
257.58 1.90 47 2,430
negative regulation of RNA polymerase II transcription preinitiation complex assembly
2,219.59 1.87 2 12
RNA polymerase II general transcription initiation factor binding
739.86 1.53 2 36
ATAC complex
298.15 1.32 3 134
regulation of tubulin deacetylation
422.78 1.27 2 63
Totals 531 595899

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
2014-05-11 Added RELATION is a GO:0090571 (RNA polymerase II transcription repressor complex)
2014-05-11 Deleted RELATION is a GO:0017053 (transcription repressor complex)
2008-05-13 Added DEFINITION A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini.
2008-05-12 Deleted DEFINITION A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini.
2008-04-01 Updated RELATION is a GO:0017053 (transcription repressor complex)
2007-06-27 Added DEFINITION A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini.
2002-05-21 Updated TERM negative cofactor 2 complex
2001-05-16 Added TERM negative co-factor 2 complex
Timestamp Action Category Detail
2002-05-21 Updated TERM negative cofactor 2 complex
2001-05-16 Added TERM negative co-factor 2 complex
Timestamp Action Category Detail
2008-05-13 Added DEFINITION A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini.
2008-05-12 Deleted DEFINITION A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini.
2007-06-27 Added DEFINITION A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini.
Timestamp Action Category Detail
2014-05-11 Added RELATION is a GO:0090571 (RNA polymerase II transcription repressor complex)
2014-05-11 Deleted RELATION is a GO:0017053 (transcription repressor complex)
2008-04-01 Updated RELATION is a GO:0017053 (transcription repressor complex)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
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