This term is obsolete.

GO:0019239 JSON

deaminase activity

Molecular Function

Definition (GO:0019239 GONUTS page)

Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R).

618,467 annotations

Ancestor Chart

Ancestor chart for GO:0019239
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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0019239

Child Term Relationship to
GO:0019239
GO:0008829
dCTP deaminase activity
is_a
GO:0004000
adenosine deaminase activity
is_a
GO:0004131
cytosine deaminase activity
is_a
GO:0004153
dihydropterin deaminase activity
is_a
GO:0035888
isoguanine deaminase activity
is_a
GO:0008660
1-aminocyclopropane-1-carboxylate deaminase activity
is_a
GO:0033973
dCTP deaminase (dUMP-forming) activity
is_a
GO:0008892
guanine deaminase activity
is_a
GO:0004126
cytidine deaminase activity
is_a
GO:0047424
methylenediurea deaminase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein P38150 559292 YB9Z_YEAST GO:0019239 InterPro domains (IPR006329 and IPR001365) are over predicting deaminase activity for a couple of proteins. The Saint-Marc C, et al 2009 paper (PMID: 19635936) indicates that "both proteins lack several residues (Figure S1) conserved in all described purine deaminases (Ribard et al. 2003)." and shows that they can not rescue a null mutation of the known AMP deaminase (AMD1). This blacklist entry could be replaced by a NOT-qualified IKR annotation when the evidence code becomes available. Reported by InterPro on 02-05-2012. SGD already have a NOT annotation for the child term 'AMP deaminase activity' therefore the blacklist entry should remain to prevent IEA annotations [6/12/2013]
IEA Review protein P40361 559292 YJH0_YEAST GO:0019239 InterPro domains (IPR006329 and IPR001365) are over predicting deaminase activity for a couple of proteins. The Saint-Marc C, et al 2009 paper (PMID: 19635936) indicates that "both proteins lack several residues (Figure S1) conserved in all described purine deaminases (Ribard et al. 2003)." and shows that they can not rescue a null mutation of the known AMP deaminase (AMD1). This blacklist entry could be replaced by a NOT-qualified IKR annotation when the evidence code becomes available. Reported by InterPro on 02-05-2012. SGD already have a NOT annotation for the child term 'AMP deaminase activity' therefore the blacklist entry should remain to prevent IEA annotations [6/12/2013]
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
InterPro IPR001365 Adenosine deaminase domain
InterPro IPR006330 Adenosine/adenine deaminase
InterPro IPR006650 Adenosine/AMP deaminase active site
InterPro IPR023512 Deaminase MtaD/DadD
Reactome R-HSA-74241
Reactome R-HSA-9014641
Reactome R-HSA-9734745
Reactome R-HSA-9754964

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0019239 based on ALL annotations
The top 100 of 989 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0019239
deaminase activity
1,134.20 100.00 175,534 175,534
GO:0043103
hypoxanthine salvage
1,131.04 16.70 29,321 29,403
GO:0006154
adenosine catabolic process
1,124.66 15.28 26,855 27,083
GO:0046103
inosine biosynthetic process
1,134.08 15.28 26,817 26,820
GO:0004000
adenosine deaminase activity
787.17 14.60 27,396 39,474
GO:0009168
purine ribonucleoside monophosphate biosynthetic process
504.51 11.21 22,875 51,426
GO:0046098
guanine metabolic process
1,126.55 8.72 15,308 15,412
GO:0008892
guanine deaminase activity
1,062.43 8.68 15,321 16,356
GO:0016814
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
497.28 8.59 16,951 38,662
GO:0006147
guanine catabolic process
1,100.36 7.06 12,418 12,800
Totals 848077 78489547
No co-occurrence statistics for GO:0019239 based on MANUAL annotations
The top 100 of 152 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0019239
deaminase activity
5,225.23 100.00 270 270
GO:0006402
mRNA catabolic process
665.03 11.11 126 990
GO:0017148
negative regulation of translation
316.38 5.66 126 2,081
GO:0120242
2-iminobutanoate deaminase activity
2,612.61 1.10 3 6
GO:0016892
RNA endonuclease activity, producing 3'-phosphomonoesters
1,119.69 1.07 3 14
GO:0046936
2'-deoxyadenosine deaminase activity
3,483.48 0.74 2 3
GO:0032261
purine nucleotide salvage
2,090.09 0.73 2 5
GO:0014074
response to purine-containing compound
401.94 0.68 2 26
GO:0033632
regulation of cell-cell adhesion mediated by integrin
401.94 0.68 2 26
GO:0046360
2-oxobutyrate biosynthetic process
387.05 0.68 2 27
Totals 1071 151997

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_pir 437

Change Log

Timestamp Action Category Detail
2023-04-02 Added XREF Reactome:R-HSA-9734745
2023-04-02 Added XREF Reactome:R-HSA-9754964
2023-04-02 Added XREF Reactome:R-HSA-74241
2022-10-08 Added RELATION is a GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds)
2022-10-08 Deleted RELATION is a GO:0016787 (hydrolase activity)
2021-02-17 Added DEFINITION Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R).
2021-02-17 Deleted DEFINITION Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3).
2019-04-01 Added XREF Reactome:R-HSA-9014641
2019-04-01 Deleted XREF reactome:R-HSA-9014641
2018-12-11 Added XREF reactome:R-HSA-9014641
Timestamp Action Category Detail
2003-03-19 Updated TERM deaminase activity
2001-10-03 Added TERM deaminase
Timestamp Action Category Detail
2021-02-17 Added DEFINITION Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R).
2021-02-17 Deleted DEFINITION Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3).
2008-05-13 Added DEFINITION Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3).
2008-05-12 Deleted DEFINITION Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3).
2004-08-20 Added DEFINITION Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3).
Timestamp Action Category Detail
2022-10-08 Added RELATION is a GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds)
2022-10-08 Deleted RELATION is a GO:0016787 (hydrolase activity)
2017-09-19 Deleted RELATION is a GO:0003824 (catalytic activity)
2017-09-19 Added RELATION is a GO:0016787 (hydrolase activity)
2008-04-01 Updated RELATION is a GO:0003824 (catalytic activity)
Timestamp Action Category Detail
2023-04-02 Added XREF Reactome:R-HSA-9734745
2023-04-02 Added XREF Reactome:R-HSA-9754964
2023-04-02 Added XREF Reactome:R-HSA-74241
2019-04-01 Added XREF Reactome:R-HSA-9014641
2019-04-01 Deleted XREF reactome:R-HSA-9014641
2018-12-11 Added XREF reactome:R-HSA-9014641
Timestamp Action Category Detail
2013-04-18 Updated SUBSET goslim_pir
2008-06-09 Added SUBSET goslim_pir
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