GO:0019786
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protein-phosphatidylethanolamide deconjugating activity
Molecular Function
Definition (GO:0019786 GONUTS page)
Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue. PMID:22240591 PMID:22652539 PMID:28330855 PMID:2882172 PMID:28901328
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
ATG8-PE deconjugation activity | narrow |
Atg8-specific protease activity | exact |
APG8-specific protease activity | narrow |
ATG8-PE hydrolase activity | narrow |
Atg8-specific peptidase activity | narrow |
APG8-PE hydrolase | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q62226 | 10090 | SHH_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113 | |
NOT-qualified manual | protein | Q63673 | 10116 | SHH_RAT | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q91YD4 | 10090 | TRPM2_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q9NHA8 | 7227 | BGBP3_DROME | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR046792 | Peptidase C54, catalytic domain |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0019786 based on ALL annotations
The top 100 of 262 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein-phosphatidylethanolamide deconjugating activity
|
19,406.02 | 100.00 | 10,211 | 10,211 |
aggrephagy
|
12,004.04 | 59.85 | 9,685 | 15,657 |
mitophagy
|
4,691.99 | 23.87 | 9,699 | 40,115 |
piecemeal microautophagy of the nucleus
|
2,866.14 | 14.65 | 9,685 | 65,575 |
autophagosome assembly
|
1,686.01 | 8.65 | 9,704 | 111,693 |
autophagy
|
1,131.83 | 5.83 | 10,106 | 173,275 |
cysteine-type endopeptidase activity
|
996.38 | 5.12 | 9,700 | 188,922 |
protein processing
|
772.01 | 3.97 | 9,688 | 243,527 |
autophagosome
|
426.76 | 1.91 | 1,303 | 59,251 |
cysteine-type peptidase activity
|
347.90 | 1.79 | 10,209 | 569,466 |
Totals | 131108 | 72967694 |
No co-occurrence statistics for GO:0019786 based on MANUAL annotations
The top 43 of 43 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein-phosphatidylethanolamide deconjugating activity
|
6,084.19 | 100.00 | 232 | 232 |
aggrephagy
|
3,117.30 | 50.78 | 228 | 445 |
piecemeal microautophagy of the nucleus
|
989.44 | 16.22 | 228 | 1,402 |
mitophagy
|
668.85 | 10.97 | 228 | 2,074 |
protein processing
|
661.20 | 10.85 | 228 | 2,098 |
cysteine-type peptidase activity
|
827.24 | 7.23 | 31 | 228 |
autophagosome assembly
|
373.61 | 6.13 | 228 | 3,713 |
cysteine-type endopeptidase activity
|
309.92 | 5.09 | 228 | 4,476 |
protein delipidation
|
3,476.68 | 4.98 | 12 | 21 |
autophagy
|
266.01 | 3.59 | 39 | 892 |
Totals | 2032 | 776058 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-06-13 | Deleted | SYNONYM | APG8-specific protease activity |
2023-06-13 | Added | SYNONYM | Atg8-specific peptidase activity |
2023-06-13 | Deleted | RELATION | is a GO:0008234 (cysteine-type peptidase activity) |
2023-06-13 | Added | SYNONYM | ATG8-PE hydrolase activity |
2023-06-13 | Added | SYNONYM | ATG8-PE deconjugation activity |
2023-06-13 | Added | SYNONYM | APG8-specific protease activity |
2023-06-13 | Deleted | RELATION | is a GO:0019783 (ubiquitin-like protein peptidase activity) |
2023-06-13 | Added | RELATION | is a GO:0016787 (hydrolase activity) |
2023-06-13 | Added | DEFINITION | Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue. |
2023-06-13 | Deleted | DEFINITION | A thiol-dependent isopeptidase activity that cleaves APG8 from a target protein to which it is conjugated. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-06-13 | Updated | TERM | protein-phosphatidylethanolamide deconjugating activity |
2022-01-28 | Updated | TERM | Atg8-specific peptidase activity |
2014-06-08 | Updated | TERM | Atg8-specific protease activity |
2003-03-19 | Updated | TERM | APG8-specific protease activity |
2002-01-08 | Updated | TERM | APG8-specific protease |
2001-11-13 | Added | TERM | APG8 specific protease |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-06-13 | Deleted | SYNONYM | APG8-specific protease activity |
2023-06-13 | Added | SYNONYM | Atg8-specific peptidase activity |
2023-06-13 | Added | SYNONYM | ATG8-PE hydrolase activity |
2023-06-13 | Added | SYNONYM | ATG8-PE deconjugation activity |
2023-06-13 | Added | SYNONYM | APG8-specific protease activity |
2023-06-13 | Added | DEFINITION | Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue. |
2023-06-13 | Deleted | DEFINITION | A thiol-dependent isopeptidase activity that cleaves APG8 from a target protein to which it is conjugated. |
2022-01-28 | Added | DEFINITION | A thiol-dependent isopeptidase activity that cleaves APG8 from a target protein to which it is conjugated. |
2022-01-28 | Added | SYNONYM | Atg8-specific protease activity |
2022-01-28 | Deleted | DEFINITION | Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier. |
2014-06-08 | Added | SYNONYM | APG8-specific protease activity |
2008-05-13 | Added | DEFINITION | Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier. |
2007-08-09 | Deleted | SYNONYM | APG8-PE hydrolase |
2007-08-09 | Added | SYNONYM | APG8-PE hydrolase |
2005-07-29 | Updated | DEFINITION | Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier. |
2005-07-27 | Added | DEFINITION | Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier, from previously modified substrates. |
2004-04-19 | Added | SYNONYM | APG8-PE hydrolase |
2004-04-05 | Deleted | SYNONYM | APG8-PE hydrolase |
2001-11-13 | Added | SYNONYM | APG8-PE hydrolase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-06-13 | Deleted | RELATION | is a GO:0008234 (cysteine-type peptidase activity) |
2023-06-13 | Deleted | RELATION | is a GO:0019783 (ubiquitin-like protein peptidase activity) |
2023-06-13 | Added | RELATION | is a GO:0016787 (hydrolase activity) |
2023-06-13 | Added | RELATION | is a GO:0140096 (catalytic activity, acting on a protein) |
2022-01-28 | Added | RELATION | is a GO:0008234 (cysteine-type peptidase activity) |
2016-11-15 | Added | RELATION | has part GO:0000045 (autophagosome assembly) |
2008-04-01 | Updated | RELATION | is a GO:0019783 (ubiquitin-like protein peptidase activity) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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