GO:0030213
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hyaluronan biosynthetic process
Biological Process
Definition (GO:0030213 GONUTS page)
The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine. PMID:33171800 PMID:35536932
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
| Synonym | Type |
|---|---|
| hyaluronan synthesis | exact |
| hyaluronan anabolism | exact |
| hyaluronan biosynthesis | exact |
| hyaluronan formation | exact |
Ancestor Chart
Ancestor chart for GO:0030213
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0030213
| Child Term | Relationship to GO:0030213 |
|---|---|
|
regulation of hyaluronan biosynthetic process
|
regulates |
|
positive regulation of hyaluronan biosynthetic process
|
positively_regulates |
|
negative regulation of hyaluronan biosynthetic process
|
negatively_regulates |
Cross-references
| Database | ID | Description |
|---|---|---|
| Reactome | R-HSA-2142850 |
Cross-Ontology Relations
| Relation | Other Ontology | ID | Term |
|---|---|---|---|
| has_primary_output | CHEBI | CHEBI:16336 | hyaluronic acid |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0030213 based on ALL annotations
The top 100 of 309 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
hyaluronan biosynthetic process
|
15,624.82 | 100.00 | 12,742 | 12,742 |
|
extracellular matrix assembly
|
14,491.46 | 91.14 | 12,505 | 13,483 |
|
hyaluronan synthase activity
|
13,991.19 | 88.32 | 12,547 | 14,012 |
|
glycosaminoglycan biosynthetic process
|
992.22 | 3.20 | 772 | 12,157 |
|
vesicle
|
326.98 | 1.65 | 933 | 44,584 |
|
atrioventricular canal development
|
1,715.08 | 0.92 | 127 | 1,157 |
|
hyaluranon cable
|
8,623.53 | 0.79 | 101 | 183 |
|
positive regulation of hyaluranon cable assembly
|
5,656.30 | 0.78 | 101 | 279 |
|
positive regulation of monocyte aggregation
|
5,890.31 | 0.74 | 95 | 252 |
|
cellular response to platelet-derived growth factor stimulus
|
1,412.58 | 0.71 | 98 | 1,084 |
| Totals | 58382 | 4184547 | ||
No co-occurrence statistics for GO:0030213 based on MANUAL annotations
The top 100 of 251 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
hyaluronan biosynthetic process
|
12,710.01 | 100.00 | 111 | 111 |
|
hyaluronan synthase activity
|
12,587.80 | 91.96 | 103 | 104 |
|
extracellular matrix assembly
|
6,106.49 | 42.16 | 86 | 179 |
|
polysaccharide biosynthetic process
|
2,376.22 | 17.73 | 86 | 460 |
|
renal water absorption
|
4,682.64 | 14.29 | 21 | 57 |
|
positive regulation of urine volume
|
3,511.98 | 12.65 | 21 | 76 |
|
endocardial cushion to mesenchymal transition
|
4,942.78 | 5.74 | 7 | 18 |
|
atrioventricular canal development
|
1,495.30 | 4.68 | 8 | 68 |
|
hyaluranon cable
|
3,177.50 | 3.97 | 5 | 20 |
|
positive regulation of hyaluranon cable assembly
|
2,647.92 | 3.85 | 5 | 24 |
| Totals | 618 | 5972 | ||
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2025-02-22 | Added | DEFINITION | The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine. |
| 2025-02-22 | Deleted | DEFINITION | The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. |
| 2024-12-05 | Added | XREF | Reactome:R-HSA-2142850 |
| 2020-11-03 | Deleted | RELATION | is a GO:0046394 (carboxylic acid biosynthetic process) |
| 2017-04-06 | Added | RELATION | is a GO:0046394 (carboxylic acid biosynthetic process) |
| 2008-05-13 | Added | DEFINITION | The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. |
| 2008-05-12 | Deleted | DEFINITION | The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. |
| 2008-04-01 | Updated | RELATION | is a GO:0006024 (glycosaminoglycan biosynthetic process) |
| 2008-04-01 | Updated | RELATION | is a GO:0030212 (hyaluronan metabolic process) |
| 2007-08-09 | Added | SYNONYM | hyaluronan synthesis |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2007-01-15 | Updated | TERM | hyaluronan biosynthetic process |
| 2001-09-01 | Added | TERM | hyaluronan biosynthesis |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2025-02-22 | Added | DEFINITION | The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine. |
| 2025-02-22 | Deleted | DEFINITION | The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. |
| 2008-05-13 | Added | DEFINITION | The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. |
| 2008-05-12 | Deleted | DEFINITION | The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. |
| 2007-08-09 | Added | SYNONYM | hyaluronan synthesis |
| 2007-08-09 | Deleted | SYNONYM | hyaluronan synthesis |
| 2007-08-09 | Deleted | SYNONYM | hyaluronan formation |
| 2007-08-09 | Deleted | SYNONYM | hyaluronan anabolism |
| 2007-08-09 | Deleted | SYNONYM | hyaluronan biosynthesis |
| 2007-08-09 | Added | SYNONYM | hyaluronan formation |
| 2007-08-09 | Added | SYNONYM | hyaluronan biosynthesis |
| 2007-08-09 | Added | SYNONYM | hyaluronan anabolism |
| 2007-01-15 | Added | SYNONYM | hyaluronan biosynthesis |
| 2006-05-04 | Updated | DEFINITION | The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. |
| 2005-08-10 | Added | SYNONYM | hyaluronan formation |
| 2005-08-10 | Added | SYNONYM | hyaluronan synthesis |
| 2005-08-10 | Added | SYNONYM | hyaluronan anabolism |
| 2003-10-24 | Updated | DEFINITION | The formation from simpler components of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. |
| 2002-11-27 | Added | DEFINITION | The formation from simpler components of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta1->4 linked D-glucuronyl-(beta1->3)-N-acetyl-D-glucosamine. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2020-11-03 | Deleted | RELATION | is a GO:0046394 (carboxylic acid biosynthetic process) |
| 2017-04-06 | Added | RELATION | is a GO:0046394 (carboxylic acid biosynthetic process) |
| 2008-04-01 | Updated | RELATION | is a GO:0006024 (glycosaminoglycan biosynthetic process) |
| 2008-04-01 | Updated | RELATION | is a GO:0030212 (hyaluronan metabolic process) |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-12-05 | Added | XREF | Reactome:R-HSA-2142850 |
| Timestamp | Action | Category | Detail |
|---|
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