This term is obsolete.

GO:0030225 JSON

macrophage differentiation

Biological Process

Definition (GO:0030225 GONUTS page)

The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.

3,816 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
macrophage cell differentiation exact

Ancestor Chart

Ancestor chart for GO:0030225
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0030225

Child Term Relationship to
GO:0030225
negative regulation of macrophage differentiation
negatively_regulates
positive regulation of macrophage differentiation
positively_regulates
regulation of macrophage differentiation
regulates
microglia differentiation
is_a

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0030225 macrophage differentiation Only in Taxon 7742 Vertebrata

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A8XY28 6238 A8XY28_CAEBR GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PL19 6945 B7PL19_IXOSC GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PVH4 6945 B7PVH4_IXOSC GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein E9PTS6 10116 E9PTS6_RAT GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein O16262 6239 NIPI4_CAEEL GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P01127 9606 PDGFB_HUMAN GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11264163
NOT-qualified manual protein P05622 10090 PGFRB_MOUSE GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11264163
NOT-qualified manual protein P12919 9685 PDGFB_FELCA GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein P31240 10090 PDGFB_MOUSE GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q05028 10116 PDGFB_RAT GO:0030097 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096

Cross-Ontology Relations

Relation Other Ontology ID Term
results_in_acquisition_of_features_of CL CL:0000235 macrophage

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0030225 based on ALL annotations
The top 100 of 1,908 co-occurring terms
Co-occurring Term PR S% #Together #Compared
macrophage differentiation
85,008.52 100.00 2,331 2,331
granulocyte differentiation
26,833.68 12.07 381 1,207
neutrophil differentiation
23,559.50 11.61 388 1,400
monocyte differentiation
20,577.26 11.23 404 1,669
myeloid cell differentiation
10,444.80 8.90 569 4,631
nephric duct formation
55,582.50 7.70 187 286
positive regulation of interleukin-5 production
18,617.16 6.29 189 863
ureter morphogenesis
22,932.53 6.21 174 645
positive regulation of interleukin-23 production
28,278.70 6.17 164 493
mesonephros development
14,651.24 5.79 187 1,085
Totals 14764 62380
No co-occurrence statistics for GO:0030225 based on MANUAL annotations
The top 100 of 1,683 co-occurring terms
Co-occurring Term PR S% #Together #Compared
macrophage differentiation
7,629.91 100.00 185 185
monocyte differentiation
2,353.91 11.60 29 94
myeloid cell differentiation
1,232.52 10.42 42 260
vascular endothelial growth factor receptor 1 binding
6,539.92 9.57 18 21
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
5,639.50 8.90 17 23
posterior lateral line ganglion development
7,629.91 8.65 16 16
posterior lateral line nerve development
7,181.09 8.60 16 17
endothelial cell chemotaxis
3,051.96 8.49 18 45
positive regulation of positive chemotaxis
2,985.62 8.45 18 46
neutrophil differentiation
2,062.14 8.37 20 74
Totals 1496 12320

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:7742 (Vertebrata)
2024-03-21 Added RELATION is a GO:1903131 (mononuclear cell differentiation)
2020-02-28 Deleted XREF MIPS_funcat:43.03.09.05
2019-05-04 Added XREF MIPS_funcat:43.03.09.05
2010-12-17 Deleted DEFINITION The process whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage.
2010-12-17 Added DEFINITION The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.
2008-05-13 Added DEFINITION The process whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage.
2008-05-12 Deleted DEFINITION The process whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage.
2008-04-01 Updated RELATION is a GO:0002573 (myeloid leukocyte differentiation)
2007-08-09 Deleted SYNONYM macrophage cell differentiation
Timestamp Action Category Detail
2005-02-21 Updated TERM macrophage differentiation
2005-01-13 Updated TERM macrophage cell differentiation
2001-09-05 Added TERM macrophage differentiation
Timestamp Action Category Detail
2010-12-17 Deleted DEFINITION The process whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage.
2010-12-17 Added DEFINITION The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.
2008-05-13 Added DEFINITION The process whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage.
2008-05-12 Deleted DEFINITION The process whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage.
2007-08-09 Deleted SYNONYM macrophage cell differentiation
2007-08-09 Added SYNONYM macrophage cell differentiation
2005-06-30 Updated DEFINITION The process whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage.
2005-02-21 Added SYNONYM macrophage cell differentiation
2005-02-19 Updated DEFINITION Processes whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage.
2005-01-21 Updated DEFINITION Processes whereby a relatively unspecialized monocyte cell acquires the specialized features of a macrophage cell.
2004-04-22 Updated DEFINITION The process by which a monocyte differentiates into a macrophage.
2002-11-27 Added DEFINITION The process by which a myeloid precursor cell acquires specializes features of a monocyte and then differentiates further into a macrophage.
Timestamp Action Category Detail
2024-03-21 Added RELATION is a GO:1903131 (mononuclear cell differentiation)
2008-04-01 Updated RELATION is a GO:0002573 (myeloid leukocyte differentiation)
Timestamp Action Category Detail
2020-02-28 Deleted XREF MIPS_funcat:43.03.09.05
2019-05-04 Added XREF MIPS_funcat:43.03.09.05
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:7742 (Vertebrata)
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