GO:0030225
JSON
macrophage differentiation
Biological Process
Definition (GO:0030225 GONUTS page)
The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
macrophage cell differentiation | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0030225
Child Term | Relationship to GO:0030225 |
---|---|
negative regulation of macrophage differentiation
|
negatively_regulates |
positive regulation of macrophage differentiation
|
positively_regulates |
regulation of macrophage differentiation
|
regulates |
microglia differentiation
|
is_a |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0030225 | macrophage differentiation | Only in Taxon | 7742 | Vertebrata |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A8XY28 | 6238 | A8XY28_CAEBR | GO:0030154 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | B7PL19 | 6945 | B7PL19_IXOSC | GO:0030154 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | B7PVH4 | 6945 | B7PVH4_IXOSC | GO:0030154 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | E9PTS6 | 10116 | E9PTS6_RAT | GO:0030097 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | O16262 | 6239 | NIPI4_CAEEL | GO:0030154 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P01127 | 9606 | PDGFB_HUMAN | GO:0030097 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11264163 | |
NOT-qualified manual | protein | P05622 | 10090 | PGFRB_MOUSE | GO:0030097 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11264163 | |
NOT-qualified manual | protein | P12919 | 9685 | PDGFB_FELCA | GO:0030097 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | P31240 | 10090 | PDGFB_MOUSE | GO:0030097 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q05028 | 10116 | PDGFB_RAT | GO:0030097 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
results_in_acquisition_of_features_of | CL | CL:0000235 | macrophage |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0030225 based on ALL annotations
The top 100 of 1,908 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
macrophage differentiation
|
85,008.52 | 100.00 | 2,331 | 2,331 |
granulocyte differentiation
|
26,833.68 | 12.07 | 381 | 1,207 |
neutrophil differentiation
|
23,559.50 | 11.61 | 388 | 1,400 |
monocyte differentiation
|
20,577.26 | 11.23 | 404 | 1,669 |
myeloid cell differentiation
|
10,444.80 | 8.90 | 569 | 4,631 |
nephric duct formation
|
55,582.50 | 7.70 | 187 | 286 |
positive regulation of interleukin-5 production
|
18,617.16 | 6.29 | 189 | 863 |
ureter morphogenesis
|
22,932.53 | 6.21 | 174 | 645 |
positive regulation of interleukin-23 production
|
28,278.70 | 6.17 | 164 | 493 |
mesonephros development
|
14,651.24 | 5.79 | 187 | 1,085 |
Totals | 14764 | 62380 |
No co-occurrence statistics for GO:0030225 based on MANUAL annotations
The top 100 of 1,683 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
macrophage differentiation
|
7,629.91 | 100.00 | 185 | 185 |
monocyte differentiation
|
2,353.91 | 11.60 | 29 | 94 |
myeloid cell differentiation
|
1,232.52 | 10.42 | 42 | 260 |
vascular endothelial growth factor receptor 1 binding
|
6,539.92 | 9.57 | 18 | 21 |
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
|
5,639.50 | 8.90 | 17 | 23 |
posterior lateral line ganglion development
|
7,629.91 | 8.65 | 16 | 16 |
posterior lateral line nerve development
|
7,181.09 | 8.60 | 16 | 17 |
endothelial cell chemotaxis
|
3,051.96 | 8.49 | 18 | 45 |
positive regulation of positive chemotaxis
|
2,985.62 | 8.45 | 18 | 46 |
neutrophil differentiation
|
2,062.14 | 8.37 | 20 | 74 |
Totals | 1496 | 12320 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:7742 (Vertebrata) |
2024-03-21 | Added | RELATION | is a GO:1903131 (mononuclear cell differentiation) |
2020-02-28 | Deleted | XREF | MIPS_funcat:43.03.09.05 |
2019-05-04 | Added | XREF | MIPS_funcat:43.03.09.05 |
2010-12-17 | Deleted | DEFINITION | The process whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage. |
2010-12-17 | Added | DEFINITION | The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. |
2008-05-13 | Added | DEFINITION | The process whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage. |
2008-05-12 | Deleted | DEFINITION | The process whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage. |
2008-04-01 | Updated | RELATION | is a GO:0002573 (myeloid leukocyte differentiation) |
2007-08-09 | Deleted | SYNONYM | macrophage cell differentiation |
Timestamp | Action | Category | Detail |
---|---|---|---|
2005-02-21 | Updated | TERM | macrophage differentiation |
2005-01-13 | Updated | TERM | macrophage cell differentiation |
2001-09-05 | Added | TERM | macrophage differentiation |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-12-17 | Deleted | DEFINITION | The process whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage. |
2010-12-17 | Added | DEFINITION | The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. |
2008-05-13 | Added | DEFINITION | The process whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage. |
2008-05-12 | Deleted | DEFINITION | The process whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage. |
2007-08-09 | Deleted | SYNONYM | macrophage cell differentiation |
2007-08-09 | Added | SYNONYM | macrophage cell differentiation |
2005-06-30 | Updated | DEFINITION | The process whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage. |
2005-02-21 | Added | SYNONYM | macrophage cell differentiation |
2005-02-19 | Updated | DEFINITION | Processes whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage. |
2005-01-21 | Updated | DEFINITION | Processes whereby a relatively unspecialized monocyte cell acquires the specialized features of a macrophage cell. |
2004-04-22 | Updated | DEFINITION | The process by which a monocyte differentiates into a macrophage. |
2002-11-27 | Added | DEFINITION | The process by which a myeloid precursor cell acquires specializes features of a monocyte and then differentiates further into a macrophage. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-21 | Added | RELATION | is a GO:1903131 (mononuclear cell differentiation) |
2008-04-01 | Updated | RELATION | is a GO:0002573 (myeloid leukocyte differentiation) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-02-28 | Deleted | XREF | MIPS_funcat:43.03.09.05 |
2019-05-04 | Added | XREF | MIPS_funcat:43.03.09.05 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:7742 (Vertebrata) |
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