GO:0030316
JSON
osteoclast differentiation
Biological Process
Definition (GO:0030316 GONUTS page)
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. PMID:12161749
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
osteoclast cell differentiation | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0030316
Child Term | Relationship to GO:0030316 |
---|---|
osteoclast development
|
part_of |
positive regulation of osteoclast differentiation
|
positively_regulates |
multinuclear osteoclast differentiation
|
is_a |
regulation of osteoclast differentiation
|
regulates |
negative regulation of osteoclast differentiation
|
negatively_regulates |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0030316 | osteoclast differentiation | Only in Taxon | 7742 | Vertebrata |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A8XY28 | 6238 | A8XY28_CAEBR | GO:0030154 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | B7PL19 | 6945 | B7PL19_IXOSC | GO:0030154 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | B7PVH4 | 6945 | B7PVH4_IXOSC | GO:0030154 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | E9PTS6 | 10116 | E9PTS6_RAT | GO:0030097 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | O16262 | 6239 | NIPI4_CAEEL | GO:0030154 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P01127 | 9606 | PDGFB_HUMAN | GO:0030097 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11264163 | |
NOT-qualified manual | protein | P05622 | 10090 | PGFRB_MOUSE | GO:0030097 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11264163 | |
NOT-qualified manual | protein | P12919 | 9685 | PDGFB_FELCA | GO:0030097 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | P31240 | 10090 | PDGFB_MOUSE | GO:0030097 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q05028 | 10116 | PDGFB_RAT | GO:0030097 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
results_in_acquisition_of_features_of | CL | CL:0000092 | osteoclast |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0030316 based on ALL annotations
The top 100 of 2,141 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
osteoclast differentiation
|
25,637.84 | 100.00 | 7,729 | 7,729 |
CSF1-CSF1R complex
|
25,622.01 | 20.94 | 1,619 | 1,620 |
regulation of MAPK cascade
|
4,584.21 | 10.62 | 1,603 | 8,965 |
cellular response to interleukin-6
|
14,365.75 | 10.38 | 873 | 1,558 |
cytokine binding
|
3,762.23 | 9.24 | 1,542 | 10,508 |
positive regulation of osteoclast differentiation
|
7,372.52 | 8.59 | 844 | 2,935 |
macrophage activation involved in immune response
|
5,313.34 | 8.43 | 961 | 4,637 |
positive regulation of macrophage differentiation
|
7,945.84 | 7.67 | 715 | 2,307 |
bone remodeling
|
5,911.14 | 7.51 | 774 | 3,357 |
growth factor binding
|
1,977.42 | 6.00 | 1,643 | 21,302 |
Totals | 61893 | 1293282 |
No co-occurrence statistics for GO:0030316 based on MANUAL annotations
The top 100 of 1,991 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
osteoclast differentiation
|
5,114.25 | 100.00 | 276 | 276 |
osteoclast proliferation
|
4,529.76 | 11.07 | 31 | 35 |
bone remodeling
|
1,841.13 | 10.59 | 36 | 100 |
positive regulation of osteoclast differentiation
|
1,349.59 | 9.95 | 38 | 144 |
CSF1-CSF1R complex
|
5,114.25 | 9.42 | 26 | 26 |
bone resorption
|
1,258.89 | 8.56 | 32 | 130 |
macrophage colony-stimulating factor receptor activity
|
4,705.11 | 8.27 | 23 | 25 |
tooth eruption
|
4,200.99 | 8.19 | 23 | 28 |
macrophage activation involved in immune response
|
1,065.47 | 6.74 | 25 | 120 |
cellular response to interleukin-6
|
922.24 | 5.85 | 22 | 122 |
Totals | 1800 | 9929 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:7742 (Vertebrata) |
2011-02-24 | Deleted | DEFINITION | The process in which a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell. |
2011-02-24 | Added | DEFINITION | The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. |
2010-12-17 | Deleted | DEFINITION | The process whereby a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell. |
2010-12-17 | Added | DEFINITION | The process in which a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell. |
2008-05-13 | Added | DEFINITION | The process whereby a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell. |
2008-05-12 | Deleted | DEFINITION | The process whereby a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell. |
2008-04-01 | Updated | RELATION | is a GO:0002573 (myeloid leukocyte differentiation) |
2007-08-09 | Deleted | SYNONYM | osteoclast cell differentiation |
2007-08-09 | Added | SYNONYM | osteoclast cell differentiation |
Timestamp | Action | Category | Detail |
---|---|---|---|
2005-02-21 | Updated | TERM | osteoclast differentiation |
2005-01-13 | Updated | TERM | osteoclast cell differentiation |
2001-10-03 | Added | TERM | osteoclast differentiation |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-02-24 | Deleted | DEFINITION | The process in which a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell. |
2011-02-24 | Added | DEFINITION | The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. |
2010-12-17 | Deleted | DEFINITION | The process whereby a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell. |
2010-12-17 | Added | DEFINITION | The process in which a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell. |
2008-05-13 | Added | DEFINITION | The process whereby a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell. |
2008-05-12 | Deleted | DEFINITION | The process whereby a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell. |
2007-08-09 | Deleted | SYNONYM | osteoclast cell differentiation |
2007-08-09 | Added | SYNONYM | osteoclast cell differentiation |
2005-06-30 | Updated | DEFINITION | The process whereby a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell. |
2005-02-21 | Added | SYNONYM | osteoclast cell differentiation |
2005-02-19 | Updated | DEFINITION | Processes whereby a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell. |
2005-01-21 | Updated | DEFINITION | Processes whereby a relatively unspecialized monocyte cell acquires the specialized features of a osteoclast cell. |
2004-07-24 | Updated | DEFINITION | The process by which a monocyte differentiates into an osteoclast. |
2004-04-24 | Updated | DEFINITION | The process by which a moncyte differentiates into an osteoclast. |
2002-11-27 | Added | DEFINITION | The process whereby a relatively unspecialized cell acquires specialized features of an osteoclast. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0002573 (myeloid leukocyte differentiation) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:7742 (Vertebrata) |
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link