This term is obsolete.

GO:0030316 JSON

osteoclast differentiation

Biological Process

Definition (GO:0030316 GONUTS page)

The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. PMID:12161749

11,056 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
osteoclast cell differentiation exact

Ancestor Chart

Ancestor chart for GO:0030316
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0030316

Child Term Relationship to
GO:0030316
osteoclast development
part_of
positive regulation of osteoclast differentiation
positively_regulates
multinuclear osteoclast differentiation
is_a
regulation of osteoclast differentiation
regulates
negative regulation of osteoclast differentiation
negatively_regulates

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0030316 osteoclast differentiation Only in Taxon 7742 Vertebrata

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A8XY28 6238 A8XY28_CAEBR GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PL19 6945 B7PL19_IXOSC GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PVH4 6945 B7PVH4_IXOSC GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein E9PTS6 10116 E9PTS6_RAT GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein O16262 6239 NIPI4_CAEEL GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P01127 9606 PDGFB_HUMAN GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11264163
NOT-qualified manual protein P05622 10090 PGFRB_MOUSE GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11264163
NOT-qualified manual protein P12919 9685 PDGFB_FELCA GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein P31240 10090 PDGFB_MOUSE GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q05028 10116 PDGFB_RAT GO:0030097 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096

Cross-Ontology Relations

Relation Other Ontology ID Term
results_in_acquisition_of_features_of CL CL:0000092 osteoclast

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0030316 based on ALL annotations
The top 100 of 2,141 co-occurring terms
Co-occurring Term PR S% #Together #Compared
osteoclast differentiation
25,637.84 100.00 7,729 7,729
CSF1-CSF1R complex
25,622.01 20.94 1,619 1,620
regulation of MAPK cascade
4,584.21 10.62 1,603 8,965
cellular response to interleukin-6
14,365.75 10.38 873 1,558
cytokine binding
3,762.23 9.24 1,542 10,508
positive regulation of osteoclast differentiation
7,372.52 8.59 844 2,935
macrophage activation involved in immune response
5,313.34 8.43 961 4,637
positive regulation of macrophage differentiation
7,945.84 7.67 715 2,307
bone remodeling
5,911.14 7.51 774 3,357
growth factor binding
1,977.42 6.00 1,643 21,302
Totals 61893 1293282
No co-occurrence statistics for GO:0030316 based on MANUAL annotations
The top 100 of 1,991 co-occurring terms
Co-occurring Term PR S% #Together #Compared
osteoclast differentiation
5,114.25 100.00 276 276
osteoclast proliferation
4,529.76 11.07 31 35
bone remodeling
1,841.13 10.59 36 100
positive regulation of osteoclast differentiation
1,349.59 9.95 38 144
CSF1-CSF1R complex
5,114.25 9.42 26 26
bone resorption
1,258.89 8.56 32 130
macrophage colony-stimulating factor receptor activity
4,705.11 8.27 23 25
tooth eruption
4,200.99 8.19 23 28
macrophage activation involved in immune response
1,065.47 6.74 25 120
cellular response to interleukin-6
922.24 5.85 22 122
Totals 1800 9929

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:7742 (Vertebrata)
2011-02-24 Deleted DEFINITION The process in which a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell.
2011-02-24 Added DEFINITION The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
2010-12-17 Deleted DEFINITION The process whereby a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell.
2010-12-17 Added DEFINITION The process in which a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell.
2008-05-13 Added DEFINITION The process whereby a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell.
2008-05-12 Deleted DEFINITION The process whereby a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell.
2008-04-01 Updated RELATION is a GO:0002573 (myeloid leukocyte differentiation)
2007-08-09 Deleted SYNONYM osteoclast cell differentiation
2007-08-09 Added SYNONYM osteoclast cell differentiation
Timestamp Action Category Detail
2005-02-21 Updated TERM osteoclast differentiation
2005-01-13 Updated TERM osteoclast cell differentiation
2001-10-03 Added TERM osteoclast differentiation
Timestamp Action Category Detail
2011-02-24 Deleted DEFINITION The process in which a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell.
2011-02-24 Added DEFINITION The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
2010-12-17 Deleted DEFINITION The process whereby a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell.
2010-12-17 Added DEFINITION The process in which a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell.
2008-05-13 Added DEFINITION The process whereby a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell.
2008-05-12 Deleted DEFINITION The process whereby a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell.
2007-08-09 Deleted SYNONYM osteoclast cell differentiation
2007-08-09 Added SYNONYM osteoclast cell differentiation
2005-06-30 Updated DEFINITION The process whereby a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell.
2005-02-21 Added SYNONYM osteoclast cell differentiation
2005-02-19 Updated DEFINITION Processes whereby a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell.
2005-01-21 Updated DEFINITION Processes whereby a relatively unspecialized monocyte cell acquires the specialized features of a osteoclast cell.
2004-07-24 Updated DEFINITION The process by which a monocyte differentiates into an osteoclast.
2004-04-24 Updated DEFINITION The process by which a moncyte differentiates into an osteoclast.
2002-11-27 Added DEFINITION The process whereby a relatively unspecialized cell acquires specialized features of an osteoclast.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0002573 (myeloid leukocyte differentiation)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:7742 (Vertebrata)
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