GO:0030674
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protein-macromolecule adaptor activity
Molecular Function
Definition (GO:0030674 GONUTS page)
The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
protein complex scaffold activity | broad |
protein binding, bridging | exact |
protein-containing complex scaffold activity | broad |
protein-protein adaptor | narrow |
protein recruiting activity | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0030674
Child Term | Relationship to GO:0030674 |
---|---|
chromatin-protein adaptor activity
|
is_a |
molecular condensate scaffold activity
|
is_a |
protein-RNA adaptor activity
|
is_a |
protein-membrane adaptor activity
|
is_a |
microtubule site clamp
|
is_a |
RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity
|
is_a |
cytoskeletal anchor activity
|
is_a |
soluble NSF attachment protein activity
|
is_a |
ubiquitin-like protein reader activity
|
is_a |
signaling adaptor activity
|
is_a |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | Q61387 | 10090 | CO72L_MOUSE | GO:0030674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:27775717 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR007131 | SLA1 homology domain 1, SHD1 |
InterPro | IPR022768 | Fascin domain |
InterPro | IPR024703 | Fascin, metazoans |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0003780 | obsolete actin cross-linking activity | consider GO:0030674 |
GO:0008077 | obsolete Hsp70/Hsp90 organizing protein activity | consider GO:0030674 |
GO:0008546 | obsolete microtubule/chromatin interaction | consider GO:0030674 |
GO:0015472 | obsolete fimbrium-specific chaperone activity | consider GO:0030674 |
GO:0030022 | obsolete adhesive extracellular matrix constituent | consider GO:0030674 |
GO:0030400 | obsolete protease substrate recruitment factor activity | consider GO:0030674 |
GO:0035656 | obsolete kinesin-associated melanosomal adaptor activity | consider GO:0030674 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0030674 based on ALL annotations
The top 100 of 3,763 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein-macromolecule adaptor activity
|
2,042.31 | 100.00 | 95,450 | 95,450 |
fibrinogen complex
|
1,931.72 | 9.72 | 9,327 | 9,861 |
Bam protein complex
|
776.16 | 9.70 | 10,993 | 28,926 |
positive regulation of heterotypic cell-cell adhesion
|
1,882.99 | 9.69 | 9,325 | 10,114 |
organelle fusion
|
2,001.52 | 9.59 | 9,175 | 9,362 |
fibrinolysis
|
1,339.28 | 9.29 | 9,325 | 14,220 |
vesicle docking involved in exocytosis
|
1,315.22 | 9.12 | 9,171 | 14,241 |
blood coagulation, common pathway
|
2,040.83 | 8.64 | 8,245 | 8,251 |
ubiquitin-dependent endocytosis
|
1,665.66 | 8.48 | 8,252 | 10,118 |
HOPS complex
|
710.52 | 8.14 | 9,172 | 26,364 |
Totals | 526310 | 9808520 |
No co-occurrence statistics for GO:0030674 based on MANUAL annotations
The top 100 of 3,054 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein-macromolecule adaptor activity
|
544.83 | 100.00 | 2,371 | 2,371 |
organelle fusion
|
525.88 | 9.33 | 222 | 230 |
vesicle docking involved in exocytosis
|
238.57 | 8.36 | 222 | 507 |
HOPS complex
|
188.43 | 7.92 | 221 | 639 |
endosome organization
|
124.13 | 7.20 | 226 | 992 |
vacuole organization
|
148.31 | 6.69 | 193 | 709 |
TORC1 complex
|
270.69 | 6.21 | 157 | 316 |
positive regulation of cell growth
|
157.31 | 5.91 | 164 | 568 |
cellular response to amino acid stimulus
|
122.43 | 5.47 | 160 | 712 |
phosphatidylinositol 3-kinase binding
|
260.85 | 4.95 | 124 | 259 |
Totals | 10678 | 219123 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_yeast | 163 |
goslim_chembl | 296 |
Change Log
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- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-07-16 | Added | SYNONYM | protein complex scaffold activity |
2024-07-16 | Added | SYNONYM | protein-containing complex scaffold activity |
2022-08-30 | Added | SYNONYM | protein recruiting activity |
2022-01-12 | Deleted | SUBSET | goslim_generic |
2020-09-17 | Added | DEFINITION | The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
2020-09-17 | Deleted | DEFINITION | The binding activity of a protein that brings together two macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
2020-07-19 | Deleted | RELATION | is a GO:0005515 (protein binding) |
2020-07-05 | Added | DEFINITION | The binding activity of a protein that brings together two macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
2020-07-05 | Deleted | DEFINITION | The binding activity of a protein that brings together another macromolecule in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
2020-02-07 | Updated | TERM | protein-macromolecule adaptor activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-02-07 | Updated | TERM | protein-macromolecule adaptor activity |
2003-06-10 | Updated | TERM | protein binding, bridging |
2003-04-23 | Updated | TERM | protein binding activity, bridging |
2003-04-18 | Added | TERM | protein binding, bridging |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-07-16 | Added | SYNONYM | protein complex scaffold activity |
2024-07-16 | Added | SYNONYM | protein-containing complex scaffold activity |
2022-08-30 | Added | SYNONYM | protein recruiting activity |
2020-09-17 | Added | DEFINITION | The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
2020-09-17 | Deleted | DEFINITION | The binding activity of a protein that brings together two macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
2020-07-05 | Added | DEFINITION | The binding activity of a protein that brings together two macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
2020-07-05 | Deleted | DEFINITION | The binding activity of a protein that brings together another macromolecule in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
2020-02-07 | Added | DEFINITION | The binding activity of a protein that brings together another macromolecule in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
2020-02-07 | Added | SYNONYM | protein binding, bridging |
2020-02-07 | Deleted | DEFINITION | The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. |
2012-10-29 | Deleted | DEFINITION | The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, permitting those molecules to function in a coordinated way. |
2012-10-29 | Added | DEFINITION | The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. |
2010-12-03 | Deleted | SYNONYM | protein-protein adaptor |
2010-12-03 | Added | DEFINITION | The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, permitting those molecules to function in a coordinated way. |
2010-12-03 | Deleted | DEFINITION | Interacting selectively and non-covalently with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other. |
2010-12-03 | Added | SYNONYM | protein-protein adaptor |
2009-07-03 | Deleted | DEFINITION | Interacting selectively with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other. |
2009-07-03 | Added | DEFINITION | Interacting selectively and non-covalently with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other. |
2008-05-13 | Added | DEFINITION | Interacting selectively with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other. |
2008-05-12 | Deleted | DEFINITION | Interacting selectively with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other. |
2007-08-09 | Deleted | SYNONYM | protein-protein adaptor |
2007-08-09 | Added | SYNONYM | protein-protein adaptor |
2006-02-09 | Deleted | SYNONYM | fimbrium-specific chaperone activity |
2006-02-09 | Deleted | SYNONYM | adhesive extracellular matrix constituent |
2006-02-09 | Deleted | SYNONYM | microtubule/chromatin interaction |
2006-02-09 | Deleted | SYNONYM | protease substrate recruitment factor activity |
2006-02-09 | Deleted | SYNONYM | Hsp70/Hsp90 organizing protein activity |
2006-02-09 | Deleted | SYNONYM | actin cross-linking activity |
2005-08-10 | Added | SYNONYM | microtubule/chromatin interaction |
2005-08-10 | Added | SYNONYM | adhesive extracellular matrix constituent |
2005-08-10 | Added | SYNONYM | actin cross-linking activity |
2005-08-10 | Added | SYNONYM | fimbrium-specific chaperone activity |
2005-08-10 | Added | SYNONYM | protease substrate recruitment factor activity |
2005-08-10 | Added | SYNONYM | Hsp70/Hsp90 organizing protein activity |
2005-03-19 | Updated | DEFINITION | Interacting selectively with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other. |
2003-04-23 | Updated | DEFINITION | Interacting selectively with two or more protein molecules, or a protein and another macromolecule or complex simultaneously, thereby physically linking the bound proteins or complexes to each other. |
2003-04-18 | Added | DEFINITION | Interacting selectively with two or more protein molecules, or a protein and another macromelecule or complex simultaneously, thereby physically linking the bound proteins or complexes to each other. |
2003-04-18 | Added | SYNONYM | protein-protein adaptor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-07-19 | Deleted | RELATION | is a GO:0005515 (protein binding) |
2019-04-18 | Deleted | RELATION | has part GO:0140312 (cargo adaptor activity) |
2019-04-01 | Added | RELATION | has part GO:0140312 (cargo adaptor activity) |
2011-08-21 | Deleted | RELATION | has part GO:0000988 (obsolete transcription factor activity, protein binding) |
2011-06-05 | Added | RELATION | has part GO:0000988 (obsolete transcription factor activity, protein binding) |
2010-12-03 | Added | RELATION | is a GO:0060090 (molecular adaptor activity) |
2008-04-01 | Updated | RELATION | is a GO:0005515 (protein binding) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-01-12 | Deleted | SUBSET | goslim_generic |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
2013-04-18 | Updated | SUBSET | goslim_yeast |
2013-04-18 | Updated | SUBSET | goslim_generic |
2012-02-10 | Added | SUBSET | goslim_generic |
2011-08-14 | Added | SUBSET | goslim_yeast |
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