This term is obsolete.

GO:0030674 JSON

protein-macromolecule adaptor activity

Molecular Function

Definition (GO:0030674 GONUTS page)

The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.

1,032,570 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
protein complex scaffold activity broad
protein binding, bridging exact
protein-containing complex scaffold activity broad
protein-protein adaptor narrow
protein recruiting activity related

Ancestor Chart

Ancestor chart for GO:0030674
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0030674

Child Term Relationship to
GO:0030674
chromatin-protein adaptor activity
is_a
molecular condensate scaffold activity
is_a
protein-RNA adaptor activity
is_a
protein-membrane adaptor activity
is_a
microtubule site clamp
is_a
RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity
is_a
cytoskeletal anchor activity
is_a
soluble NSF attachment protein activity
is_a
ubiquitin-like protein reader activity
is_a
signaling adaptor activity
is_a

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein Q61387 10090 CO72L_MOUSE GO:0030674 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:27775717

Cross-references

Database ID Description
InterPro IPR007131 SLA1 homology domain 1, SHD1
InterPro IPR022768 Fascin domain
InterPro IPR024703 Fascin, metazoans

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0003780 obsolete actin cross-linking activity consider GO:0030674
GO:0008077 obsolete Hsp70/Hsp90 organizing protein activity consider GO:0030674
GO:0008546 obsolete microtubule/chromatin interaction consider GO:0030674
GO:0015472 obsolete fimbrium-specific chaperone activity consider GO:0030674
GO:0030022 obsolete adhesive extracellular matrix constituent consider GO:0030674
GO:0030400 obsolete protease substrate recruitment factor activity consider GO:0030674
GO:0035656 obsolete kinesin-associated melanosomal adaptor activity consider GO:0030674

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0030674 based on ALL annotations
The top 100 of 3,763 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein-macromolecule adaptor activity
2,042.31 100.00 95,450 95,450
fibrinogen complex
1,931.72 9.72 9,327 9,861
Bam protein complex
776.16 9.70 10,993 28,926
positive regulation of heterotypic cell-cell adhesion
1,882.99 9.69 9,325 10,114
organelle fusion
2,001.52 9.59 9,175 9,362
fibrinolysis
1,339.28 9.29 9,325 14,220
vesicle docking involved in exocytosis
1,315.22 9.12 9,171 14,241
blood coagulation, common pathway
2,040.83 8.64 8,245 8,251
ubiquitin-dependent endocytosis
1,665.66 8.48 8,252 10,118
HOPS complex
710.52 8.14 9,172 26,364
Totals 526310 9808520
No co-occurrence statistics for GO:0030674 based on MANUAL annotations
The top 100 of 3,054 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein-macromolecule adaptor activity
544.83 100.00 2,371 2,371
organelle fusion
525.88 9.33 222 230
vesicle docking involved in exocytosis
238.57 8.36 222 507
HOPS complex
188.43 7.92 221 639
endosome organization
124.13 7.20 226 992
vacuole organization
148.31 6.69 193 709
TORC1 complex
270.69 6.21 157 316
positive regulation of cell growth
157.31 5.91 164 568
cellular response to amino acid stimulus
122.43 5.47 160 712
phosphatidylinositol 3-kinase binding
260.85 4.95 124 259
Totals 10678 219123

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_yeast 163
goslim_chembl 296

Change Log

Timestamp Action Category Detail
2024-07-16 Added SYNONYM protein complex scaffold activity
2024-07-16 Added SYNONYM protein-containing complex scaffold activity
2022-08-30 Added SYNONYM protein recruiting activity
2022-01-12 Deleted SUBSET goslim_generic
2020-09-17 Added DEFINITION The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
2020-09-17 Deleted DEFINITION The binding activity of a protein that brings together two macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
2020-07-19 Deleted RELATION is a GO:0005515 (protein binding)
2020-07-05 Added DEFINITION The binding activity of a protein that brings together two macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
2020-07-05 Deleted DEFINITION The binding activity of a protein that brings together another macromolecule in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
2020-02-07 Updated TERM protein-macromolecule adaptor activity
Timestamp Action Category Detail
2020-02-07 Updated TERM protein-macromolecule adaptor activity
2003-06-10 Updated TERM protein binding, bridging
2003-04-23 Updated TERM protein binding activity, bridging
2003-04-18 Added TERM protein binding, bridging
Timestamp Action Category Detail
2024-07-16 Added SYNONYM protein complex scaffold activity
2024-07-16 Added SYNONYM protein-containing complex scaffold activity
2022-08-30 Added SYNONYM protein recruiting activity
2020-09-17 Added DEFINITION The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
2020-09-17 Deleted DEFINITION The binding activity of a protein that brings together two macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
2020-07-05 Added DEFINITION The binding activity of a protein that brings together two macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
2020-07-05 Deleted DEFINITION The binding activity of a protein that brings together another macromolecule in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
2020-02-07 Added DEFINITION The binding activity of a protein that brings together another macromolecule in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
2020-02-07 Added SYNONYM protein binding, bridging
2020-02-07 Deleted DEFINITION The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
2012-10-29 Deleted DEFINITION The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, permitting those molecules to function in a coordinated way.
2012-10-29 Added DEFINITION The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
2010-12-03 Deleted SYNONYM protein-protein adaptor
2010-12-03 Added DEFINITION The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, permitting those molecules to function in a coordinated way.
2010-12-03 Deleted DEFINITION Interacting selectively and non-covalently with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other.
2010-12-03 Added SYNONYM protein-protein adaptor
2009-07-03 Deleted DEFINITION Interacting selectively with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other.
2008-05-13 Added DEFINITION Interacting selectively with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other.
2008-05-12 Deleted DEFINITION Interacting selectively with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other.
2007-08-09 Deleted SYNONYM protein-protein adaptor
2007-08-09 Added SYNONYM protein-protein adaptor
2006-02-09 Deleted SYNONYM fimbrium-specific chaperone activity
2006-02-09 Deleted SYNONYM adhesive extracellular matrix constituent
2006-02-09 Deleted SYNONYM microtubule/chromatin interaction
2006-02-09 Deleted SYNONYM protease substrate recruitment factor activity
2006-02-09 Deleted SYNONYM Hsp70/Hsp90 organizing protein activity
2006-02-09 Deleted SYNONYM actin cross-linking activity
2005-08-10 Added SYNONYM microtubule/chromatin interaction
2005-08-10 Added SYNONYM adhesive extracellular matrix constituent
2005-08-10 Added SYNONYM actin cross-linking activity
2005-08-10 Added SYNONYM fimbrium-specific chaperone activity
2005-08-10 Added SYNONYM protease substrate recruitment factor activity
2005-08-10 Added SYNONYM Hsp70/Hsp90 organizing protein activity
2005-03-19 Updated DEFINITION Interacting selectively with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other.
2003-04-23 Updated DEFINITION Interacting selectively with two or more protein molecules, or a protein and another macromolecule or complex simultaneously, thereby physically linking the bound proteins or complexes to each other.
2003-04-18 Added DEFINITION Interacting selectively with two or more protein molecules, or a protein and another macromelecule or complex simultaneously, thereby physically linking the bound proteins or complexes to each other.
2003-04-18 Added SYNONYM protein-protein adaptor
Timestamp Action Category Detail
2020-07-19 Deleted RELATION is a GO:0005515 (protein binding)
2019-04-18 Deleted RELATION has part GO:0140312 (cargo adaptor activity)
2019-04-01 Added RELATION has part GO:0140312 (cargo adaptor activity)
2011-08-21 Deleted RELATION has part GO:0000988 (obsolete transcription factor activity, protein binding)
2011-06-05 Added RELATION has part GO:0000988 (obsolete transcription factor activity, protein binding)
2010-12-03 Added RELATION is a GO:0060090 (molecular adaptor activity)
2008-04-01 Updated RELATION is a GO:0005515 (protein binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
2022-01-12 Deleted SUBSET goslim_generic
2015-05-19 Added SUBSET goslim_chembl
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-11 Added SUBSET goslim_ChEMBL
2013-04-18 Updated SUBSET goslim_yeast
2013-04-18 Updated SUBSET goslim_generic
2012-02-10 Added SUBSET goslim_generic
2011-08-14 Added SUBSET goslim_yeast
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