This term is obsolete.

GO:0031647 JSON

regulation of protein stability

Biological Process

Definition (GO:0031647 GONUTS page)

Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.

118,050 annotations

Ancestor Chart

Ancestor chart for GO:0031647
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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0031647

Child Term Relationship to
GO:0031647
GO:0031648
protein destabilization
is_a
GO:0036506
maintenance of unfolded protein
is_a
GO:0050821
protein stabilization
is_a

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5ZYZ0 10116 A0A8I5ZYZ0_RAT GO:0031647 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D4A3L4 10116 D4A3L4_RAT GO:0031647 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F1MA98 10116 TPR_RAT GO:0031647 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein F6ZDS4 10090 TPR_MOUSE GO:0031647 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein O18515 6087 O18515_HYDVU GO:0031647 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein P12270 9606 TPR_HUMAN GO:0031647 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:21613532
NOT-qualified manual protein Q07666 9606 KHDR1_HUMAN GO:0031647 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21613532
NOT-qualified manual protein Q5EE04 8355 TPR_XENLA GO:0031647 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q8BGE7 10090 TRIM6_MOUSE GO:0031647 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:22328504
NOT-qualified manual protein Q91V33 10116 KHDR1_RAT GO:0031647 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR014268 Glycosyltransferase-stabilising protein GtfB

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:1903992 obsolete regulation of protein stabilization consider GO:0031647

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0031647 based on ALL annotations
The top 100 of 2,758 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0031647
regulation of protein stability
11,355.58 100.00 17,450 17,450
GO:0101005
deubiquitinase activity
1,534.32 9.60 4,346 32,165
GO:0016579
protein deubiquitination
506.55 4.29 9,142 204,941
GO:0017122
protein N-acetylglucosaminyltransferase complex
5,456.58 4.05 740 1,540
GO:0004843
cysteine-type deubiquitinase activity
458.51 3.90 9,167 227,033
GO:0018242
protein O-linked glycosylation via serine
3,565.18 3.88 740 2,357
GO:0031648
protein destabilization
1,623.68 2.99 636 4,448
GO:0032435
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
651.19 1.84 461 8,039
GO:0019005
SCF ubiquitin ligase complex
211.86 1.59 1,676 89,833
GO:1900180
regulation of protein localization to nucleus
4,082.26 1.58 284 790
Totals 74484 1933758
No co-occurrence statistics for GO:0031647 based on MANUAL annotations
The top 100 of 2,477 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0031647
regulation of protein stability
580.40 100.00 2,432 2,432
GO:0004843
cysteine-type deubiquitinase activity
257.24 40.35 1,990 4,490
GO:0042981
regulation of apoptotic process
69.11 4.29 153 1,285
GO:0016579
protein deubiquitination
164.80 3.45 92 324
GO:0005829
cytosol
13.51 2.32 2,085 89,580
GO:0071108
protein K48-linked deubiquitination
160.26 1.46 37 134
GO:0010506
regulation of autophagy
23.50 1.38 50 1,235
GO:0050821
protein stabilization
15.78 1.33 62 2,281
GO:0090263
positive regulation of canonical Wnt signaling pathway
22.32 1.28 46 1,196
GO:0101005
deubiquitinase activity
31.14 1.25 39 727
Totals 11496 452864

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_pir 438

Change Log

Timestamp Action Category Detail
2015-06-11 Added DEFINITION Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
2015-06-11 Deleted DEFINITION Any process that affects the structure and integrity of a protein by altering the likelihood of its degradation or aggregation.
2015-04-30 Deleted RELATION is a GO:0010608 (post-transcriptional regulation of gene expression)
2013-04-18 Updated SUBSET goslim_pir
2009-10-07 Deleted RELATION is a GO:0019538 (protein metabolic process)
2009-06-25 Added RELATION is a GO:0065008 (regulation of biological quality)
2009-06-25 Deleted RELATION is a GO:0044267 (cellular protein metabolic process)
2009-06-25 Added RELATION is a GO:0019538 (protein metabolic process)
2008-06-09 Added SUBSET goslim_pir
2008-06-03 Deleted RELATION is a GO:0065008 (regulation of biological quality)
Timestamp Action Category Detail
2005-10-15 Added TERM regulation of protein stability
Timestamp Action Category Detail
2015-06-11 Added DEFINITION Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
2015-06-11 Deleted DEFINITION Any process that affects the structure and integrity of a protein by altering the likelihood of its degradation or aggregation.
2008-05-13 Added DEFINITION Any process that affects the structure and integrity of a protein by altering the likelihood of its degradation or aggregation.
2008-05-12 Deleted DEFINITION Any process that affects the structure and integrity of a protein by altering the likelihood of its degradation or aggregation.
2005-10-15 Added DEFINITION Any process that affects the structure and integrity of a protein by altering the likelihood of its degradation or aggregation.
Timestamp Action Category Detail
2015-04-30 Deleted RELATION is a GO:0010608 (post-transcriptional regulation of gene expression)
2009-10-07 Deleted RELATION is a GO:0019538 (protein metabolic process)
2009-06-25 Added RELATION is a GO:0065008 (regulation of biological quality)
2009-06-25 Deleted RELATION is a GO:0044267 (cellular protein metabolic process)
2009-06-25 Added RELATION is a GO:0019538 (protein metabolic process)
2008-06-03 Deleted RELATION is a GO:0065008 (regulation of biological quality)
2008-06-03 Added RELATION is a GO:0010608 (post-transcriptional regulation of gene expression)
2008-04-01 Updated RELATION is a GO:0044267 (cellular protein metabolic process)
2008-04-01 Updated RELATION is a GO:0065008 (regulation of biological quality)
Timestamp Action Category Detail
Timestamp Action Category Detail
2013-04-18 Updated SUBSET goslim_pir
2008-06-09 Added SUBSET goslim_pir
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