GO:0032389
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MutLalpha complex
Cellular Component
Definition (GO:0032389 GONUTS page)
A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
MutL-alpha complex | exact |
MLH1/PMS2 complex | exact |
MMR complex | broad |
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0032389 | MutLalpha complex | Only in Taxon | 2759 | Eukaryota |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q12175 | 559292 | MSH5_YEAST | GO:0032300 | Requested by InterPro in response to GO consortium request to blacklist since protein is not part of this complex. Reported by InterPro on 13th November, 2019. | IPR011184 |
NOT-qualified manual | protein | A0A096MJ18 | 10116 | A0A096MJ18_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A096MK97 | 10116 | A0A096MK97_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2JW23 | 10116 | A0A0G2JW23_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2K8T1 | 10116 | A0A0G2K8T1_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A1B0GR71 | 10090 | A0A1B0GR71_MOUSE | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636 | |
NOT-qualified manual | protein | A0A1B0GRK6 | 10090 | A0A1B0GRK6_MOUSE | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636 | |
NOT-qualified manual | protein | A0A1D8PHF8 | 237561 | A0A1D8PHF8_CANAL | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8760936 | |
NOT-qualified manual | protein | A0A1W2Q633 | 10116 | A0A1W2Q633_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5Y8H4 | 10116 | A0A8I5Y8H4_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0032389 based on ALL annotations
The top 100 of 252 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
MutLalpha complex
|
14,649.92 | 100.00 | 13,526 | 13,526 |
mismatch repair complex
|
3,521.36 | 24.04 | 13,524 | 56,264 |
meiosis I cell cycle process
|
4,266.25 | 16.89 | 3,881 | 13,327 |
somatic hypermutation of immunoglobulin genes
|
9,770.41 | 11.94 | 1,718 | 2,576 |
mismatched DNA binding
|
1,120.83 | 7.60 | 12,365 | 161,618 |
ATP-dependent DNA damage sensor activity
|
689.91 | 4.71 | 13,524 | 287,176 |
mismatch repair
|
636.16 | 4.34 | 13,526 | 311,488 |
DNA damage response
|
214.59 | 1.44 | 6,892 | 470,520 |
MutSalpha complex binding
|
4,522.80 | 1.32 | 184 | 596 |
positive regulation of isotype switching to IgG isotypes
|
2,749.12 | 1.07 | 152 | 810 |
Totals | 121959 | 62919598 |
No co-occurrence statistics for GO:0032389 based on MANUAL annotations
The top 79 of 79 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
MutLalpha complex
|
5,535.42 | 100.00 | 255 | 255 |
mismatch repair
|
931.09 | 16.82 | 255 | 1,516 |
somatic hypermutation of immunoglobulin genes
|
2,158.82 | 12.34 | 39 | 100 |
MutSalpha complex binding
|
1,992.75 | 3.32 | 9 | 25 |
somatic recombination of immunoglobulin gene segments
|
1,107.08 | 2.79 | 8 | 40 |
positive regulation of isotype switching to IgG isotypes
|
868.30 | 2.68 | 8 | 51 |
positive regulation of isotype switching to IgA isotypes
|
582.68 | 2.48 | 8 | 76 |
ATP hydrolysis activity
|
129.72 | 2.34 | 253 | 10,796 |
single base insertion or deletion binding
|
3,690.28 | 2.33 | 6 | 9 |
meiotic metaphase I homologous chromosome alignment
|
2,767.71 | 1.54 | 4 | 8 |
Totals | 1043 | 772762 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
2020-11-03 | Added | RELATION | is a GO:0140513 (nuclear protein-containing complex) |
2020-11-03 | Deleted | RELATION | part of GO:0005634 (nucleus) |
2019-09-12 | Deleted | RELATION | is a GO:0044428 (obsolete nuclear part) |
2019-09-12 | Added | RELATION | part of GO:0005634 (nucleus) |
2009-06-11 | Added | RELATION | is a GO:0044428 (obsolete nuclear part) |
2009-02-25 | Added | SYNONYM | MutL-alpha complex |
2008-05-13 | Added | DEFINITION | A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2. |
2008-05-12 | Deleted | DEFINITION | A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2. |
2008-04-01 | Updated | RELATION | is a GO:0032300 (mismatch repair complex) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2006-10-13 | Added | TERM | MutLalpha complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-02-25 | Added | SYNONYM | MutL-alpha complex |
2008-05-13 | Added | DEFINITION | A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2. |
2008-05-12 | Deleted | DEFINITION | A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2. |
2007-08-09 | Added | SYNONYM | MMR complex |
2007-08-09 | Deleted | SYNONYM | MMR complex |
2007-08-09 | Deleted | SYNONYM | MLH1/PMS2 complex |
2007-08-09 | Added | SYNONYM | MLH1/PMS2 complex |
2006-10-21 | Added | DEFINITION | A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2. |
2006-10-13 | Added | SYNONYM | MLH1/PMS2 complex |
2006-10-13 | Added | SYNONYM | MMR complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-11-03 | Added | RELATION | is a GO:0140513 (nuclear protein-containing complex) |
2020-11-03 | Deleted | RELATION | part of GO:0005634 (nucleus) |
2019-09-12 | Deleted | RELATION | is a GO:0044428 (obsolete nuclear part) |
2019-09-12 | Added | RELATION | part of GO:0005634 (nucleus) |
2009-06-11 | Added | RELATION | is a GO:0044428 (obsolete nuclear part) |
2008-04-01 | Updated | RELATION | is a GO:0032300 (mismatch repair complex) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
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