This term is obsolete.

GO:0032389 JSON

MutLalpha complex

Cellular Component

Definition (GO:0032389 GONUTS page)

A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2.

13,569 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
MutL-alpha complex exact
MLH1/PMS2 complex exact
MMR complex broad

Ancestor Chart

Ancestor chart for GO:0032389
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Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0032389 MutLalpha complex Only in Taxon 2759 Eukaryota

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q12175 559292 MSH5_YEAST GO:0032300 Requested by InterPro in response to GO consortium request to blacklist since protein is not part of this complex. Reported by InterPro on 13th November, 2019. IPR011184
NOT-qualified manual protein A0A096MJ18 10116 A0A096MJ18_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A096MK97 10116 A0A096MK97_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2JW23 10116 A0A0G2JW23_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2K8T1 10116 A0A0G2K8T1_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A1B0GR71 10090 A0A1B0GR71_MOUSE GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636
NOT-qualified manual protein A0A1B0GRK6 10090 A0A1B0GRK6_MOUSE GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636
NOT-qualified manual protein A0A1D8PHF8 237561 A0A1D8PHF8_CANAL GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8760936
NOT-qualified manual protein A0A1W2Q633 10116 A0A1W2Q633_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5Y8H4 10116 A0A8I5Y8H4_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0032389 based on ALL annotations
The top 100 of 252 co-occurring terms
Co-occurring Term PR S% #Together #Compared
MutLalpha complex
14,649.92 100.00 13,526 13,526
mismatch repair complex
3,521.36 24.04 13,524 56,264
meiosis I cell cycle process
4,266.25 16.89 3,881 13,327
somatic hypermutation of immunoglobulin genes
9,770.41 11.94 1,718 2,576
mismatched DNA binding
1,120.83 7.60 12,365 161,618
ATP-dependent DNA damage sensor activity
689.91 4.71 13,524 287,176
mismatch repair
636.16 4.34 13,526 311,488
DNA damage response
214.59 1.44 6,892 470,520
MutSalpha complex binding
4,522.80 1.32 184 596
positive regulation of isotype switching to IgG isotypes
2,749.12 1.07 152 810
Totals 121959 62919598
No co-occurrence statistics for GO:0032389 based on MANUAL annotations
The top 79 of 79 co-occurring terms
Co-occurring Term PR S% #Together #Compared
MutLalpha complex
5,535.42 100.00 255 255
mismatch repair
931.09 16.82 255 1,516
somatic hypermutation of immunoglobulin genes
2,158.82 12.34 39 100
MutSalpha complex binding
1,992.75 3.32 9 25
somatic recombination of immunoglobulin gene segments
1,107.08 2.79 8 40
positive regulation of isotype switching to IgG isotypes
868.30 2.68 8 51
positive regulation of isotype switching to IgA isotypes
582.68 2.48 8 76
ATP hydrolysis activity
129.72 2.34 253 10,796
single base insertion or deletion binding
3,690.28 2.33 6 9
meiotic metaphase I homologous chromosome alignment
2,767.71 1.54 4 8
Totals 1043 772762

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
2020-11-03 Added RELATION is a GO:0140513 (nuclear protein-containing complex)
2020-11-03 Deleted RELATION part of GO:0005634 (nucleus)
2019-09-12 Deleted RELATION is a GO:0044428 (obsolete nuclear part)
2019-09-12 Added RELATION part of GO:0005634 (nucleus)
2009-06-11 Added RELATION is a GO:0044428 (obsolete nuclear part)
2009-02-25 Added SYNONYM MutL-alpha complex
2008-05-13 Added DEFINITION A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2.
2008-05-12 Deleted DEFINITION A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2.
2008-04-01 Updated RELATION is a GO:0032300 (mismatch repair complex)
Timestamp Action Category Detail
2006-10-13 Added TERM MutLalpha complex
Timestamp Action Category Detail
2009-02-25 Added SYNONYM MutL-alpha complex
2008-05-13 Added DEFINITION A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2.
2008-05-12 Deleted DEFINITION A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2.
2007-08-09 Added SYNONYM MMR complex
2007-08-09 Deleted SYNONYM MMR complex
2007-08-09 Deleted SYNONYM MLH1/PMS2 complex
2007-08-09 Added SYNONYM MLH1/PMS2 complex
2006-10-21 Added DEFINITION A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2.
2006-10-13 Added SYNONYM MLH1/PMS2 complex
2006-10-13 Added SYNONYM MMR complex
Timestamp Action Category Detail
2020-11-03 Added RELATION is a GO:0140513 (nuclear protein-containing complex)
2020-11-03 Deleted RELATION part of GO:0005634 (nucleus)
2019-09-12 Deleted RELATION is a GO:0044428 (obsolete nuclear part)
2019-09-12 Added RELATION part of GO:0005634 (nucleus)
2009-06-11 Added RELATION is a GO:0044428 (obsolete nuclear part)
2008-04-01 Updated RELATION is a GO:0032300 (mismatch repair complex)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
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