This term is obsolete.

GO:0034061 JSON

DNA polymerase activity

Molecular Function

Definition (GO:0034061 GONUTS page)

Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).

1,694,258 annotations

Ancestor Chart

Ancestor chart for GO:0034061
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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0034061

Child Term Relationship to
GO:0034061
GO:0003964
RNA-directed DNA polymerase activity
is_a
GO:0003887
DNA-directed DNA polymerase activity
is_a
GO:0003912
DNA nucleotidylexotransferase activity
is_a
GO:0030337
DNA polymerase processivity factor activity
positively_regulates
GO:0042575
DNA polymerase complex
capable_of

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q4H4F3 1397 BTRD_NIACI GO:0016779 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17226887
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
InterPro IPR001726 DNA nucleotidylexotransferase (TdT) / DNA-directed DNA/RNA polymerase mu
InterPro IPR018944 DNA polymerase lambda, fingers domain
RHEA 22508

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:61560 2'-deoxyribonucleoside 5'-triphosphate(4-)
has_participant CHEBI CHEBI:173112 DNA 5'-phosphate polyanion
has_participant CHEBI CHEBI:33019 diphosphate(3-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0034061 based on ALL annotations
The top 100 of 548 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0034061
DNA polymerase activity
1,262.20 100.00 156,992 156,992
GO:0003887
DNA-directed DNA polymerase activity
307.29 24.24 154,123 633,065
GO:0071897
DNA biosynthetic process
238.49 18.08 126,659 670,341
GO:0006261
DNA-templated DNA replication
249.73 17.24 89,875 454,259
GO:0008408
3'-5' exonuclease activity
250.50 16.14 72,809 366,862
GO:0140640
catalytic activity, acting on a nucleic acid
448.90 11.33 22,387 62,947
GO:0042276
error-prone translesion synthesis
334.59 11.08 25,091 94,652
GO:0009360
DNA polymerase III complex
248.34 10.82 30,445 154,740
GO:0006260
DNA replication
117.93 9.31 151,167 1,617,907
GO:0008409
5'-3' exonuclease activity
246.89 9.00 22,448 114,765
Totals 1681085 153116497
No co-occurrence statistics for GO:0034061 based on MANUAL annotations
The top 22 of 22 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0034061
DNA polymerase activity
201,647.58 100.00 7 7
GO:0022616
DNA strand elongation
33,607.93 8.33 1 6
GO:0042575
DNA polymerase complex
25,205.95 7.14 1 8
GO:0039686
bidirectional double-stranded viral DNA replication
4,689.48 2.04 1 43
GO:1902074
response to salt
2,145.19 1.00 1 94
GO:0019985
translesion synthesis
1,531.50 0.75 3 395
GO:0042025
host cell nucleus
1,214.74 0.58 1 166
GO:0070987
error-free translesion synthesis
1,145.73 0.55 1 176
GO:0070935
3'-UTR-mediated mRNA stabilization
1,066.92 0.51 1 189
GO:0008409
5'-3' exonuclease activity
576.14 0.28 1 350
Totals 33 358262

Change Log

Timestamp Action Category Detail
2024-07-11 Added XREF RHEA:22508
2024-07-11 Deleted SYNONYM deoxyribonucleic acid polymerase activity
2024-07-11 Added DEFINITION Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).
2024-07-11 Deleted DEFINITION Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group.
2024-07-11 Deleted SYNONYM DNA nucleotidyltransferase activity
2024-07-11 Deleted SYNONYM deoxyribonucleate nucleotidyltransferase activity
2024-07-11 Deleted SYNONYM deoxynucleate polymerase activity
2024-07-11 Deleted SYNONYM deoxyribonucleic polymerase activity
2020-10-08 Added SYNONYM deoxynucleate polymerase activity
2020-10-08 Deleted SYNONYM deoxyribonucleic polymerase activity
Timestamp Action Category Detail
2008-01-07 Added TERM DNA polymerase activity
Timestamp Action Category Detail
2024-07-11 Deleted SYNONYM deoxyribonucleic acid polymerase activity
2024-07-11 Added DEFINITION Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).
2024-07-11 Deleted DEFINITION Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group.
2024-07-11 Deleted SYNONYM DNA nucleotidyltransferase activity
2024-07-11 Deleted SYNONYM deoxyribonucleate nucleotidyltransferase activity
2024-07-11 Deleted SYNONYM deoxynucleate polymerase activity
2024-07-11 Deleted SYNONYM deoxyribonucleic polymerase activity
2020-10-08 Added SYNONYM deoxynucleate polymerase activity
2020-10-08 Deleted SYNONYM deoxyribonucleic polymerase activity
2020-10-08 Deleted SYNONYM deoxyribonucleic acid polymerase activity
2020-10-08 Deleted SYNONYM deoxyribonucleate nucleotidyltransferase activity
2020-10-08 Deleted SYNONYM deoxynucleate polymerase activity
2020-10-08 Deleted SYNONYM DNA nucleotidyltransferase activity
2020-10-08 Added SYNONYM DNA nucleotidyltransferase activity
2020-10-08 Added SYNONYM deoxyribonucleic acid polymerase activity
2020-10-08 Added SYNONYM deoxyribonucleic polymerase activity
2020-10-08 Added SYNONYM deoxyribonucleate nucleotidyltransferase activity
2014-06-08 Deleted DEFINITION Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and primer.
2014-06-08 Added DEFINITION Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group.
2008-05-13 Added DEFINITION Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and primer.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and primer.
2008-04-05 Deleted SYNONYM DNA polymerase activity
2008-01-27 Added DEFINITION Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and primer.
2008-01-07 Added SYNONYM DNA nucleotidyltransferase activity
2008-01-07 Added SYNONYM deoxyribonucleic acid polymerase activity
2008-01-07 Added SYNONYM deoxyribonucleic polymerase activity
2008-01-07 Added SYNONYM deoxynucleate polymerase activity
2008-01-07 Added SYNONYM DNA polymerase activity
2008-01-07 Added SYNONYM deoxyribonucleate nucleotidyltransferase activity
Timestamp Action Category Detail
2017-09-19 Added RELATION is a GO:0140097 (catalytic activity, acting on DNA)
2014-06-08 Added RELATION part of GO:0071897 (DNA biosynthetic process)
2008-04-01 Updated RELATION is a GO:0016779 (nucleotidyltransferase activity)
Timestamp Action Category Detail
2024-07-11 Added XREF RHEA:22508
Timestamp Action Category Detail
2016-07-23 Deleted SUBSET goslim_metagenomics
2013-04-18 Updated SUBSET goslim_metagenomics
2012-02-17 Added SUBSET goslim_metagenomics
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