Note that the p50 subunit is encoded by NFKB1 gene in human and the p65 subunit is encoded by the RELA gene in human. Similar nomenclature is used in other vertebrate species. The p50 subunit has a precursor form p105 in some publications.
GO:0035525
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NF-kappaB p50/p65 complex
Cellular Component
Definition (GO:0035525 GONUTS page)
A heterodimer of NF-kappa B p50 and p65 subunits. PMID:20393192 PMID:9299584
Comments
Note that the p50 subunit is encoded by NFKB1 gene in human and the p65 subunit is encoded by the RELA gene in human. Similar nomenclature is used in other vertebrate species. The p50 subunit has a precursor form p105 in some publications.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
NF-kappa p105/RelA complex | related |
NF-kappa B1/p65 complex | exact |
NF-kappa p50/RelA complex | exact |
NF-kappa B1/RelA complex | exact |
NF-kappa p105/p65 complex | related |
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0035525 | NF-kappaB p50/p65 complex | Only in Taxon | 2759 | Eukaryota |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A096MJ18 | 10116 | A0A096MJ18_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A096MK97 | 10116 | A0A096MK97_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2JW23 | 10116 | A0A0G2JW23_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2K8T1 | 10116 | A0A0G2K8T1_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A1B0GR71 | 10090 | A0A1B0GR71_MOUSE | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636 | |
NOT-qualified manual | protein | A0A1B0GRK6 | 10090 | A0A1B0GRK6_MOUSE | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636 | |
NOT-qualified manual | protein | A0A1D8PHF8 | 237561 | A0A1D8PHF8_CANAL | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8760936 | |
NOT-qualified manual | protein | A0A1W2Q633 | 10116 | A0A1W2Q633_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5Y8H4 | 10116 | A0A8I5Y8H4_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A0E5 | 10116 | A0A8I6A0E5_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0035525 based on ALL annotations
The top 100 of 195 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NF-kappaB p50/p65 complex
|
107,284.71 | 100.00 | 1,847 | 1,847 |
positive regulation of miRNA metabolic process
|
70,236.75 | 9.37 | 182 | 278 |
non-canonical NF-kappaB signal transduction
|
12,436.51 | 9.10 | 549 | 4,736 |
cellular response to nicotine
|
43,103.35 | 8.59 | 182 | 453 |
cellular response to angiotensin
|
42,081.50 | 8.55 | 182 | 464 |
response to muscle stretch
|
14,463.44 | 5.79 | 170 | 1,261 |
cellular response to interleukin-6
|
12,532.62 | 5.65 | 182 | 1,558 |
canonical NF-kappaB signal transduction
|
6,182.36 | 5.07 | 549 | 9,527 |
I-kappaB/NF-kappaB complex
|
67,052.95 | 4.99 | 95 | 152 |
positive regulation of hyaluronan biosynthetic process
|
35,761.57 | 4.71 | 96 | 288 |
Totals | 17985 | 4724087 |
No co-occurrence statistics for GO:0035525 based on MANUAL annotations
The top 100 of 172 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NF-kappaB p50/p65 complex
|
31,367.40 | 100.00 | 45 | 45 |
positive regulation of miRNA metabolic process
|
16,606.27 | 16.98 | 9 | 17 |
NF-kappaB complex
|
20,911.60 | 16.33 | 8 | 12 |
prolactin signaling pathway
|
24,396.87 | 14.89 | 7 | 9 |
non-canonical NF-kappaB signal transduction
|
5,301.53 | 14.72 | 24 | 142 |
cellular response to nicotine
|
8,822.08 | 13.24 | 9 | 32 |
toll-like receptor TLR6:TLR2 signaling pathway
|
11,556.41 | 12.28 | 7 | 19 |
positive regulation of Schwann cell differentiation
|
10,455.80 | 10.53 | 6 | 18 |
nucleotide-binding oligomerization domain containing 2 signaling pathway
|
5,576.43 | 9.76 | 8 | 45 |
ankyrin repeat binding
|
5,934.37 | 9.33 | 7 | 37 |
Totals | 701 | 25834 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
2010-05-13 | Added | SYNONYM | NF-kappa p50/RelA complex |
2010-05-13 | Added | SYNONYM | NF-kappa p105/p65 complex |
2010-05-13 | Added | SYNONYM | NF-kappa B1/RelA complex |
2010-05-13 | Added | RELATION | is a GO:0071159 (NF-kappaB complex) |
2010-05-13 | Added | DEFINITION | A heterodimer of NF-kappa B p50 and p65 subunits. |
2010-05-13 | Added | TERM | NF-kappaB p50/p65 complex |
2010-05-13 | Added | SYNONYM | NF-kappa B1/p65 complex |
2010-05-13 | Added | SYNONYM | NF-kappa p105/RelA complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-05-13 | Added | TERM | NF-kappaB p50/p65 complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-05-13 | Added | SYNONYM | NF-kappa p50/RelA complex |
2010-05-13 | Added | SYNONYM | NF-kappa p105/p65 complex |
2010-05-13 | Added | SYNONYM | NF-kappa B1/RelA complex |
2010-05-13 | Added | DEFINITION | A heterodimer of NF-kappa B p50 and p65 subunits. |
2010-05-13 | Added | SYNONYM | NF-kappa B1/p65 complex |
2010-05-13 | Added | SYNONYM | NF-kappa p105/RelA complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-05-13 | Added | RELATION | is a GO:0071159 (NF-kappaB complex) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
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