This term is obsolete.
Note that the p50 subunit is encoded by NFKB1 gene in human and the p65 subunit is encoded by the RELA gene in human. Similar nomenclature is used in other vertebrate species. The p50 subunit has a precursor form p105 in some publications.

GO:0035525 JSON

NF-kappaB p50/p65 complex

Cellular Component

Definition (GO:0035525 GONUTS page)

A heterodimer of NF-kappa B p50 and p65 subunits. PMID:20393192 PMID:9299584

Comments

Note that the p50 subunit is encoded by NFKB1 gene in human and the p65 subunit is encoded by the RELA gene in human. Similar nomenclature is used in other vertebrate species. The p50 subunit has a precursor form p105 in some publications.

1,890 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
NF-kappa p105/RelA complex related
NF-kappa B1/p65 complex exact
NF-kappa p50/RelA complex exact
NF-kappa B1/RelA complex exact
NF-kappa p105/p65 complex related

Ancestor Chart

Ancestor chart for GO:0035525
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Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0035525 NF-kappaB p50/p65 complex Only in Taxon 2759 Eukaryota

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A096MJ18 10116 A0A096MJ18_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A096MK97 10116 A0A096MK97_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2JW23 10116 A0A0G2JW23_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2K8T1 10116 A0A0G2K8T1_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A1B0GR71 10090 A0A1B0GR71_MOUSE GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636
NOT-qualified manual protein A0A1B0GRK6 10090 A0A1B0GRK6_MOUSE GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636
NOT-qualified manual protein A0A1D8PHF8 237561 A0A1D8PHF8_CANAL GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8760936
NOT-qualified manual protein A0A1W2Q633 10116 A0A1W2Q633_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5Y8H4 10116 A0A8I5Y8H4_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A0E5 10116 A0A8I6A0E5_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0035525 based on ALL annotations
The top 100 of 195 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NF-kappaB p50/p65 complex
107,284.71 100.00 1,847 1,847
positive regulation of miRNA metabolic process
70,236.75 9.37 182 278
non-canonical NF-kappaB signal transduction
12,436.51 9.10 549 4,736
cellular response to nicotine
43,103.35 8.59 182 453
cellular response to angiotensin
42,081.50 8.55 182 464
response to muscle stretch
14,463.44 5.79 170 1,261
cellular response to interleukin-6
12,532.62 5.65 182 1,558
canonical NF-kappaB signal transduction
6,182.36 5.07 549 9,527
I-kappaB/NF-kappaB complex
67,052.95 4.99 95 152
positive regulation of hyaluronan biosynthetic process
35,761.57 4.71 96 288
Totals 17985 4724087
No co-occurrence statistics for GO:0035525 based on MANUAL annotations
The top 100 of 172 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NF-kappaB p50/p65 complex
31,367.40 100.00 45 45
positive regulation of miRNA metabolic process
16,606.27 16.98 9 17
NF-kappaB complex
20,911.60 16.33 8 12
prolactin signaling pathway
24,396.87 14.89 7 9
non-canonical NF-kappaB signal transduction
5,301.53 14.72 24 142
cellular response to nicotine
8,822.08 13.24 9 32
toll-like receptor TLR6:TLR2 signaling pathway
11,556.41 12.28 7 19
positive regulation of Schwann cell differentiation
10,455.80 10.53 6 18
nucleotide-binding oligomerization domain containing 2 signaling pathway
5,576.43 9.76 8 45
ankyrin repeat binding
5,934.37 9.33 7 37
Totals 701 25834

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
2010-05-13 Added SYNONYM NF-kappa p50/RelA complex
2010-05-13 Added SYNONYM NF-kappa p105/p65 complex
2010-05-13 Added SYNONYM NF-kappa B1/RelA complex
2010-05-13 Added RELATION is a GO:0071159 (NF-kappaB complex)
2010-05-13 Added DEFINITION A heterodimer of NF-kappa B p50 and p65 subunits.
2010-05-13 Added TERM NF-kappaB p50/p65 complex
2010-05-13 Added SYNONYM NF-kappa B1/p65 complex
2010-05-13 Added SYNONYM NF-kappa p105/RelA complex
Timestamp Action Category Detail
2010-05-13 Added TERM NF-kappaB p50/p65 complex
Timestamp Action Category Detail
2010-05-13 Added SYNONYM NF-kappa p50/RelA complex
2010-05-13 Added SYNONYM NF-kappa p105/p65 complex
2010-05-13 Added SYNONYM NF-kappa B1/RelA complex
2010-05-13 Added DEFINITION A heterodimer of NF-kappa B p50 and p65 subunits.
2010-05-13 Added SYNONYM NF-kappa B1/p65 complex
2010-05-13 Added SYNONYM NF-kappa p105/RelA complex
Timestamp Action Category Detail
2010-05-13 Added RELATION is a GO:0071159 (NF-kappaB complex)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
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