This term is obsolete.

GO:0043124 JSON

negative regulation of canonical NF-kappaB signal transduction

Biological Process

Definition (GO:0043124 GONUTS page)

Any process that stops, prevents, or reduces the frequency, rate or extent of a canonical NF-kappaB signaling cascade.

15,270 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
down regulation of I-kappaB kinase/NF-kappaB cascade exact
downregulation of I-kappaB kinase/NF-kappaB cascade exact
negative regulation of I-kappaB kinase/NF-kappaB signaling exact
inhibition of I-kappaB kinase/NF-kappaB cascade exact
negative regulation of I-kappaB kinase/NF-kappaB cascade exact
down-regulation of I-kappaB kinase/NF-kappaB cascade exact

Ancestor Chart

Ancestor chart for GO:0043124
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Ancestor chart

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A6JH76 10116 A6JH76_RAT GO:0043122 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein B5DFG9 10116 B5DFG9_RAT GO:0043122 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F1LXQ8 10116 F1LXQ8_RAT GO:0043122 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F1M784 10116 F1M784_RAT GO:0043122 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q9EQ32 10090 BCAP_MOUSE GO:0043122 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:22187458

Cross-references

Database ID Description
InterPro IPR038753 NF-kappa-B inhibitor-like protein 1
InterPro IPR039669 TRAF family member-associated NF-kappa-B activator
InterPro IPR042227 NF-kappa-B inhibitor-interacting Ras-like protein

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0043124 based on ALL annotations
The top 100 of 1,967 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative regulation of canonical NF-kappaB signal transduction
13,164.69 100.00 15,052 15,052
Ral protein signal transduction
12,786.42 15.87 2,400 2,471
GTPase activating protein binding
9,685.85 15.08 2,400 3,262
positive regulation of JNK cascade
1,591.22 7.06 2,184 18,069
mitogen-activated protein kinase binding
5,034.90 5.97 994 2,599
cellular response to lipopolysaccharide
974.50 5.19 2,223 30,031
negative regulation of ERK1 and ERK2 cascade
1,572.22 5.02 1,200 10,048
negative regulation of tumor necrosis factor production
2,701.81 4.93 918 4,473
regulation of canonical NF-kappaB signal transduction
1,038.54 4.90 1,720 21,803
negative regulation of interleukin-6 production
2,610.24 4.08 736 3,712
Totals 55601 574317
No co-occurrence statistics for GO:0043124 based on MANUAL annotations
The top 100 of 1,791 co-occurring terms
Co-occurring Term PR S% #Together #Compared
negative regulation of canonical NF-kappaB signal transduction
3,061.89 100.00 461 461
negative regulation of tumor necrosis factor production
632.85 9.42 68 329
protein sequestering activity
688.62 8.56 56 249
NF-kappaB binding
520.13 7.36 53 312
negative regulation of non-canonical NF-kappaB signal transduction
670.70 7.36 46 210
negative regulation of cytokine production involved in inflammatory response
743.35 7.09 42 173
negative regulation of interleukin-1 beta production
775.16 6.91 40 158
cellular response to interleukin-1
474.71 5.89 40 258
negative regulation of inflammatory response
252.39 5.81 76 922
negative regulation of interleukin-6 production
461.06 5.73 39 259
Totals 2738 19342

Change Log

Timestamp Action Category Detail
2023-07-06 Added SYNONYM negative regulation of I-kappaB kinase/NF-kappaB signaling
2023-07-06 Added SYNONYM downregulation of I-kappaB kinase/NF-kappaB cascade
2023-07-06 Updated TERM negative regulation of canonical NF-kappaB signal transduction
2023-07-06 Added SYNONYM inhibition of I-kappaB kinase/NF-kappaB cascade
2023-07-06 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
2023-07-06 Added SYNONYM down regulation of I-kappaB kinase/NF-kappaB cascade
2023-07-06 Deleted SYNONYM down-regulation of I-kappaB kinase/NF-kappaB cascade
2023-07-06 Added SYNONYM down-regulation of I-kappaB kinase/NF-kappaB cascade
2023-07-06 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of a canonical NF-kappaB signaling cascade.
2023-07-06 Deleted SYNONYM inhibition of I-kappaB kinase/NF-kappaB cascade
Timestamp Action Category Detail
2023-07-06 Updated TERM negative regulation of canonical NF-kappaB signal transduction
2013-12-04 Updated TERM negative regulation of I-kappaB kinase/NF-kappaB signaling
2004-03-07 Added TERM negative regulation of I-kappaB kinase/NF-kappaB cascade
Timestamp Action Category Detail
2023-07-06 Added SYNONYM negative regulation of I-kappaB kinase/NF-kappaB signaling
2023-07-06 Added SYNONYM downregulation of I-kappaB kinase/NF-kappaB cascade
2023-07-06 Added SYNONYM inhibition of I-kappaB kinase/NF-kappaB cascade
2023-07-06 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
2023-07-06 Added SYNONYM down regulation of I-kappaB kinase/NF-kappaB cascade
2023-07-06 Deleted SYNONYM down-regulation of I-kappaB kinase/NF-kappaB cascade
2023-07-06 Added SYNONYM down-regulation of I-kappaB kinase/NF-kappaB cascade
2023-07-06 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of a canonical NF-kappaB signaling cascade.
2023-07-06 Deleted SYNONYM inhibition of I-kappaB kinase/NF-kappaB cascade
2023-07-06 Deleted SYNONYM negative regulation of I-kappaB kinase/NF-kappaB cascade
2023-07-06 Deleted SYNONYM downregulation of I-kappaB kinase/NF-kappaB cascade
2023-07-06 Deleted SYNONYM down regulation of I-kappaB kinase/NF-kappaB cascade
2023-07-06 Added SYNONYM negative regulation of I-kappaB kinase/NF-kappaB cascade
2013-12-04 Deleted SYNONYM downregulation of I-kappaB kinase/NF-kappaB cascade
2013-12-04 Added SYNONYM downregulation of I-kappaB kinase/NF-kappaB cascade
2013-12-04 Deleted SYNONYM down-regulation of I-kappaB kinase/NF-kappaB cascade
2013-12-04 Deleted SYNONYM down regulation of I-kappaB kinase/NF-kappaB cascade
2013-12-04 Added SYNONYM negative regulation of I-kappaB kinase/NF-kappaB cascade
2013-12-04 Added SYNONYM down-regulation of I-kappaB kinase/NF-kappaB cascade
2013-12-04 Added SYNONYM down regulation of I-kappaB kinase/NF-kappaB cascade
2013-12-04 Deleted DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade.
2013-12-04 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
2010-10-03 Added DEFINITION Any process that stops, prevents, or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade.
2010-10-03 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade.
2008-05-13 Added DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade.
2008-05-12 Deleted DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade.
2007-08-09 Deleted SYNONYM inhibition of I-kappaB kinase/NF-kappaB cascade
2007-08-09 Deleted SYNONYM downregulation of I-kappaB kinase/NF-kappaB cascade
2007-08-09 Deleted SYNONYM down-regulation of I-kappaB kinase/NF-kappaB cascade
2007-08-09 Deleted SYNONYM down regulation of I-kappaB kinase/NF-kappaB cascade
2007-08-09 Added SYNONYM down regulation of I-kappaB kinase/NF-kappaB cascade
2007-08-09 Added SYNONYM downregulation of I-kappaB kinase/NF-kappaB cascade
2007-08-09 Added SYNONYM inhibition of I-kappaB kinase/NF-kappaB cascade
2007-08-09 Added SYNONYM down-regulation of I-kappaB kinase/NF-kappaB cascade
2007-02-23 Added SYNONYM down regulation of I-kappaB kinase/NF-kappaB cascade
2007-02-23 Added SYNONYM downregulation of I-kappaB kinase/NF-kappaB cascade
2007-02-23 Added SYNONYM inhibition of I-kappaB kinase/NF-kappaB cascade
2007-02-23 Added SYNONYM down-regulation of I-kappaB kinase/NF-kappaB cascade
2006-05-04 Updated DEFINITION Any process that stops, prevents or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade.
2005-10-21 Updated DEFINITION Any process that stops, prevents or reduces the rate, frequency or extent of an I-kappaB kinase/NF-kappaB induced cascade.
2004-03-07 Added DEFINITION Any process that stops, prevents or reduces the rate of an I-kappaB kinase/NF-kappaB induced cascade.
Timestamp Action Category Detail
2013-12-04 Added RELATION is a GO:1902532 (negative regulation of intracellular signal transduction)
2013-12-04 Deleted RELATION is a GO:0010741 (negative regulation of intracellular protein kinase cascade)
2008-10-02 Added RELATION is a GO:0010741 (negative regulation of intracellular protein kinase cascade)
2008-10-02 Deleted RELATION is a GO:0009968 (negative regulation of signal transduction)
2008-04-01 Added RELATION negatively regulates GO:0007249 (canonical NF-kappaB signal transduction)
2008-04-01 Updated RELATION is a GO:0043122 (regulation of canonical NF-kappaB signal transduction)
2008-04-01 Updated RELATION is a GO:0009968 (negative regulation of signal transduction)
Timestamp Action Category Detail
Timestamp Action Category Detail
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