GO:0043124
JSON
negative regulation of canonical NF-kappaB signal transduction
Biological Process
Definition (GO:0043124 GONUTS page)
Any process that stops, prevents, or reduces the frequency, rate or extent of a canonical NF-kappaB signaling cascade.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
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down regulation of I-kappaB kinase/NF-kappaB cascade | exact |
downregulation of I-kappaB kinase/NF-kappaB cascade | exact |
negative regulation of I-kappaB kinase/NF-kappaB signaling | exact |
inhibition of I-kappaB kinase/NF-kappaB cascade | exact |
negative regulation of I-kappaB kinase/NF-kappaB cascade | exact |
down-regulation of I-kappaB kinase/NF-kappaB cascade | exact |
Ancestor Chart
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
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signalling | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A6JH76 | 10116 | A6JH76_RAT | GO:0043122 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | B5DFG9 | 10116 | B5DFG9_RAT | GO:0043122 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F1LXQ8 | 10116 | F1LXQ8_RAT | GO:0043122 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F1M784 | 10116 | F1M784_RAT | GO:0043122 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q9EQ32 | 10090 | BCAP_MOUSE | GO:0043122 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:22187458 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR038753 | NF-kappa-B inhibitor-like protein 1 |
InterPro | IPR039669 | TRAF family member-associated NF-kappa-B activator |
InterPro | IPR042227 | NF-kappa-B inhibitor-interacting Ras-like protein |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0043124 based on ALL annotations
The top 100 of 1,967 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative regulation of canonical NF-kappaB signal transduction
|
13,164.69 | 100.00 | 15,052 | 15,052 |
Ral protein signal transduction
|
12,786.42 | 15.87 | 2,400 | 2,471 |
GTPase activating protein binding
|
9,685.85 | 15.08 | 2,400 | 3,262 |
positive regulation of JNK cascade
|
1,591.22 | 7.06 | 2,184 | 18,069 |
mitogen-activated protein kinase binding
|
5,034.90 | 5.97 | 994 | 2,599 |
cellular response to lipopolysaccharide
|
974.50 | 5.19 | 2,223 | 30,031 |
negative regulation of ERK1 and ERK2 cascade
|
1,572.22 | 5.02 | 1,200 | 10,048 |
negative regulation of tumor necrosis factor production
|
2,701.81 | 4.93 | 918 | 4,473 |
regulation of canonical NF-kappaB signal transduction
|
1,038.54 | 4.90 | 1,720 | 21,803 |
negative regulation of interleukin-6 production
|
2,610.24 | 4.08 | 736 | 3,712 |
Totals | 55601 | 574317 |
No co-occurrence statistics for GO:0043124 based on MANUAL annotations
The top 100 of 1,791 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
negative regulation of canonical NF-kappaB signal transduction
|
3,061.89 | 100.00 | 461 | 461 |
negative regulation of tumor necrosis factor production
|
632.85 | 9.42 | 68 | 329 |
protein sequestering activity
|
688.62 | 8.56 | 56 | 249 |
NF-kappaB binding
|
520.13 | 7.36 | 53 | 312 |
negative regulation of non-canonical NF-kappaB signal transduction
|
670.70 | 7.36 | 46 | 210 |
negative regulation of cytokine production involved in inflammatory response
|
743.35 | 7.09 | 42 | 173 |
negative regulation of interleukin-1 beta production
|
775.16 | 6.91 | 40 | 158 |
cellular response to interleukin-1
|
474.71 | 5.89 | 40 | 258 |
negative regulation of inflammatory response
|
252.39 | 5.81 | 76 | 922 |
negative regulation of interleukin-6 production
|
461.06 | 5.73 | 39 | 259 |
Totals | 2738 | 19342 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-07-06 | Added | SYNONYM | negative regulation of I-kappaB kinase/NF-kappaB signaling |
2023-07-06 | Added | SYNONYM | downregulation of I-kappaB kinase/NF-kappaB cascade |
2023-07-06 | Updated | TERM | negative regulation of canonical NF-kappaB signal transduction |
2023-07-06 | Added | SYNONYM | inhibition of I-kappaB kinase/NF-kappaB cascade |
2023-07-06 | Deleted | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling. |
2023-07-06 | Added | SYNONYM | down regulation of I-kappaB kinase/NF-kappaB cascade |
2023-07-06 | Deleted | SYNONYM | down-regulation of I-kappaB kinase/NF-kappaB cascade |
2023-07-06 | Added | SYNONYM | down-regulation of I-kappaB kinase/NF-kappaB cascade |
2023-07-06 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of a canonical NF-kappaB signaling cascade. |
2023-07-06 | Deleted | SYNONYM | inhibition of I-kappaB kinase/NF-kappaB cascade |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-07-06 | Updated | TERM | negative regulation of canonical NF-kappaB signal transduction |
2013-12-04 | Updated | TERM | negative regulation of I-kappaB kinase/NF-kappaB signaling |
2004-03-07 | Added | TERM | negative regulation of I-kappaB kinase/NF-kappaB cascade |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-07-06 | Added | SYNONYM | negative regulation of I-kappaB kinase/NF-kappaB signaling |
2023-07-06 | Added | SYNONYM | downregulation of I-kappaB kinase/NF-kappaB cascade |
2023-07-06 | Added | SYNONYM | inhibition of I-kappaB kinase/NF-kappaB cascade |
2023-07-06 | Deleted | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling. |
2023-07-06 | Added | SYNONYM | down regulation of I-kappaB kinase/NF-kappaB cascade |
2023-07-06 | Deleted | SYNONYM | down-regulation of I-kappaB kinase/NF-kappaB cascade |
2023-07-06 | Added | SYNONYM | down-regulation of I-kappaB kinase/NF-kappaB cascade |
2023-07-06 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of a canonical NF-kappaB signaling cascade. |
2023-07-06 | Deleted | SYNONYM | inhibition of I-kappaB kinase/NF-kappaB cascade |
2023-07-06 | Deleted | SYNONYM | negative regulation of I-kappaB kinase/NF-kappaB cascade |
2023-07-06 | Deleted | SYNONYM | downregulation of I-kappaB kinase/NF-kappaB cascade |
2023-07-06 | Deleted | SYNONYM | down regulation of I-kappaB kinase/NF-kappaB cascade |
2023-07-06 | Added | SYNONYM | negative regulation of I-kappaB kinase/NF-kappaB cascade |
2013-12-04 | Deleted | SYNONYM | downregulation of I-kappaB kinase/NF-kappaB cascade |
2013-12-04 | Added | SYNONYM | downregulation of I-kappaB kinase/NF-kappaB cascade |
2013-12-04 | Deleted | SYNONYM | down-regulation of I-kappaB kinase/NF-kappaB cascade |
2013-12-04 | Deleted | SYNONYM | down regulation of I-kappaB kinase/NF-kappaB cascade |
2013-12-04 | Added | SYNONYM | negative regulation of I-kappaB kinase/NF-kappaB cascade |
2013-12-04 | Added | SYNONYM | down-regulation of I-kappaB kinase/NF-kappaB cascade |
2013-12-04 | Added | SYNONYM | down regulation of I-kappaB kinase/NF-kappaB cascade |
2013-12-04 | Deleted | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade. |
2013-12-04 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling. |
2010-10-03 | Added | DEFINITION | Any process that stops, prevents, or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade. |
2010-10-03 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade. |
2008-05-13 | Added | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade. |
2008-05-12 | Deleted | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade. |
2007-08-09 | Deleted | SYNONYM | inhibition of I-kappaB kinase/NF-kappaB cascade |
2007-08-09 | Deleted | SYNONYM | downregulation of I-kappaB kinase/NF-kappaB cascade |
2007-08-09 | Deleted | SYNONYM | down-regulation of I-kappaB kinase/NF-kappaB cascade |
2007-08-09 | Deleted | SYNONYM | down regulation of I-kappaB kinase/NF-kappaB cascade |
2007-08-09 | Added | SYNONYM | down regulation of I-kappaB kinase/NF-kappaB cascade |
2007-08-09 | Added | SYNONYM | downregulation of I-kappaB kinase/NF-kappaB cascade |
2007-08-09 | Added | SYNONYM | inhibition of I-kappaB kinase/NF-kappaB cascade |
2007-08-09 | Added | SYNONYM | down-regulation of I-kappaB kinase/NF-kappaB cascade |
2007-02-23 | Added | SYNONYM | down regulation of I-kappaB kinase/NF-kappaB cascade |
2007-02-23 | Added | SYNONYM | downregulation of I-kappaB kinase/NF-kappaB cascade |
2007-02-23 | Added | SYNONYM | inhibition of I-kappaB kinase/NF-kappaB cascade |
2007-02-23 | Added | SYNONYM | down-regulation of I-kappaB kinase/NF-kappaB cascade |
2006-05-04 | Updated | DEFINITION | Any process that stops, prevents or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade. |
2005-10-21 | Updated | DEFINITION | Any process that stops, prevents or reduces the rate, frequency or extent of an I-kappaB kinase/NF-kappaB induced cascade. |
2004-03-07 | Added | DEFINITION | Any process that stops, prevents or reduces the rate of an I-kappaB kinase/NF-kappaB induced cascade. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2013-12-04 | Added | RELATION | is a GO:1902532 (negative regulation of intracellular signal transduction) |
2013-12-04 | Deleted | RELATION | is a GO:0010741 (negative regulation of intracellular protein kinase cascade) |
2008-10-02 | Added | RELATION | is a GO:0010741 (negative regulation of intracellular protein kinase cascade) |
2008-10-02 | Deleted | RELATION | is a GO:0009968 (negative regulation of signal transduction) |
2008-04-01 | Added | RELATION | negatively regulates GO:0007249 (canonical NF-kappaB signal transduction) |
2008-04-01 | Updated | RELATION | is a GO:0043122 (regulation of canonical NF-kappaB signal transduction) |
2008-04-01 | Updated | RELATION | is a GO:0009968 (negative regulation of signal transduction) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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