This term is obsolete.

GO:0043197 JSON

dendritic spine

Cellular Component

Definition (GO:0043197 GONUTS page)

A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.

57,028 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
stubby dendritic spine narrow
sessile dendritic spine narrow
mushroom dendritic spine narrow
dendrite spine exact
thin dendritic spine narrow
branched dendritic spine narrow

Ancestor Chart

Ancestor chart for GO:0043197
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0043197

Child Term Relationship to
GO:0043197
thorny excrescence
is_a
dendritic spine head
part_of
dendritic spine neck
part_of
actin cytoskeleton of dendritic spine
part_of
cytoskeleton of dendritic spine
part_of
dendritic spine cytoplasm
part_of
spine apparatus
part_of
dendritic spine membrane
part_of

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0043197 dendritic spine Only in Taxon 6072 Eumetazoa

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A088MLT8 10090 IQIP1_MOUSE GO:0030425 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18550753
NOT-qualified manual protein A0A8I5ZWB0 10116 A0A8I5ZWB0_RAT GO:0045202 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8J8XYU9 10116 A0A8J8XYU9_RAT GO:0045202 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6I6C4 10116 A6I6C4_RAT GO:0045202 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6I6C5 10116 A6I6C5_RAT GO:0045202 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P05067-PRO_0000000093 9606 A4_HUMAN GO:0030425 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17251419
NOT-qualified manual protein P35353 10116 CRFR1_RAT GO:0043197 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12911751
NOT-qualified manual protein P97479 10090 MYO7A_MOUSE GO:0045202 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8842737
NOT-qualified manual protein Q8CJE3 10116 Q8CJE3_RAT GO:0045202 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000266, ECO:0000314 from these references: GO_REF:0000096, PMID:8842737

Cross-references

Database ID Description
NIF_Subcellular sao1799103720
UniProtKB-SubCell SL-0284 Dendritic spine
Wikipedia Dendritic_spine

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0043197 based on ALL annotations
The top 100 of 3,519 co-occurring terms
Co-occurring Term PR S% #Together #Compared
dendritic spine
4,163.79 100.00 47,590 47,590
synaptic receptor adaptor activity
3,940.14 12.57 6,025 6,367
regulation of dendritic spine morphogenesis
2,771.34 10.57 5,312 7,981
ionotropic glutamate receptor binding
1,225.69 9.83 6,122 20,797
postsynaptic density
551.16 9.45 11,811 89,228
amyloid-beta binding
888.29 6.41 3,996 18,731
postsynaptic membrane
288.12 5.77 12,277 177,424
A-type (transient outward) potassium channel activity
2,650.03 5.67 2,787 4,379
synapse
202.21 4.60 21,958 452,146
chemical synaptic transmission
255.06 4.27 5,863 95,711
Totals 299683 5009678
No co-occurrence statistics for GO:0043197 based on MANUAL annotations
The top 100 of 3,001 co-occurring terms
Co-occurring Term PR S% #Together #Compared
dendritic spine
1,285.55 100.00 1,098 1,098
AMPA glutamate receptor activity
1,222.84 17.60 195 205
AMPA glutamate receptor complex
486.62 14.08 201 531
synaptic transmission, glutamatergic
298.53 11.68 209 900
modulation of chemical synaptic transmission
240.43 11.33 245 1,310
postsynaptic density
191.19 10.61 297 1,997
postsynaptic density membrane
222.44 10.49 231 1,335
postsynaptic membrane
206.30 9.97 229 1,427
regulation of dendritic spine morphogenesis
897.46 9.69 111 159
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
210.83 9.57 205 1,250
Totals 7027 72202

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_synapse 357

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:6072 (Eumetazoa)
2022-11-22 Added DEFINITION A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
2022-11-22 Deleted DEFINITION A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
2020-04-06 Added DEFINITION A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
2020-04-06 Deleted DEFINITION A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including "thin", "stubby", "mushroom", and "branched", with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
2019-09-12 Deleted RELATION is a GO:0120038 (obsolete plasma membrane bounded cell projection part)
2017-05-01 Added RELATION is a GO:0120038 (obsolete plasma membrane bounded cell projection part)
2017-05-01 Deleted RELATION is a GO:0044463 (obsolete cell projection part)
2016-03-09 Added SUBSET goslim_synapse
2016-02-04 Added DEFINITION A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including "thin", "stubby", "mushroom", and "branched", with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
Timestamp Action Category Detail
2004-07-31 Added TERM dendritic spine
Timestamp Action Category Detail
2022-11-22 Added DEFINITION A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
2022-11-22 Deleted DEFINITION A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
2020-04-06 Added DEFINITION A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
2020-04-06 Deleted DEFINITION A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including "thin", "stubby", "mushroom", and "branched", with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
2016-02-04 Added DEFINITION A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including "thin", "stubby", "mushroom", and "branched", with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
2016-02-04 Deleted DEFINITION A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically recieving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including "thin", "stubby", "mushroom", and "branched", with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
2016-01-20 Added DEFINITION A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically recieving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including "thin", "stubby", "mushroom", and "branched", with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
2016-01-20 Deleted DEFINITION Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity.
2012-12-23 Added SYNONYM branched dendritic spine
2012-12-23 Added SYNONYM thin dendritic spine
2012-12-23 Added SYNONYM stubby dendritic spine
2012-12-23 Added SYNONYM sessile dendritic spine
2012-12-23 Added SYNONYM mushroom dendritic spine
2010-02-07 Added SYNONYM dendrite spine
2008-05-13 Added DEFINITION Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity.
2008-05-12 Deleted DEFINITION Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity.
2004-07-31 Added DEFINITION Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity.
Timestamp Action Category Detail
2019-09-12 Deleted RELATION is a GO:0120038 (obsolete plasma membrane bounded cell projection part)
2017-05-01 Added RELATION is a GO:0120038 (obsolete plasma membrane bounded cell projection part)
2017-05-01 Deleted RELATION is a GO:0044463 (obsolete cell projection part)
2016-01-20 Deleted RELATION part of GO:0098794 (postsynapse)
2016-01-20 Deleted RELATION is a GO:0044456 (obsolete synapse part)
2016-01-20 Added RELATION is a GO:0098794 (postsynapse)
2015-07-11 Added RELATION part of GO:0098794 (postsynapse)
2015-07-11 Added RELATION is a GO:0044456 (obsolete synapse part)
2010-02-07 Added RELATION is a GO:0044309 (neuron spine)
2008-04-01 Updated RELATION part of GO:0030425 (dendrite)
2008-04-01 Updated RELATION is a GO:0044463 (obsolete cell projection part)
Timestamp Action Category Detail
2010-02-04 Added XREF NIF_Subcellular:sao1799103720
2009-02-25 Added XREF Wikipedia:Dendritic_spine
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:6072 (Eumetazoa)
2016-03-09 Added SUBSET goslim_synapse
2016-01-20 Deleted SUBSET goslim_synapse
2015-08-12 Added SUBSET goslim_synapse
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