GO:0043197
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dendritic spine
Cellular Component
Definition (GO:0043197 GONUTS page)
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
stubby dendritic spine | narrow |
sessile dendritic spine | narrow |
mushroom dendritic spine | narrow |
dendrite spine | exact |
thin dendritic spine | narrow |
branched dendritic spine | narrow |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0043197
Child Term | Relationship to GO:0043197 |
---|---|
thorny excrescence
|
is_a |
dendritic spine head
|
part_of |
dendritic spine neck
|
part_of |
actin cytoskeleton of dendritic spine
|
part_of |
cytoskeleton of dendritic spine
|
part_of |
dendritic spine cytoplasm
|
part_of |
spine apparatus
|
part_of |
dendritic spine membrane
|
part_of |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0043197 | dendritic spine | Only in Taxon | 6072 | Eumetazoa |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A088MLT8 | 10090 | IQIP1_MOUSE | GO:0030425 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18550753 | |
NOT-qualified manual | protein | A0A8I5ZWB0 | 10116 | A0A8I5ZWB0_RAT | GO:0045202 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8J8XYU9 | 10116 | A0A8J8XYU9_RAT | GO:0045202 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6I6C4 | 10116 | A6I6C4_RAT | GO:0045202 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6I6C5 | 10116 | A6I6C5_RAT | GO:0045202 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P05067-PRO_0000000093 | 9606 | A4_HUMAN | GO:0030425 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17251419 | |
NOT-qualified manual | protein | P35353 | 10116 | CRFR1_RAT | GO:0043197 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12911751 | |
NOT-qualified manual | protein | P97479 | 10090 | MYO7A_MOUSE | GO:0045202 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8842737 | |
NOT-qualified manual | protein | Q8CJE3 | 10116 | Q8CJE3_RAT | GO:0045202 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000266, ECO:0000314 from these references: GO_REF:0000096, PMID:8842737 |
Cross-references
Database | ID | Description |
---|---|---|
NIF_Subcellular | sao1799103720 | |
UniProtKB-SubCell | SL-0284 | Dendritic spine |
Wikipedia | Dendritic_spine |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0043197 based on ALL annotations
The top 100 of 3,519 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
dendritic spine
|
4,163.79 | 100.00 | 47,590 | 47,590 |
synaptic receptor adaptor activity
|
3,940.14 | 12.57 | 6,025 | 6,367 |
regulation of dendritic spine morphogenesis
|
2,771.34 | 10.57 | 5,312 | 7,981 |
ionotropic glutamate receptor binding
|
1,225.69 | 9.83 | 6,122 | 20,797 |
postsynaptic density
|
551.16 | 9.45 | 11,811 | 89,228 |
amyloid-beta binding
|
888.29 | 6.41 | 3,996 | 18,731 |
postsynaptic membrane
|
288.12 | 5.77 | 12,277 | 177,424 |
A-type (transient outward) potassium channel activity
|
2,650.03 | 5.67 | 2,787 | 4,379 |
synapse
|
202.21 | 4.60 | 21,958 | 452,146 |
chemical synaptic transmission
|
255.06 | 4.27 | 5,863 | 95,711 |
Totals | 299683 | 5009678 |
No co-occurrence statistics for GO:0043197 based on MANUAL annotations
The top 100 of 3,001 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
dendritic spine
|
1,285.55 | 100.00 | 1,098 | 1,098 |
AMPA glutamate receptor activity
|
1,222.84 | 17.60 | 195 | 205 |
AMPA glutamate receptor complex
|
486.62 | 14.08 | 201 | 531 |
synaptic transmission, glutamatergic
|
298.53 | 11.68 | 209 | 900 |
modulation of chemical synaptic transmission
|
240.43 | 11.33 | 245 | 1,310 |
postsynaptic density
|
191.19 | 10.61 | 297 | 1,997 |
postsynaptic density membrane
|
222.44 | 10.49 | 231 | 1,335 |
postsynaptic membrane
|
206.30 | 9.97 | 229 | 1,427 |
regulation of dendritic spine morphogenesis
|
897.46 | 9.69 | 111 | 159 |
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
|
210.83 | 9.57 | 205 | 1,250 |
Totals | 7027 | 72202 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_synapse | 357 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:6072 (Eumetazoa) |
2022-11-22 | Added | DEFINITION | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
2022-11-22 | Deleted | DEFINITION | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
2020-04-06 | Added | DEFINITION | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
2020-04-06 | Deleted | DEFINITION | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including "thin", "stubby", "mushroom", and "branched", with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
2019-09-12 | Deleted | RELATION | is a GO:0120038 (obsolete plasma membrane bounded cell projection part) |
2017-05-01 | Added | RELATION | is a GO:0120038 (obsolete plasma membrane bounded cell projection part) |
2017-05-01 | Deleted | RELATION | is a GO:0044463 (obsolete cell projection part) |
2016-03-09 | Added | SUBSET | goslim_synapse |
2016-02-04 | Added | DEFINITION | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including "thin", "stubby", "mushroom", and "branched", with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2004-07-31 | Added | TERM | dendritic spine |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-11-22 | Added | DEFINITION | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
2022-11-22 | Deleted | DEFINITION | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
2020-04-06 | Added | DEFINITION | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
2020-04-06 | Deleted | DEFINITION | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including "thin", "stubby", "mushroom", and "branched", with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
2016-02-04 | Added | DEFINITION | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including "thin", "stubby", "mushroom", and "branched", with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
2016-02-04 | Deleted | DEFINITION | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically recieving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including "thin", "stubby", "mushroom", and "branched", with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
2016-01-20 | Added | DEFINITION | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically recieving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including "thin", "stubby", "mushroom", and "branched", with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
2016-01-20 | Deleted | DEFINITION | Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity. |
2012-12-23 | Added | SYNONYM | branched dendritic spine |
2012-12-23 | Added | SYNONYM | thin dendritic spine |
2012-12-23 | Added | SYNONYM | stubby dendritic spine |
2012-12-23 | Added | SYNONYM | sessile dendritic spine |
2012-12-23 | Added | SYNONYM | mushroom dendritic spine |
2010-02-07 | Added | SYNONYM | dendrite spine |
2008-05-13 | Added | DEFINITION | Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity. |
2008-05-12 | Deleted | DEFINITION | Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity. |
2004-07-31 | Added | DEFINITION | Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-09-12 | Deleted | RELATION | is a GO:0120038 (obsolete plasma membrane bounded cell projection part) |
2017-05-01 | Added | RELATION | is a GO:0120038 (obsolete plasma membrane bounded cell projection part) |
2017-05-01 | Deleted | RELATION | is a GO:0044463 (obsolete cell projection part) |
2016-01-20 | Deleted | RELATION | part of GO:0098794 (postsynapse) |
2016-01-20 | Deleted | RELATION | is a GO:0044456 (obsolete synapse part) |
2016-01-20 | Added | RELATION | is a GO:0098794 (postsynapse) |
2015-07-11 | Added | RELATION | part of GO:0098794 (postsynapse) |
2015-07-11 | Added | RELATION | is a GO:0044456 (obsolete synapse part) |
2010-02-07 | Added | RELATION | is a GO:0044309 (neuron spine) |
2008-04-01 | Updated | RELATION | part of GO:0030425 (dendrite) |
2008-04-01 | Updated | RELATION | is a GO:0044463 (obsolete cell projection part) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-02-04 | Added | XREF | NIF_Subcellular:sao1799103720 |
2009-02-25 | Added | XREF | Wikipedia:Dendritic_spine |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:6072 (Eumetazoa) |
2016-03-09 | Added | SUBSET | goslim_synapse |
2016-01-20 | Deleted | SUBSET | goslim_synapse |
2015-08-12 | Added | SUBSET | goslim_synapse |
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