GO:0044022
JSON
histone H3S28 kinase activity
Molecular Function
Definition (GO:0044022 GONUTS page)
Catalysis of the reaction: histone H3-serine (position 28) + ATP = histone H3-phosphoserine (position 28) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 28 of histone H3.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
| Synonym | Type |
|---|---|
| histone kinase activity (H3-S28 specific) | exact |
| histone-serine kinase activity (H3-S28 specific) | exact |
| histone serine kinase activity (H3-S28 specific) | exact |
Ancestor Chart
Ancestor chart for GO:0044022
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
| Annotating to catalytic activities using the IPI evidence code | Link |
| Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
| Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
|---|---|---|---|---|---|---|---|
| IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
| NOT-qualified manual | protein | A0A0B4K7S5 | 7227 | A0A0B4K7S5_DROME | GO:0004672 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514 | |
| NOT-qualified manual | protein | A0A126GUQ5 | 7227 | A0A126GUQ5_DROME | GO:0004672 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514 | |
| NOT-qualified manual | protein | A0A1L8END5 | 8355 | A0A1L8END5_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | A0A1L8EV37 | 8355 | A0A1L8EV37_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | A0A1L8GLD7 | 8355 | A0A1L8GLD7_XENLA | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | A0A287AG10 | 9823 | A0A287AG10_PIG | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | A0A2I2UNM6 | 9685 | A0A2I2UNM6_FELCA | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | A0A2K5VFW3 | 9541 | A0A2K5VFW3_MACFA | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18508765 | |
| NOT-qualified manual | protein | A0A3B3IMS5 | 8090 | A0A3B3IMS5_ORYLA | GO:0004674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
| Database | ID | Description |
|---|---|---|
| EC | 2.7.11.1 |
Replaces
This term can be used instead of these obsolete terms:
| GO Identifier | GO Term Name | Reason |
|---|---|---|
| GO:0043988 | obsolete histone H3-S28 phosphorylation | consider GO:0044022 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0044022 based on ALL annotations
The top 100 of 5,109 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
histone H3S28 kinase activity
|
648.27 | 100.00 | 305,668 | 305,668 |
|
histone H2AS1 kinase activity
|
648.27 | 99.98 | 305,611 | 305,611 |
|
histone H3S57 kinase activity
|
648.27 | 99.97 | 305,570 | 305,570 |
|
histone H4S1 kinase activity
|
648.27 | 99.97 | 305,570 | 305,570 |
|
histone H2AS121 kinase activity
|
648.26 | 99.97 | 305,570 | 305,573 |
|
histone H2BS14 kinase activity
|
648.25 | 99.97 | 305,570 | 305,579 |
|
3-phosphoinositide-dependent protein kinase activity
|
648.17 | 99.95 | 305,570 | 305,614 |
|
histone H3S10 kinase activity
|
647.98 | 99.95 | 305,646 | 305,781 |
|
histone H2AXS139 kinase activity
|
648.06 | 99.94 | 305,570 | 305,670 |
|
histone H3T45 kinase activity
|
648.05 | 99.93 | 305,570 | 305,672 |
| Totals | 7407126 | 44133362 | ||
No co-occurrence statistics for GO:0044022 based on MANUAL annotations
The top 72 of 72 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
histone H3S28 kinase activity
|
100,823.79 | 100.00 | 14 | 14 |
|
histone H2AS1 kinase activity
|
88,220.81 | 46.67 | 7 | 8 |
|
histone H3S10 kinase activity
|
41,720.19 | 38.71 | 12 | 29 |
|
positive regulation of mitotic sister chromatid segregation
|
13,443.17 | 7.41 | 2 | 15 |
|
repair of mitotic kinetochore microtubule attachment defect
|
12,602.97 | 7.14 | 2 | 16 |
|
interleukin-1-mediated signaling pathway
|
7,089.17 | 6.77 | 9 | 128 |
|
positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore
|
50,411.90 | 6.67 | 1 | 2 |
|
post-translational protein modification
|
6,068.10 | 5.99 | 13 | 216 |
|
positive regulation of CREB transcription factor activity
|
7,468.43 | 5.13 | 2 | 27 |
|
cell cycle G2/M phase transition
|
8,401.98 | 4.00 | 1 | 12 |
| Totals | 266 | 714391 | ||
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-08-16 | Added | XREF | EC:2.7.11.1 |
| 2023-05-16 | Added | RELATION | is a GO:0004674 (protein serine/threonine kinase activity) |
| 2023-03-06 | Added | DEFINITION | Catalysis of the reaction: histone H3-serine (position 28) + ATP = histone H3-phosphoserine (position 28) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 28 of histone H3. |
| 2023-03-06 | Deleted | DEFINITION | Catalysis of the reaction: (histone H3)-serine (position 28) + ATP = (histone H3-phosphoserine (position 28) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 28 of histone H3. |
| 2023-02-28 | Added | RELATION | is a GO:0140996 (histone H3 kinase activity) |
| 2023-02-28 | Deleted | RELATION | is a GO:0035174 (obsolete histone serine kinase activity) |
| 2023-01-18 | Added | DEFINITION | Catalysis of the reaction: (histone H3)-serine (position 28) + ATP = (histone H3-phosphoserine (position 28) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 28 of histone H3. |
| 2023-01-18 | Deleted | DEFINITION | Catalysis of the transfer of a phosphate group to the serine-28 residue of histone H3. |
| 2022-07-18 | Updated | TERM | histone H3S28 kinase activity |
| 2022-07-18 | Added | SYNONYM | histone kinase activity (H3-S28 specific) |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2022-07-18 | Updated | TERM | histone H3S28 kinase activity |
| 2009-01-31 | Added | TERM | histone kinase activity (H3-S28 specific) |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2023-03-06 | Added | DEFINITION | Catalysis of the reaction: histone H3-serine (position 28) + ATP = histone H3-phosphoserine (position 28) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 28 of histone H3. |
| 2023-03-06 | Deleted | DEFINITION | Catalysis of the reaction: (histone H3)-serine (position 28) + ATP = (histone H3-phosphoserine (position 28) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 28 of histone H3. |
| 2023-01-18 | Added | DEFINITION | Catalysis of the reaction: (histone H3)-serine (position 28) + ATP = (histone H3-phosphoserine (position 28) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 28 of histone H3. |
| 2023-01-18 | Deleted | DEFINITION | Catalysis of the transfer of a phosphate group to the serine-28 residue of histone H3. |
| 2022-07-18 | Added | SYNONYM | histone kinase activity (H3-S28 specific) |
| 2022-06-20 | Deleted | DEFINITION | Catalysis of the transfer of a phosphate group to the serine-28 residue of the N-terminal tail of histone H3. |
| 2022-06-20 | Added | DEFINITION | Catalysis of the transfer of a phosphate group to the serine-28 residue of histone H3. |
| 2009-01-31 | Added | SYNONYM | histone serine kinase activity (H3-S28 specific) |
| 2009-01-31 | Added | SYNONYM | histone-serine kinase activity (H3-S28 specific) |
| 2009-01-31 | Added | DEFINITION | Catalysis of the transfer of a phosphate group to the serine-28 residue of the N-terminal tail of histone H3. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2023-05-16 | Added | RELATION | is a GO:0004674 (protein serine/threonine kinase activity) |
| 2023-02-28 | Added | RELATION | is a GO:0140996 (histone H3 kinase activity) |
| 2023-02-28 | Deleted | RELATION | is a GO:0035174 (obsolete histone serine kinase activity) |
| 2022-05-26 | Deleted | RELATION | part of GO:0043988 (obsolete histone H3-S28 phosphorylation) |
| 2010-06-15 | Added | RELATION | part of GO:0043988 (obsolete histone H3-S28 phosphorylation) |
| 2010-06-14 | Deleted | RELATION | part of GO:0043988 (obsolete histone H3-S28 phosphorylation) |
| 2010-06-08 | Added | RELATION | part of GO:0043988 (obsolete histone H3-S28 phosphorylation) |
| 2009-01-31 | Added | RELATION | is a GO:0035174 (obsolete histone serine kinase activity) |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-08-16 | Added | XREF | EC:2.7.11.1 |
| Timestamp | Action | Category | Detail |
|---|
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