GO:0045576
JSON
mast cell activation
Biological Process
Definition (GO:0045576 GONUTS page)
The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors.
Ancestor Chart
Ancestor chart for GO:0045576
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0045576
| Child Term | Relationship to GO:0045576 |
|---|---|
|
positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway
|
positively_regulates |
|
negative regulation of mast cell activation
|
negatively_regulates |
|
positive regulation of mast cell activation
|
positively_regulates |
|
mast cell activation involved in immune response
|
is_a |
|
regulation of mast cell activation
|
regulates |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
| Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
|---|---|---|---|---|---|
| GO:0045576 | mast cell activation | Only in Taxon | 7742 | Vertebrata |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
| Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
|---|---|---|---|---|---|---|---|
| NOT-qualified manual | protein | D3ZIE4 | 10116 | FYB1_RAT | GO:0045576 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | O35601 | 10090 | FYB1_MOUSE | GO:0045576 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:15153494 | |
| NOT-qualified manual | protein | P08101 | 10090 | FCGR2_MOUSE | GO:0045576 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8769481 | |
| NOT-qualified manual | protein | P31994 | 9606 | FCG2B_HUMAN | GO:0045576 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: PMID:26683154 | |
| NOT-qualified manual | protein | Q63203 | 10116 | FCGR2_RAT | GO:0045576 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-Ontology Relations
| Relation | Other Ontology | ID | Term |
|---|---|---|---|
| has_primary_input | CL | CL:0000097 | mast cell |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0045576 based on ALL annotations
The top 100 of 493 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
mast cell activation
|
486,866.97 | 100.00 | 407 | 407 |
|
TCR signalosome
|
410,230.56 | 21.46 | 91 | 108 |
|
positive regulation of dense core granule biogenesis
|
457,886.80 | 19.17 | 79 | 84 |
|
mast cell chemotaxis
|
223,147.36 | 17.22 | 88 | 192 |
|
negative regulation of catecholamine secretion
|
43,059.59 | 6.70 | 88 | 995 |
|
adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation
|
40,619.26 | 6.01 | 72 | 863 |
|
protein localization to secretory granule
|
34,197.68 | 5.38 | 76 | 1,082 |
|
mast cell degranulation
|
29,250.29 | 5.14 | 107 | 1,781 |
|
peripheral nervous system myelin maintenance
|
29,018.56 | 4.93 | 90 | 1,510 |
|
positive regulation of T cell differentiation
|
23,936.19 | 4.25 | 97 | 1,973 |
| Totals | 2852 | 246261 | ||
No co-occurrence statistics for GO:0045576 based on MANUAL annotations
The top 100 of 450 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
mast cell activation
|
27,144.86 | 100.00 | 52 | 52 |
|
mast cell secretagogue receptor activity
|
27,144.87 | 21.15 | 11 | 11 |
|
mast cell degranulation
|
5,428.97 | 14.84 | 19 | 95 |
|
transmembrane receptor protein tyrosine kinase inhibitor activity
|
23,751.76 | 13.21 | 7 | 8 |
|
negative regulation of cytotoxic T cell differentiation
|
23,751.76 | 13.21 | 7 | 8 |
|
negative regulation of T cell costimulation
|
21,112.68 | 12.96 | 7 | 9 |
|
negative regulation of IP-10 production
|
14,616.47 | 12.07 | 7 | 13 |
|
negative regulation of monocyte activation
|
11,875.88 | 11.48 | 7 | 16 |
|
TCR signalosome
|
20,358.65 | 11.11 | 6 | 8 |
|
Fc receptor mediated inhibitory signaling pathway
|
10,556.34 | 11.11 | 7 | 18 |
| Totals | 486 | 5476 | ||
Change Log
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| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:7742 (Vertebrata) |
| 2008-05-13 | Added | DEFINITION | The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors. |
| 2008-05-12 | Deleted | DEFINITION | The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors. |
| 2008-04-01 | Updated | RELATION | is a GO:0002274 (myeloid leukocyte activation) |
| 2003-11-11 | Updated | DEFINITION | The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors. |
| 2002-11-27 | Added | DEFINITION | The change in morphology and behavior of mast cells resulting from exposure to a mitogen or to an antigen to which they have been primed. |
| 2002-08-14 | Added | TERM | mast cell activation |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2002-08-14 | Added | TERM | mast cell activation |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2008-05-13 | Added | DEFINITION | The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors. |
| 2008-05-12 | Deleted | DEFINITION | The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors. |
| 2003-11-11 | Updated | DEFINITION | The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors. |
| 2002-11-27 | Added | DEFINITION | The change in morphology and behavior of mast cells resulting from exposure to a mitogen or to an antigen to which they have been primed. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2008-04-01 | Updated | RELATION | is a GO:0002274 (myeloid leukocyte activation) |
| Timestamp | Action | Category | Detail |
|---|
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:7742 (Vertebrata) |
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