GO:0046982
JSON
protein heterodimerization activity
Molecular Function
Definition (GO:0046982 GONUTS page)
Binding to a nonidentical protein to form a heterodimer.
Ancestor Chart
Ancestor chart for GO:0046982
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Binding term considerations | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | P21333-1 | 9606 | FLNA_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 | |
NOT-qualified manual | protein | P63026 | 9913 | VAMP2_BOVIN | GO:0005515 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699 | |
NOT-qualified manual | protein | Q792S6-2 | 10116 | BOK_RAT | GO:0046982 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9804769 | |
NOT-qualified manual | protein | Q86V48 | 9606 | LUZP1_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 | |
NOT-qualified manual | protein | Q9FKA0 | 3702 | NAC92_ARATH | GO:0046982 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:16359384 | |
NOT-qualified manual | protein | Q9LJW3 | 3702 | NAC59_ARATH | GO:0046982 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:16359384 | |
NOT-qualified manual | protein | Q9R0N8-2 | 10090 | SYT6_MOUSE | GO:0046982 | 3 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:10531344 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR009072 | Histone-fold |
InterPro | IPR029387 | Organic solute transporter subunit beta |
InterPro | IPR037606 | Diacylglycerol kinase delta, SAM domain |
InterPro | IPR037933 | Protein max-like |
InterPro | IPR039127 | Multifunctional methyltransferase subunit Trm112 |
InterPro | IPR042974 | Junctional adhesion molecule C |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0046982 based on ALL annotations
The top 100 of 6,184 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein heterodimerization activity
|
761.21 | 100.00 | 260,315 | 260,315 |
nucleosome
|
586.72 | 41.01 | 121,573 | 157,730 |
structural constituent of chromatin
|
364.58 | 30.99 | 121,686 | 254,071 |
transcription factor TFIID complex
|
380.12 | 11.13 | 32,619 | 65,322 |
RNA polymerase II general transcription initiation factor activity
|
294.51 | 8.46 | 25,422 | 65,708 |
chromosome
|
77.86 | 8.44 | 84,820 | 829,301 |
RNA polymerase II preinitiation complex assembly
|
431.46 | 8.29 | 23,043 | 40,654 |
SAGA complex
|
252.55 | 6.27 | 18,697 | 56,355 |
CCAAT-binding factor complex
|
528.29 | 5.20 | 13,865 | 19,978 |
transcription initiation at RNA polymerase II promoter
|
131.49 | 4.93 | 16,800 | 97,260 |
Totals | 1494186 | 49475040 |
No co-occurrence statistics for GO:0046982 based on MANUAL annotations
The top 100 of 4,299 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein heterodimerization activity
|
986.40 | 100.00 | 1,431 | 1,431 |
protein homodimerization activity
|
98.92 | 8.56 | 527 | 5,255 |
neuron development
|
153.98 | 5.11 | 101 | 647 |
cell adhesion molecule binding
|
77.00 | 3.83 | 100 | 1,281 |
response to xenobiotic stimulus
|
66.29 | 3.21 | 83 | 1,235 |
E-box binding
|
80.73 | 2.69 | 55 | 672 |
DNA-binding transcription activator activity, RNA polymerase II-specific
|
35.08 | 2.64 | 133 | 3,740 |
sequence-specific double-stranded DNA binding
|
40.85 | 2.53 | 87 | 2,101 |
identical protein binding
|
28.14 | 2.52 | 252 | 8,833 |
transcription regulator complex
|
32.86 | 2.48 | 127 | 3,812 |
Totals | 7109 | 212678 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_chembl | 296 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Added | DEFINITION | Binding to a nonidentical protein to form a heterodimer. |
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer. |
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
2009-07-03 | Added | DEFINITION | Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer. |
2009-07-03 | Deleted | DEFINITION | Interacting selectively with a nonidentical protein to form a heterodimer. |
2008-05-13 | Added | DEFINITION | Interacting selectively with a nonidentical protein to form a heterodimer. |
2008-05-12 | Deleted | DEFINITION | Interacting selectively with a nonidentical protein to form a heterodimer. |
2008-04-01 | Updated | RELATION | is a GO:0046983 (protein dimerization activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-07-31 | Updated | TERM | protein heterodimerization activity |
2003-07-30 | Added | TERM | heterodimerization activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Added | DEFINITION | Binding to a nonidentical protein to form a heterodimer. |
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer. |
2009-07-03 | Added | DEFINITION | Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer. |
2009-07-03 | Deleted | DEFINITION | Interacting selectively with a nonidentical protein to form a heterodimer. |
2008-05-13 | Added | DEFINITION | Interacting selectively with a nonidentical protein to form a heterodimer. |
2008-05-12 | Deleted | DEFINITION | Interacting selectively with a nonidentical protein to form a heterodimer. |
2003-07-30 | Added | DEFINITION | Interacting selectively with a nonidentical protein to form a heterodimer. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0046983 (protein dimerization activity) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
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