This term is obsolete.

GO:0046982 JSON

protein heterodimerization activity

Molecular Function

Definition (GO:0046982 GONUTS page)

Binding to a nonidentical protein to form a heterodimer.

260,893 annotations

Ancestor Chart

Ancestor chart for GO:0046982
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P21333-1 9606 FLNA_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684
NOT-qualified manual protein P63026 9913 VAMP2_BOVIN GO:0005515 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699
NOT-qualified manual protein Q792S6-2 10116 BOK_RAT GO:0046982 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9804769
NOT-qualified manual protein Q86V48 9606 LUZP1_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684
NOT-qualified manual protein Q9FKA0 3702 NAC92_ARATH GO:0046982 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:16359384
NOT-qualified manual protein Q9LJW3 3702 NAC59_ARATH GO:0046982 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:16359384
NOT-qualified manual protein Q9R0N8-2 10090 SYT6_MOUSE GO:0046982 3 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:10531344

Cross-references

Database ID Description
InterPro IPR009072 Histone-fold
InterPro IPR029387 Organic solute transporter subunit beta
InterPro IPR037606 Diacylglycerol kinase delta, SAM domain
InterPro IPR037933 Protein max-like
InterPro IPR039127 Multifunctional methyltransferase subunit Trm112
InterPro IPR042974 Junctional adhesion molecule C

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0046982 based on ALL annotations
The top 100 of 6,184 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein heterodimerization activity
761.21 100.00 260,315 260,315
nucleosome
586.72 41.01 121,573 157,730
structural constituent of chromatin
364.58 30.99 121,686 254,071
transcription factor TFIID complex
380.12 11.13 32,619 65,322
RNA polymerase II general transcription initiation factor activity
294.51 8.46 25,422 65,708
chromosome
77.86 8.44 84,820 829,301
RNA polymerase II preinitiation complex assembly
431.46 8.29 23,043 40,654
SAGA complex
252.55 6.27 18,697 56,355
CCAAT-binding factor complex
528.29 5.20 13,865 19,978
transcription initiation at RNA polymerase II promoter
131.49 4.93 16,800 97,260
Totals 1494186 49475040
No co-occurrence statistics for GO:0046982 based on MANUAL annotations
The top 100 of 4,299 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein heterodimerization activity
986.40 100.00 1,431 1,431
protein homodimerization activity
98.92 8.56 527 5,255
neuron development
153.98 5.11 101 647
cell adhesion molecule binding
77.00 3.83 100 1,281
response to xenobiotic stimulus
66.29 3.21 83 1,235
E-box binding
80.73 2.69 55 672
DNA-binding transcription activator activity, RNA polymerase II-specific
35.08 2.64 133 3,740
sequence-specific double-stranded DNA binding
40.85 2.53 87 2,101
identical protein binding
28.14 2.52 252 8,833
transcription regulator complex
32.86 2.48 127 3,812
Totals 7109 212678

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_chembl 296

Change Log

Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to a nonidentical protein to form a heterodimer.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-19 Added SUBSET goslim_chembl
2015-05-11 Added SUBSET goslim_ChEMBL
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2009-07-03 Deleted DEFINITION Interacting selectively with a nonidentical protein to form a heterodimer.
2008-05-13 Added DEFINITION Interacting selectively with a nonidentical protein to form a heterodimer.
2008-05-12 Deleted DEFINITION Interacting selectively with a nonidentical protein to form a heterodimer.
2008-04-01 Updated RELATION is a GO:0046983 (protein dimerization activity)
Timestamp Action Category Detail
2003-07-31 Updated TERM protein heterodimerization activity
2003-07-30 Added TERM heterodimerization activity
Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to a nonidentical protein to form a heterodimer.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2009-07-03 Deleted DEFINITION Interacting selectively with a nonidentical protein to form a heterodimer.
2008-05-13 Added DEFINITION Interacting selectively with a nonidentical protein to form a heterodimer.
2008-05-12 Deleted DEFINITION Interacting selectively with a nonidentical protein to form a heterodimer.
2003-07-30 Added DEFINITION Interacting selectively with a nonidentical protein to form a heterodimer.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0046983 (protein dimerization activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-19 Added SUBSET goslim_chembl
2015-05-11 Added SUBSET goslim_ChEMBL
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